{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:33:06Z","timestamp":1785821586635,"version":"3.56.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:00:00Z","timestamp":1461715200000},"content-version":"vor","delay-in-days":392,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.jcin.2014.11.022","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T14:15:45Z","timestamp":1430144145000},"page":"681-688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Long-Term Outcomes of Percutaneous Paravalvular Regurgitation Closure After Transcatheter Aortic Valve Replacement"],"prefix":"10.1016","volume":"8","author":[{"given":"Francesco","family":"Saia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Gafoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ciuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Marrozzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Marzocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2014.11.022_bib1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2014.11.022_bib2","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","article-title":"Transcatheter versus surgical aortic-valve replacement in high-risk patients","volume":"364","author":"Smith","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2014.11.022_bib3","first-page":"160","article-title":"Reoperation for aortic valve periprosthetic leakage: identification of patients at risk and results of operation","volume":"4","author":"Miller","year":"1995","journal-title":"J\u00a0Heart Valve Dis"},{"key":"10.1016\/j.jcin.2014.11.022_bib4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0002-8703(99)70124-9","article-title":"Natural history of early aortic paraprosthetic regurgitation: a five-year follow-up","volume":"138","author":"Rallidis","year":"1999","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2014.11.022_bib5","first-page":"312","article-title":"Valvular leak after transcatheter aortic valve implantation: a clinician update on epidemiology, pathophysiology and clinical implications","volume":"1","author":"Tarantini","year":"2011","journal-title":"Am J Cardiovasc Dis"},{"key":"10.1016\/j.jcin.2014.11.022_bib6","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/hrt.2010.217158","article-title":"Aortic regurgitation after transcatheter aortic valve implantation: incidence and early outcome. Results from the German Transcatheter Aortic Valve Interventions Registry","volume":"97","author":"Abdel-Wahab","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.jcin.2014.11.022_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/CIRCULATIONAHA.110.946533","article-title":"Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis","volume":"123","author":"Tamburino","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2014.11.022_bib8","first-page":"432","article-title":"Predictors of moderate-to-severe paravalvular aortic regurgitation immediately after CoreValve implantation and the impact of postdilatation","volume":"78","author":"Takagi","year":"2011","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2014.11.022_bib9","first-page":"713","article-title":"The valve-in-valve technique: transcatheter treatment of aortic bioprosthesis malposition","volume":"73","author":"Ussia","year":"2009","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2014.11.022_bib10","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijcard.2009.07.040","article-title":"\u201cBail out\u201d procedures for malpositioning of aortic valve prosthesis (CoreValve)","volume":"145","author":"Vavouranakis","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2014.11.022_bib11","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jcin.2010.04.013","article-title":"Transcatheter closure of paravalvular defects using a purpose-specific occluder","volume":"3","author":"Nietlispach","year":"2010","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2014.11.022_bib12","first-page":"305","article-title":"Percutaneous closure of perivalvular leaks with Amplatzer occluders: feasibility, safety, and shortterm results","volume":"16","author":"Shapira","year":"2007","journal-title":"J\u00a0Heart Valve Dis"},{"key":"10.1016\/j.jcin.2014.11.022_bib13","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4244\/EIJV9I2A47","article-title":"Percutaneous treatment of paravalvular leaks after transcatheter aortic valve implantation with the CoreValve self-expanding bioprosthesis","volume":"9","author":"Saia","year":"2013","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2014.11.022_bib14","first-page":"300","article-title":"Management of paravalvular regurgitation after Edwards SAPIEN transcatheter aortic valve replacement: management of paravalvular regurgitation after TAVR","volume":"82","author":"Martinez","year":"2013","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2014.11.022_bib15","first-page":"147","article-title":"Paravalvular leak closure after transcatheter aortic valve replacement with a self-expanding prosthesis","volume":"84","author":"Gafoor","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2014.11.022_bib16","first-page":"901","article-title":"Device closure of paravalvular defects following transcatheter aortic valve replacement with the Edwards Sapien valve","volume":"81","author":"Whisenant","year":"2013","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2014.11.022_bib17","first-page":"280","article-title":"Low profile vascular plugs for paravalvular leaks after TAVR","volume":"83","author":"Feldman","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2014.11.022_bib18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jtcvs.2007.09.011","article-title":"Reliability of risk algorithms in predicting early and late operative outcomes in high-risk patients undergoing aortic valve replacement","volume":"135","author":"Dewey","year":"2008","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jcin.2014.11.022_bib19","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S1010-7940(99)00106-2","article-title":"Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients","volume":"15","author":"Roques","year":"1999","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jcin.2014.11.022_bib20","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1093\/eurheartj\/ehs255","article-title":"Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document","volume":"33","author":"Kappetein","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2014.11.022_bib21","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jacc.2012.08.1039","article-title":"Paravalvular leak after transcatheter aortic valve replacement: the new Achilles' heel? A comprehensive review of the literature","volume":"61","author":"G\u00e9n\u00e9reux","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2014.11.022_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jacc.2013.02.088","article-title":"Evaluation and management of paravalvular aortic regurgitation after transcatheter aortic valve replacement","volume":"62","author":"Sinning","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2014.11.022_bib23","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/eurheartj\/ehs347","article-title":"Review of surgical prosthetic paravalvular leaks: diagnosis and catheter-based closure","volume":"34","author":"Kliger","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2014.11.022_bib24","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jcin.2012.04.011","article-title":"Impact of paravalvular leakage on outcome in patients after transcatheter aortic valve implantation","volume":"5","author":"Vasa-Nicotera","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2014.11.022_bib25","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1056\/NEJMoa1200384","article-title":"Two-year outcomes after transcatheter or surgical aortic-valve replacement","volume":"366","author":"Kodali","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2014.11.022_bib26","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.4244\/EIJV8I12A213","article-title":"Incidence, outcome and correlates of residual paravalvular aortic regurgitation after transcatheter aortic valve implantation and importance of haemodynamic assessment","volume":"8","author":"Patsalis","year":"2013","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2014.11.022_bib27","first-page":"502","article-title":"Clinical impact of paravalvular leaks on biomarkers and survival after transcatheter aortic valve implantation","volume":"85","author":"Schewel","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2014.11.022_bib28","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.jcin.2012.09.003","article-title":"Impact of post-procedural aortic regurgitation on mortality after transcatheter aortic valve implantation","volume":"5","author":"Hayashida","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2014.11.022_bib29","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.jacc.2012.11.050","article-title":"Transcatheter aortic valve implantation with the Edwards SAPIEN versus the Medtronic CoreValve Revalving system devices: a multicenter collaborative study: the PRAGMATIC Plus Initiative (Pooled-RotterdAm-Milano-Toulouse In Collaboration)","volume":"61","author":"Chieffo","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2014.11.022_bib30","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jcin.2009.07.003","article-title":"Determinants of significant paravalvular regurgitation after transcatheter aortic valve: implantation impact of device and annulus discongruence","volume":"2","author":"D\u00e9taint","year":"2009","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2014.11.022_bib31","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jacc.2013.04.036","article-title":"The\u00a0impact of integration of a multidetector computed tomography annulus area sizing algorithm on outcomes of transcatheter aortic valve replacement: a prospective, multicenter, controlled trial","volume":"62","author":"Binder","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2014.11.022_bib32","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.jacc.2014.05.067","article-title":"Transcatheter aortic valve replacement for severe symptomatic aortic stenosis using a repositionable valve system: 30-day primary endpoint results from the REPRISE II study","volume":"64","author":"Meredith","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2014.11.022_bib33","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.amjcard.2014.07.019","article-title":"Comparison of hemodynamic performance of the balloon-expandable SAPIEN 3 versus SAPIEN XT transcatheter valve","volume":"114","author":"Amat-Santos","year":"2014","journal-title":"Am J Cardiol"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879815002496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879815002496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:01:04Z","timestamp":1761847264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879815002496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1936879815002496"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2014.11.022","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725470025.793541312","asserted-by":"object"}]},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-Term Outcomes of Percutaneous Paravalvular Regurgitation Closure After Transcatheter Aortic Valve Replacement","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2014.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}