{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:33:27Z","timestamp":1777894407965,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jchromb.2026.124993","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:13:52Z","timestamp":1772093632000},"page":"124993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Elucidating the molecular basis of Salvia miltiorrhiza Salvianolic acids and Tanshinones in treating ischemic stroke: A multidimensional strategy of in vivo Chemomics, targeted network pharmacology, and metabolomics"],"prefix":"10.1016","volume":"1275","author":[{"given":"Rongjin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoufang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junpeng","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2026.124993_bb0005","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jep.2016.04.060","article-title":"Neuroprotective effects of Danggui-Jakyak-san on rat stroke model through antioxidant\/antiapoptotic pathway","volume":"188","author":"Kim","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2026.124993_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112719","article-title":"Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: applications for natural compounds from medicinal herbs","volume":"148","author":"Zhu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jchromb.2026.124993_bb0015","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1161\/STROKEAHA.122.039005","article-title":"Focused update on stroke Neuroimmunology: current Progress in preclinical and clinical research and recent mechanistic insight","volume":"53","author":"Boltze","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.jchromb.2026.124993_bb0020","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities","volume":"53","author":"Candelario-Jalil","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.jchromb.2026.124993_bb0025","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/aps.2017.193","article-title":"Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jchromb.2026.124993_bb0030","doi-asserted-by":"crossref","first-page":"1108518","DOI":"10.3389\/fphar.2023.1108518","article-title":"Network pharmacology and experimental study of phenolic acids in salvia miltiorrhiza bung in preventing ischemic stroke","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.124993_bb0035","article-title":"Salvia miltiorrhiza alleviates memory deficit induced by ischemic brain injury in a transient MCAO mouse model by inhibiting Ferroptosis","volume":"12","author":"Ko","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jchromb.2026.124993_bb0040","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2174\/0113895575299721240227070032","article-title":"Tanshinone IIA against cerebral ischemic stroke and ischemia- reperfusion injury: a review of the current documents","volume":"24","author":"Arefnezhad","year":"2024","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.jchromb.2026.124993_bb0045","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1142\/S0192415X22500781","article-title":"Tanshinone IIA microemulsion protects against cerebral ischemia reperfusion injury via regulating H3K18ac and H4K8ac in vivo and in vitro","volume":"50","author":"Ma","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jchromb.2026.124993_bb0050","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1039\/D2FO02842E","article-title":"An integrated study on the comprehensive mechanism of Schisandra chinensis polysaccharides mitigating Alzheimer's disease in rats using a UPLC-Q-TOF-MS based serum and urine metabolomics strategy","volume":"14","author":"Fu","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.jchromb.2026.124993_bb0055","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1002\/jssc.202100310","article-title":"Chemical profiling of Zilong Jin tablets using ultra high performance liquid chromatography-quadrupole\/orbitrap high resolution mass spectrometry","volume":"44","author":"Kang","year":"2021","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jchromb.2026.124993_bb0060","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1002\/jssc.202200267","article-title":"A multidimensional strategy to rapidly identify the chemical constituents in Shengxian decoction by using ultra-performance liquid chromatography coupled with ion mobility spectrometry quadrupole time-of-flight mass spectrometry","volume":"45","author":"Wang","year":"2022","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jchromb.2026.124993_bb0065","article-title":"Network pharmacology to unveil the mechanism of Moluodan in the treatment of chronic atrophic gastritis","volume":"95","author":"Zhou","year":"2022","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.jchromb.2026.124993_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112823","article-title":"Protective effect of total Saponins from American ginseng against cigarette smoke-induced COPD in mice based on integrated metabolomics and network pharmacology","volume":"149","author":"Lin","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jchromb.2026.124993_bb0075","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1021\/acs.jproteome.6b00779","article-title":"Discovery of metabolite biomarkers for acute ischemic stroke progression","volume":"16","author":"Liu","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jchromb.2026.124993_bb0080","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/joim.12117","article-title":"Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: tools for individualized medicine","volume":"274","author":"Halama","year":"2013","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jchromb.2026.124993_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119822","article-title":"To establish a new quality assessment method based on the regulation of intestinal microbiota in type 2 diabetes by lignans of Schisandra chinensis (Turcz.) Baill","volume":"348","author":"Shi","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2026.124993_bb0090","article-title":"Salvia miltiorrhiza Bge. Processed with porcine cardiac blood inhibited GLRX5-mediated ferroptosis alleviating cerebral ischemia-reperfusion injury","volume":"129","author":"Zhou","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.jchromb.2026.124993_bb0095","doi-asserted-by":"crossref","first-page":"1431692","DOI":"10.3389\/fphar.2024.1431692","article-title":"Combining systems pharmacology, metabolomics, and transcriptomics to reveal the mechanism of Salvia miltiorrhiza-cortex moutan herb pair for the treatment of ischemic stroke","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.124993_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116698","article-title":"Porcine cardiac blood - Salvia miltiorrhiza root alleviates cerebral ischemia reperfusion injury by inhibiting oxidative stress induced apoptosis through PI3K\/AKT\/Bcl-2\/Bax signaling pathway","volume":"316","author":"Zhou","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2026.124993_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177164","article-title":"Bruceine a attenuates fibrogenesis and inflammation through NR2F2-regulated HMGB1 inflammatory signaling cascades in hepatic fibrosis","volume":"987","author":"Sun","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.124993_bb0110","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","article-title":"Neuroinflammation: friend and foe for ischemic stroke","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jchromb.2026.124993_bb0115","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/pros.22779","article-title":"Serum levels of arachidonic acid metabolites change during prostate cancer progression","volume":"74","author":"Rodr\u00edguez-Blanco","year":"2014","journal-title":"Prostate"},{"key":"10.1016\/j.jchromb.2026.124993_bb0120","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s13311-019-00787-4","article-title":"Early and sustained increases in leukotriene B(4) levels are associated with poor clinical outcome in ischemic stroke patients","volume":"17","author":"Chan","year":"2020","journal-title":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics"},{"key":"10.1016\/j.jchromb.2026.124993_bb0125","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbi.2024.02.030","article-title":"Neopterin, kynurenine metabolites, and indexes related to vitamin B6 are associated with post-stroke cognitive impairment: the nor-COAST study","volume":"118","author":"Sandvig","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jchromb.2026.124993_bb0130","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nrd3793","article-title":"Kynurenines in the CNS: recent advances and new questions","volume":"12","author":"V\u00e9csei","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jchromb.2026.124993_bb0135","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.2174\/1381612822666151214125950","article-title":"The kynurenine pathway in the acute and chronic phases of cerebral ischemia","volume":"22","author":"Cuartero","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jchromb.2026.124993_bb0140","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1111\/j.1460-9568.2007.05838.x","article-title":"Altered kynurenine metabolism correlates with infarct volume in stroke","volume":"26","author":"Darlington","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jchromb.2026.124993_bb0145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1468-1331.2006.01220.x","article-title":"Tryptophan metabolism and oxidative stress in patients with chronic brain injury","volume":"13","author":"Mackay","year":"2006","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jchromb.2026.124993_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plefa.2018.12.001","article-title":"Lowering the linoleic acid to alpha-linoleic acid ratio decreases the production of inflammatory mediators by cultured human endothelial cells","volume":"141","author":"Bork","year":"2019","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.jchromb.2026.124993_bb0155","article-title":"Amino acid signature of oxidative stress in patients with type 2 diabetes: targeted exploratory metabolomic research","volume":"10","author":"Bala","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jchromb.2026.124993_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108815","article-title":"Metabolomic study of the protective effect of Gandi capsule for diabetic nephropathy","volume":"314","author":"Liu","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jchromb.2026.124993_bb0165","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12031-015-0659-6","article-title":"Serum phenylalanine, tyrosine, and their ratio in acute ischemic stroke: on the trail of a biomarker?","volume":"58","author":"Ormstad","year":"2016","journal-title":"Journal of molecular neuroscience : MN"},{"key":"10.1016\/j.jchromb.2026.124993_bb0170","unstructured":"S.I. Alaqel, A. Khan, M.N. Alanazi, N. Nayeem, H.B. Khaled, M. Imran, Integrative transcriptomic and structural analysis identifies PTGS2 as a key target in ischemic stroke associated with neuroinflammation, Mol. Divers., DOI https:\/\/doi.org\/10.1007\/s11030-025-11244-0(2025)."},{"key":"10.1016\/j.jchromb.2026.124993_bb0175","article-title":"Embelin improves alcoholic steatohepatitis in alcohol-associated liver disease via ATF6-mediated P2X7r-NLRP3 signaling pathway","volume":"140","author":"Zhang","year":"2025","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.jchromb.2026.124993_bb0180","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.phrs.2016.07.038","article-title":"Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases","volume":"111","author":"Roskoski","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jchromb.2026.124993_bb0185","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4103\/1673-5374.198992","article-title":"Inhibition of cerebral ischemia\/reperfusion injury-induced apoptosis: nicotiflorin and JAK2\/STAT3 pathway","volume":"12","author":"Hu","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jchromb.2026.124993_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.714943","article-title":"Janus kinase inhibition ameliorates ischemic stroke injury and Neuroinflammation through reducing NLRP3 Inflammasome activation via JAK2\/STAT3 pathway inhibition","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jchromb.2026.124993_bb0195","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1471-4159.2011.07446.x","article-title":"Blocking epidermal growth factor receptor attenuates reactive astrogliosis through inhibiting cell cycle progression and protects against ischemic brain injury in rats","volume":"119","author":"Yang","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jchromb.2026.124993_bb0200","doi-asserted-by":"crossref","DOI":"10.1177\/1759091415602463","article-title":"Crosstalk between MAPK\/ERK and PI3K\/AKT signal pathways during brain ischemia\/reperfusion","volume":"7","author":"Zhou","year":"2015","journal-title":"ASN Neuro"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226000826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226000826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:19:37Z","timestamp":1777619977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226000826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":40,"alternative-id":["S1570023226000826"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.124993","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating the molecular basis of Salvia miltiorrhiza Salvianolic acids and Tanshinones in treating ischemic stroke: A multidimensional strategy of in vivo Chemomics, targeted network pharmacology, and metabolomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.124993","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124993"}}