{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:16:48Z","timestamp":1792729008417,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":387,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jcin.2016.01.038","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T18:15:40Z","timestamp":1463422540000},"page":"1051-1057","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Clinical Implications of Leaks Following Left Atrial Appendage Ligation With\u00a0the\u00a0LARIAT Device"],"prefix":"10.1016","volume":"9","author":[{"given":"Carola","family":"Gianni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Di Biase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghamitra","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yal\u00e7\u0131n","family":"G\u00f6ko\u011flan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut F.","family":"G\u00fcne\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Al-Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. David","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney P.","family":"Horton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Krumerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen C.","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Valderr\u00e1bano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2016.01.038_bib1","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) study","volume":"285","author":"Go","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2016.01.038_bib2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: the Framingham study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/j.jcin.2016.01.038_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/CIRCULATIONAHA.105.595140","article-title":"Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota 1980 to 2000, and\u00a0implications on the projections for future\u00a0prevalence","volume":"114","author":"Miyasaka","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2016.01.038_bib4","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.amjcard.2009.07.022","article-title":"Increasing prevalence of atrial fibrillation and flutter in the United States","volume":"104","author":"Naccarelli","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0003-4975(95)00887-X","article-title":"Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation","volume":"61","author":"Blackshear","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jcin.2016.01.038_bib6","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S1010-7940(00)00419-X","article-title":"The left atrial appendage: our most lethal human attachment! Surgical implications","volume":"17","author":"Johnson","year":"2000","journal-title":"Eur J Cardiothoracic Surg"},{"key":"10.1016\/j.jcin.2016.01.038_bib7","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archinte.1994.00420130036007","article-title":"Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials","volume":"154","year":"1994","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jcin.2016.01.038_bib8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/qjmed\/hcm076","article-title":"Risk factors for anticoagulation-related bleeding complications in patients with atrial fibrillation: a systematic review","volume":"100","author":"Hughes","year":"2007","journal-title":"QJM"},{"key":"10.1016\/j.jcin.2016.01.038_bib9","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/jama.1949.02900440011003","article-title":"Resection of the left auricular appendix; a prophylaxis for recurrent arterial emboli","volume":"140","author":"Madden","year":"1949","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2016.01.038_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jacc.2005.03.042","article-title":"Percutaneous Left Atrial Appendage Transcatheter Occlusion (PLAATO system) to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation: results from the international multi-center feasibility trials","volume":"46","author":"Ostermayer","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib11","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.jacc.2007.02.035","article-title":"Initial worldwide experience with the Watchman left atrial appendage system for stroke prevention in atrial fibrillation","volume":"49","author":"Sick","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib12","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ccd.22764","article-title":"Left atrial appendage closure with Amplatzer cardiac plug in atrial fibrillation: initial European experience","volume":"77","author":"Park","year":"2011","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2016.01.038_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jacc.2012.06.046","article-title":"Percutaneous left atrial appendage suture ligation using the lariat device in patients with atrial fibrillation: initial clinical experience","volume":"62","author":"Bartus","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib14","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","article-title":"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial","volume":"374","author":"Holmes","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2016.01.038_bib15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/CIRCINTERVENTIONS.109.914978","article-title":"Catheter-based left atrial appendage (LAA) ligation for the prevention of embolic events arising from the LAA initial experience in a canine model","volume":"3","author":"Lee","year":"2010","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2016.01.038_bib16","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0735-1097(00)00765-8","article-title":"Surgical left atrial appendage ligation is frequently incomplete: a transesophageal echocardiograhic study","volume":"36","author":"Katz","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jacc.2008.03.067","article-title":"Success of surgical left atrial appendage closure. Assessment by transesophageal echocardiography","volume":"52","author":"Kanderian","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib18","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0735-1097(03)00954-9","article-title":"Role of left atrial appendage obliteration in stroke reduction in patients with mitral valve prosthesis: a transesophageal echocardiographic study","volume":"42","author":"Garc\u00eda-Fern\u00e1ndez","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib19","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.hrthm.2015.03.028","article-title":"Association between incomplete surgical ligation of left atrial appendage and stroke and systemic embolization","volume":"12","author":"Aryana","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jcin.2016.01.038_bib20","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.hrthm.2014.01.022","article-title":"LAA ligation using the LARIAT suture delivery device: tips and tricks for a successful procedure","volume":"11","author":"Koneru","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jcin.2016.01.038_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1540-8167.2011.02216.x","article-title":"Intraprocedural and long-term incomplete occlusion of the left atrial appendage following placement of the Watchman device: a single center experience","volume":"23","author":"Bai","year":"2012","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib22","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/j.hrthm.2014.06.035","article-title":"Initial experience with post Lariat left atrial appendage leak closure with Amplatzer septal occluder device and repeat Lariat application","volume":"11","author":"Pillai","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jcin.2016.01.038_bib23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.amjcard.2012.11.061","article-title":"Initial experience with a novel percutaneous left atrial appendage exclusion device in patients with atrial fibrillation, increased stroke risk, and contraindications to anticoagulation","volume":"111","author":"Massumi","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ccd.25065","article-title":"Early results with the Lariat device for left atrial appendage exclusion in patients with atrial fibrillation at high risk for stroke and anticoagulation","volume":"86","author":"Stone","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2016.01.038_bib25","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.hrthm.2014.07.032","article-title":"Multicenter study on acute and long-term safety and efficacy of percutaneous left atrial appendage closure using an epicardial suture snaring device","volume":"11","author":"Miller","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jcin.2016.01.038_bib26","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jacc.2014.03.057","article-title":"Early safety and efficacy of percutaneous left atrial appendage suture ligation","volume":"64","author":"Price","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib27","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.hrthm.2015.03.020","article-title":"Endocardial (Watchman) vs epicardial (Lariat) left atrial appendage exclusion devices: understanding the differences in the location and type of leaks and their clinical implications","volume":"12","author":"Pillarisetti","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jcin.2016.01.038_bib28","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.echo.2008.09.024","article-title":"Real-time three-dimensional transesophageal echocardiography of the left atrial appendage: initial experience in the clinical setting","volume":"21","author":"Shah","year":"2008","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcin.2016.01.038_bib29","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/CIRCIMAGING.111.963892","article-title":"Evaluation of the left atrial appendage with real-time 3-dimensional transesophageal echocardiography implications for catheter-based left atrial appendage closure","volume":"4","author":"Nucifora","year":"2011","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jcin.2016.01.038_bib30","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10554-014-0393-0","article-title":"Three-dimensional assessment of left atrial appendage orifice geometry and potential implications for device closure","volume":"30","author":"O\u2019Brien","year":"2014","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jcin.2016.01.038_bib31","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jacc.2011.11.028","article-title":"The clinical impact of incomplete left atrial appendage closure with the Watchman device in patients with atrial fibrillation","volume":"59","author":"Viles-Gonzalez","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10840-011-9613-x","article-title":"Incomplete occlusion of the left atrial appendage with the percutaneous left atrial appendage transcatheter occlusion device is not associated with increased risk of stroke","volume":"33","author":"Viles-Gonzalez","year":"2012","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib33","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.ijcard.2012.10.031","article-title":"Left atrial appendage closure with the Amplatzer\u2122 Cardiac Plug: impact of shape and device sizing on follow-up leaks","volume":"168","author":"Freixa","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2016.01.038_bib34","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.hrthm.2014.01.019","article-title":"The effects of LAA ligation on LAA electrical activity","volume":"11","author":"Han","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jcin.2016.01.038_bib35","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ccd.25251","article-title":"Percutaneous management of late leak after lariat transcatheter ligation of the left atrial appendage in patients with atrial fibrillation at high risk for stroke","volume":"83","author":"Mosley","year":"2014","journal-title":"Catheter Cardiovasc Interv"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879816001758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879816001758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T01:46:59Z","timestamp":1658108819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879816001758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S1936879816001758"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2016.01.038","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Implications of Leaks Following Left Atrial Appendage Ligation With\u00a0the\u00a0LARIAT Device","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2016.01.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American College of Cardiology Foundation. Published by Elsevier","name":"copyright","label":"Copyright"}]}}