{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:02:31Z","timestamp":1791219751859,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"vor","delay-in-days":392,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jcin.2017.05.064","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T14:23:03Z","timestamp":1503325383000},"page":"1646-1658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Comparison of Ticagrelor Versus Prasugrel for Inflammation, Vascular Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non\u2013ST-Segment Elevation Acute Coronary Syndrome Requiring Coronary Stenting"],"prefix":"10.1016","volume":"10","author":[{"given":"Han Saem","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Jun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-A","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Joon","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Woong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Sun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2017.05.064_bib1","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1161\/CIR.0000000000000133","article-title":"2014 AHA\/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"130","author":"Amsterdam","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2017.05.064_bib2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/CIRCULATIONAHA.111.047498","article-title":"Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial","volume":"124","author":"Mahaffey","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2017.05.064_bib3","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1056\/NEJMoa0706482","article-title":"Prasugrel versus clopidogrel in patients with acute coronary syndromes","volume":"357","author":"Wiviott","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2017.05.064_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/1074248413511693","article-title":"Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1","volume":"19","author":"Armstrong","year":"2014","journal-title":"J\u00a0Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.jcin.2017.05.064_bib5","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.jacc.2014.03.031","article-title":"Adenosine-mediated effects of ticagrelor: evidence and potential clinical relevance","volume":"63","author":"Cattaneo","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2017.05.064_bib6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3109\/09537104.2013.842965","article-title":"Lower mortality following pulmonary adverse events and sepsis with ticagrelor compared with clopidogrel in the PLATO study","volume":"25","author":"Storey","year":"2014","journal-title":"Platelets"},{"key":"10.1016\/j.jcin.2017.05.064_bib7","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1161\/CIRCULATIONAHA.109.913376","article-title":"Diabetes and antiplatelet therapy in acute coronary syndrome","volume":"123","author":"Ferreiro","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2017.05.064_bib8","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1161\/01.ATV.0000091502.96745.95","article-title":"Significant differential effects of hormone therapy or tibolone on markers of cardiovascular disease in postmenopausal women: a randomized, double-blind, placebo-controlled, crossover study","volume":"23","author":"Koh","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcin.2017.05.064_bib9","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/eurheartj\/ehi311","article-title":"Significant differential effects of lower doses of hormone therapy or tibolone on markers of cardiovascular disease in post-menopausal women: a randomized, double-blind, crossover study","volume":"26","author":"Koh","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2017.05.064_bib10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1160\/TH14-12-1068","article-title":"Effect of P2Y12 inhibitors on inflammation and immunity","volume":"114","author":"Thomas","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jcin.2017.05.064_bib11","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1161\/CIRCULATIONAHA.116.023402","article-title":"Pharmacodynamic comparison of prasugrel versus ticagrelor in patients with type 2 diabetes mellitus and coronary artery disease: the OPTIMUS (Optimizing Antiplatelet Therapy in Diabetes Mellitus)-4 study","volume":"134","author":"Franchi","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2017.05.064_bib12","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1161\/CIRCINTERVENTIONS.111.965707","article-title":"Diagnostic accuracy of combined intracoronary pressure and flow velocity information during baseline conditions: adenosine-free assessment of functional coronary lesion severity","volume":"5","author":"van de Hoef","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2017.05.064_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fimmu.2013.00085","article-title":"Regulation of inflammation by adenosine","volume":"4","author":"Hasko","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcin.2017.05.064_bib14","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/ATVBAHA.111.226845","article-title":"Regulation of neutrophil function by adenosine","volume":"32","author":"Barletta","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcin.2017.05.064_bib15","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/ATVBAHA.111.226852","article-title":"Regulation of macrophage function by adenosine","volume":"32","author":"Hasko","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcin.2017.05.064_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-3-540-89615-9_6","article-title":"Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology","author":"Mustafa","year":"2009","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jcin.2017.05.064_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1161\/CIRCINTERVENTIONS.113.000293","article-title":"Differential effect of ticagrelor versus prasugrel on coronary blood flow velocity in patients with non-ST-elevation acute coronary syndrome undergoing percutaneous coronary intervention: an exploratory study","volume":"6","author":"Alexopoulos","year":"2013","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2017.05.064_bib18","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jacc.2012.11.032","article-title":"Ticagrelor enhances adenosine-induced coronary vasodilatory responses in humans","volume":"61","author":"Wittfeldt","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2017.05.064_bib19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/FJC.0b013e3182471d14","article-title":"Adenosine A(2)A and A(3) receptors are involved in the human endothelial progenitor cells migration","volume":"59","author":"Fernandez","year":"2012","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.jcin.2017.05.064_bib20","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/clc.22575","article-title":"Similar impact of clopidogrel or ticagrelor on carotid atherosclerotic plaque inflammation","volume":"39","author":"Oh","year":"2016","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jcin.2017.05.064_bib21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/clc.20732","article-title":"Changes in inflammatory biomarkers in patients treated with ticagrelor or clopidogrel","volume":"33","author":"Husted","year":"2010","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jcin.2017.05.064_bib22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/CIRCINTERVENTIONS.112.972158","article-title":"Basal stenosis resistance: another adenosine-free contender for the lesion assessment crown?","volume":"5","author":"Kern","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2017.05.064_bib23","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCULATIONAHA.116.024014","article-title":"Protective effects of ticagrelor on myocardial injury after infarction","volume":"134","author":"Vilahur","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2017.05.064_bib24","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1093\/eurheartj\/ehl153","article-title":"Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain","volume":"27","author":"Cavusoglu","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2017.05.064_bib25","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1295","article-title":"Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms","volume":"11","author":"Shibata","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jcin.2017.05.064_bib26","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ijcard.2015.03.414","article-title":"Ticagrelor increases endothelial progenitor cell level compared with clopidogrel in acute coronary syndromes: a prospective randomized study","volume":"187","author":"Bonello","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2017.05.064_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1253\/circj.CJ-09-0665","article-title":"Mechanisms of myocardial regeneration","volume":"74","author":"Hosoda","year":"2010","journal-title":"Circ J"},{"key":"10.1016\/j.jcin.2017.05.064_bib28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1182\/blood-2004-05-1831","article-title":"Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction","volume":"105","author":"Massa","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jcin.2017.05.064_bib29","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1253\/circj.CJ-11-1485","article-title":"Correlation between circulating angiogenic cell mobilizations and recovery of coronary flow reserve in patients with acute myocardial infarction","volume":"76","author":"Jeong","year":"2012","journal-title":"Circ J"},{"key":"10.1016\/j.jcin.2017.05.064_bib30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJMoa022287","article-title":"Circulating endothelial progenitor cells, vascular function, and cardiovascular risk","volume":"348","author":"Hill","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2017.05.064_bib31","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1161\/CIRCINTERVENTIONS.112.974048","article-title":"Letter by Sen et\u00a0al regarding article, \u201cDiagnostic accuracy of combined intracoronary pressure and flow velocity information during baseline conditions: adenosine-free assessment of functional coronary lesion severity\u201d","volume":"5","author":"Sen","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2017.05.064_bib32","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1161\/CIRCINTERVENTIONS.112.973255","article-title":"Letter by Michiels et\u00a0al regarding article, \u201cDiagnostic accuracy of combined intracoronary pressure and flow velocity information during baseline conditions: adenosine-free assessment of functional coronary lesion severity\u201d","volume":"5","author":"Michiels","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2017.05.064_bib33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1161\/CIRCINTERVENTIONS.111.965392","article-title":"Comparison of hyperemic efficacy between central and peripheral venous adenosine infusion for fractional flow reserve measurement","volume":"5","author":"Seo","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2017.05.064_bib34","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0140-6736(91)91571-B","article-title":"Different interactions of platelets with arterial and venous coronary bypass vessels","volume":"337","author":"Yang","year":"1991","journal-title":"Lancet"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879817312487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879817312487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:05:50Z","timestamp":1761847550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879817312487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":34,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S1936879817312487"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2017.05.064","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Ticagrelor Versus Prasugrel for Inflammation, Vascular Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non\u2013ST-Segment Elevation Acute Coronary Syndrome Requiring Coronary Stenting","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2017.05.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}