{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:00:02Z","timestamp":1792083602602,"version":"4.4.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024104","name":"Veterin\u00e6rinstituttets","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["243907"],"award-info":[{"award-number":["243907"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["196085\/V10"],"award-info":[{"award-number":["196085\/V10"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jchromb.2026.125336","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:39:59Z","timestamp":1791729599000},"page":"125336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Selective extraction of microcystins and nodularins with immobilized polyclonal antibodies for LC\u2013MS analysis"],"prefix":"10.1016","volume":"1285","author":[{"given":"Ingunn A.","family":"Samdal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ine","family":"Van Nieuwenhove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Uhlig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Sandvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjersti L.E.","family":"L\u00f8vberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher O.","family":"Miles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2026.125336_bb0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cca.2013.07.005","article-title":"Nodularins in poisoning","volume":"425","author":"Chen","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jchromb.2026.125336_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11080456","article-title":"Diagnosing microcystin intoxication of canines: clinicopathological indications, pathological characteristics, and analytical detection in postmortem and antemortem samples","volume":"11","author":"Foss","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.jchromb.2026.125336_bb0015","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s00204-019-02524-4","article-title":"Global geographical and historical overview of cyanotoxin distribution and cyanobacterial poisonings","volume":"93","author":"Svircev","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jchromb.2026.125336_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9090267","article-title":"Recreational exposure during algal bloom in Carrasco Beach, Uruguay: a liver failure case report","volume":"9","author":"Vidal","year":"2017","journal-title":"Toxins"},{"key":"10.1016\/j.jchromb.2026.125336_bb0025","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00204-016-1913-6","article-title":"Cyanotoxins: producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation","volume":"91","author":"Buratti","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jchromb.2026.125336_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/md9112164","article-title":"An acute case of intoxication with cyanobacteria and cyanotoxins in recreational water in Salto Grande dam, Argentina","volume":"9","author":"Giannuzzi","year":"2011","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.jchromb.2026.125336_bb0035","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1021\/es200285c","article-title":"Evaluating microcystin exposure risk through fish consumption","volume":"45","author":"Poste","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jchromb.2026.125336_bb0040","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.jglr.2017.08.006","article-title":"Microcystin in Lake Erie fish: risk to human health and relationship to cyanobacterial blooms","volume":"43","author":"Wituszynski","year":"2017","journal-title":"J. Great Lakes Res."},{"key":"10.1016\/j.jchromb.2026.125336_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12050298","article-title":"Microcystins in European noble crayfish Astacus astacus in Lake Steinsfjorden, a Planktothrix-dominated lake","volume":"12","author":"Samdal","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.jchromb.2026.125336_bb0050","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.hal.2016.09.007","article-title":"Evidence of freshwater algal toxins in marine shellfish: implications for human and aquatic health","volume":"59","author":"Gibble","year":"2016","journal-title":"Harmful Algae"},{"key":"10.1016\/j.jchromb.2026.125336_bb0055","doi-asserted-by":"crossref","unstructured":"Chorus, I., Welker, M., 2021. Toxic Cyanobacteria in Water: A Guide to their Public Health Consequences, Monitoring and Management, 2nd ed. CRC Press on behalf of WHO, Geneva, Switzerland, p. 859.","DOI":"10.1201\/9781003081449"},{"key":"10.1016\/j.jchromb.2026.125336_bb0060","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1289\/ehp.00108435","article-title":"Assessing potential health risks from microcystin toxins in blue\u2013green algae dietary supplements","volume":"108","author":"Gilroy","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.jchromb.2026.125336_bb0065","doi-asserted-by":"crossref","first-page":"8016","DOI":"10.1021\/acs.jafc.0c02024","article-title":"Microcystin toxins at potentially hazardous levels in algal dietary supplements revealed by a combination of bioassay, immunoassay, and mass spectrometric methods","volume":"68","author":"Miller","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jchromb.2026.125336_bb0070","doi-asserted-by":"crossref","first-page":"8557","DOI":"10.1021\/ja00233a049","article-title":"Nodularin, microcystin, and the configuration of Adda","volume":"110","author":"Rinehart","year":"1988","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jchromb.2026.125336_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11120714","article-title":"Structural diversity, characterization and toxicology of microcystins","volume":"11","author":"Boua\u00efcha","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.jchromb.2026.125336_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117017","article-title":"CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria","volume":"196","author":"Jones","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.jchromb.2026.125336_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111884","article-title":"Comprehensive insights into the occurrence and toxicological issues of nodularins","volume":"162","author":"Chen","year":"2021","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.jchromb.2026.125336_bb0090","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1128\/aem.55.8.1990-1995.1989","article-title":"Occurrence of the hepatotoxic cyanobacterium Nodularia spumigena in the Baltic Sea and structure of the toxin","volume":"55","author":"Sivonen","year":"1989","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jchromb.2026.125336_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/md17110643","article-title":"Novel microcystins from Planktothrix prolifica NIVA-CYA 544 identified by LC\u2013MS\/MS, functional group derivatization and 15N-labeling","volume":"17","author":"Mallia","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.jchromb.2026.125336_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12120795","article-title":"Immunoaffinity extraction and alternative approaches for the analysis of toxins in environmental, food or biological matrices","volume":"12","author":"Delaunay","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.jchromb.2026.125336_bb0105","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0041-0101(99)00194-4","article-title":"Immunoaffinity purification method for detection and quantification of microcystins in lake water","volume":"38","author":"Kondo","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.jchromb.2026.125336_bb0110","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0041-0101(01)00287-2","article-title":"Determination of microcystins in lake water using reusable immunoaffinity column","volume":"40","author":"Kondo","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.jchromb.2026.125336_bb0115","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0278-6915(00)00044-2","article-title":"Immunoaffinity column as clean-up tool for determination of trace amounts of microcystins in tap water","volume":"38","author":"Tsutsumi","year":"2000","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jchromb.2026.125336_bb0120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s00244-008-9275-6","article-title":"Necessity of screening water chestnuts for microcystins after cyanobacterial blooms break out","volume":"57","author":"Xiao","year":"2009","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.jchromb.2026.125336_bb0125","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0039-9140(02)00610-0","article-title":"HPLC and HPCE analysis of microcystins RR, LR and YR present in cyanobacteria and water by using immunoaffinity extraction","volume":"59","author":"Aguete","year":"2003","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2026.125336_bb0130","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.toxicon.2003.08.001","article-title":"Extraction of 15 microcystins and nodularin using immunoaffinity columns","volume":"42","author":"Aranda-Rodriguez","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.jchromb.2026.125336_bb0135","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0021-9673(01)00924-4","article-title":"Determination of microcystins in blue\u2013green algae, fish and water using liquid chromatography with ultraviolet detection after sample clean-up employing immunoaffinity chromatography","volume":"922","author":"Lawrence","year":"2001","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jchromb.2026.125336_bb0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.talanta.2006.02.029","article-title":"Generation and characterization of polyclonal antibodies against microcystins\u2014application to immunoassays and immunoaffinity sample preparation prior to analysis by liquid chromatography and UV detection","volume":"70","author":"Mhadhbi","year":"2006","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2026.125336_bb0145","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.aca.2013.07.019","article-title":"Immobilized antibody on a hybrid organic\u2013inorganic monolith: capillary immunoextraction coupled on-line to nanoLC-UV for the analysis of microcystin-LR","volume":"792","author":"Brothier","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jchromb.2026.125336_bb0150","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1128\/AEM.68.11.5288-5295.2002","article-title":"Rapid isolation of a single-chain antibody against the cyanobacterial toxin microcystin-LR by phage display and its use in the immunoaffinity concentration of microcystins from water","volume":"68","author":"McElhiney","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jchromb.2026.125336_bb0155","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2116\/analsci.18P384","article-title":"Microcystin-LR enrichment from freshwater by a recombinant plant-derived antibody using sol\u2013gel-glass immunoextraction","volume":"35","author":"Neumann","year":"2019","journal-title":"Anal. Sci."},{"key":"10.1016\/j.jchromb.2026.125336_bb0160","doi-asserted-by":"crossref","first-page":"8035","DOI":"10.1021\/es5012675","article-title":"Multihapten approach leading to a sensitive ELISA with broad cross-reactivity to microcystins and nodularin","volume":"48","author":"Samdal","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jchromb.2026.125336_bb0165","doi-asserted-by":"crossref","first-page":"12466","DOI":"10.1021\/acs.analchem.5c07801","article-title":"Broad cross-reactivity of a microcystin ELISA confirmed using 19 quantitative reference materials","volume":"98","author":"Samdal","year":"2026","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2026.125336_bb0170","series-title":"CRM-MCLR: certified calibration solution for microcystin-LR","author":"Thomas","year":"2013"},{"key":"10.1016\/j.jchromb.2026.125336_bb0175","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jchromb.2026.125336_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12040228","article-title":"Investigation of in vitro endocrine activities of Microcystis and Planktothrix cyanobacterial strains","volume":"12","author":"Mallia","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.jchromb.2026.125336_bb0185","author":"Nonga","year":"2011"},{"key":"10.1016\/j.jchromb.2026.125336_bb0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.toxicon.2013.03.016","article-title":"Identification of microcystins in a Lake Victoria cyanobacterial bloom using LC\u2013MS with thiol derivatization","volume":"70","author":"Miles","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.jchromb.2026.125336_bb0195","doi-asserted-by":"crossref","first-page":"769","DOI":"10.4155\/bio.10.31","article-title":"Immunoaffinity chromatography: an introduction to applications and recent developments","volume":"2","author":"Moser","year":"2010","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jchromb.2026.125336_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.hal.2024.102739","article-title":"Identification of novel microcystins in algal extracts by a liquid chromatography\u2013high-resolution mass spectrometry data analysis pipeline","volume":"139","author":"Cottrill","year":"2024","journal-title":"Harmful Algae"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226004253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226004253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:31:41Z","timestamp":1792081901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226004253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":40,"alternative-id":["S1570023226004253"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125336","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective extraction of microcystins and nodularins with immobilized polyclonal antibodies for LC\u2013MS analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.125336","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"125336"}}