{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:02:24Z","timestamp":1785517344383,"version":"3.56.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jchromb.2026.125208","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:59:14Z","timestamp":1783407554000},"page":"125208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrating lipidomics and network pharmacology reveals Valproic acid remodels the lipid metabolic microenvironment in hepatocellular carcinoma"],"prefix":"10.1016","volume":"1281","author":[{"given":"Shansen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya'nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2026.125208_bb0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.semcancer.2022.02.004","article-title":"The altered lipidome of hepatocellular carcinoma","volume":"86","author":"Tan","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217061","article-title":"Hepatocellular carcinoma and lipid metabolism: novel targets and therapeutic strategies","volume":"597","author":"Cao","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jchromb.2026.125208_bb0015","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/hep.31391","article-title":"Lipid remodeling in hepatocyte proliferation and hepatocellular carcinoma","volume":"73","author":"Hall","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jchromb.2026.125208_bb0020","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/HEP.0000000000000962","article-title":"Comprehensive profiling of lipid metabolic reprogramming expands precision medicine for HCC","volume":"81","author":"Liu","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.jchromb.2026.125208_bb0025","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1158\/0008-5472.CAN-23-3966","article-title":"Estrogen induces LCAT to maintain cholesterol homeostasis and suppress hepatocellular carcinoma development","volume":"84","author":"He","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.jchromb.2026.125208_bb0030","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.7150\/ijbs.64714","article-title":"Targeted inhibition of LPL\/FABP4\/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer","volume":"17","author":"Yang","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jchromb.2026.125208_bb0035","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.apsb.2021.09.019","article-title":"Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jchromb.2026.125208_bb0040","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/hep.21054","article-title":"HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL","volume":"43","author":"Pathil","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jchromb.2026.125208_bb0045","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/fcp.12608","article-title":"Valproic acid reverses sorafenib resistance through inhibiting activated notch\/Akt signaling pathway in hepatocellular carcinoma","volume":"35","author":"Yang","year":"2021","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2020.105820","article-title":"Valproic acid overcomes sorafenib resistance by reducing the migration of Jagged2-mediated Notch1 signaling pathway in hepatocellular carcinoma cells","volume":"126","author":"Liu","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0055","doi-asserted-by":"crossref","first-page":"9091","DOI":"10.7150\/thno.115661","article-title":"The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma","volume":"15","author":"Liu","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.jchromb.2026.125208_bb0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/ajco.13443","article-title":"A clinical trial with valproic acid and hydralazine in combination with gemcitabine and cisplatin followed by doxorubicin and dacarbazine for advanced hepatocellular carcinoma","volume":"18","author":"Liu","year":"2022","journal-title":"Asia-Pac. J. Clin. Oncol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0065","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3389\/fphar.2019.00819","article-title":"Lipidomic profiling reveals disruption of lipid metabolism in Valproic acid-induced hepatotoxicity","volume":"10","author":"Xu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0070","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/abbs\/gmab002","article-title":"Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C\/EBP\u03b1\/SREBP-1 pathway","volume":"53","author":"Pang","year":"2021","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.jchromb.2026.125208_bb0075","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1124\/mol.119.118646","article-title":"Obeticholic acid ameliorates Valproic acid-induced hepatic steatosis and oxidative stress","volume":"97","author":"Gai","year":"2020","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.taap.2017.03.022","article-title":"Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis","volume":"324","author":"Bai","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0085","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.bcp.2009.10.011","article-title":"Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis","volume":"79","author":"Aires","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0090","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.tibs.2016.08.010","article-title":"Lipidomics: techniques, applications, and outcomes related to biomedical sciences","volume":"41","author":"Yang","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jchromb.2026.125208_bb0095","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","article-title":"Network pharmacology: curing causal mechanisms instead of treating symptoms","volume":"43","author":"Nogales","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jchromb.2026.125208_bb0100","doi-asserted-by":"crossref","first-page":"W530","DOI":"10.1093\/nar\/gkab294","article-title":"PLIP 2021: expanding the scope of the protein-ligand interaction profiler to DNA and RNA","volume":"49","author":"Adasme","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jchromb.2026.125208_bb0105","doi-asserted-by":"crossref","first-page":"16415","DOI":"10.1038\/s41598-021-95845-3","article-title":"Evaluation of acetylation and methylation in oral rinse of patients with head and neck cancer history exposed to valproic acid","volume":"11","author":"Gama","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2026.125208_bb0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12967-023-04015-8","article-title":"Valproic acid inhibits cell growth in both MCF-7 and MDA-MB231 cells by triggering different responses in a cell type-specific manner","volume":"21","author":"Giordano","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jchromb.2026.125208_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25031760","article-title":"Mechanistic insights about Sorafenib-, Valproic acid- and metformin-induced cell death in hepatocellular carcinoma","volume":"25","author":"Franco-Ju\u00e1rez","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jchromb.2026.125208_bb0120","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s13046-019-1160-9","article-title":"Valproic acid exhibits anti-tumor activity selectively against EGFR\/ErbB2\/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs","volume":"38","author":"Lin","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jchromb.2026.125208_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120976","article-title":"Valproic acid regulates MIEF1 through MST2-HIPPO to suppress breast cancer growth","volume":"309","author":"Du","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.jchromb.2026.125208_bb0130","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3389\/fcell.2020.00732","article-title":"Valproic acid synergizes with cisplatin and Cetuximab in vitro and in vivo in head and neck Cancer by targeting the mechanisms of resistance","volume":"8","author":"Iannelli","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0135","article-title":"Predicting effect of anti-PD-1\/PD-L1 inhibitors therapy for hepatocellular carcinoma by detecting plasma metabolite based on UHPLC-MS","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0140","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-025-14306-6","article-title":"From genes to therapy: a lipid metabolism-related genetic risk model predicts HCC outcomes and enhances immunotherapy","volume":"25","author":"Xu","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jchromb.2026.125208_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103967","article-title":"Valproic acid induced liver injury: an insight into molecular toxicological mechanism","volume":"95","author":"Ezhilarasan","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125208_bb0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10545-008-0841-x","article-title":"Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review","volume":"31","author":"Silva","year":"2008","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.jchromb.2026.125208_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112677","article-title":"LCAT- targeted therapies: Progress, failures and future","volume":"147","author":"Yang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jchromb.2026.125208_bb0160","article-title":"LCAT in Cancer biology: embracing epigenetic regulation, immune interactions, and therapeutic implications","volume":"26","author":"Gao","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jchromb.2026.125208_bb0165","first-page":"3527","article-title":"Diagnostic value of systemic cholesteryl Ester\/free cholesterol ratio in hepatocellular carcinoma","volume":"37","author":"Krautbauer","year":"2017","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jchromb.2026.125208_bb0170","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1021\/jacsau.4c00991","article-title":"Epigenetic modifier drug Valproic acid enhances Cancer metaphase chromosome elasticity and Electron transport: an atomic force microscopy approach","volume":"5","author":"Agrawal","year":"2025","journal-title":"JACS Au"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226002977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226002977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:20:33Z","timestamp":1785514833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226002977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":34,"alternative-id":["S1570023226002977"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125208","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating lipidomics and network pharmacology reveals Valproic acid remodels the lipid metabolic microenvironment in hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125208"}}