{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:56:45Z","timestamp":1790888205198,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":392,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.jcin.2015.11.041","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T17:40:55Z","timestamp":1458582055000},"page":"589-598","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Transcatheter Alcohol-Mediated Perivascular Renal Denervation With\u00a0the\u00a0Peregrine System"],"prefix":"10.1016","volume":"9","author":[{"given":"Tim A.","family":"Fischell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Ebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Ikeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Minarsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Haratani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vartan E.","family":"Ghazarossian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2015.11.041_bib1","first-page":"1497","article-title":"Renal sympathectomy: its scope and limitations","volume":"28","author":"Harris","year":"1935","journal-title":"Proc R Soc Med"},{"key":"10.1016\/j.jcin.2015.11.041_bib2","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1001\/jama.1953.03690160001001","article-title":"Splanchnicectomy for essential hypertension; results in 1,266 cases","volume":"152","author":"Smithwick","year":"1953","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2015.11.041_bib3","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/HYPERTENSIONAHA.109.138610","article-title":"Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept","volume":"54","author":"Schlaich","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.jcin.2015.11.041_bib4","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0140-6736(09)60566-3","article-title":"Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study","volume":"373","author":"Krum","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2015.11.041_bib5","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/HYPERTENSIONAHA.110.163014","article-title":"Catheter-based renal sympathetic denervation for resistant hypertension: durability of blood pressure reduction out to 24 Months","volume":"57","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.jcin.2015.11.041_bib6","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(10)62039-9","article-title":"Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial","volume":"376","author":"Esler","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2015.11.041_bib7","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.4244\/EIJY14M10_14","article-title":"Controlled circumferential renal sympathetic denervation with preservation for the renal arterial wall using intraluminal ultrasound: a next generation approach for treating sympathetic overactivity","volume":"10","author":"Sakakura","year":"2015","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2015.11.041_bib8","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/clc.22008","article-title":"Catheter-based renal denervation for resistant hypertension: rationale and design of the SYMPLICITY HTN-3 trial","volume":"35","author":"Kandzari","year":"2012","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1161\/HYPERTENSIONAHA.112.193870","article-title":"Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension","volume":"60","author":"Mahfoud","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jcin.2015.11.041_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/CIRCULATIONAHA.110.971580","article-title":"Device-based antihypertensive therapy: therapeutic modulation of the autonomic nervous system","volume":"123","author":"Krum","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.11.041_bib11","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1161\/HYPERTENSIONAHA.112.200865","article-title":"Health-related quality of life after renal denervation in patients with treatment-resistant hypertension","volume":"60","author":"Lambert","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jcin.2015.11.041_bib12","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4244\/EIJV8I9A166","article-title":"First-in-human use of the OneShot\u2122 renal denervation system from Covidien","volume":"8","author":"Ormiston","year":"2013","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2015.11.041_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11906-012-0264-9","article-title":"Renal denervation in human hypertension: mechanisms, current findings, and future prospects","volume":"14","author":"Schlaich","year":"2012","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.jcin.2015.11.041_bib14","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/ajh.2011.35","article-title":"Renal denervation and hypertension","volume":"24","author":"Schlaich","year":"2011","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jcin.2015.11.041_bib15","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJMoa1402670","article-title":"A\u00a0controlled trial of renal denervation for resistant hypertension","volume":"370","author":"Bhatt","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2015.11.041_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jacc.2014.05.012","article-title":"Impact of renal denervation on 24-hour ambulatory blood pressure: results from SYMPLICITY HTN-3","volume":"64","author":"Bakris","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/eurheartj\/ehu441","article-title":"Predictors of blood pressure response in the SYMPLICITY HTN-3 trial","volume":"36","author":"Kandzari","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2015.11.041_bib18","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.carrev.2015.05.008","article-title":"Renal denervation for drug-resistant hypertension: there is still hope","volume":"16","author":"Papademetriou","year":"2015","journal-title":"Cardiovasc Revasc Med"},{"key":"10.1016\/j.jcin.2015.11.041_bib19","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/ndt\/gfu192","article-title":"Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study","volume":"29","author":"Vink","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jcin.2015.11.041_bib20","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.jacc.2014.07.937","article-title":"Innervation patterns may limit response to endovascular renal denervation","volume":"64","author":"Tzafriri","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib21","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jacc.2014.03.059","article-title":"Anatomic assessment of sympathetic peri-arterial renal nerves in man","volume":"64","author":"Sakakura","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib22","doi-asserted-by":"crossref","first-page":"e002474","DOI":"10.1161\/CIRCINTERVENTIONS.115.002474","article-title":"Multimodality intra-arterial imaging assessment of the vascular trauma induced by balloon-based and nonballoon based renal denervation systems","volume":"8","author":"Karanasos","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2015.11.041_bib23","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.jacc.2012.09.027","article-title":"Renal artery stenosis after renal sympathetic denervation","volume":"60","author":"Kaltenbach","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib24","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1097\/HJH.0000000000000323","article-title":"Renal artery stenosis following renal denervation: a matter of concern","volume":"32","author":"Persu","year":"2014","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.jcin.2015.11.041_bib25","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0140-6736(12)61145-3","article-title":"Secondary rise in blood pressure after renal denervation","volume":"380","author":"Vonend","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2015.11.041_bib26","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ijcard.2014.04.049","article-title":"Late renal artery stenosis after renal denervation: is it the tip of the iceberg?","volume":"174","author":"Versaci","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4244\/EIJV9I1A20","article-title":"Ethanol-mediated perivascular renal sympathetic denervation preclinical validation of safety and efficacy in a porcine model","volume":"9","author":"Fischell","year":"2013","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2015.11.041_bib28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.carrev.2015.04.008","article-title":"Next generation renal denervation: chemical \u201cperivascular\u201d renal denervation with alcohol using a novel drug infusion catheter","volume":"16","author":"Fischell","year":"2015","journal-title":"Cardiovasc Revasc Med"},{"key":"10.1016\/j.jcin.2015.11.041_bib29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11886-012-0258-x","article-title":"The role of renal denervation in the treatment of heart failure","volume":"14","author":"Sobotka","year":"2012","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.jcin.2015.11.041_bib30","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/HYPERTENSIONAHA.112.191965","article-title":"Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea","volume":"60","author":"Linz","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jcin.2015.11.041_bib31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1161\/HYPERTENSIONAHA.111.173799","article-title":"Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea","volume":"58","author":"Witkowski","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.jcin.2015.11.041_bib32","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jacc.2011.11.034","article-title":"Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension","volume":"59","author":"Brandt","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fphys.2012.00010","article-title":"Effects\u00a0of renal denervation on sympathetic activation, blood pressure, and glucose metabolism in patients with resistant hypertension","volume":"3","author":"Schlaich","year":"2012","journal-title":"Front Physiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib34","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/CIRCULATIONAHA.110.991869","article-title":"Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study","volume":"123","author":"Mahfoud","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2015.11.041_bib35","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/j.ijcard.2013.01.218","article-title":"Feasibility of catheter-based renal nerve ablation and effects on sympathetic nerve activity and blood pressure in patients with end-stage renal disease","volume":"168","author":"Schlaich","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib36","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1681\/ASN.2011111062","article-title":"Renal denervation in moderate to severe CKD","volume":"23","author":"Hering","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jcin.2015.11.041_bib37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/HYPERTENSIONAHA.111.00182","article-title":"Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial fibrillation","volume":"61","author":"Linz","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.jcin.2015.11.041_bib38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00392-011-0365-5","article-title":"Renal sympathetic denervation for treatment of electrical storm: first-in-man experience","volume":"101","author":"Ukena","year":"2012","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib39","first-page":"116","article-title":"Histopathological lesions in the sciatic nerve of the rat following perineural application of phenol and alcohol solutions","volume":"16","author":"Moller","year":"1969","journal-title":"Danish Med Bull"},{"key":"10.1016\/j.jcin.2015.11.041_bib40","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00270-013-0570-x","article-title":"MR-guided periarterial ethanol injection for renal sympathetic denervation: a feasibility study in pigs","volume":"36","author":"Streitparth","year":"2013","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.jcin.2015.11.041_bib41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0306-3623(87)90036-X","article-title":"The effect of ethanol on spontaneous contractions and on the contraction produced by periarterial nerve stimulation and by acetylcholine in the rat isolated ileum","volume":"18","author":"Wali","year":"1987","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.jcin.2015.11.041_bib42","first-page":"5","article-title":"Comparison of phenol and alcohol neurolysis of tibial nerve motor branches to the gastrocnemius muscle for treatment of spastic foot after stroke: a randomized controlled pilot study","volume":"46","author":"Kocabas","year":"2010","journal-title":"Eur J Phys Rehabil Med"},{"key":"10.1016\/j.jcin.2015.11.041_bib43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1533-2500.2008.00255.x","article-title":"Alcohol neurolysis of the sciatic and femoral nerves to improve pressure ulcer healing","volume":"9","author":"Wilkes","year":"2009","journal-title":"Pain Pract"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879815018956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879815018956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:03:08Z","timestamp":1761847388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879815018956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1936879815018956"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2015.11.041","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcatheter Alcohol-Mediated Perivascular Renal Denervation With\u00a0the\u00a0Peregrine System","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2015.11.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}