{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:26:09Z","timestamp":1790774769446,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T00:00:00Z","timestamp":1471392000000},"content-version":"vor","delay-in-days":382,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.jcin.2015.03.029","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T14:15:19Z","timestamp":1439820919000},"page":"1248-1260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Acute Thrombogenicity of a Durable Polymer Everolimus-Eluting Stent Relative to Contemporary Drug-Eluting Stents With Biodegradable Polymer Coatings Assessed Ex\u00a0Vivo\u00a0in\u00a0a Swine Shunt Model"],"prefix":"10.1016","volume":"8","author":[{"given":"Fumiyuki","family":"Otsuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Yahagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Acampado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sheehy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saami K.","family":"Yazdani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Sakakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Euller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.L.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank D.","family":"Kolodgie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2015.03.029_bib1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jcin.2009.04.003","article-title":"The risk of stent thrombosis in patients with acute coronary syndromes treated with bare-metal and drug-eluting stents","volume":"2","author":"Kukreja","year":"2009","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2015.03.029_bib2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jacc.2004.09.079","article-title":"Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation","volume":"45","author":"Ong","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.03.029_bib3","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1016\/j.jacc.2014.02.607","article-title":"Causes of\u00a0early stent thrombosis in patients presenting with acute coronary syndrome: an ex\u00a0vivo human autopsy study","volume":"63","author":"Nakano","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.03.029_bib4","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1161\/CIRCULATIONAHA.110.003210","article-title":"Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings","volume":"123","author":"Kolandaivelu","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.03.029_bib5","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0140-6736(12)60324-9","article-title":"Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis","volume":"379","author":"Palmerini","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2015.03.029_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jacc.2011.02.023","volume":"58","author":"Smits","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.03.029_bib7","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0140-6736(12)61223-9","article-title":"Everolimus-eluting stent versus bare-metal stent in ST-segment elevation myocardial infarction (EXAMINATION): 1 year results of a randomised controlled trial","volume":"380","author":"Sabate","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2015.03.029_bib8","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jmbbm.2010.04.003","article-title":"A\u00a0method to develop mock arteries suitable for cell seeding and in-vitro cell culture experiments","volume":"3","author":"Colombo","year":"2010","journal-title":"J\u00a0Mech Behav Biomed Mater"},{"key":"10.1016\/j.jcin.2015.03.029_bib9","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bimj.200810425","article-title":"Simultaneous inference in general parametric models","volume":"50","author":"Hothorn","year":"2008","journal-title":"Biom J"},{"key":"10.1016\/j.jcin.2015.03.029_bib10","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1080\/01621459.1955.10501294","article-title":"A\u00a0multiple comparison procedure for comparing several treatments with a control","volume":"50","author":"Dunnett","year":"1955","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.jcin.2015.03.029_bib11","first-page":"35","article-title":"Biodegradable polymer biolimus-eluting stent (Nobori) for the treatment of coronary artery lesions: review of concept and clinical results","volume":"7","author":"Schurtz","year":"2014","journal-title":"Med Devices (Auckl)"},{"key":"10.1016\/j.jcin.2015.03.029_bib12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4244\/EIJV9I3A51","article-title":"Polymer coatings on drug-eluting stents: Samson's hair and Achilles' heel?","volume":"9","author":"Basalus","year":"2013","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2015.03.029_bib13","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1161\/01.CIR.101.7.812","article-title":"Stent and artery geometry determine intimal thickening independent of arterial injury","volume":"101","author":"Garasic","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.03.029_bib14","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1161\/01.CIR.103.23.2816","article-title":"Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO) trial","volume":"103","author":"Kastrati","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.03.029_bib15","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1182\/blood-2011-02-331579","article-title":"S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation","volume":"118","author":"Aslan","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jcin.2015.03.029_bib16","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1182\/blood-2006-08-042192","article-title":"mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets","volume":"109","author":"Weyrich","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jcin.2015.03.029_bib17","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/CIRCULATIONAHA.108.804203","article-title":"Early stent thrombosis in patients with acute coronary syndromes treated with drug-eluting and bare metal stents: the Acute Catheterization and Urgent Intervention Triage Strategy trial","volume":"119","author":"Aoki","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.03.029_bib18","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jcin.2012.07.012","article-title":"Development and validation of a stent thrombosis risk score in patients with acute coronary syndromes","volume":"5","author":"Dangas","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2015.03.029_bib19","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1136\/hrt.2003.026047","article-title":"Findings of intravascular ultrasound during acute stent thrombosis","volume":"90","author":"Alfonso","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.jcin.2015.03.029_bib20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1161\/CIRCINTERVENTIONS.110.959791","article-title":"Intravascular ultrasound findings of early stent thrombosis after primary percutaneous intervention in acute myocardial infarction: a Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) substudy","volume":"4","author":"Choi","year":"2011","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2015.03.029_bib21","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.jacc.2011.06.049","article-title":"Impact of the everolimus-eluting stent on stent thrombosis: a meta-analysis of 13 randomized trials","volume":"58","author":"Baber","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.03.029_bib22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(12)61852-2","article-title":"Abluminal biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent (COMPARE II): a randomised, controlled, non-inferiority trial","volume":"381","author":"Smits","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2015.03.029_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jacc.2013.04.045","article-title":"Biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent: a randomized, controlled, noninferiority trial","volume":"62","author":"Natsuaki","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.03.029_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/heart.89.2.133","article-title":"Drug eluting stents: are human and animal studies comparable?","volume":"89","author":"Virmani","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.jcin.2015.03.029_bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/cvr\/cvt115","article-title":"Biological responses in stented arteries","volume":"99","author":"Chaabane","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jcin.2015.03.029_bib26","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1073\/pnas.96.5.2311","article-title":"Blood-borne tissue factor: another view of thrombosis","volume":"96","author":"Giesen","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcin.2015.03.029_bib27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1182\/blood.V96.1.170","article-title":"Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor","volume":"96","author":"Rauch","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jcin.2015.03.029_bib28","doi-asserted-by":"crossref","first-page":"e71447","DOI":"10.1371\/journal.pone.0071447","article-title":"Cathepsin G-dependent modulation of platelet thrombus formation in\u00a0vivo by blood neutrophils","volume":"8","author":"Faraday","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jcin.2015.03.029_bib29","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1161\/01.CIR.0000019071.72887.BD","article-title":"Morphological predictors of restenosis after coronary stenting in humans","volume":"105","author":"Farb","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.03.029_bib30","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1161\/01.ATV.20.12.2553","article-title":"Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries","volume":"20","author":"Welt","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcin.2015.03.029_bib31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/(SICI)1097-4636(19980101)39:1<130::AID-JBM15>3.0.CO;2-J","article-title":"Blood and tissue compatibility of modified polyester: thrombosis, inflammation, and healing","volume":"39","author":"Chinn","year":"1998","journal-title":"J\u00a0Biomed Mater Res"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879815008109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879815008109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:02:06Z","timestamp":1761847326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879815008109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S1936879815008109"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2015.03.029","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Thrombogenicity of a Durable Polymer Everolimus-Eluting Stent Relative to Contemporary Drug-Eluting Stents With Biodegradable Polymer Coatings Assessed Ex\u00a0Vivo\u00a0in\u00a0a Swine Shunt Model","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2015.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}