{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:12:10Z","timestamp":1788484330476,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002385","name":"Ministry of Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jchromb.2026.125258","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:10:07Z","timestamp":1786979407000},"page":"125258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bioactive metabolites of Lagenaria siceraria cultivated in Egypt: Insights from LC-QTOF-MS\/MS metabolomic profiling and chemometric analysis"],"prefix":"10.1016","volume":"1283","author":[{"given":"Nagham H.","family":"Kamal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema R.","family":"Saber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana M.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Benavente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala M.","family":"El-Hefnawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meselhy R.","family":"Meselhy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma M.","family":"Eltanany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2026.125258_bb0005","series-title":"Therapeutic importance of Cucurbitaceae: a Medicinally Important Family","author":"Mukherjee","year":"2022"},{"issue":"3","key":"10.1016\/j.jchromb.2026.125258_bb0010","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00253-015-7190-0","article-title":"Biotechnology and pharmacological evaluation of Indian vegetable crop Lagenaria siceraria: an overview","volume":"100","author":"Roopan","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jchromb.2026.125258_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.927361","article-title":"Lagenaria siceraria fruit: a review of its phytochemistry, pharmacology, and promising traditional uses","volume":"9","author":"Saeed","year":"2022","journal-title":"Front. Nutr."},{"issue":"5","key":"10.1016\/j.jchromb.2026.125258_bb0020","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/09546634.2015.1021663","article-title":"Triterpenes with healing activity: a systematic review","volume":"26","author":"Agra","year":"2015","journal-title":"J. Dermatol. Treat."},{"issue":"2011","key":"10.1016\/j.jchromb.2026.125258_bb0025","first-page":"63","article-title":"Total phenolic content, flavonoid concentration and antioxidant activity of Marrubium peregrinum L. extracts","volume":"33","author":"Stankovic","year":"2011","journal-title":"Kragujevac J. Sci."},{"issue":"11","key":"10.1016\/j.jchromb.2026.125258_bb0030","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/horticulturae7110493","article-title":"Sterols and triterpene diols in virgin olive oil: a comprehensive review on their properties and significance, with a special emphasis on the influence of variety and ripening degree","volume":"7","author":"Luki\u0107","year":"2021","journal-title":"Horticulturae"},{"key":"10.1016\/j.jchromb.2026.125258_bb0035","article-title":"The potential application of natural products in cutaneous wound healing: a review of preclinical evidence","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jchromb.2026.125258_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030444","article-title":"Evidence for natural products as alternative wound-healing therapies","volume":"13","author":"Moses","year":"2023","journal-title":"Biomolecules"},{"issue":"17","key":"10.1016\/j.jchromb.2026.125258_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23179573","article-title":"A comprehensive review of natural compounds for wound healing: targeting bioactivity perspective","volume":"23","author":"Trinh","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jchromb.2026.125258_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ph17060733","article-title":"Wound healing efficacy of Cucurbitaceae seed oils in rats: comprehensive phytochemical, pharmacological, and histological studies tackling AGE\/RAGE and Nrf2\/Ho-1 cue","volume":"17","author":"Emad","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jchromb.2026.125258_bb0055","doi-asserted-by":"crossref","DOI":"10.2147\/JEP.S303808","article-title":"Wound healing activity of 80% methanol leaf extract of Zehneria scabra (L.f) sond (Cucurbitaceae) in mice","volume":"13","author":"Tekleyes","year":"2021","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125258_bb0060","first-page":"209","article-title":"Bottle gourd (Lagenaria Siceraria)\u2018a vegetable food for human health\u2019\u2014a comprehensive review","volume":"1","author":"Upaganlawar","year":"2009","journal-title":"Pharmacol. Online"},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0065","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.foodchem.2011.10.063","article-title":"Antioxidant activity of a new phenolic glycoside from Lagenaria siceraria stand. Fruits","volume":"132","author":"Mohan","year":"2012","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.jchromb.2026.125258_bb0070","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00253-015-7190-0","article-title":"Biotechnology and pharmacological evaluation of Indian vegetable crop Lagenaria siceraria: an overview","volume":"100","author":"Roopan","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0075","doi-asserted-by":"crossref","DOI":"10.1186\/s43094-024-00678-2","article-title":"Enhanced wound healing activity of naturally derived Lagenaria siceraria seed oil binary nanoethosomal gel: formulation, characterization, in vitro\/in vivo efficiency","volume":"10","author":"Kamal","year":"2024","journal-title":"Futur. J. Pharm. Sci."},{"key":"10.1016\/j.jchromb.2026.125258_bb0080","series-title":"Wound Healing Properties of Lagenaria siceraria L. Extract and Its Nanoformulation(Doctoral dissertation, University of Petra (Jordan))","author":"Alazzawi","year":"2022"},{"key":"10.1016\/j.jchromb.2026.125258_bib321","doi-asserted-by":"crossref","unstructured":"Ibrahim, Rana M., Shymaa IA Abdel-dayem, Florbella Pereira, Fatema R. Saber, \u0141ukasz Kulinowski, Benita Hry\u0107, Gokhan Zengin, Muhammad A. Alsherbiny, and Krystyna Skalicka-Wo\u017aniak. \"Deciphering Organ-Specific Chemistry and Bioactivities of Plumeria rubra L. via Integrated Metabolomics, Biological Evaluation, and Molecular Docking Studies.\" Biocatal Agric Biotechnol 74(2026): 104093.","DOI":"10.1016\/j.bcab.2026.104093"},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0085","first-page":"48","article-title":"A rapid microtitre plate Folin-Ciocalteu method for the assessment of polyphenols","volume":"8","author":"Attard","year":"2013","journal-title":"Cent. Eur. J. Biol."},{"issue":"3","key":"10.1016\/j.jchromb.2026.125258_bb0090","first-page":"254","article-title":"Comparison of total flavanoid content of Azadirachta indica root bark extracts prepared by different methods of extraction","volume":"2","author":"Kiranmai","year":"2011","journal-title":"Res. J. Pharm., Biol. Chem. Sci."},{"key":"10.1016\/j.jchromb.2026.125258_bb0095","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s40199-020-00342-z","article-title":"Validated spectrophotometric method for quantification of total triterpenes in plant matrices","volume":"28","author":"Pedrosa","year":"2020","journal-title":"DARU J. Pharm. Sci."},{"key":"10.1016\/j.jchromb.2026.125258_bb0100","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s12906-024-04669-x","article-title":"Uncovering the therapeutic potential of green pea waste in breast cancer: a multi-target approach utilizing LC-MS\/MS metabolomics, molecular networking, and network pharmacology","volume":"24","author":"Khalil","year":"2024","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jchromb.2026.125258_bb0105","doi-asserted-by":"crossref","first-page":"116512","DOI":"10.1016\/j.jpba.2024.116512","article-title":"Metabolomics analysis of Cucumis melo var. flexuosus organs in correlation to its anti-inflammatory activity aided by chemometrics","volume":"252","author":"El-Sayed","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2026.125258_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.112742","article-title":"Unveiling the functional components and antivirulence activity of mustard leaves using an LC-MS\/MS, molecular networking, and multivariate data analysis integrated","volume":"168","author":"Ibrahim","year":"2023","journal-title":"Food Res. Int."},{"issue":"4","key":"10.1016\/j.jchromb.2026.125258_bb0115","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/es5002105","article-title":"Identifying small molecules via high resolution mass spectrometry: communicating confidence","volume":"48","author":"Schymanski","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jchromb.2026.125258_bb0120","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/pca.3322","article-title":"Identification of cyclooxygenase-II inhibitory saponins from fenugreek wastes: insights from liquid chromatography\u2013tandem mass spectrometry metabolomics, molecular networking, and molecular docking","volume":"35","author":"Khalil","year":"2024","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jchromb.2026.125258_bb0125","article-title":"Exploring geographic variations in quinoa grains: unveiling anti-Alzheimer activity via GC\u2013MS, LC-QTOF-MS\/MS, molecular networking, and chemometric analysis","author":"Younis","year":"2024","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0130","doi-asserted-by":"crossref","first-page":"13131","DOI":"10.1038\/s41598-017-13357-5","article-title":"Cytotoxicity of thymoquinone alone or in combination with cisplatin (CDDP) against oral squamous cell carcinoma in vitro","volume":"7","author":"Alaufi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2026.125258_bb0135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/7651_2019_235","article-title":"In vitro wound healing assays to investigate epidermal migration","volume":"2109","author":"Main","year":"2020","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0140","first-page":"29","article-title":"DPPH free radical scavenging activity of two extracts from agelanthus dodoneifolius (Loranthaceae) leaves","volume":"8","author":"Boly","year":"2016","journal-title":"Int. J. Toxicol. Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.jchromb.2026.125258_bb0145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0308-8146(00)00324-1","article-title":"The hydrophilic and lipophilic contribution to total antioxidant activity","volume":"73","author":"Arnao","year":"2001","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0150","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u2018antioxidant power\u2019: the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jchromb.2026.125258_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113178","article-title":"A comprehensive analytical framework integrating liquid chromatography-tandem mass spectrometry metabolomics with chemometrics for metabolite profiling of lettuce varieties and discovery of antibacterial agents","volume":"172","author":"Otify","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jchromb.2026.125258_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116795","article-title":"Metabolomics analysis insight into medicinal plant science","volume":"157","author":"Waris","year":"2022","journal-title":"TrAC Trends Anal. Chem."},{"issue":"20","key":"10.1016\/j.jchromb.2026.125258_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29204848","article-title":"Identification of the hypoglycemic active components of Lonicera japonica Thunb. and Lonicera hypoglauca Miq. by UPLC-Q-TOF-MS","volume":"29","author":"Wu","year":"2024","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0170","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/13880209.2024.2354341","article-title":"Comprehensive profiling of the chemical constituents in Dayuanyin decoction using UPLC-QTOF-MS combined with molecular networking","volume":"62","author":"Peng","year":"2024","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0175","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1194\/jlr.M900198-JLR200","article-title":"Identification of endogenous acyl amino acids based on a targeted lipidomics approach 1 [S]","volume":"51","author":"Tan","year":"2010","journal-title":"J. Lipid Res."},{"issue":"5","key":"10.1016\/j.jchromb.2026.125258_bb0180","first-page":"576","article-title":"Identification of phenolic compounds in Myricaria bracteata leaves by high-performance liquid chromatography with a diode array detector and liquid chromatography with tandem mass spectrometry","volume":"27","author":"Chernonosov","year":"2017","journal-title":"Rev. Bras"},{"key":"10.1016\/j.jchromb.2026.125258_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112828","article-title":"Chemical characterization of extracts of leaves of Kadsua coccinea (Lem.) A.C. Sm. By UHPLC-Q-Exactive orbitrap mass spectrometry and assessment of their antioxidant and anti-inflammatory activities","volume":"149","author":"Shi","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.jchromb.2026.125258_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11306-019-1581-7","article-title":"Metabolites profiling of date palm (Phoenix dactylifera L.) commercial by-products (pits and pollen) in relation to its antioxidant effect: a multiplex approach of MS and NMR metabolomics","volume":"15","author":"Otify","year":"2019","journal-title":"Metabolomics"},{"issue":"6","key":"10.1016\/j.jchromb.2026.125258_bb0195","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/jf4053989","article-title":"Identification and characterisation of the phenolic glycosides of <i>Lagenaria siceraria<\/i> Stand. (bottle gourd) fruit by liquid chromatography tandem mass spectrometry","volume":"62","author":"Jaiswal","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.jchromb.2026.125258_bb0200","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1021\/np100181c","article-title":"Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius","volume":"73","author":"Chang","year":"2010","journal-title":"J. Nat. Prod."},{"issue":"3","key":"10.1016\/j.jchromb.2026.125258_bb0205","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.foodchem.2008.02.045","article-title":"Cymbopogon citratus leaves: characterization of flavonoids by HPLC\u2013PDA\u2013ESI\/MS\/MS and an approach to their potential as a source of bioactive polyphenols","volume":"110","author":"Figueirinha","year":"2008","journal-title":"Food Chem."},{"issue":"12","key":"10.1016\/j.jchromb.2026.125258_bb0210","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1039\/C5FO00875A","article-title":"Mechanistic evidence of Passiflora edulis (Passifloraceae) anxiolytic activity in relation to its metabolite fingerprint as revealed via LC-MS and chemometrics","volume":"6","author":"Otify","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.jchromb.2026.125258_bb0215","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jpba.2019.05.041","article-title":"Chemical profiling, antioxidant, enzyme inhibitory and molecular modelling studies on the leaves and stem bark extracts of three African medicinal plants","volume":"174","author":"Sadeer","year":"2019","journal-title":"Pharm. Biomed. Anal."},{"issue":"5","key":"10.1016\/j.jchromb.2026.125258_bb0220","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/pca.820","article-title":"Distinction of the C-glycosylfavone isomer pairs orientin\/isoorientin and vitexin\/isovitexin using HPLC-MS exact mass measurement and in-source CID","volume":"16","author":"Pereira","year":"2005","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jchromb.2026.125258_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.114991","article-title":"Exploring the effects of different processing techniques on the composition and biological activity of Platycodon grandiflorus (Jacq.) a.DC. By metabonomics and pharmacologic design","volume":"289","author":"Zhang","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jchromb.2026.125258_bb0230","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1007\/s00216-016-9376-4","article-title":"Comparative metabolite profiling and fingerprinting of genus Passiflora leaves using a multiplex approach of UPLC-MS and NMR analyzed by chemometric tools","volume":"408","author":"Farag","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"issue":"11","key":"10.1016\/j.jchromb.2026.125258_bb0235","first-page":"838","article-title":"Analysis of mammalian sphingolipids by liquid chromatography tandem mass spectrometry (LC-MS\/MS) and tissue imaging mass spectrometry (TIMS)","volume":"1811","author":"Sullards","year":"2011","journal-title":"Elsevier"},{"issue":"11","key":"10.1016\/j.jchromb.2026.125258_bb0240","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1007\/s12039-016-1175-0","article-title":"Stereoselective total synthesis of sphingolipids","volume":"128","author":"Jangili","year":"2016","journal-title":"J. Chem. Sci."},{"issue":"4","key":"10.1016\/j.jchromb.2026.125258_bb0245","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/03602532.2024.2405163","article-title":"Drug metabolism and transport mediated the hepatotoxicity of Pleuropterus multiflorus root: a review","volume":"56","author":"Wu","year":"2024","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.jchromb.2026.125258_bb0250","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ab.2015.01.003","article-title":"Extraction parameters for metabolomics from cell extracts","volume":"475","author":"Ser","year":"2015","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0255","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1038\/s41598-022-08479-4","article-title":"Metabolomics-based profiling of 4 avocado varieties using HPLC\u2013MS\/MS and GC\/MS and evaluation of their antidiabetic activity","volume":"12","author":"Younis","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2026.125258_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1213602","article-title":"LC-MS-based metabolomics reveals the mechanism of anti-gouty arthritis effect of Wuwei Shexiang pill","volume":"14","author":"Lang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125258_bb0265","doi-asserted-by":"crossref","first-page":"1452558","DOI":"10.3389\/fphys.2024.1452558","article-title":"Preliminary screening of biomarkers and drug candidates in a mouse model of \u03b2-thalassemia based on quasi-targeted metabolomics","volume":"15","author":"Guo","year":"2024","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0270","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13020-023-00745-5","article-title":"A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example","volume":"18","author":"Hu","year":"2023","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jms.585","article-title":"Mass spectrometry in the structural analysis of flavonoids","volume":"39","author":"Cuyckens","year":"2004","journal-title":"J. Mass Spectrom."},{"issue":"4","key":"10.1016\/j.jchromb.2026.125258_bb0280","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/foods12040771","article-title":"How does Lagenaria siceraria (bottle gourd) metabolome compare to cucumis sativus (cucumber) F. Cucurbitaceae? A multiplex approach of HR-UPLC\/MS\/MS and GC\/MS using molecular networking and chemometrics","volume":"12","author":"El-Akad","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.jchromb.2026.125258_bb0285","doi-asserted-by":"crossref","first-page":"103189","DOI":"10.1016\/j.fochx.2025.103189","article-title":"Untargeted metabolomics reveals phenolic compound dynamics during mung bean fermentation","volume":"31","author":"Lang","year":"2025","journal-title":"Food Chem. X"},{"key":"10.1016\/j.jchromb.2026.125258_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.135587","article-title":"Metabolic profiling of Ochradenus baccatus Delile. Utilizing UHPLC-HRESIMS in relation to the in vitro biological investigations","volume":"412","author":"Pecio","year":"2023","journal-title":"Food Chem."},{"issue":"7","key":"10.1016\/j.jchromb.2026.125258_bb0295","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.3390\/ijms25073790","article-title":"Exploring skin wound healing models and the impact of natural lipids on the healing process","volume":"25","author":"Choudhary","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jchromb.2026.125258_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcab.2022.102464","article-title":"Antioxidant and antiglycation activities and inhibitory action of Passiflora cincinnata on collagenase, elastase and tyrosinase: in vitro and in silico study","volume":"44","author":"da Costa Gomes","year":"2022","journal-title":"Biocatal. Agric. Biotechnol."},{"issue":"5","key":"10.1016\/j.jchromb.2026.125258_bb0305","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.bcp.2010.12.001","article-title":"Inhibition of human leukocyte elastase, plasmin and matrix metalloproteinases by oleic acid and oleoyl-galardin derivative(s)","volume":"81","author":"Moroy","year":"2011","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.jchromb.2026.125258_bb0310","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3390\/biom10060879","article-title":"Premna odorata: seasonal metabolic variation in the essential oil composition of its leaf and verification of its anti-ageing potential via in vitro assays and molecular modelling","volume":"10","author":"Altyar","year":"2020","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0315","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1080\/13880209.2023.2229379","article-title":"Metabolomics reveals the effects of hydroxysafflor yellow a on neurogenesis and axon regeneration after experimental traumatic brain injury","volume":"61","author":"Hu","year":"2023","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.jchromb.2026.125258_bb0320","first-page":"1","volume":"12","author":"Marimoutou","year":"2015","journal-title":"J. Inflammation (United Kingdom)"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226003478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226003478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:15:52Z","timestamp":1788480952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226003478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":65,"alternative-id":["S1570023226003478"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125258","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioactive metabolites of Lagenaria siceraria cultivated in Egypt: Insights from LC-QTOF-MS\/MS metabolomic profiling and chemometric analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125258","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125258"}}