{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:18:46Z","timestamp":1793031526828,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016589","name":"Tokyo Metropolitan Institute of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K10098"],"award-info":[{"award-number":["25K10098"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K06780"],"award-info":[{"award-number":["22K06780"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jchromb.2026.125030","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T15:52:36Z","timestamp":1774194756000},"page":"125030","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A simple HPLC method for selective determination of hydrogen sulfide and bound sulfane sulfur in human plasma"],"prefix":"10.1016","volume":"1276","author":[{"given":"Kaho","family":"Arai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Kayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2026.125030_bb0005","series-title":"Enzymatic Basis of Detoxication","first-page":"245","article-title":"Rhodanese and the sulfane pool","volume":"2","author":"Westley","year":"1980"},{"key":"10.1016\/j.jchromb.2026.125030_bb0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.nu.06.070186.001143","article-title":"Metabolism of sulfur-containing amino acids","volume":"6","author":"Stipanuk","year":"1986","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.jchromb.2026.125030_bb0015","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/abio.1993.1556","article-title":"Determination of bound sulfur in serum by gas dialysis\/high-performance liquid chromatography","volume":"215","author":"Ogasawara","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jchromb.2026.125030_bb0020","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1039\/an9911601359","article-title":"Determination of trace amounts of sulphide in human red blood cells by high-performance liquid chromatography with fluorimetric detection after derivatization with p-phenylenediamine and iron (III)","volume":"116","author":"Ogasawara","year":"1991","journal-title":"Analyst"},{"key":"10.1016\/j.jchromb.2026.125030_bb0025","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1248\/cpb.40.3000","article-title":"High performance liquid chromatographic determination of bound sulfide and sulfite and thiosulfate at their low levels in human serum by pre-column fluorescence derivatization with monobromobimane","volume":"11","author":"Togawa","year":"1992","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.jchromb.2026.125030_bb0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0076-6879(87)43009-7","article-title":"Sulfane sulfur","volume":"143","author":"Wood","year":"1987","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jchromb.2026.125030_bb0035","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1248\/bpb.17.1535","article-title":"Tissue and subcellular distribution of bound and acid-labile sulfur, and the enzymic capacity for sulfide production in the rat","volume":"17","author":"Ogasawara","year":"1994","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jchromb.2026.125030_bb0040","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jchromb.2026.125030_bb0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/bs.mie.2014.11.036","article-title":"Mechanistic chemical perspective of hydrogen sulfide signaling","volume":"554","author":"Nagy","year":"2015","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jchromb.2026.125030_bb0050","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1039\/C4CS00298A","article-title":"Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems","volume":"44","author":"Lin","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jchromb.2026.125030_bb0055","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/antiox12030590","article-title":"Organelle-targeted fluorescent probes for sulfane sulfur species","volume":"12","author":"Roy","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jchromb.2026.125030_bb0060","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.redox.2017.03.020","article-title":"Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation","volume":"12","author":"Koike","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.jchromb.2026.125030_bb0065","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj2640625","article-title":"Sulphane Sulphur in biological systems: a possible regulatory role","volume":"264","author":"Toohey","year":"1989","journal-title":"Biochem. J."},{"key":"10.1016\/j.jchromb.2026.125030_bb0070","first-page":"201","article-title":"Mammalian cyanide detoxification with sulphane sulphur","volume":"140","author":"Westley","year":"1988","journal-title":"Ciba Found. Symp."},{"key":"10.1016\/j.jchromb.2026.125030_bb0075","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.freeradbiomed.2011.01.025","article-title":"Measurement of plasma hydrogen sulfide in vivo and in vitro","volume":"50","author":"Shen","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jchromb.2026.125030_bb0080","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.redox.2018.01.007","article-title":"Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease","volume":"15","author":"Rajpal","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.jchromb.2026.125030_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102633","article-title":"Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias","volume":"62","author":"Reekes","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.jchromb.2026.125030_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102517","article-title":"Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H2S homeostasis","volume":"58","author":"Ko\u017eich","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.jchromb.2026.125030_bb0095","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.3390\/jcm10194460","article-title":"Circulating hydrogen sulfide (H2S) and nitric oxide (NO) levels are significantly reduced in HIV patients concomitant with increased oxidative stress biomarkers","volume":"10","author":"Islam","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jchromb.2026.125030_bb0100","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1038\/s41598-019-39389-7","article-title":"Rapid measurement of hydrogen sulphide in human blood plasma using a microfluidic method","volume":"9","author":"Karunya","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2026.125030_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jare.2019.11.010","article-title":"Point-of-care testing and optimization of sample treatment for fluorometric determination of hydrogen sulphide in plasma of cardiovascular patients","volume":"27","author":"Alyan","year":"2019","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jchromb.2026.125030_bb0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2169\/internalmedicine.56.7403","article-title":"Clinical implication of plasma hydrogen Sulfide levels in Japanese patients with type 2 diabetes","volume":"56","author":"Suzuki","year":"2017","journal-title":"Intern. Med."},{"key":"10.1016\/j.jchromb.2026.125030_bb0115","doi-asserted-by":"crossref","first-page":"R1930","DOI":"10.1152\/ajpregu.00025.2008","article-title":"Reappraisal of H2S\/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling","volume":"294","author":"Whitfield","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jchromb.2026.125030_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152557","article-title":"A HPLC-based methylene blue\/methylene green method for accurate measurement of hydrogen sulfide in plasma","volume":"782","author":"Arif","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jchromb.2026.125030_bb0125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41467-025-66795-5","article-title":"Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples","volume":"17","author":"Miljkovic","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jchromb.2026.125030_bb0130","doi-asserted-by":"crossref","first-page":"30422","DOI":"10.1021\/jacs.4c10266","article-title":"Simultaneous quantitation of persulfides, biothiols, and hydrogen sulfide through sulfur exchange reaction with trityl spin probes","volume":"146","author":"Tan","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jchromb.2026.125030_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.forsciint.2020.110525","article-title":"Fatal poisoning of four workers in a farm: distribution of hydrogen sulfide and thiosulfate in 10 different biological matrices","volume":"316","author":"Moretti","year":"2020","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.jchromb.2026.125030_bb0140","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1520\/JFS2001216","article-title":"Fatal and nonfatal poisoning by hydrogen sulfide at an industrial waste site","volume":"47","author":"Kage","year":"2002","journal-title":"J. Forensic Sci."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226001194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226001194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:19:25Z","timestamp":1778822365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226001194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":28,"alternative-id":["S1570023226001194"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125030","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A simple HPLC method for selective determination of hydrogen sulfide and bound sulfane sulfur in human plasma","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125030"}}