{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:38:23Z","timestamp":1792093103216,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG-31750"],"award-info":[{"award-number":["AG-31750"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL-92954"],"award-info":[{"award-number":["HL-92954"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jcin.2015.06.017","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T17:45:38Z","timestamp":1442857538000},"page":"1445-1453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":469,"title":["Prevalence of Coronary Microvascular Dysfunction Among Patients With Chest\u00a0Pain and Nonobstructive Coronary\u00a0Artery Disease"],"prefix":"10.1016","volume":"8","author":[{"given":"Jaskanwal D.","family":"Sara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Jay","family":"Widmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Matsuzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Lennon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2015.06.017_bib1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa0907272","article-title":"Low diagnostic yield of elective coronary angiography","volume":"362","author":"Patel","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2015.06.017_bib2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jcin.2014.01.157","article-title":"Angina pectoris and myocardial ischemia in the absence of obstructive coronary artery disease: practical considerations for diagnostic tests","volume":"7","author":"Radico","year":"2014","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2015.06.017_bib3","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/eurheartj\/ehr331","article-title":"Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events","volume":"33","author":"Jespersen","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2015.06.017_bib4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1001\/archinternmed.2009.50","article-title":"Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project","volume":"169","author":"Gulati","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jcin.2015.06.017_bib5","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1161\/01.CIR.0000130642.79868.B2","article-title":"Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE)","volume":"109","author":"Johnson","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib6","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/S0195-668X(03)00279-3","article-title":"Symptoms, myocardial ischaemia and quality of life in women: results from the NHLBI-sponsored WISE Study","volume":"24","author":"Olson","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2015.06.017_bib7","series-title":"Ischemic Heart Disease: A Rational Basis for Clinical Practise and Clinical Research","first-page":"71","author":"Maseri","year":"1995"},{"key":"10.1016\/j.jcin.2015.06.017_bib8","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/0735-1097(89)90414-2","article-title":"Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium","volume":"14","author":"Zeiher","year":"1989","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib9","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/0140-6736(91)92372-9","article-title":"Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine","volume":"338","author":"Drexler","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2015.06.017_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1172\/JCI116183","article-title":"Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions","volume":"91","author":"Egashira","year":"1993","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcin.2015.06.017_bib11","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1056\/NEJM199306103282302","article-title":"Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary angiograms","volume":"328","author":"Egashira","year":"1993","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2015.06.017_bib12","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1161\/01.CIR.96.10.3390","article-title":"Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects","volume":"96","author":"Hasdai","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib13","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1161\/01.CIR.86.6.1864","article-title":"Endothelial dysfunction in patients with chest pain and normal coronary arteries","volume":"86","author":"Quyyumi","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib14","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1056\/NEJMra061889","article-title":"Coronary microvascular dysfunction","volume":"356","author":"Camici","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2015.06.017_bib15","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1001\/jama.2009.425","article-title":"Persistent chest pain and no obstructive coronary artery disease","volume":"301","author":"Phan","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2015.06.017_bib16","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.4065\/73.12.1133","article-title":"Prevalence of coronary blood flow reserve abnormalities among patients with nonobstructive coronary artery disease and chest pain","volume":"73","author":"Hasdai","year":"1998","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jcin.2015.06.017_bib17","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jcin.2012.01.023","article-title":"Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study","volume":"5","author":"Wei","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2015.06.017_bib18","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1161\/CIRCULATIONAHA.113.004096","article-title":"Clinical usefulness, angiographic characteristics, and safety evaluation of intracoronary acetylcholine provocation testing among 921 consecutive white patients with unobstructed coronary arteries","volume":"129","author":"Ong","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib19","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1161\/CIRCULATIONAHA.114.012636","article-title":"Invasive evaluation of patients with angina in the absence of obstructive coronary artery disease","volume":"131","author":"Lee","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0167-5273(95)02548-0","article-title":"Evaluation of patients with minimally obstructive coronary artery disease and angina","volume":"53","author":"Hasdai","year":"1996","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib21","doi-asserted-by":"crossref","first-page":"H393","DOI":"10.1152\/ajpheart.00765.2012","article-title":"Circulating humanin levels are associated with preserved coronary endothelial function","volume":"304","author":"Widmer","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib22","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1161\/01.CIR.96.10.3369","article-title":"Prognostic value of intracoronary flow velocity and diameter stenosis in assessing the short- and long-term outcomes of coronary balloon angioplasty: the DEBATE Study (Doppler Endpoints Balloon Angioplasty Trial Europe)","volume":"96","author":"Serruys","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib23","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.105.609990","article-title":"The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health\u2013National Heart, Lung, and Blood Institute\u2013sponsored Women's Ischemia Syndrome Evaluation","volume":"114","author":"Shaw","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib24","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/CIRCULATIONAHA.113.008507","article-title":"Effects of sex on coronary microvascular dysfunction and cardiac outcomes","volume":"129","author":"Murthy","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib25","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.jacc.2010.01.054","article-title":"Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia: results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study","volume":"55","author":"Pepine","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ahj.2013.03.015","article-title":"Sex differences in clinical outcomes in patients with stable angina and no obstructive coronary artery disease","volume":"166","author":"Sedlak","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2015.06.017_bib27","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/01.CIR.101.9.948","article-title":"Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction","volume":"101","author":"Suwaidi","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/01.CIR.88.1.77","article-title":"Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans","volume":"88","author":"Egashira","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1161\/01.CIR.89.1.45","article-title":"Constrictor and dilator responses to intracoronary acetylcholine in adjacent segments of the same coronary artery in patients with coronary artery disease. Endothelial function revisited","volume":"89","author":"el-Tamimi","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/hrt.75.3.261","article-title":"Variable coronary vasomotor responses to acetylcholine in patients with normal coronary arteriograms: evidence for localised endothelial dysfunction","volume":"75","author":"Tousoulis","year":"1996","journal-title":"Heart"},{"key":"10.1016\/j.jcin.2015.06.017_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s40256-013-0052-1","article-title":"Management of microvascular angina pectoris","volume":"14","author":"Lanza","year":"2014","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.jcin.2015.06.017_bib32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jacc.2010.08.626","article-title":"3-year follow-up of patients with coronary artery spasm as cause of acute coronary syndrome: the CASPAR (coronary artery spasm in patients with acute coronary syndrome) study follow-up","volume":"57","author":"Ong","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCINTERVENTIONS.108.841056","article-title":"Lack of correlation between noninvasive stress tests and invasive coronary vasomotor dysfunction in patients with nonobstructive coronary artery disease","volume":"2","author":"Cassar","year":"2009","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2015.06.017_bib34","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1056\/NEJMoa012369","article-title":"Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging","volume":"346","author":"Panting","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2015.06.017_bib35","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0735-1097(10)80122-6","article-title":"Mechanisms of angina pectoris in syndrome X","volume":"17","author":"Maseri","year":"1991","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib36","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/0735-1097(91)90676-Z","article-title":"Absence of myocardial dysfunction during stress in patients with syndrome X","volume":"18","author":"Nihoyannopoulos","year":"1991","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0735-1097(96)00481-0","article-title":"Investigation of the mechanism of chest pain in patients with angiographically normal coronary arteries using transesophageal dobutamine stress echocardiography","volume":"29","author":"Panza","year":"1997","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib38","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S0735-1097(97)00091-0","article-title":"A\u00a0reappraisal of exercise electrocardiographic indexes of the severity of ischemic heart disease: angiographic and scintigraphic correlates","volume":"29","author":"Bogaty","year":"1997","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/01.CIR.95.2.299","article-title":"Is noninvasive testing for coronary artery disease accurate?","volume":"95","author":"Douglas","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib40","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","article-title":"2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the Management of Stable Coronary Artery Disease of the European Society of Cardiology","volume":"34","author":"Montalescot","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2015.06.017_bib41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/01.ATV.0000051384.43104.FC","article-title":"Endothelial dysfunction: a marker of atherosclerotic risk","volume":"23","author":"Bonetti","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcin.2015.06.017_bib42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s00259-011-1956-0","article-title":"Coronary risk factors and myocardial blood flow in patients evaluated for coronary artery disease: a quantitative [15O]H2O PET\/CT study","volume":"39","author":"Danad","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jcin.2015.06.017_bib43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/01.CIR.90.1.50","article-title":"Coronary vasodilator reserve, pain perception, and sex in patients with syndrome X","volume":"90","author":"Rosen","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib44","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0002-9149(01)01424-2","article-title":"Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory)","volume":"87","author":"Sharaf","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib45","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.CIR.0000153339.27064.14","article-title":"Endothelial function: cardiac events","volume":"111","author":"Lerman","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib46","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1161\/CIRCULATIONAHA.106.641654","article-title":"Smoking is associated with epicardial coronary endothelial dysfunction and elevated white blood cell count in patients with chest pain and early coronary artery disease","volume":"115","author":"Lavi","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.06.017_bib47","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.atherosclerosis.2005.11.009","article-title":"Dietary reversal of experimental hypercholesterolemia improves endothelial dysfunction of epicardial arteries but not of small coronary vessels in pigs","volume":"188","author":"Sattler","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jcin.2015.06.017_bib48","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/clc.19","article-title":"Coronary microvascular reactivity is only partially predicted by atherosclerosis risk factors or coronary artery disease in women evaluated for suspected ischemia: results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE)","volume":"30","author":"Wessel","year":"2007","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jcin.2015.06.017_bib49","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1161\/01.CIR.92.11.3337","article-title":"Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP","volume":"92","author":"Cohen","year":"1995","journal-title":"Circulation"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879815009863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879815009863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:02:21Z","timestamp":1761847341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879815009863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1936879815009863"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2015.06.017","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of Coronary Microvascular Dysfunction Among Patients With Chest\u00a0Pain and Nonobstructive Coronary\u00a0Artery Disease","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2015.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}