{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:34:51Z","timestamp":1793356491720,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jchromb.2026.125314","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:30:33Z","timestamp":1790137833000},"page":"125314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["An integrated FIDI-MS and UPLC-Q-TOF\/MS strategy for rapid functional screening and chemical characterization of antioxidants in Polygonum multiflorum"],"prefix":"10.1016","volume":"1284","author":[{"given":"Minglin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Sani","family":"Ocholi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2026.125314_bb0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-026-02583-x","article-title":"Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications","volume":"11","author":"Akter","year":"2026","journal-title":"Sig. Transduct. Target. Ther."},{"key":"10.1016\/j.jchromb.2026.125314_bb0010","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1080\/15548627.2025.2481126","article-title":"Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease","volume":"21","author":"Wei","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.jchromb.2026.125314_bb0015","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.apsb.2021.11.003","article-title":"Mitochondrial complex I as a therapeutic target for Alzheimer\u2019s disease","volume":"12","author":"Trushina","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jchromb.2026.125314_bb0020","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.cmet.2024.08.010","article-title":"Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages","volume":"36","author":"Wei","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.jchromb.2026.125314_bb0025","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/cvr\/cvac134","article-title":"Mitochondrial calcium and reactive oxygen species in cardiovascular disease","volume":"119","author":"Murphy","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jchromb.2026.125314_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100505","article-title":"Natural melanin\/alginate hydrogels achieve cardiac repair through ROS scavenging and macrophage polarization","volume":"8","author":"Zhou","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jchromb.2026.125314_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14010046","article-title":"Neurotoxic effect of myricitrin in copper-induced oxidative stress is mediated by increased intracellular Ca2+ levels and ROS\/p53\/p38 axis","volume":"14","author":"Vla\u0161i\u0107","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.jchromb.2026.125314_bb0040","article-title":"2,3,5,4\u2019-Tetrahydroxystilbene-2-O-\u03b2-glucoside attenuates reactive oxygen species-dependent inflammation and apoptosis in <i>Porphyromonas gingivalis<\/i>-infected brain endothelial cells","volume":"11","author":"Charoensaensuk","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jchromb.2026.125314_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155554","article-title":"Nanodelivery system of traditional Chinese medicine bioactive compounds: application in the treatment of prostate cancer","volume":"135","author":"Zou","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2026.125314_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464196","article-title":"Thorough evaluation of the Chinese medicine preparations and intermediates using high performance liquid chromatography fingerprints and ultraviolet quantum fingerprints along with antioxidant activity: Shuanghuanglian oral solution as an example","volume":"1705","author":"Wang","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2026.125314_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463118","article-title":"A trinity fingerprint evaluation system of traditional Chinese medicine","volume":"1673","author":"Yang","year":"2022","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2026.125314_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114398","article-title":"Antioxidant capacity of flavonoids from folium Artemisiae Argyi and the molecular mechanism in Caenorhabditis elegans","volume":"279","author":"Hu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2026.125314_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113864","article-title":"Polygonum multiflorum: recent updates on newly isolated compounds, potential hepatotoxic compounds and their mechanisms","volume":"271","author":"Teka","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2026.125314_bb0070","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1002\/jcp.30127","article-title":"Tetrahydroxy stilbene glycoside attenuates acetaminophen-induced hepatotoxicity by UHPLC-Q-TOF\/MS-based metabolomics and multivariate data analysis","volume":"236","author":"Gao","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jchromb.2026.125314_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115461","article-title":"Polygonum multiflorum Thunb. induces hepatotoxicity in SD rats and hepatocyte spheroids by disrupting the metabolism of bilirubin and bile acid","volume":"296","author":"Wang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2026.125314_bb0080","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1021\/acs.jpclett.1c01965","article-title":"Unravelling melatonin\u2019s varied antioxidizing protection of membrane lipids determined by its spatial distribution","volume":"12","author":"Zhang","year":"2021","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.jchromb.2026.125314_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2026.130014","article-title":"Revealing oxidative chemistry at the water-air interface using a levitated water droplet","volume":"309","author":"Yu","year":"2026","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2026.125314_bb0090","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1021\/jacs.3c00300","article-title":"Fast hydroxyl radical generation at the air-water interface of aerosols mediated by water-soluble PM2.5 under ultraviolet a radiation","volume":"145","author":"Zhang","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jchromb.2026.125314_bb0095","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1021\/acs.jpclett.2c00211","article-title":"Mass spectrometry and cryogenic Electron microscopy illuminate molecular-level mechanisms of the oxidative and structural damage to lipid membranes by radical-bearing graphene oxide","volume":"13","author":"Mu","year":"2022","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.jchromb.2026.125314_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202414542","article-title":"Optimizing photosensitizers with type I and type II ROS generation through modulating triplet lifetime and intersystem crossing efficiency","volume":"35","author":"Yue","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jchromb.2026.125314_bb0105","first-page":"28","article-title":"Antioxidant activity of bergenin by molecular spectroscopy","volume":"27","author":"Zhang","year":"2019","journal-title":"Chem. Chem. Technol."},{"key":"10.1016\/j.jchromb.2026.125314_bb0110","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.foodchem.2007.03.022","article-title":"Antioxidant activity of stilbene glycoside from Polygonum multiflorum Thunb in vivo","volume":"104","author":"Lv","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.jchromb.2026.125314_bb0115","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.toxrep.2018.05.009","article-title":"Acute toxicity of water and aqueous extract of soils from Champot\u00f3n river in Lactuca sativa L","volume":"5","author":"Chan-Keb","year":"2018","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.jchromb.2026.125314_bb0120","doi-asserted-by":"crossref","first-page":"13391","DOI":"10.1021\/acsomega.1c01448","article-title":"Radical scavenging activity of natural anthraquinones: a theoretical insight","volume":"6","author":"Trung","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.jchromb.2026.125314_bb0125","first-page":"54","article-title":"Antioxidant activity and vitamin C concentration analysis of Gandaria (Bouae macrophylla Griff) ethanol extract using spectrophotometry UV\u2013Vis","volume":"3","author":"Kholifah","year":"2023","journal-title":"J. Fund. Appl. Pharm. Sci."},{"key":"10.1016\/j.jchromb.2026.125314_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/165457","article-title":"Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay","volume":"2015","author":"Lee","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jchromb.2026.125314_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154017","article-title":"Activating PGC-1\u03b1-mediated signaling cascades in the aorta contributes to the amelioration of vascular senescence and atherosclerosis by 2,3,4\u2032,5-tetrahydroxystilbene-2-O-\u03b2-d-glycoside","volume":"99","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2026.125314_bb0140","first-page":"875","article-title":"DPPH free radical scavenging activity of some Bangladeshi medicinal plants","volume":"3","author":"Hasan","year":"2009","journal-title":"J. Med. Plant Res."},{"key":"10.1016\/j.jchromb.2026.125314_bb0145","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-022-01634-z","article-title":"A physicochemical double-cross-linked gelatin hydrogel with enhanced antibacterial and anti-inflammatory capabilities for improving wound healing","volume":"20","author":"Lu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jchromb.2026.125314_bb0150","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.carres.2012.07.020","article-title":"Anthraquinone glycosides from Cassia roxburghii and evaluation of its free radical scavenging activity","volume":"360","author":"El-Toumy","year":"2012","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.jchromb.2026.125314_bb0155","first-page":"3713","article-title":"Antioxidant activity and free radical scavenging properties of captopril","volume":"23","author":"Asori","year":"2011","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.jchromb.2026.125314_bb0160","first-page":"100","article-title":"Radical scavenging effects of different Veronica species","volume":"5","author":"Harput","year":"2011","journal-title":"Rec. Nat. Prod."},{"key":"10.1016\/j.jchromb.2026.125314_bb0165","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3109\/13880200903490505","article-title":"Antioxidant activity and total phenolic content of methanol extracts of Ixora coccinea","volume":"48","author":"Torey","year":"2010","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jchromb.2026.125314_bb0170","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/0972060X.2012.10644029","article-title":"Antioxidant activity, free radical scavenging potential and chemical composition of Litsea cubeba essential oil","volume":"15","author":"Wang","year":"2012","journal-title":"J. Essent. Oil Bear. Pl"},{"key":"10.1016\/j.jchromb.2026.125314_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123496","article-title":"Emodin-derived red-emissive carbon dots: light-driven ROS generation and antioxidant activities in non-illuminative regimes","volume":"324","author":"Jiang","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.jchromb.2026.125314_bb0180","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/1071576029009137","article-title":"Free radical scavenging properties of sulfinpyrazone","volume":"36","author":"Yang","year":"2002","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.jchromb.2026.125314_bb0185","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/13880200590951720","article-title":"Free radical scavenging activity of extracts from Thai plants in Guttiferae and Schisandraceae families","volume":"43","author":"Manosroi","year":"2005","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jchromb.2026.125314_bb0190","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1021\/jf990092f","article-title":"2,2-Diphenyl-1-picrylhydrazyl radical-scavenging active components from Polygonum multiflorum thunb","volume":"47","author":"Chen","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jchromb.2026.125314_bb0195","doi-asserted-by":"crossref","DOI":"10.34133\/bmr.0098","article-title":"Polygonum multiflorum extracellular vesicle-like nanovesicle for skin photoaging therapy","volume":"28","author":"He","year":"2024","journal-title":"Biomater. Res."},{"key":"10.1016\/j.jchromb.2026.125314_bb0200","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1134\/S1068162024040319","article-title":"Enhancing the antioxidant activity by the combination use of resveratrol and emodin","volume":"50","author":"Lu","year":"2024","journal-title":"Russ. J. Bioorg. Chem."},{"key":"10.1016\/j.jchromb.2026.125314_bb0205","doi-asserted-by":"crossref","DOI":"10.1186\/s13065-022-00858-2","article-title":"In vitro total phenolics, total flavonoids, antioxidant and antibacterial activities of selected medicinal plants using different solvent systems","volume":"16","author":"Mehmood","year":"2022","journal-title":"BMC Chem."},{"issue":"14","key":"10.1016\/j.jchromb.2026.125314_bb0210","doi-asserted-by":"crossref","first-page":"10076","DOI":"10.1021\/acs.analchem.0c01887","article-title":"AGREE-analytical GREEnness metric approach and software","volume":"92","author":"Pena-Pereira","year":"2020","journal-title":"Anal. Chem."},{"issue":"19","key":"10.1016\/j.jchromb.2026.125314_bb0215","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1039\/D3GC02347H","article-title":"Blue applicability grade index (BAGI) and software: a new tool for the evaluation of method practicality","volume":"25","author":"Manousi","year":"2023","journal-title":"Green Chem."},{"issue":"21","key":"10.1016\/j.jchromb.2026.125314_bb0220","doi-asserted-by":"crossref","first-page":"8657","DOI":"10.1039\/D1GC02318G","article-title":"Complementary green analytical procedure index (ComplexGAPI) and software","volume":"23","author":"Plotka-Wasylka","year":"2021","journal-title":"Green Chem."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226004034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226004034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:36:41Z","timestamp":1793353001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226004034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":44,"alternative-id":["S1570023226004034"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125314","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An integrated FIDI-MS and UPLC-Q-TOF\/MS strategy for rapid functional screening and chemical characterization of antioxidants in Polygonum multiflorum","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125314","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125314"}}