{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:19:03Z","timestamp":1787847543808,"version":"build-2784847793"},"reference-count":26,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":437,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006221","name":"Cordis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015237","name":"Medicines Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002736","name":"Covidien","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.jcin.2014.01.166","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T15:46:33Z","timestamp":1405957593000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Impact of Delay to Reperfusion on Reperfusion Success, Infarct Size, and Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction"],"prefix":"10.1016","volume":"7","author":[{"given":"Alejandra","family":"Guerchicoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin J.","family":"Brener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Witzenbichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Gersh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Michael","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2014.01.166_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0140-6736(03)12113-7","article-title":"Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials","volume":"361","author":"Keeley","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2014.01.166_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1056\/NEJM200008103430602","volume":"343","author":"Schomig","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2014.01.166_bib3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/01.CIR.0000086346.32856.9C","article-title":"Therapy-dependent influence of time-to-treatment interval on myocardial salvage in patients with acute myocardial infarction treated with coronary artery stenting or thrombolysis","volume":"108","author":"Schomig","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2014.01.166_bib4","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.amjcard.2010.01.005","article-title":"Time to treatment and three-year mortality after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction-a DANish trial in acute myocardial infarction-2 (DANAMI-2) substudy","volume":"105","author":"Maeng","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2014.01.166_bib5","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1053\/euhj.2001.3035","article-title":"Incidence and clinical significance of distal embolization during primary angioplasty for acute myocardial infarction","volume":"23","author":"Henriques","year":"2002","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2014.01.166_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCULATIONAHA.107.747642","volume":"118","author":"Thiele","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2014.01.166_bib7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa0706416","article-title":"Thrombus aspiration during primary percutaneous coronary intervention","volume":"358","author":"Svilaas","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2014.01.166_bib8","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ahj.2010.10.006","volume":"161","author":"Gibson","year":"2011","journal-title":"Am Heart\u00a0J"},{"key":"10.1016\/j.jcin.2014.01.166_bib9","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1001\/jama.2012.421","article-title":"Intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction: the INFUSE-AMI randomized trial","volume":"307","author":"Stone","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2014.01.166_bib10","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1056\/NEJM198504043121437","article-title":"The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. TIMI Study Group","volume":"312","year":"1985","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2014.01.166_bib11","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1056\/NEJMoa0708191","article-title":"Bivalirudin during primary PCI in acute myocardial infarction","volume":"358","author":"Stone","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2014.01.166_bib12","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1056\/NEJM199311253292204","article-title":"The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction. The GUSTO Angiographic Investigators","volume":"329","year":"1993","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2014.01.166_bib13","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.CIR.97.23.2302","article-title":"Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction: myocardial blush grade. Zwolle Myocardial Infarction Study Group","volume":"97","author":"van 't Hof","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2014.01.166_bib14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/01.CIR.0000022691.71708.94","article-title":"Integrated analysis of myocardial blush and ST-segment elevation recovery after successful primary angioplasty: real-time grading of microvascular reperfusion and prediction of early and late recovery of left ventricular function","volume":"106","author":"Poli","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2014.01.166_bib15","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1001\/jama.283.22.2941","article-title":"Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in\u00a0patients undergoing angioplasty for acute myocardial infarction","volume":"283","author":"Cannon","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2014.01.166_bib16","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/eurheartj\/ehi810","article-title":"Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients","volume":"27","author":"Boersma","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2014.01.166_bib17","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/eurheartj\/ehs215","article-title":"ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"33","author":"Steg","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2014.01.166_bib18","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1016\/j.jacc.2012.11.019","article-title":"2013 ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"61","author":"O'Gara","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2014.01.166_bib19","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1001\/archinternmed.2010.381","article-title":"Trends in door-to-balloon time and mortality in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"170","author":"Flynn","year":"2010","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jcin.2014.01.166_bib20","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1001\/archinternmed.2009.223","article-title":"The dissociation between door-to-balloon time improvement and improvements in other acute myocardial infarction care processes and patient outcomes","volume":"169","author":"Wang","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jcin.2014.01.166_bib21","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.CIR.0000121424.76486.20","article-title":"Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction: every minute of delay counts","volume":"109","author":"De Luca","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2014.01.166_bib22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jacc.2010.04.020","volume":"56","author":"Brodie","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2014.01.166_bib23","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.amjcard.2007.06.027","article-title":"Predictors of infarct size after primary coronary angioplasty in acute myocardial infarction from pooled analysis from four contemporary trials","volume":"100","author":"Stone","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2014.01.166_bib24","doi-asserted-by":"crossref","first-page":"L526","DOI":"10.1161\/CIRCINTERVENTIONS.113.000644","article-title":"Intralesional abciximab and thrombus aspiration in patients with large anterior myocardial infarction: one-year results from the INFUSE-AMI trial","volume":"6","author":"Stone","year":"2013","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2014.01.166_bib25","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/eurheartj\/ehn125","article-title":"Reperfusion after primary angioplasty for ST-elevation myocardial infarction: predictors of success and relationship to clinical outcomes in the APEX-AMI angiographic study","volume":"29","author":"Brener","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2014.01.166_bib26","doi-asserted-by":"crossref","first-page":"13G","DOI":"10.1016\/0002-9149(93)90102-I","article-title":"Reperfusion in acute myocardial infarction: effect of timing and modulating factors in experimental models","volume":"72","author":"Reimer","year":"1993","journal-title":"Am J Cardiol"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879814007353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879814007353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:00:33Z","timestamp":1761847233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879814007353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1936879814007353"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2014.01.166","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Delay to Reperfusion on Reperfusion Success, Infarct Size, and Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2014.01.166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}