{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:34:15Z","timestamp":1793356455084,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009967","name":"Xinjiang Production and Construction Corps","doi-asserted-by":"publisher","award":["2025\\u202FdB050"],"award-info":[{"award-number":["2025\\u202FdB050"]}],"id":[{"id":"10.13039\/501100009967","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jchromb.2026.125295","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:19:10Z","timestamp":1788995950000},"page":"125295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multi-omics based mechanistic study of Fufang Xuelian capsule in treating ankylosing spondylitis via the gut-joint axis"],"prefix":"10.1016","volume":"1284","author":[{"given":"Xina","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baorui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2026.125295_bb0005","first-page":"1","article-title":"The factors related to work productivity and disease costs in patients with ankylosing spondylitis","volume":"12","author":"Aydan","year":"2025","journal-title":"Eur. J. Rheumatol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.abst.2024.12.002","article-title":"Unraveling ankylosing spondylitis: exploring the genetic and immunological factors and latest treatment innovations","volume":"7","author":"Hazra","year":"2025","journal-title":"Advances in Biomarker Sciences and Technology"},{"key":"10.1016\/j.jchromb.2026.125295_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1286491","article-title":"Investigating the shared genetic architecture between hypothyroidism and rheumatoid arthritis","volume":"14","author":"Peng","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.70112","article-title":"Gut microbiota combined with metabolomics to reveal the mechanism of Tang Wang Ming mu granule in the treatment of diabetic retinopathy in mice","volume":"39","author":"Xing","year":"2025","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jchromb.2026.125295_bb0025","article-title":"Integrative analysis of intestinal flora and untargeted metabolomics in attention-deficit\/hyperactivity disorder","volume":"16","author":"Lu","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.116942","article-title":"Integrated metabolomics and gut microbiota analysis to explore the protective effects of Gushudan on postmenopausal osteoporosis rats via gut-bone axis","volume":"263","author":"Liang","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2026.125295_bb0035","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2281382","article-title":"The gut-joint axis mediates the TNF-induced RA process and PBMT therapeutic effects through the metabolites of gut microbiota","volume":"15","author":"Meng","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jchromb.2026.125295_bb0040","doi-asserted-by":"crossref","first-page":"7841","DOI":"10.2147\/JIR.S517979","article-title":"Dysbiosis of gut microbiota in ankylosing spondylitis patients","volume":"18","author":"Yang","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jchromb.2026.125295_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1092118","article-title":"Gut-joint axis: gut dysbiosis can contribute to the onset of rheumatoid arthritis via multiple pathways","volume":"13","author":"Romero-Figueroa","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18103\/mra.v13i6.6549","article-title":"Metabolomics: analytical insights into disease mechanisms and biomarker discovery","volume":"13","author":"Tomar","year":"2025","journal-title":"Med. Res. Arch."},{"key":"10.1016\/j.jchromb.2026.125295_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1542100","article-title":"Functional metabolomics: unlocking the role of small molecular metabolites","volume":"12","author":"Chen","year":"2025","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.jchromb.2026.125295_bb0060","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1039\/D4MO00076E","article-title":"Serum metabolomics reveals the metabolic profile and potential biomarkers of ankylosing spondylitis","volume":"20","author":"Li","year":"2024","journal-title":"Molecular Omics"},{"key":"10.1016\/j.jchromb.2026.125295_bb0065","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1093\/ecco-jcc\/jjae085","article-title":"Serum metabolites relate to mucosal and transmural inflammation in paediatric Crohn disease","volume":"18","author":"Suarez","year":"2024","journal-title":"J. Crohn's Colitis"},{"key":"10.1016\/j.jchromb.2026.125295_bb0070","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2232143","article-title":"Gut microbiota-related bile acid metabolism-FXR\/TGR5 axis impacts the response to anti-\u03b14\u03b27-integrin therapy in humanized mice with colitis","volume":"15","author":"Han","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jchromb.2026.125295_bb0075","article-title":"Comparison of differences in chemical composition and related antioxidant activity of snow Lotus from different origins","volume":"20","author":"Zhang","year":"2022","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jchromb.2026.125295_bb0080","article-title":"Systems pharmacology\u2013based dissection of anti-cancer mechanism of traditional Chinese herb Saussurea involucrata","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0085","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S2225-4110(16)30058-X","article-title":"Antifatigue and antioxidant activity of alcoholic extract from Saussurea involucrata","volume":"1","author":"Lee","year":"2011","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.jchromb.2026.125295_bb0090","doi-asserted-by":"crossref","unstructured":"B. Liu, M. Luo, D. Meng, et al., Tetrahydropalmatine exerts analgesic effects by promoting apoptosis and inhibiting the activation of glial cells in rats with inflammatory pain, Mol. Pain, 17 (2021) 9, https:\/\/doi.org\/https:\/\/doi.org\/10.1177\/17448069211042117.","DOI":"10.1177\/17448069211042117"},{"key":"10.1016\/j.jchromb.2026.125295_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200713","article-title":"Structure characterization and anti-rheumatoid arthritis activity of a polysaccharide from Notopterygium incisum","volume":"67","author":"Ye","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jchromb.2026.125295_bb0100","first-page":"926","article-title":"Anti-rheumatoid arthritic effect of volatile components in notopterygium incisum in rats via anti-inflammatory and anti-angiogenic activities","volume":"16","author":"Bi","year":"2018","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jchromb.2026.125295_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119263","article-title":"Systematic insight into the dual COX-2\/5-LOX inhibitory mechanism of Duhuo Jisheng decoction for treatment of osteoarthritis based on in silico and bioassay","volume":"340","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0110","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1080\/13880209.2023.2252854","article-title":"Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking andin vivoexperimental verification","volume":"61","author":"Xin","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0115","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1007\/s10787-025-01780-4","article-title":"Carica papaya in health and disease: a review of its bioactive compounds for treating various disease conditions, including anti-inflammatory and anti-arthritic activities","volume":"33","author":"Akanda","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jchromb.2026.125295_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21121702","article-title":"A review on phytochemistry and pharmacology of cortex Periplocae","volume":"21","author":"Li","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2026.125295_bb0125","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12967-015-0636-4","article-title":"Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in complete Freund's adjuvant-induced mice: roles of dynorphin\/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel","volume":"13","author":"Wang","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jchromb.2026.125295_bb0130","unstructured":"Q. Zhao, B. Shi, Y. Teng, et al., Clinical study on the treatment of ankylosing spondylitis with Compound Xuelian Capsules combined with celecoxib, Drugs & Clinic, 35 (2020) 1106\u20131110 in Chinese, https:\/\/doi.org\/10.7501\/j.issn.1674-5515.2020.06.011."},{"key":"10.1016\/j.jchromb.2026.125295_bb0135","first-page":"93","article-title":"Effects of warm acupuncture combined with compound Xuelian capsule on cartilage metabolism and inflammatory response in ankylosing spondylitis","volume":"33","author":"Wang","year":"2024","journal-title":"China Pharm."},{"key":"10.1016\/j.jchromb.2026.125295_bb0140","unstructured":"W.J. Li Weiguo, Li Jinglong, Clinical study on Compound Xuelian Capsules combined with sodium hyaluronate in treatment of knee osteoarthritis Drugs & Clinic, 36 (2021) 799\u2013803 in Chinese, https:\/\/doi.org\/10.7501\/j.issn.1674-5515.2021.04.034."},{"key":"10.1016\/j.jchromb.2026.125295_bb0145","unstructured":"W.S. Zhan Liann\u00dc, Zhang Lei Clinical study on Compound Xuelian Capsules combined with tofacitinib in treatment of rheumatoid arthritis, Drugs & Clinic 39 (2024) 3173\u20133177 in Chinese, https:\/\/doi.org\/10.7501\/j.issn.1674-5515.2024.12.027."},{"key":"10.1016\/j.jchromb.2026.125295_bb0150","doi-asserted-by":"crossref","DOI":"10.1155\/mi\/6551954","article-title":"Taohong siwu decoction regulates MSC-mediated H-type angiogenesis to accelerate bone fracture healing through VHL\/HIF-1\u03b1 ubiquitination","volume":"2026","author":"Li","year":"2026","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.jchromb.2026.125295_bb0155","article-title":"Effectiveness and safety of Chinese herbal formula combined with western medicine for ankylosing spondylitis","volume":"100","author":"Liu","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.jchromb.2026.125295_bb0160","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.2147\/DDDT.S502193","article-title":"Network pharmacology and experimental validation reveal Sishen pill's efficacy in treating NSAID-induced small intestinal ulcers","volume":"19","author":"Zhou","year":"2025","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.jchromb.2026.125295_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135626","article-title":"Study on pro-inflammatory effect and mechanism of galectin-9 (LGALS9) in osteoarthritis: exacerbating inflammatory response by activating JNK and ERK1\/2 pathways","volume":"280","author":"Ge","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0170","doi-asserted-by":"crossref","DOI":"10.1186\/s13020-024-01001-0","article-title":"Metabolomics integrated with network pharmacology of blood-entry constituents reveals the bioactive component of Xuefu Zhuyu decoction and its angiogenic effects in treating traumatic brain injury","volume":"19","author":"Li","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.jchromb.2026.125295_bb0175","first-page":"415","article-title":"Revisiting the gut\u2013joint axis: links between gut inflammation and spondyloarthritis, nature reviews","volume":"16","author":"Gracey","year":"2020","journal-title":"Rheumatology"},{"key":"10.1016\/j.jchromb.2026.125295_bb0180","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41419-025-08230-7","article-title":"Piezo1-mediated autophagy promotes immune-inflammatory responses in ankylosing spondylitis","volume":"17","author":"Zhao","year":"2026","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jchromb.2026.125295_bb0185","doi-asserted-by":"crossref","unstructured":"L. Drago, Prevotella copri and microbiota in rheumatoid arthritis: fully convincing evidence?, J. Clin. Med., 8 (2019) 1837\u20131840, https:\/\/doi.org\/https:\/\/doi.org\/10.3390\/jcm8111837.","DOI":"10.3390\/jcm8111837"},{"key":"10.1016\/j.jchromb.2026.125295_bb0190","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1186\/s12967-025-06681-2","article-title":"Limosilactobacillus reuteri prevents progression of ankylosing spondylitis in mice by restoring gut microbiota-metabolism homeostasis","volume":"23","author":"Yang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jchromb.2026.125295_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.650313","article-title":"Use of short-chain fatty acids for the recovery of the intestinal epithelial barrier affected by bacterial toxins","volume":"12","author":"P\u00e9rez-Reytor","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2026.124914","article-title":"Dual-configuration arabinogalactan-II synergizes with rhamnogalacturonan-I in Lycium barbarum pectin to construct an intestinal anti-inflammatory glycan scaffold","volume":"381","author":"Li","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jchromb.2026.125295_bb0205","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2406379","article-title":"Akkermansia in the gastrointestinal tract as a modifier of human health","volume":"16","author":"Panzetta","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jchromb.2026.125295_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1653472","article-title":"The role of Akkermansia muciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism","volume":"16","author":"Xu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1213602","article-title":"LC-MS-based metabolomics reveals the mechanism of anti-gouty arthritis effect of Wuwei Shexiang pill","volume":"14","author":"Lang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0220","article-title":"12R- HETE acts as an endogenous ligand for Nur77 in the intestines and regulates NKp46+ ILC3 development","author":"Huang Ningning","year":"2026","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jchromb.2026.125295_bb0225","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/s12276-023-01028-7","article-title":"Immune regulation through tryptophan metabolism","volume":"55","author":"Seo","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jchromb.2026.125295_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107896","article-title":"Microbial modulation of tryptophan metabolism links gut microbiota to disease and its treatment","volume":"219","author":"Zhao","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jchromb.2026.125295_bb0235","doi-asserted-by":"crossref","DOI":"10.1007\/s10735-026-10832-0","article-title":"An integrated multi-omics approach for deciphering podophyllotoxin-induced nephrotoxicity via the microbiome-gut-kidney (MGK) axis based on the toxicological evidence (TEC) concept","volume":"57","author":"Guo","year":"2026","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0240","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40168-024-01750-y","article-title":"Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding","volume":"12","author":"Wang","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.jchromb.2026.125295_bb0245","doi-asserted-by":"crossref","DOI":"10.1038\/s41522-025-00745-3","article-title":"Lactobacillus regulate muscle fiber type conversion in Chinese native pigs via tryptophan metabolism","volume":"11","author":"Song","year":"2025","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.jchromb.2026.125295_bb0250","doi-asserted-by":"crossref","first-page":"18792","DOI":"10.1021\/acs.jafc.3c06183","article-title":"Indole-3-lactic acid, a tryptophan metabolite of Lactiplantibacillus plantarum DPUL-S164, improved intestinal barrier damage by activating AhR and Nrf2 Signaling pathways","volume":"71","author":"Wang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jchromb.2026.125295_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115766","article-title":"Identification of the key tryptophan metabolic characteristics of Lactiplantibacillus plantarum for aryl hydrocarbon receptor activation and ulcerative colitis alleviation","volume":"203","author":"Zuo","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jchromb.2026.125295_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111360","article-title":"Metabolomics with gut microbiota analysis of podophyllotoxin-mediated cardiotoxicity in mice based on the toxicological evidence chain (TEC) concept","volume":"406","author":"Sun","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jchromb.2026.125295_bb0265","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00214","article-title":"Strategies to dissect host-microbial immune interactions that determine mucosal homeostasis vs. intestinal inflammation in gnotobiotic mice","volume":"11","author":"Rogala","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.738152","article-title":"Qingchang Wenzhong decoction accelerates intestinal mucosal healing through modulation of dysregulated gut microbiome, intestinal barrier and immune responses in mice","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/nu15153378","article-title":"Amino acid catabolism: an overlooked area of metabolism","volume":"15","author":"Torres","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jchromb.2026.125295_bb0280","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/s41586-023-06990-w","article-title":"Bile salt hydrolase catalyses formation of amine-conjugated bile acids","volume":"626","author":"Rimal","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jchromb.2026.125295_bb0285","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/CS20220697","article-title":"Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease","volume":"137","author":"Gillard","year":"2023","journal-title":"Clin. Sci."},{"key":"10.1016\/j.jchromb.2026.125295_bb0290","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1136\/gutjnl-2022-327756","article-title":"Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis","volume":"72","author":"Sun","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.jchromb.2026.125295_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/cells15151398","article-title":"Gut microbial functional ecology and microbiota-derived metabolites in rheumatoid arthritis autoimmunity","volume":"15","author":"Rong","year":"2026","journal-title":"Cells"},{"key":"10.1016\/j.jchromb.2026.125295_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.20892\/j.issn.2095-3941.2023.0394","article-title":"Bile acids, gut microbiota, and therapeutic insights in hepatocellular carcinoma","volume":"21","author":"Song","year":"2023","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.jchromb.2026.125295_bb0305","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41584-022-00784-6","article-title":"Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases","volume":"18","author":"Burg","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0310","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1403823","article-title":"Targeting dysregulated intracellular immunometabolism within synovial microenvironment in rheumatoid arthritis with natural products","volume":"15","author":"Hu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0315","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1713148","article-title":"Immunocyte lipid metabolic reprogramming: a novel pathway for targeted intervention in autoimmune diseases","volume":"16","author":"Cui","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jchromb.2026.125295_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117617","article-title":"Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK\/TSC1\/mTOR\/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept","volume":"290","author":"Li","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jchromb.2026.125295_bb0325","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.cmet.2025.12.017","article-title":"Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis","volume":"38","author":"Ding","year":"2026","journal-title":"Cell Metab."},{"key":"10.1016\/j.jchromb.2026.125295_bb0330","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1172\/JCI134091","article-title":"IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis","volume":"130","author":"Faust","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jchromb.2026.125295_bb0335","doi-asserted-by":"crossref","DOI":"10.1002\/iub.70023","article-title":"Modulation of osteogenic differentiation by CYBB in osteoporotic models","volume":"77","author":"Wang","year":"2025","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jchromb.2026.125295_bb0340","doi-asserted-by":"crossref","DOI":"10.3390\/biom12111653","article-title":"Effects of \u03b22 integrins on osteoclasts, macrophages, chondrocytes, and synovial fibroblasts in osteoarthritis","volume":"12","author":"Hu","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jchromb.2026.125295_bb0345","article-title":"Stem cell-derived extracellular vesicles for treating joint injury and osteoarthritis","volume":"9","author":"Li","year":"2019","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jchromb.2026.125295_bb0350","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000028828","article-title":"Rheumatoid arthritis in a patient with compound heterozygous variants in the COL11A2 gene and progressive hearing loss","volume":"101","author":"Tsuchida","year":"2022","journal-title":"Medicine"},{"key":"10.1016\/j.jchromb.2026.125295_bb0355","doi-asserted-by":"crossref","DOI":"10.4110\/in.2025.25.e32","article-title":"Enigmatic roles of complement anaphylatoxin signaling in health and disease","volume":"25","author":"Shadid","year":"2025","journal-title":"Immune Netw."},{"key":"10.1016\/j.jchromb.2026.125295_bb0360","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/ard-2023-224014","article-title":"Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis","volume":"83","author":"Moulin","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jchromb.2026.125295_bb0365","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-91943-8","article-title":"Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs","volume":"15","author":"Talemi","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2026.125295_bb0370","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-92553-0","article-title":"Decoding pathogenic MMP9 variants in rheumatoid arthritis using computational and molecular dynamics approaches","volume":"15","author":"Sharif","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2026.125295_bb0375","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/metabo14040214","article-title":"Unveiling the nexus: cellular metabolomics unravels the impact of estrogen on nicotinamide metabolism in mitigating rheumatoid arthritis pathogenesis","volume":"14","author":"Malik","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.jchromb.2026.125295_bb0380","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1302\/2046-3758.1411.BJR-2025-0259.R1","article-title":"Xuetongsu attenuates bone destruction in rheumatoid arthritis by suppressing RANKL\/RANK\/NFATc1 pathway to inhibit osteoclastogenesis and bone resorption","volume":"14","author":"Zheng","year":"2025","journal-title":"Bone & Joint Research"},{"key":"10.1016\/j.jchromb.2026.125295_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111634","article-title":"Investigating podophyllotoxin-induced cardiotoxicity in rats by toxicological evidence chain (TEC): focus on the Akt1\/Srebp-1c\/PUFAs axis","volume":"419","author":"Liu","year":"2025","journal-title":"Chem. Biol. Interact."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226003843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226003843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:35:43Z","timestamp":1793352943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226003843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":77,"alternative-id":["S1570023226003843"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125295","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics based mechanistic study of Fufang Xuelian capsule in treating ankylosing spondylitis via the gut-joint axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125295","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125295"}}