{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:45:01Z","timestamp":1784547901324,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":391,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jcin.2020.12.042","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:56:28Z","timestamp":1617238588000},"page":"819-827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation"],"prefix":"10.1016","volume":"14","author":[{"given":"Sang-Don","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Orban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Karam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lubos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kalbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Stolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Neuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Butter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Praz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Kassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniela","family":"Petrescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Iliadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Unterhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Lurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Massberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Hausleiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2020.12.042_bib1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jacc.2015.02.009","article-title":"Secondary mitral regurgitation in heart failure: pathophysiology, prognosis, and therapeutic considerations","volume":"65","author":"Asgar","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib2","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1001\/jamacardio.2017.2976","article-title":"Survival and cardiovascular outcomes of patients with secondary mitral regurgitation: a systematic review and meta-analysis","volume":"2","author":"Sannino","year":"2017","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/eurheartj\/ehx402","article-title":"Refining the prognostic impact of functional mitral regurgitation in chronic heart failure","volume":"39","author":"Goliasch","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2020.12.042_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/joic.12376","article-title":"Predictors for long-term survival after transcatheter edge-to-edge mitral valve repair","volume":"30","author":"Orban","year":"2017","journal-title":"J\u00a0Interv Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/joic.12193","article-title":"Long-term outcome of patients with severe biventricular heart failure and severe mitral regurgitation after percutaneous edge-to-edge mitral valve repair","volume":"28","author":"Orban","year":"2015","journal-title":"J\u00a0Interv Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib6","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous repair or medical treatment for secondary mitral regurgitation","volume":"379","author":"Obadia","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2020.12.042_bib7","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2020.12.042_bib8","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/ejhf.1616","article-title":"Percutaneous repair or medical treatment for secondary mitral regurgitation: outcomes at 2 years","volume":"21","author":"Iung","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jcin.2020.12.042_bib9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1001\/jamacardio.2019.0195","article-title":"MitraClip and tertiary mitral regurgitation-mitral regurgitation gets curiouser and curiouser","volume":"4","author":"Carabello","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcmg.2018.11.006","article-title":"Proportionate and disproportionate functional mitral regurgitation: a new conceptual framework that reconciles the results of the MITRA-FR and COAPT trials","volume":"12","author":"Grayburn","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcin.2020.12.042_bib11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/CIRCULATIONAHA.119.039612","article-title":"Contrasting effects of pharmacological, procedural, and surgical interventions on proportionate and disproportionate functional mitral regurgitation in chronic heart failure","volume":"140","author":"Packer","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2020.12.042_bib12","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.athoracsur.2012.05.105","article-title":"Longitudinal outcome of isolated mitral repair in older patients: results from 14,604 procedures performed from 1991 to 2007","volume":"94","author":"Badhwar","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jcin.2020.12.042_bib13","doi-asserted-by":"crossref","first-page":"E276","DOI":"10.1532\/HSF98.20111030","article-title":"Sex differences in procedure selection and outcomes of patients undergoing mitral valve surgery","volume":"14","author":"Vassileva","year":"2011","journal-title":"Heart Surg Forum"},{"key":"10.1016\/j.jcin.2020.12.042_bib14","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.athoracsur.2013.04.055","article-title":"Gender differences in long-term survival of Medicare beneficiaries undergoing mitral valve operations","volume":"96","author":"Vassileva","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jcin.2020.12.042_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00392-013-0614-x","article-title":"Percutaneous interventional mitral regurgitation treatment using the Mitra-Clip system","volume":"103","author":"Boekstegers","year":"2014","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib16","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1016\/j.jacc.2014.10.016","article-title":"Defining \u201csevere\u201d secondary mitral regurgitation: emphasizing an integrated approach","volume":"64","author":"Grayburn","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib17","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/ehjci\/jet105","article-title":"Recommendations for the echocardiographic assessment of native valvular regurgitation: an executive summary from the European Association of Cardiovascular Imaging","volume":"14","author":"Lancellotti","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jcin.2020.12.042_bib18","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Nishimura","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jcin.2020.12.042_bib20","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1161\/CIRCULATIONAHA.113.002200","article-title":"Long-term survival of patients undergoing mitral valve repair and replacement: a longitudinal analysis of Medicare fee-for-service beneficiaries","volume":"127","author":"Vassileva","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2020.12.042_bib21","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/ejcts\/ezw151","article-title":"Male-female differences and survival in patients undergoing isolated mitral valve surgery: a nationwide cohort study in the Netherlands","volume":"50","author":"Mokhles","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jcin.2020.12.042_bib22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jcmg.2016.02.013","article-title":"Sex differences in mitral regurgitation before and after mitral valve surgery","volume":"9","author":"Grayburn","year":"2016","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jcin.2020.12.042_bib23","doi-asserted-by":"crossref","first-page":"e1159","DOI":"10.1161\/CIR.0000000000000503","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"135","author":"Nishimura","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2020.12.042_bib24","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2020.12.042_bib25","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcin.2020.12.042_bib26","doi-asserted-by":"crossref","first-page":"e257","DOI":"10.4244\/EIJV12I2A40","article-title":"Gender in the ACCESS-EU registry: a prospective, multicentre, non-randomised post-market approval study of MitraClip(R) therapy in Europe","volume":"12","author":"Gafoor","year":"2016","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2020.12.042_bib27","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2014.06.1166","article-title":"Percutaneous mitral valve edge-to-edge repair: in-hospital results and 1-year follow-up of 628 patients of the 2011-2012 Pilot European Sentinel Registry","volume":"64","author":"Nickenig","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib28","first-page":"889","article-title":"Gender-related clinical and echocardiographic outcomes at 30-day and 12-month follow up after MitraClip implantation in the GRASP registry","volume":"85","author":"Attizzani","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2020.12.042_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.amjcard.2015.04.019","article-title":"Effect of gender on results of percutaneous edge-to-edge mitral valve repair with MitraClip system","volume":"116","author":"Estevez-Loureiro","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2020.12.042_bib30","doi-asserted-by":"crossref","first-page":"3934842","DOI":"10.1155\/2016\/3934842","article-title":"Transcatheter mitral valve repair in surgical high-risk patients: gender-specific acute and long-term outcomes","volume":"2016","author":"Tigges","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jcin.2020.12.042_bib31","first-page":"819","article-title":"Gender-related differences in patients undergoing transcatheter mitral valve interventions in clinical practice: 1-year results from the German TRAMI registry","volume":"95","author":"Werner","year":"2020","journal-title":"Catheter Cardiovasc Interv"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879821000765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879821000765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:13:57Z","timestamp":1761848037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879821000765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S1936879821000765"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2020.12.042","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2020.12.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}