{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:09:51Z","timestamp":1772993391300,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":391,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jcin.2021.06.014","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T15:00:45Z","timestamp":1632150045000},"page":"2039-2046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Randomized Trials Are Needed for Transcatheter Mitral Valve Replacement"],"prefix":"10.1016","volume":"14","author":[{"given":"Jason H.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Sorajja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod H.","family":"Thourani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul Prakash","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassem","family":"Chehab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Cowger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Heimansohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Badhwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gorav","family":"Ailawadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2021.06.014_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s13239-020-00460-4","article-title":"Transcatheter mitral valve replacement: state of the art","volume":"11","author":"Goode","year":"2020","journal-title":"Cardiovasc Eng Technol"},{"issue":"4","key":"10.1016\/j.jcin.2021.06.014_bib2","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2021.06.014_bib3","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2021.06.014_bib4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.echo.2015.12.012","article-title":"Survival in patients with degenerative mitral stenosis: results from a large retrospective cohort study","volume":"29","author":"Pasca","year":"2016","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jcin.2021.06.014_bib5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0022-5223(03)00081-3","article-title":"Mitral valve surgery in patients with extensive calcification of the mitral annulus","volume":"126","author":"Feindel","year":"2003","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jcin.2021.06.014_bib6","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.jacc.2018.02.054","article-title":"1-Year outcomes of transcatheter mitral valve replacement in patients with severe mitral annular calcification","volume":"71","author":"Guerrero","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2021.06.014_bib7","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.athoracsur.2018.03.086","article-title":"Isolated mitral valve surgery: the Society of Thoracic Surgeons Adult Cardiac Surgery Database analysis","volume":"106","author":"Gammie","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jcin.2021.06.014_bib8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jacc.2015.05.049","article-title":"Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the Mitral Valve Academic Research Consortium","volume":"66","author":"Stone","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2021.06.014_bib9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2015.05.046","article-title":"Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 1: clinical trial design principles: a consensus document from the Mitral Valve Academic Research Consortium","volume":"66","author":"Stone","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2021.06.014_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/sim.1425","article-title":"Non-inferiority trials: design concepts and issues\u2014the encounters of academic consultants in statistics","volume":"22","author":"D\u2019Agostino","year":"2003","journal-title":"Stat Med"},{"issue":"3","key":"10.1016\/j.jcin.2021.06.014_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/24748706.2021.1902595","article-title":"Consensus document on non-suitability for\u00a0transcatheter mitral valve repair by edge-to-edge therapy","volume":"5","author":"Lim","year":"2021","journal-title":"Structural Heart"},{"key":"10.1016\/j.jcin.2021.06.014_bib12","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1016\/j.jcin.2020.06.053","article-title":"Transcatheter edge-to-edge mitral valve repair with the MitraClip G4 system","volume":"13","author":"Chakravarty","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2021.06.014_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jacc.2017.10.061","article-title":"Early experience with new transcatheter mitral valve\u00a0replacement","volume":"71","author":"Bapat","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2021.06.014_bib14","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.jacc.2018.12.066","article-title":"Initial feasibility study of a new transcatheter mitral prosthesis: the first 100 patients","volume":"73","author":"Sorajja","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2021.06.014_bib15","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.jacc.2017.09.015","article-title":"Outcomes with transcatheter mitral valve repair in\u00a0the United States: an STS\/ACC TVT Registry\u00a0report","volume":"70","author":"Sorajja","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879821011377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879821011377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:14:38Z","timestamp":1761848078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879821011377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":15,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1936879821011377"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2021.06.014","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized Trials Are Needed for Transcatheter Mitral Valve Replacement","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2021.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}