{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T09:15:40Z","timestamp":1783156540848,"version":"3.54.6"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFE0110500"],"award-info":[{"award-number":["2025YFE0110500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011198","name":"State Key Laboratory of Drug Research","doi-asserted-by":"publisher","award":["2025SKLDRS0361"],"award-info":[{"award-number":["2025SKLDRS0361"]}],"id":[{"id":"10.13039\/501100011198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jchromb.2026.125129","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:21:26Z","timestamp":1778818886000},"page":"125129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Intact mass and peptide mapping approaches to characterize lipoprotein species of fHbp"],"prefix":"10.1016","volume":"1280","author":[{"given":"Zhen","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2026.125129_bb0005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/mi.2014.93","article-title":"A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine","volume":"8","author":"Dunne","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jchromb.2026.125129_bb0010","doi-asserted-by":"crossref","unstructured":"L. Smithers, S. Olatunji, M. Caffrey, Bacterial lipoprotein posttranslational modifications. New insights and opportunities for antibiotic and vaccine development, Front. Microbiol., 12 (2021) 788445.","DOI":"10.3389\/fmicb.2021.788445"},{"key":"10.1016\/j.jchromb.2026.125129_bb0015","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/pharmaceutics14020423","article-title":"Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases","volume":"14","author":"Yang","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jchromb.2026.125129_bb0020","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.vaccine.2018.01.070","article-title":"Effectiveness of acellular pertussis vaccine and evolution of pertussis incidence in the community of Madrid from 1998 to 2015","volume":"36","author":"Latasa","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jchromb.2026.125129_bb0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jpba.2019.02.029","article-title":"Quantitative determination of bioactive proteins in diphtheria tetanus acellular pertussis (DTaP) vaccine by liquid chromatography tandem mass spectrometry","volume":"169","author":"Long","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2026.125129_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103404","article-title":"Distinctive cellular response to aluminum based adjuvants","volume":"78","author":"Nies","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125129_bb0035","doi-asserted-by":"crossref","unstructured":"L. Smithers, S. Olatunji, M. Caffrey, Bacterial lipoprotein posttranslational modifications. New insights and opportunities for antibiotic and vaccine development, Front. Microbiol., 12 (2021) 788445.","DOI":"10.3389\/fmicb.2021.788445"},{"key":"10.1016\/j.jchromb.2026.125129_bb0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/microorganisms9010177","article-title":"Performance of a four-antigen Staphylococcus aureus vaccine in preclinical models of invasive S. aureus disease","volume":"9","author":"Scully","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.jchromb.2026.125129_bb0045","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00393-19","article-title":"Anti-Factor H antibody reactivity in young adults vaccinated with a Meningococcal Serogroup B vaccine containing Factor H Binding Protein","volume":"4","author":"Sharkey","year":"2019","journal-title":"mSphere"},{"key":"10.1016\/j.jchromb.2026.125129_bb0050","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1128\/IAI.72.4.2088-2100.2004","article-title":"Vaccine potential of the Neisseria meningitidis 2086 lipoprotein","volume":"72","author":"Fletcher","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jchromb.2026.125129_bb0055","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/vaccines13010036","article-title":"Lipoprotein signal peptide as adjuvants: leveraging Lipobox-driven TLR2 activation in modern vaccine design","volume":"13","author":"Umar","year":"2025","journal-title":"Vaccines"},{"key":"10.1016\/j.jchromb.2026.125129_bb0060","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/pharmaceutics14020423","article-title":"Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases","volume":"14","author":"Yang","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jchromb.2026.125129_bb0065","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/vaccines13010036","article-title":"Lipoprotein signal peptide as adjuvants: leveraging Lipobox-driven TLR2 activation in modern vaccine design","volume":"13","author":"Umar","year":"2025","journal-title":"Vaccines"},{"key":"10.1016\/j.jchromb.2026.125129_bb0070","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1208\/s12248-016-9979-x","article-title":"The dual role of lipids of the lipoproteins in Trumenba, a self-Adjuvanting vaccine against meningococcal meningitis B disease","volume":"18","author":"Luo","year":"2016","journal-title":"AAPS J."},{"key":"10.1016\/j.jchromb.2026.125129_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2025.124712","article-title":"A combination of multiple LC\u2013MS approaches for the comprehensive characterization of recombinant herpes zoster vaccine","volume":"1263","author":"Long","year":"2025","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2026.125129_bb0080","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1039\/D5AN00557D","article-title":"A mass spectrometry-based proteomics strategy to detect long-chain S-acylated peptides","volume":"150","author":"Sardana","year":"2025","journal-title":"Analyst"},{"key":"10.1016\/j.jchromb.2026.125129_bb0085","unstructured":"https:\/\/www.uniprot.org\/uniprotkb\/E6MV22\/entry (accessed 28 March 2026)."},{"key":"10.1016\/j.jchromb.2026.125129_bb0090","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.1021\/ja1096804","article-title":"Radical conversion and migration in Electron capture dissociation","volume":"133","author":"Moore","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jchromb.2026.125129_bb0095","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1007\/s13361-013-0662-5","article-title":"Electron capture dissociation and collision induced dissociation of S-Dipalmitoylated peptides","volume":"24","author":"Kaczorowska","year":"2013","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2026.125129_bb0100","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1111\/j.1742-4658.2005.05029.x","article-title":"Lipopeptide structure determines TLR2 dependent cell activation level","volume":"272","author":"Buwitt-Beckmann","year":"2005","journal-title":"FEBS J."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226002187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226002187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:20:17Z","timestamp":1783153217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226002187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":20,"alternative-id":["S1570023226002187"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125129","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intact mass and peptide mapping approaches to characterize lipoprotein species of fHbp","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125129"}}