{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:38:26Z","timestamp":1792093106189,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":391,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jcin.2023.11.039","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T14:05:22Z","timestamp":1708956322000},"page":"474-487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Coronary Vasomotor Dysfunction Is\u00a0Associated With Cardiovascular Events in Patients With Nonobstructive Coronary\u00a0Artery Disease"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-4377","authenticated-orcid":false,"given":"Yoshihisa","family":"Kanaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaskanwal Deep Singh","family":"Sara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilke","family":"Ozcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-2510","authenticated-orcid":false,"given":"Nadia","family":"Akhiyat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhiram","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E.","family":"Raphael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunekazu","family":"Kakuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2023.11.039_bib1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa0907272","article-title":"Low diagnostic yield of elective coronary angiography","volume":"362","author":"Patel","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2023.11.039_bib2","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1093\/eurheartj\/ehy185","article-title":"Determinants of long-term clinical outcomes in patients with angina but without obstructive coronary artery disease: a systematic review and meta-analysis","volume":"39","author":"Radico","year":"2018","journal-title":"Eur Heart J"},{"issue":"22","key":"10.1016\/j.jcin.2023.11.039_bib3","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1016\/j.jacc.2021.07.053","article-title":"2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"78","author":"Gulati","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2023.11.039_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2023.11.039_bib5","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/01.CIR.101.9.948","article-title":"Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction","volume":"101","author":"Suwaidi","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2023.11.039_bib6","article-title":"Coronary endothelial dysfunction is associated with increased risk of incident atrial fibrillation","volume":"9","author":"Corban","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2023.11.039_bib7","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1056\/NEJMc070666","article-title":"Coronary microvascular dysfunction","volume":"356","author":"Duran","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2023.11.039_bib8","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.jcin.2015.06.017","article-title":"Prevalence of coronary microvascular dysfunction among patients with chest pain and nonobstructive coronary artery disease","volume":"8","author":"Sara","year":"2015","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2023.11.039_bib9","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jacc.2018.11.040","article-title":"Impact of abnormal coronary reactivity on long-term clinical outcomes in women","volume":"73","author":"AlBadri","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2023.11.039_bib10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ejhf.2010","article-title":"Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction","volume":"23","author":"Ahmad","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jcin.2023.11.039_bib11","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/eurheartj\/ehab775","article-title":"Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis","volume":"43","author":"Kelshiker","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2023.11.039_bib12","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1161\/01.CIR.87.5.1461","article-title":"The nitrovasodilators. New ideas about old drugs","volume":"87","author":"Harrison","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2023.11.039_bib13","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/eurheartj\/ehz641","article-title":"How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart\u00a0Failure Association (HFA) of the European Society of Cardiology (ESC)","volume":"40","author":"Pieske","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2023.11.039_bib14","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2023.11.039_bib15","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jacc.2021.07.042","article-title":"Coronary microvascular dysfunction across the spectrum of cardiovascular diseases: JACC state-of-the-art review","volume":"78","author":"Del Buono","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2023.11.039_bib16","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.116.024534","article-title":"Ischemia and no obstructive coronary artery disease (INOCA): developing evidence-based therapies and research agenda for the next decade","volume":"135","author":"Bairey Merz","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2023.11.039_bib17","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1016\/j.jacc.2019.08.1056","article-title":"Coronary functional abnormalities in patients with angina and nonobstructive coronary artery disease","volume":"74","author":"Suda","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2023.11.039_bib18","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/ejhf.1671","article-title":"Endothelium-dependent and independent coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction","volume":"22","author":"Yang","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jcin.2023.11.039_bib19","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/CIRCULATIONAHA.114.009625","article-title":"Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction","volume":"131","author":"Mohammed","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2023.11.039_bib20","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1093\/eurheartj\/ehv100","article-title":"Coronary vascular regulation, remodelling, and collateralization: mechanisms and clinical implications on behalf of the working group on coronary pathophysiology and microcirculation","volume":"36","author":"Pries","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2023.11.039_bib21","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/eurheartj\/eht132","article-title":"Coronary endothelial dysfunction in patients with early coronary artery disease is associated with the increase in intravascular lipid core plaque","volume":"34","author":"Choi","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2023.11.039_bib22","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.3390\/biomedicines10123010","article-title":"Pathophysiology and outcomes of endothelium function in coronary microvascular diseases: a systematic review of randomized controlled trials and multicenter study","volume":"10","author":"Avtaar Singh","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jcin.2023.11.039_bib23","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/HCO.0000000000000571","article-title":"Role of local coronary blood flow patterns and shear stress on the development of microvascular and epicardial endothelial dysfunction and coronary plaque","volume":"33","author":"Siasos","year":"2018","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.jcin.2023.11.039_bib24","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/01.CIR.0000115525.92645.16","article-title":"Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women\u2019s Ischemia Syndrome Evaluation (WISE)","volume":"109","author":"von Mering","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2023.11.039_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/ehjcvp\/pvu020","article-title":"Pharmacotherapy for coronary microvascular dysfunction","volume":"1","author":"Ong","year":"2015","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"10.1016\/j.jcin.2023.11.039_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jcin.2019.11.001","article-title":"1-Year outcomes of angina management guided by invasive coronary function testing (CorMicA)","volume":"13","author":"Ford","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2023.11.039_bib27","article-title":"Local production of soluble urokinase plasminogen activator receptor and plasminogen activator inhibitor-1 in the coronary circulation is associated with coronary endothelial dysfunction in humans","volume":"7","author":"Corban","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2023.11.039_bib28","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1161\/CIRCRESAHA.115.308165","article-title":"PreSERVE-AMI: a randomized, double-blind, placebo-controlled clinical trial of intracoronary administration of autologous CD34+ cells in patients with left ventricular dysfunction post STEMI","volume":"120","author":"Quyyumi","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jcin.2023.11.039_bib29","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1161\/CIRCRESAHA.121.319644","article-title":"IMPROvE-CED trial: Intracoronary Autologous CD34+ Cell Therapy for Treatment of Coronary Endothelial Dysfunction in Patients With Angina and Nonobstructive Coronary Arteries","volume":"130","author":"Corban","year":"2022","journal-title":"Circ Res"},{"key":"10.1016\/j.jcin.2023.11.039_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.121.010802","article-title":"Autologous CD34+ stem cell therapy increases coronary flow reserve and reduces angina in patients with coronary microvascular dysfunction","volume":"15","author":"Henry","year":"2022","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2023.11.039_bib31","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.jacc.2013.07.076","article-title":"Anatomic versus physiologic assessment of coronary artery disease. Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making","volume":"62","author":"Gould","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2023.11.039_bib32","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/heartjnl-2013-305124","article-title":"Impact of hyperaemic microvascular resistance on fractional flow reserve measurements in\u00a0patients with stable coronary artery disease: insights from combined stenosis and microvascular resistance assessment","volume":"100","author":"van de Hoef","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.jcin.2023.11.039_bib33","article-title":"Significance of microvascular function in visual-functional mismatch between invasive coronary angiography and fractional flow reserve","volume":"6","author":"Yonetsu","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2023.11.039_bib34","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.jacc.2021.08.017","article-title":"Microvascular resistance reserve for assessment of coronary microvascular function: JACC technology corner","volume":"78","author":"De Bruyne","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2023.11.039_bib35","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1093\/eurheartj\/ehad378","article-title":"Microvascular resistance reserve: diagnostic and prognostic performance in the ILIAS registry","volume":"44","author":"Boerhout","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2023.11.039_bib36","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jcin.2022.12.012","article-title":"Microvascular resistance reserve to assess microvascular dysfunction in ANOCA patients","volume":"16","author":"de Vos","year":"2023","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2023.11.039_bib37","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1093\/eurheartj\/ehaa503","volume":"41","author":"Kunadian","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2023.11.039_bib38","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879823016072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879823016072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:19:21Z","timestamp":1761848361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879823016072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S1936879823016072"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2023.11.039","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coronary Vasomotor Dysfunction Is\u00a0Associated With Cardiovascular Events in Patients With Nonobstructive Coronary\u00a0Artery Disease","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2023.11.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}