{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:54:16Z","timestamp":1790733256162,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.jcin.2021.08.034","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T20:19:13Z","timestamp":1633465153000},"page":"2127-2140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Subphenotyping of Patients With Aortic Stenosis by Unsupervised Agglomerative Clustering of Echocardiographic and Hemodynamic Data"],"prefix":"10.1016","volume":"14","author":[{"given":"Mark","family":"Lachmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rippen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erion","family":"Xhepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"von Scheidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Trenkwalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Rheude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Stundl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Thalmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Harmsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Yuasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Kastrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Ludwig","family":"Laugwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kupatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jcin.2021.08.034_bib1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic stenosis in the elderly","volume":"62","author":"Osnabrugge","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.jcin.2021.08.034_bib2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ejhf.1322","article-title":"Haemodynamic mechanisms and long-term prognostic impact of pulmonary hypertension in patients with severe aortic stenosis undergoing valve replacement: impact of PH in severe aortic stenosis","volume":"21","author":"Weber","year":"2019","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"10.1016\/j.jcin.2021.08.034_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.echo.2016.11.006","article-title":"Comprehensive right-sided assessment for transcatheter aortic valve replacement risk stratification: time for a change","volume":"30","author":"Cavalcante","year":"2017","journal-title":"J\u00a0Am Soc Echocardiogr"},{"issue":"45","key":"10.1016\/j.jcin.2021.08.034_bib4","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"G\u00e9n\u00e9reux","year":"2017","journal-title":"Eur Heart J"},{"issue":"23","key":"10.1016\/j.jcin.2021.08.034_bib5","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1161\/CIR.0000000000000029","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"129","author":"Nishimura","year":"2014","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.jcin.2021.08.034_bib6","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1038\/onc.2014.291","article-title":"Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategies","volume":"34","author":"Du","year":"2015","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.jcin.2021.08.034_bib7","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jcmg.2018.02.005","article-title":"Phenotypic clustering of left ventricular diastolic function parameters","volume":"12","author":"Lancaster","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"5","key":"10.1016\/j.jcin.2021.08.034_bib8","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jcmg.2019.12.018","article-title":"Interpatient similarities in cardiac function","volume":"13","author":"Tokodi","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"5","key":"10.1016\/j.jcin.2021.08.034_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.009707","article-title":"Unsupervised cluster analysis of patients with aortic stenosis reveals distinct population with different phenotypes and outcomes","volume":"13","author":"Kwak","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"issue":"2","key":"10.1016\/j.jcin.2021.08.034_bib10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jcmg.2018.11.025","article-title":"Network tomography for understanding phenotypic presentations in aortic stenosis","volume":"12","author":"Casaclang-Verzosa","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Img"},{"issue":"36","key":"10.1016\/j.jcin.2021.08.034_bib11","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.jcin.2021.08.034_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.jcin.2021.08.034_bib13","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.114.002358","volume":"8","author":"O\u2019Sullivan","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"issue":"21","key":"10.1016\/j.jcin.2021.08.034_bib14","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/j.jcin.2019.08.031","article-title":"Impact of pulmonary hypertension hemodynamic status on long-term outcome\u00a0after transcatheter aortic valve replacement","volume":"12","author":"Schewel","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"issue":"6","key":"10.1016\/j.jcin.2021.08.034_bib15","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/aje\/kwt312","article-title":"Comparison of random forest and parametric imputation models for imputing missing data using MICE: a CALIBER study","volume":"179","author":"Shah","year":"2014","journal-title":"Am J Epidemiol"},{"issue":"1","key":"10.1016\/j.jcin.2021.08.034_bib16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/bioinformatics\/btr597","article-title":"MissForest\u2014non-parametric missing value imputation for mixed-type data","volume":"28","author":"Stekhoven","year":"2012","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.jcin.2021.08.034_bib17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/biomet\/63.3.581","article-title":"Inference and missing data","volume":"63","author":"Rubin","year":"1976","journal-title":"Biometrika"},{"issue":"18","key":"10.1016\/j.jcin.2021.08.034_bib18","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1056\/NEJMoa1202277","article-title":"Transcatheter aortic-valve replacement for inoperable severe aortic stenosis","volume":"366","author":"Makkar","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"10","key":"10.1016\/j.jcin.2021.08.034_bib19","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1136\/heartjnl-2017-311978","article-title":"Outcomes of persistent pulmonary hypertension following transcatheter aortic valve replacement","volume":"104","author":"Masri","year":"2018","journal-title":"Heart"},{"issue":"1","key":"10.1016\/j.jcin.2021.08.034_bib20","doi-asserted-by":"crossref","first-page":"14723","DOI":"10.1038\/s41598-017-15316-6","article-title":"Causes of death in patients with severe aortic stenosis: an observational study","volume":"7","author":"Minamino-Muta","year":"2017","journal-title":"Sci Rep"},{"issue":"23","key":"10.1016\/j.jcin.2021.08.034_bib21","doi-asserted-by":"crossref","first-page":"e739","DOI":"10.1161\/CIRCULATIONAHA.111.075853","article-title":"Low-flow\/low-gradient aortic stenosis","volume":"124","author":"Awtry","year":"2011","journal-title":"Circulation"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879821015715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879821015715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:14:43Z","timestamp":1761848083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879821015715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":21,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1936879821015715"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2021.08.034","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subphenotyping of Patients With Aortic Stenosis by Unsupervised Agglomerative Clustering of Echocardiographic and Hemodynamic Data","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2021.08.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}