{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:12:27Z","timestamp":1784157147284,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007658","name":"Baxter Healthcare Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jcin.2016.05.003","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T13:45:58Z","timestamp":1470145558000},"page":"1576-1585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"title":["The RENEW Trial"],"prefix":"10.1016","volume":"9","author":[{"given":"Thomas J.","family":"Povsic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay H.","family":"Traverse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. David","family":"Fortuin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Schaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean J.","family":"Kereiakes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Schatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas M.","family":"Zeiher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan J.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Marc","family":"Jolicoeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Bass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Dignacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziangoiong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein R.","family":"Al-Khalidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Junge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Nada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Losordo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2016.05.003_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nrcardio.2013.200","article-title":"Treatment of refractory angina in patients not suitable for revascularization","volume":"11","author":"Henry","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jcin.2016.05.003_bib2","first-page":"886","article-title":"Patients with coronary artery disease not amenable to traditional revascularization: Prevalence and 3-year mortality","volume":"75","author":"Williams","year":"2010","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2016.05.003_bib3","first-page":"399","article-title":"Recommendations for advancing the care of Canadians living with refractory angina pectoris: a Canadian Cardiovascular Society position statement","volume":"25","author":"McGillion","year":"2010","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jcin.2016.05.003_bib4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijcard.2009.09.538","article-title":"Fatality, morbidity and quality of life in patients with refractory angina pectoris","volume":"147","author":"Andr\u00e9ll","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2016.05.003_bib5","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/eurheartj\/eht165","article-title":"Long-term survival in patients with refractory angina","volume":"34","author":"Henry","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2016.05.003_bib6","article-title":"Predictors of long-term clinical endpoints in patients with refractory angina","volume":"4","author":"Povsic","year":"2015","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2016.05.003_bib7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0140-6736(15)00459-6","article-title":"Ranolazine in patients with incomplete revascularisation after percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"387","author":"Weisz","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2016.05.003_bib8","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0735-1097(99)00140-0","article-title":"The\u00a0multicenter study of enhanced external counterpulsation (MUST-EECP): effect of EECP on exercise-induced myocardial ischemia and anginal episodes","volume":"33","author":"Arora","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.05.003_bib9","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/CIRCRESAHA.115.303463","article-title":"Selected CD133+ progenitor cells\u00a0to promote angiogenesis in patients with refractory angina: final results of the PROGENITOR randomized trial","volume":"115","author":"Jimenez-Quevedo","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.jcin.2016.05.003_bib10","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1093\/eurheartj\/ehm485","article-title":"Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial)","volume":"28","author":"Tse","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2016.05.003_bib11","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1001\/jama.2009.685","article-title":"Intramyocardial bone marrow cell injection for chronic myocardial ischemia","volume":"301","author":"van Ramshorst","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2016.05.003_bib12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/01.CIR.0000046450.89986.50","article-title":"Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia","volume":"107","author":"Kawamoto","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2016.05.003_bib13","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1161\/CIRCULATIONAHA.106.644518","article-title":"CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells","volume":"114","author":"Kawamoto","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2016.05.003_bib14","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1161\/CIRCULATIONAHA.105.541268","article-title":"Dose-dependent contribution of CD34-positive cell transplantation to concurrent vasculogenesis and cardiomyogenesis for functional regenerative recovery after myocardial infarction","volume":"113","author":"Iwasaki","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2016.05.003_bib15","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/CIRCRESAHA.111.245993","article-title":"Intramyocardial, autologous CD34+ cell therapy for refractory angina","volume":"109","author":"Losordo","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.jcin.2016.05.003_bib16","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1161\/CIRCULATIONAHA.106.687376","article-title":"Intramyocardial transplantation of autologous cd34+ stem cells for intractable angina: a phase I\/IIa double-blind, randomized controlled trial","volume":"115","author":"Losordo","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2016.05.003_bib17","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000320217","article-title":"Intracoronary autologous CD34+ stem cell therapy for intractable angina","volume":"117","author":"Wang","year":"2010","journal-title":"Cardiology"},{"key":"10.1016\/j.jcin.2016.05.003_bib18","article-title":"Bone marrow stem cell treatment for ischemic heart disease in patients with no option of revascularization: a systematic review and meta-analysis","volume":"9","author":"Fisher","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jcin.2016.05.003_bib19","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/CIRCRESAHA.115.308056","article-title":"Impact of\u00a0cell therapy on myocardial perfusion and cardiovascular outcomes in patients with angina refractory to medical therapy: a systematic review and meta-analysis","volume":"118","author":"Khan","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jcin.2016.05.003_bib20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.amjcard.2013.03.021","article-title":"Meta-Analysis of stem cell therapy in chronic ischemic cardiomyopathy","volume":"112","author":"Kandala","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2016.05.003_bib21","first-page":"908","article-title":"Stem cell therapy is a promising tool for refractory angina: a meta-analysis of randomized controlled trials","volume":"29","author":"Li","year":"2013","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jcin.2016.05.003_bib22","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.ahj.2013.03.003","article-title":"A\u00a0phase 3, randomized, double-blinded, active-controlled, unblinded standard of care study assessing the efficacy and safety of intramyocardial autologous CD34+ cell administration in patients with refractory angina: design of the RENEW study","volume":"165","author":"Povsic","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2016.05.003_bib23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ahj.2012.06.022","article-title":"Incidence and clinical significance of cardiac biomarker elevation during stem cell mobilisation, aphaeresis and intramyocardial delivery: an analysis from ACT34-CMI","volume":"164","author":"Povsic","year":"2012","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2016.05.003_bib24","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jacc.2003.11.045","article-title":"Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina","volume":"43","author":"Chaitman","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.05.003_bib25","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1161\/01.CIR.0000061911.47710.8A","article-title":"The\u00a0VIVA trial: Vascular Endothelial Growth Factor in Ischemia for Vascular Angiogenesis","volume":"107","author":"Henry","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2016.05.003_bib26","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jacc.2007.06.010","article-title":"Effects of Ad5FGF-4 in patients with angina: an analysis of pooled data from the AGENT-3 and AGENT-4 trials","volume":"50","author":"Henry","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.05.003_bib27","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.jacc.2005.06.079","article-title":"A\u00a0blinded, randomized, placebo-controlled trial of percutaneous laser myocardial revascularization to improve angina symptoms in patients with severe coronary disease","volume":"46","author":"Leon","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.05.003_bib28","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1161\/01.CIR.0000015982.70785.B7","article-title":"Phase\u00a01\/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia","volume":"105","author":"Losordo","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2016.05.003_bib29","doi-asserted-by":"crossref","DOI":"10.3727\/096368916X691484","article-title":"Autologous CD34+ cell therapy for refractory angina: 2-year outcomes from the ACT34-CMI study","author":"Henry","year":"2016","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jcin.2016.05.003_bib30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1136\/jme.2004.008771","article-title":"Stopping trials early for commercial reasons: the risk\u2013benefit relationship as a moral compass","volume":"31","author":"Iltis","year":"2005","journal-title":"J\u00a0Med Ethics"},{"key":"10.1016\/j.jcin.2016.05.003_bib31","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/ndt\/gfg469","article-title":"Stopping a medical research project for financial reasons","volume":"18","author":"Dr\u00fceke","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jcin.2016.05.003_bib32","first-page":"106","article-title":"When business and science clash, how can we avoid harming patients? The case of AVOID-HF\u2217","volume":"4","author":"Mark","year":"2016","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jcin.2016.05.003_bib33","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1001\/jama.289.16.2128","article-title":"Stopping medical research to save money: a broken pact with researchers and patients","volume":"289","author":"Psaty","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2016.05.003_bib34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/bmj.323.7303.53","article-title":"Responsibilities of sponsors are limited in premature discontinuation of trials","volume":"323","author":"Ashcroft","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.jcin.2016.05.003_bib35","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/bmj.322.7286.569","article-title":"Societal responsibilities of clinical trial sponsors: lack of commercial pay off is not a legitimate reason for stopping a trial","volume":"322","author":"Evans","year":"2001","journal-title":"BMJ"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879816305271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879816305271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:03:24Z","timestamp":1761847404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879816305271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":35,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S1936879816305271"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2016.05.003","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The RENEW Trial","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2016.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American College of Cardiology Foundation. Published by Elsevier","name":"copyright","label":"Copyright"}]}}