{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:10:03Z","timestamp":1792293003072,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":390,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jcin.2016.07.003","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T15:16:53Z","timestamp":1474298213000},"page":"1928-1938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Percutaneous Intervention to Treat Platypnea\u2013Orthodeoxia Syndrome"],"prefix":"10.1016","volume":"9","author":[{"given":"Ashish H.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Osten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Leventhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Bach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Benson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Horlick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2016.07.003_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0025-6196(12)61253-1","article-title":"Platypnea-orthodeoxia: clinical profile, diagnostic workup, management, and report of seven cases","volume":"59","author":"Seward","year":"1984","journal-title":"Mayo Clinic proceedings Mayo Clinic"},{"key":"10.1016\/j.jcin.2016.07.003_bib2","first-page":"64","article-title":"Platypnea-orthodeoxia syndrome: etiology, differential diagnosis, and management","volume":"47","author":"Cheng","year":"1999","journal-title":"Cathet Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2016.07.003_bib3","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1161\/CIRCULATIONAHA.112.125047","article-title":"Platypnea-orthodeoxia syndrome as a presentation of hereditary hemorrhagic telangiectasia","volume":"126","author":"Kumar","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2016.07.003_bib4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00270-004-0035-3","article-title":"Transcatheter closure of patent foramen ovale in patients with platypnea-orthodeoxia: results of a multicentric French registry","volume":"28","author":"Guerin","year":"2005","journal-title":"Cardiovasc Interv Radiol"},{"key":"10.1016\/j.jcin.2016.07.003_bib5","first-page":"578","article-title":"Management of platypnea-orthodeoxia syndrome by transcatheter closure of atrial communication: hemodynamic characteristics, clinical and echocardiographic outcome","volume":"16","author":"Delgado","year":"2004","journal-title":"J\u00a0Invas Cardiol"},{"key":"10.1016\/j.jcin.2016.07.003_bib6","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1378\/chest.119.5.1624-a","article-title":"Platypnea-orthodeoxia syndrome: a probably underestimated syndrome?","volume":"119","author":"Godart","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.jcin.2016.07.003_bib7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.hrtlng.2007.09.006","article-title":"Hypoxemia-orthodeoxia related to patent foramen ovale without pulmonary hypertension","volume":"37","author":"Toffart","year":"2008","journal-title":"Heart Lung"},{"key":"10.1016\/j.jcin.2016.07.003_bib8","doi-asserted-by":"crossref","first-page":"E55","DOI":"10.1002\/clc.20461","article-title":"Anatomical factors triggering platypnea-orthodeoxia in adults","volume":"32","author":"Sanikommu","year":"2009","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jcin.2016.07.003_bib9","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.hlc.2013.01.007","article-title":"Platypnoea-orthodeoxia syndrome secondary to patent foramen ovale (PFO): a challenging subset for PFO percutaneous closure","volume":"22","author":"Zavalloni","year":"2013","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.jcin.2016.07.003_bib10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.ejim.2013.08.698","article-title":"Platypnea-orthodeoxia syndrome in the elderly treated by percutaneous patent foramen ovale closure: a case series and literature review","volume":"24","author":"Blanche","year":"2013","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jcin.2016.07.003_bib11","first-page":"77","article-title":"Platypnea-orthodeoxia: management by transcatheter buttoned device implantation","volume":"54","author":"Rao","year":"2001","journal-title":"Cathet Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2016.07.003_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12928-014-0244-x","article-title":"Transcatheter closure of right-to-left atrial shunt in patients with platypnea-orthodeoxia syndrome associated with aortic elongation","volume":"29","author":"Takaya","year":"2014","journal-title":"Cardiovasc Interv Ther"},{"key":"10.1016\/j.jcin.2016.07.003_bib13","first-page":"195","article-title":"Closure of patent foramen ovale in patients with orthodeoxia-platypnea using the Amplatzer devices","volume":"50","author":"Waight","year":"2000","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2016.07.003_bib14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0003-4975(96)01015-6","article-title":"Right-to-left interatrial shunt after pneumonectomy","volume":"63","author":"Bakris","year":"1997","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jcin.2016.07.003_bib15","first-page":"247","article-title":"Orthodeoxia-platypnea due to intracardiac shunting\u2013relief with transcatheter double umbrella closure","volume":"36","author":"Landzberg","year":"1995","journal-title":"Catheter Cardiovasc Diagn"},{"key":"10.1016\/j.jcin.2016.07.003_bib16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/euhj.1999.1944","article-title":"Atrial right-to-left shunting causing severe hypoxaemia despite normal right-sided pressures. Report of 11 consecutive cases corrected by percutaneous closure","volume":"21","author":"Godart","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2016.07.003_bib17","first-page":"701","article-title":"The effect of patent foramen ovale closure in patients with platypnea-orthodeoxia syndrome","volume":"86","author":"Mojadidi","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2016.07.003_bib18","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1161\/01.STR.28.12.2376","article-title":"Surgical closure of patent foramen ovale in cryptogenic stroke patients","volume":"28","author":"Homma","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.jcin.2016.07.003_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4244\/EIJV7I3A63","article-title":"Percutaneous versus surgical closure of secundum atrial septal defects: a systematic review and meta-analysis of currently available clinical evidence","volume":"7","author":"Butera","year":"2011","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2016.07.003_bib20","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0735-1097(91)90539-L","article-title":"Atrial septal aneurysm and stroke: a transesophageal echocardiographic study","volume":"18","author":"Pearson","year":"1991","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2016.07.003_bib21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1136\/heart.89.3.342","article-title":"Contrast echocardiography","volume":"89","author":"Stewart","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.jcin.2016.07.003_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.blre.2012.12.003","article-title":"Regulation of erythropoiesis by hypoxia-inducible factors","volume":"27","author":"Haase","year":"2013","journal-title":"Blood Rev"},{"key":"10.1016\/j.jcin.2016.07.003_bib23","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1161\/01.STR.24.12.1865","article-title":"Atrial septal aneurysm and patent foramen ovale as risk factors for cryptogenic stroke in patients less than 55 years of age. A study using transesophageal echocardiography","volume":"24","author":"Cabanes","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.jcin.2016.07.003_bib24","doi-asserted-by":"crossref","first-page":"e222","DOI":"10.1161\/CIRCULATIONAHA.110.979427","article-title":"Platypnea-orthodeoxia syndrome associated with bioprosthetic tricuspid valve stenosis and reverse Lutembacher syndrome","volume":"123","author":"Burke","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2016.07.003_bib25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/oxfordjournals.eurheartj.a060927","article-title":"Cyanosis and clubbing in a patient with iatrogenic Lutembacher syndrome","volume":"16","author":"Essop","year":"1995","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2016.07.003_bib26","article-title":"Assessment of left and right atrial 3D hemodynamics in patients with atrial fibrillation: a 4D flow MRI study","author":"Markl","year":"2016","journal-title":"The international journal of cardiovascular imaging"},{"key":"10.1016\/j.jcin.2016.07.003_bib27","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1378\/chest.128.2.998","article-title":"A\u00a0mystery featuring right-to-left shunting despite normal intracardiac pressure","volume":"128","author":"Zanchetta","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jcin.2016.07.003_bib28","first-page":"16","article-title":"4D cardiovascular magnetic resonance velocity mapping of alterations of right heart flow patterns and main pulmonary artery hemodynamics in tetralogy of Fallot","volume":"14","author":"Francois","year":"2012","journal-title":"J\u00a0Cardiovasc Magn Resonance"},{"key":"10.1016\/j.jcin.2016.07.003_bib29","doi-asserted-by":"crossref","first-page":"e4747","DOI":"10.1371\/journal.pone.0004747","article-title":"Theory and validation of magnetic resonance fluid motion estimation using intensity flow data","volume":"4","author":"Wong","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.jcin.2016.07.003_bib30","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jcmg.2012.01.015","article-title":"Platypnea-orthodeoxia syndrome due to PFO and aortic dilation","volume":"5","author":"Shiraishi","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcin.2016.07.003_bib31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/clc.22301","article-title":"Cardiac platypnea-orthodeoxia syndrome: an often unrecognized malady","volume":"37","author":"Knapper","year":"2014","journal-title":"Clin Cardiol"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879816310597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879816310597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:03:59Z","timestamp":1761847439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879816310597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":31,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S1936879816310597"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2016.07.003","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Percutaneous Intervention to Treat Platypnea\u2013Orthodeoxia Syndrome","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2016.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American College of Cardiology Foundation. Published by Elsevier","name":"copyright","label":"Copyright"}]}}