{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:33Z","timestamp":1778825313860,"version":"3.51.4"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFE0106300"],"award-info":[{"award-number":["2021YFE0106300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012176","name":"Project 211","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["B20055"],"award-info":[{"award-number":["B20055"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jchromb.2026.125037","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:06:10Z","timestamp":1774929970000},"page":"125037","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Exploring the mechanism of Bushen KaiXuan Tongluo formula in ameliorating diabetic kidney disease based on transcriptomics and animal experiments"],"prefix":"10.1016","volume":"1278","author":[{"given":"Miao","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baosheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhuo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guimin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiyan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jchromb.2026.125037_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/jcm14030727","article-title":"Mechanisms, biomarkers, and treatment approaches for diabetic kidney disease: current insights and future perspectives","volume":"14","author":"Joumaa","year":"2025","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jchromb.2026.125037_bb0010","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s10020-024-01020-5","article-title":"Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy","volume":"30","author":"Liu","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.jchromb.2026.125037_bb0015","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1111\/dom.15559","article-title":"The potential for improved outcomes in the prevention and therapy of diabetic kidney disease through \u2018stacking\u2019 of drugs from different classes","volume":"26","author":"Bell","year":"2024","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.jchromb.2026.125037_bb0020","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1186\/s12882-025-04364-0","article-title":"Kidney transcriptomics signature of prospective rapid diabetic kidney disease progression","volume":"26","author":"Acoba","year":"2025","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.jchromb.2026.125037_bb0025","doi-asserted-by":"crossref","unstructured":"J. Li, Z. Song, Y. Li, et al., NR4A1 silencing alleviates high-glucose-stimulated HK-2 cells pyroptosis and fibrosis via hindering NLRP3 activation and PI3K\/AKT pathway, World J. Diabetes 16 (2025) 97544, doi:https:\/\/doi.org\/10.4239\/wjd.v16.i3.97544.","DOI":"10.4239\/wjd.v16.i3.97544"},{"key":"10.1016\/j.jchromb.2026.125037_bb0030","first-page":"551","article-title":"Efficacy observation of bushen kaixuan tongluo formula combined with western medicine in the treatment of stage G3a diabetic nephropathy","volume":"43","author":"Zhou","year":"2024","journal-title":"Beijing J. Tradit. Chin. Med."},{"key":"10.1016\/j.jchromb.2026.125037_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2025.124752","article-title":"Network pharmacology and untargeted metabolomics reveal the mechanisms of bushen kaixuan tongluo formula in diabetic kidney disease","volume":"1265","author":"Wang","year":"2025","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2026.125037_bb0040","doi-asserted-by":"crossref","unstructured":"M. Feijen, A.D. Egorova, T. Kuijken, et al., One-year mortality in patients undergoing an implantable cardioverter defibrillator or cardiac resynchronization therapy pulse generator replacement: identifying patients at risk, J. Clin. Med. 12 (2023) 17, doi:https:\/\/doi.org\/10.3390\/jcm12175654.","DOI":"10.3390\/jcm12175654"},{"issue":"3","key":"10.1016\/j.jchromb.2026.125037_bb0045","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-23-0357","article-title":"Insulin induces bioenergetic changes and alters mitochondrial dynamics in podocytes","volume":"261","author":"Audzeyenka","year":"2024","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jchromb.2026.125037_bb0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.nbd.2006.01.017","article-title":"Mitochondria in DRG neurons undergo hyperglycemic mediated injury through bim, bax and the fission protein drp1","volume":"23","author":"Leinninger","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jchromb.2026.125037_bb0055","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1007\/s10753-018-0845-0","article-title":"Inhibition of NF-\u03baB reduces renal inflammation and expression of PEPCK in type 2 diabetic mice","volume":"41","author":"Liu","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.jchromb.2026.125037_bb0060","doi-asserted-by":"crossref","unstructured":"W. Yang, K. Su, M. Liao, et al., Renal tubule-specific angiotensinogen deletion attenuates SGLT2 expression and ameliorates diabetic kidney disease in murine models of type 1 diabetes, Diabetes 74 (2025) 554\u2013568, doi:https:\/\/doi.org\/10.2337\/db24-0553.","DOI":"10.2337\/db24-0553"},{"key":"10.1016\/j.jchromb.2026.125037_bb0065","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","article-title":"Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jchromb.2026.125037_bb0070","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1002\/ptr.7875","article-title":"Astragaloside IV attenuates high glucose-induced NF-\u03baB-mediated inflammation through activation of PI3K\/AKT-ERK-dependent Nrf2\/ARE signaling pathway in glomerular mesangial cells","volume":"37","author":"Su","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jchromb.2026.125037_bb0075","doi-asserted-by":"crossref","unstructured":"Z. Xu, K. Cai, S. Su, et al., Salvianolic acid b and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K\/Akt\/NF-\u03baB signaling pathway, J. Ethnopharmacol. 319 (2024) 117356, doi:https:\/\/doi.org\/10.1016\/j.jep.2023.117356.","DOI":"10.1016\/j.jep.2023.117356"},{"key":"10.1016\/j.jchromb.2026.125037_bb0080","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3390\/molecules29051029","article-title":"Hirudin in the treatment of chronic kidney disease","volume":"29","author":"Liu","year":"2024","journal-title":"Molecules"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226001261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226001261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:20:26Z","timestamp":1778822426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226001261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":16,"alternative-id":["S1570023226001261"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125037","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the mechanism of Bushen KaiXuan Tongluo formula in ameliorating diabetic kidney disease based on transcriptomics and animal experiments","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"125037"}}