{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:47:08Z","timestamp":1792568828280,"version":"4.5.0"},"reference-count":159,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005485","name":"American College of Cardiology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005485","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jcin.2024.01.284","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T08:32:52Z","timestamp":1712565172000},"page":"961-978","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Chronological vs Biological Age in Interventional Cardiology"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-6416","authenticated-orcid":false,"given":"Abdulla A.","family":"Damluji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Nanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Rymer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajar","family":"Kochar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lowenstern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8319-5637","authenticated-orcid":false,"given":"Suzanne J.","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R.","family":"Narins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-0959","authenticated-orcid":false,"given":"Mohamad","family":"Alkhouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2024.01.284_bib1","article-title":"Assessment and management of older adults undergoing PCI, part 1","volume":"2","author":"Nanna","year":"2023","journal-title":"J\u00a0Am Coll Cardiol Adv"},{"key":"10.1016\/j.jcin.2024.01.284_bib2","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1161\/CIR.0000000000001112","article-title":"Management of acute coronary syndrome in the older adult population: a scientific statement from the American Heart Association","volume":"147","author":"Damluji","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jacc.2023.05.038","article-title":"Impact of geroscience on therapeutic strategies for older adults with cardiovascular disease: JACC scientific statement","volume":"82","author":"Forman","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib4","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jcin.2012.06.011","article-title":"The impact of frailty status on survival after transcatheter aortic valve replacement in older adults with severe aortic stenosis: a single-center experience","volume":"5","author":"Green","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jcin.2022.12.008","article-title":"The heterogeneity of old age: healthy aging in older adults undergoing TAVR","volume":"16","author":"Damluji","year":"2023","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib6","article-title":"Biological age in healthy elderly predicts aging-related diseases including dementia","volume":"11","author":"Wu","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcin.2024.01.284_bib7","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.jacc.2018.02.059","article-title":"Domain management approach to heart failure in the geriatric patient: present and future","volume":"71","author":"Gorodeski","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib8","article-title":"A\u00a0geriatric approach to percutaneous coronary interventions in older adults, part II: a JACC: Advances expert panel","volume":"2","author":"Nanna","year":"2023","journal-title":"J\u00a0Am Coll Cardiol Adv"},{"key":"10.1016\/j.jcin.2024.01.284_bib9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1532-5415.2007.01156.x","article-title":"Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept","volume":"55","author":"Inouye","year":"2007","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jcin.2024.01.284_bib10","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1093\/eurheartj\/ehab468","article-title":"Frailty and cardiovascular outcomes in the National Health and Aging Trends Study","volume":"42","author":"Damluji","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib11","article-title":"Frailty among older adults with acute myocardial infarction and outcomes from percutaneous coronary interventions","volume":"8","author":"Damluji","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2024.01.284_bib12","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/CIRCOUTCOMES.111.961375","article-title":"Influence of frailty and health status on outcomes in patients with coronary disease undergoing percutaneous revascularization","volume":"4","author":"Singh","year":"2011","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jcin.2024.01.284_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12471-019-1240-7","article-title":"Frailty score for elderly patients is associated with short-term clinical outcomes in patients with ST-segment elevated myocardial infarction treated with primary percutaneous coronary intervention","volume":"27","author":"Hermans","year":"2019","journal-title":"Neth Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jacc.2021.04.067","article-title":"Predicting in-hospital mortality in patients undergoing percutaneous coronary intervention","volume":"78","author":"Castro-Dominguez","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib15","article-title":"The Essential Frailty Toolset in older adults undergoing coronary artery bypass surgery","volume":"10","author":"Solomon","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2024.01.284_bib16","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jacc.2017.06.024","article-title":"Frailty in older adults undergoing aortic valve replacement: the FRAILTY-AVR study","volume":"70","author":"Afilalo","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1212\/01.wnl.0000310773.65918.cd","article-title":"Prevalence of dementia after age 90: results from the 90+ study","volume":"71","author":"Corrada","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jcin.2024.01.284_bib18","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.jacc.2016.08.046","article-title":"Serial changes in cognitive function following transcatheter aortic valve replacement","volume":"68","author":"Auffret","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib19","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/STROKEAHA.123.040499","article-title":"Cognitive impairment in patients with cardiac disease: implications for clinical practice","volume":"54","author":"van Nieuwkerk","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.jcin.2024.01.284_bib20","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/jgs.18120","article-title":"Readmission and adverse outcomes after percutaneous coronary intervention in patients with dementia","volume":"71","author":"Park","year":"2023","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jcin.2024.01.284_bib21","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jcin.2024.01.284_bib22","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1046\/j.1532-5415.2003.51465.x","article-title":"The Mini-Cog as a screen for dementia: validation in a population-based sample","volume":"51","author":"Borson","year":"2003","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jcin.2024.01.284_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12170-016-0491-8","article-title":"Multimorbidity in older patients with cardiovascular disease","volume":"10","author":"Dunlay","year":"2016","journal-title":"Curr Cardiovasc Risk Rep"},{"key":"10.1016\/j.jcin.2024.01.284_bib24","doi-asserted-by":"crossref","first-page":"E99","DOI":"10.1097\/JCN.0000000000000748","article-title":"Multimorbidity in patients with acute coronary syndrome is associated with greater mortality, higher readmission rates, and increased length of stay: a systematic review","volume":"35","author":"Breen","year":"2020","journal-title":"J\u00a0Cardiovasc Nurs"},{"key":"10.1016\/j.jcin.2024.01.284_bib25","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ehjqcco\/qcaa065","article-title":"Poor quality of life in patients with and without frailty: co-prevalence and prognostic implications in patients undergoing percutaneous coronary interventions and cardiac catheterization","volume":"7","author":"Kanwar","year":"2021","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"10.1016\/j.jcin.2024.01.284_bib26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijcard.2010.09.050","article-title":"Quality of life after percutaneous coronary intervention in the elderly with acute coronary syndrome","volume":"155","author":"Li","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1477-7525-1-80","article-title":"Problems and solutions in calculating quality-adjusted life years (QALYs)","volume":"1","author":"Prieto","year":"2003","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.jcin.2024.01.284_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ahj.2019.09.008","article-title":"Age, knowledge, preferences, and risk tolerance for\u00a0invasive cardiac care","volume":"219","author":"Nanna","year":"2020","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib29","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1111\/jgs.17831","article-title":"An age-old dilemma: defining the optimal revascularization approach in older adults","volume":"70","author":"Hanna","year":"2022","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jcin.2024.01.284_bib30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0735-1097(94)00397-9","article-title":"Development and evaluation of the Seattle Angina Questionnaire: a new functional status measure for coronary artery disease","volume":"25","author":"Spertus","year":"1995","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib31","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1056\/NEJMoa1916370","article-title":"Health-status outcomes with invasive or conservative care in coronary disease","volume":"382","author":"Spertus","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib32","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.118.004755","article-title":"Days alive and out of hospital: exploring a patient-centered, pragmatic outcome in a clinical trial of patients with acute coronary syndromes","volume":"11","author":"Fanaroff","year":"2018","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jcin.2024.01.284_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1276370","article-title":"Beyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease","volume":"10","author":"Kalra","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib34","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1001\/jamainternmed.2019.4235","article-title":"Association of patient priorities\u2013aligned decision-making with patient outcomes and ambulatory health care burden among older adults with multiple chronic conditions: a nonrandomized clinical trial","volume":"179","author":"Tinetti","year":"2019","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib35","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.122.012438","article-title":"Management of stable angina in the older adult population","volume":"16","author":"Nanna","year":"2023","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.01.284_bib36","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.jacc.2023.03.378","article-title":"Stable coronary artery disease in the age of geriatric cardiology","volume":"81","author":"Goyal","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib37","article-title":"Contemporary revascularization dilemmas in older adults","volume":"9","author":"Kumar","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2024.01.284_bib38","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(15)01166-6","article-title":"Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial","volume":"387","author":"Tegn","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2024.01.284_bib39","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.jacc.2023.02.048","article-title":"Health status and clinical outcomes in older adults with chronic coronary disease: the ISCHEMIA trial","volume":"81","author":"Nguyen","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib40","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1001\/jama.289.9.1117","article-title":"Outcome of elderly patients with chronic symptomatic coronary artery disease with an invasive vs optimized medical treatment strategy: one-year results of the randomized TIME trial","volume":"289","author":"Pfisterer","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2024.01.284_bib41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1001\/jamainternmed.2023.0047","article-title":"Effect of routine invasive vs conservative strategy in older adults with frailty and non\u2013ST-segment elevation acute myocardial infarction: a randomized clinical trial","volume":"183","author":"Sanchis","year":"2023","journal-title":"JAMA Intern Med"},{"issue":"25","key":"10.1016\/j.jcin.2024.01.284_bib42","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1056\/NEJMoa2310610","article-title":"A\u00a0placebo-controlled trial of percutaneous coronary intervention for stable angina","volume":"389","author":"Rajkumar","year":"2023","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib43","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1001\/jama.2022.5776","article-title":"Effect of transcatheter aortic valve implantation vs surgical aortic valve replacement on all-cause mortality in patients with aortic stenosis: a randomized clinical trial","volume":"327","author":"Toff","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2024.01.284_bib44","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.amjcard.2016.11.045","article-title":"Comparative outcomes of surgical and transcatheter aortic valve replacement for aortic stenosis in nonagenarians","volume":"119","author":"Zack","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib45","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.116.003364","article-title":"Referral to cardiac rehabilitation after percutaneous coronary intervention, coronary artery bypass surgery, and valve surgery","volume":"10","author":"Beatty","year":"2017","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jcin.2024.01.284_bib46","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jacc.2021.11.029","article-title":"Interventions for frailty among older adults with cardiovascular disease: JACC state-of-the-art review","volume":"79","author":"Ijaz","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.743710","article-title":"Relationship between sarcopenia and cardiovascular diseases in the elderly: an overview","volume":"8","author":"He","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib48","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.119.005691","article-title":"Sex-based differences in presentation, treatment, and complications among older adults hospitalized for acute myocardial infarction","volume":"12","author":"Nanna","year":"2019","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jcin.2024.01.284_bib49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ahj.2020.03.021","article-title":"Sarcopenia and health-related quality of life in older adults after transcatheter aortic valve replacement","volume":"224","author":"Damluji","year":"2020","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib50","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/00000542-200204000-00031","article-title":"Practice guidelines for sedation and analgesia by non-anesthesiologists","volume":"96","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jcin.2024.01.284_bib51","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth Universal definition of myocardial infarction (2018)","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib52","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1161\/CIRCULATIONAHA.119.040631","article-title":"Assessment and treatment of patients with type 2 myocardial infarction and acute nonischemic myocardial injury","volume":"140","author":"DeFilippis","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib53","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jcin.2008.05.007","article-title":"Trends in the prevalence and outcomes of radial and femoral approaches to percutaneous coronary intervention: a report from the National Cardiovascular Data Registry","volume":"1","author":"Rao","year":"2008","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib54","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4244\/EIJ-D-20-00052","article-title":"Validation of the Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria in patients undergoing percutaneous coronary intervention and comparison with contemporary bleeding risk scores","volume":"16","author":"Ueki","year":"2020","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2024.01.284_bib55","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.jcin.2022.08.041","article-title":"Position statement on vascular access safety for percutaneous devices in AMI complicated by cardiogenic shock","volume":"15","author":"Damluji Abdulla","year":"2022","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib56","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.amjcard.2015.05.015","article-title":"Impact of the HAS-BLED score on long-term outcomes after percutaneous coronary intervention","volume":"116","author":"Konishi","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib57","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.amjcard.2013.10.030","article-title":"Results of primary percutaneous coronary intervention in patients >\/=75 years treated by the transradial approach","volume":"113","author":"Rodriguez-Leor","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib58","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1001\/jama.2013.1556","article-title":"Association between bleeding events and in-hospital mortality after percutaneous coronary intervention","volume":"309","author":"Chhatriwalla","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2024.01.284_bib59","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S0140-6736(11)60404-2","article-title":"Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial","volume":"377","author":"Jolly","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2024.01.284_bib60","first-page":"629","article-title":"Transradial versus transfemoral approach for coronary angiography and intervention in patients above 75 years of age","volume":"72","author":"Achenbach","year":"2008","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.01.284_bib61","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.amjcard.2004.07.089","article-title":"Comparison of transradial and transfemoral approaches for coronary angiography and angioplasty in octogenarians (the OCTOPLUS study)","volume":"94","author":"Louvard","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib62","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.120.009328","article-title":"Transradial access for high-risk percutaneous coronary intervention: implications of the risk-treatment paradox","volume":"14","author":"Amin","year":"2021","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.01.284_bib63","first-page":"357","article-title":"Anatomic variations of the radial artery in patients undergoing transradial coronary intervention","volume":"49","author":"Yokoyama","year":"2000","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.01.284_bib64","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1186\/s12913-014-0506-4","article-title":"Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study","volume":"14","author":"Dodson","year":"2014","journal-title":"BMC Health Serv Res"},{"key":"10.1016\/j.jcin.2024.01.284_bib65","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1161\/CIRCULATIONAHA.107.182615","volume":"115","author":"Alexander","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib66","first-page":"101","article-title":"Acute coronary syndrome in the older adults","volume":"13","author":"Dai","year":"2016","journal-title":"J\u00a0Geriatr Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib67","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ahj.2004.06.003","article-title":"Impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE)","volume":"149","author":"Avezum","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib68","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1001\/jama.286.6.708","article-title":"Representation of elderly persons and women in published randomized trials of acute coronary syndromes","volume":"286","author":"Lee","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2024.01.284_bib69","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.007812","article-title":"Temporal trends of percutaneous coronary interventions in older adults with acute myocardial infarction","volume":"12","author":"Damluji","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.01.284_bib70","first-page":"174","article-title":"An overview of PCI in the very elderly","volume":"12","author":"Shanmugam","year":"2015","journal-title":"J\u00a0Geriatr Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib71","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1161\/CIRCULATIONAHA.107.182616","volume":"115","author":"Alexander","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib72","article-title":"Long-term outcomes following heart team revascularization recommendations in complex coronary artery disease","volume":"8","author":"Patterson","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"2","key":"10.1016\/j.jcin.2024.01.284_bib73","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jacc.2021.09.006","article-title":"2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Lawton","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib74","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/CIRCULATIONAHA.113.006588","article-title":"Rethinking composite end points in clinical trials: insights from patients and trialists","volume":"130","author":"Stolker","year":"2014","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.jcin.2024.01.284_bib75","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1111\/jgs.18390","article-title":"Preoperative frailty and adverse outcomes following coronary artery bypass grafting surgery in US veterans","volume":"71","author":"Kochar","year":"2023","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jcin.2024.01.284_bib76","article-title":"Long-term mortality of older patients with acute myocardial infarction treated in US clinical practice","volume":"7","author":"Kochar","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2024.01.284_bib77","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.jacc.2018.12.088","article-title":"Age, STEMI, and Cardiogenic shock: never too old for PCI?","volume":"73","author":"Navarese","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib78","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"for the SHOCK Investigators. Early revascularization in acute myocardial infarction complicated by cardiogenic shock","volume":"341","author":"Hochman","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib79","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0195-668X(02)00844-8","article-title":"Early revascularization is associated with improved survival in elderly patients with acute myocardial infarction complicated by cardiogenic shock: a report from the SHOCK trial registry","volume":"24","author":"Dzavik","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib80","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.jacc.2019.01.055","article-title":"Percutaneous coronary intervention in older patients with ST-segment elevation myocardial infarction and cardiogenic shock","volume":"73","author":"Damluji","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib81","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.jcin.2019.04.027","article-title":"Procedural success rates and mortality in elderly patients with percutaneous coronary intervention for cardiogenic shock","volume":"12","author":"Zeymer","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib82","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1056\/NEJMc1911289","article-title":"Behavioral heuristics in coronary-artery bypass graft surgery","volume":"382","author":"Olenski","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib83","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1161\/CIR.0000000000001005","article-title":"Lower extremity peripheral artery disease: contemporary epidemiology, management gaps, and future directions: a scientific statement from the American Heart Association","volume":"144","author":"Criqui","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib84","first-page":"e38","article-title":"Heart disease and stroke statistics\u20142016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib85","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1161\/01.CIR.0000112642.63927.54","article-title":"Relationship of high and low ankle brachial index to all-cause and cardiovascular disease mortality: the Strong Heart Study","volume":"109","author":"Resnick","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib86","article-title":"Smoking cessation behaviors among older U.S. adults","volume":"16","author":"Henley","year":"2019","journal-title":"Prev Med Rep"},{"key":"10.1016\/j.jcin.2024.01.284_bib87","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1583\/08-2459.1","article-title":"Complications after peripheral vascular interventions in octogenarians","volume":"15","author":"Dick","year":"2008","journal-title":"J\u00a0Endovasc Ther"},{"key":"10.1016\/j.jcin.2024.01.284_bib88","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.avsg.2022.07.007","article-title":"Major adverse limb events among patients with premature peripheral artery disease compared with those at the common age undergoing revascularization in the Vascular Quality Initiative","volume":"87","author":"Kim","year":"2022","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jcin.2024.01.284_bib89","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1161\/STROKEAHA.111.000513","article-title":"Outcomes of carotid endarterectomy in the elderly: report from the National Cardiovascular Data Registry","volume":"44","author":"Rajamani","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.jcin.2024.01.284_bib90","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1161\/CIRCULATIONAHA.108.805465","article-title":"One-year clinical outcomes, midterm survival, and predictors of mortality after carotid stenting in elderly patients","volume":"119","author":"Chiam","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib91","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.amjcard.2019.07.066","article-title":"Meta-analysis of temporal and surgical risk dependent associations with outcomes after transcatheter versus surgical aortic valve implantation","volume":"124","author":"Khan","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib92","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"G\u00e9n\u00e9reux","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib93","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.jacc.2016.01.055","article-title":"Should transcatheter aortic valve replacement be performed in nonagenarians? Insights from the STS\/ACC TVT registry","volume":"67","author":"Arsalan","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib94","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jcin.2021.01.042","article-title":"Age-related outcomes after transcatheter aortic valve replacement: insights from the SwissTAVI registry","volume":"14","author":"Attinger-Toller","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib95","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ejcts\/ezab389","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease: developed by the Task Force for the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"60","author":"Beyersdorf","year":"2021","journal-title":"Eur J Cardiothorac Surg"},{"issue":"4","key":"10.1016\/j.jcin.2024.01.284_bib96","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib97","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.jacc.2018.03.459","article-title":"Valvular heart disease in patients\u00a0\u226580 years of age","volume":"71","author":"Kodali","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib98","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/jamainternmed.2018.6738","article-title":"Evaluation of changes in functional status in the year after aortic valve replacement","volume":"179","author":"Kim","year":"2019","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib99","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1016\/j.jacc.2019.10.030","article-title":"Sarcopenia in older adults undergoing transcatheter aortic valve replacement","volume":"74","author":"Mamane","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ahj.2018.04.021","article-title":"Importance of geriatric nutritional risk index assessment in patients undergoing transcatheter aortic valve replacement","volume":"202","author":"Shibata","year":"2018","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib101","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.jcin.2020.04.015","article-title":"Impact of left ventricular outflow tract calcification on procedural outcomes after transcatheter aortic valve replacement","volume":"13","author":"Okuno","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib102","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/j.jcin.2020.07.006","article-title":"Coronary cannulation after transcatheter aortic valve replacement: the RE-ACCESS study","volume":"13","author":"Barbanti","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib103","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.jcin.2014.04.019","article-title":"Feasibility and exploratory efficacy evaluation of the Embrella Embolic Deflector system for the prevention of cerebral emboli in patients undergoing transcatheter aortic valve replacement: the PROTAVI-C pilot study","volume":"7","author":"Rod\u00e9s-Cabau","year":"2014","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib104","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev-physiol-021119-034338","article-title":"Contributions of aging to cerebral small vessel disease","volume":"82","author":"De Silva","year":"2020","journal-title":"Ann Rev Physiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib105","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/jamainternmed.2019.6767","article-title":"Early experience with cerebral embolic protection during transcatheter aortic valve replacement in the United States","volume":"180","author":"Alkhouli","year":"2020","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib106","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrcardio.2016.9","article-title":"Assessment, treatment, and prognostic implications of CAD in patients undergoing TAVI","volume":"13","author":"Danson","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib107","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4244\/EIJ-D-22-00958","volume":"19","author":"Tarantini","year":"2023","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2024.01.284_bib108","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.amjcard.2019.08.024","article-title":"Meta-analysis comparing outcomes in patients undergoing transcatheter aortic valve implantation with versus without percutaneous coronary intervention","volume":"124","author":"Lateef","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib109","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.jcin.2021.06.041","article-title":"ACTIVATION (Percutaneous Coronary Intervention Prior to Transcatheter Aortic Valve Implantation): a randomized clinical trial","volume":"14","author":"Patterson","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib110","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jacc.2022.05.006","article-title":"Evolution and prognostic impact of cardiac damage after aortic valve replacement","volume":"80","author":"G\u00e9n\u00e9reux","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib111","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1093\/eurheartj\/ehw229","article-title":"Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the OxVALVE Population Cohort Study","volume":"37","author":"d\u2019Arcy","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib112","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1136\/heartjnl-2014-307120","article-title":"Clinical impact and evolution of mitral regurgitation following transcatheter aortic valve replacement: a meta-analysis","volume":"101","author":"Nombela-Franco","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.jcin.2024.01.284_bib113","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.amjcard.2014.06.022","article-title":"Meta-analysis of mortality outcomes and mitral regurgitation evolution in 4,839 patients having transcatheter aortic valve implantation for severe aortic stenosis","volume":"114","author":"Sannino","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib114","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.jcin.2020.03.052","article-title":"Transcatheter aortic valve replacement in patients with multivalvular heart disease","volume":"13","author":"Khan","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijcard.2019.03.048","article-title":"Fate and long-term prognostic implications of mitral regurgitation in patients undergoing transcatheter aortic valve replacement","volume":"288","author":"Abdelghani","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib116","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jacc.2020.11.006","article-title":"Prevalence and outcomes of concomitant aortic stenosis and cardiac amyloidosis","volume":"77","author":"Nitsche","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib117","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1093\/eurheartj\/ehaa170","article-title":"Prevalence and outcome of dual aortic stenosis and cardiac amyloid pathology in patients referred for transcatheter aortic valve implantation","volume":"41","author":"Scully","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib118","first-page":"618","article-title":"Burden of atrial fibrillation\u2013associated ischemic stroke in the United States","volume":"4","author":"Alkhouli","year":"2018","journal-title":"J\u00a0Am Coll Cardiol EP"},{"key":"10.1016\/j.jcin.2024.01.284_bib119","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1016\/j.jacc.2018.04.013","article-title":"Stroke prevention in nonvalvular atrial fibrillation: a stakeholder perspective","volume":"71","author":"Alkhouli","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mayocp.2020.11.012","article-title":"Stroke prevention in very elderly patients with nonvalvular atrial fibrillation revisited","volume":"96","author":"Alkhouli","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jcin.2024.01.284_bib121","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.mayocp.2018.08.043","article-title":"Perception of the risk of stroke and the risks and benefits of oral anticoagulation for stroke prevention in patients with atrial fibrillation: a cross-sectional study","volume":"94","author":"Hijazi","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jcin.2024.01.284_bib122","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10840-022-01274-1","article-title":"Oral anticoagulant underutilization among elderly patients with atrial fibrillation: insights from the United States Medicare database","volume":"66","author":"Munir","year":"2023","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib123","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1016\/j.jacc.2019.10.040","article-title":"Ischemic stroke risk in patients with nonvalvular atrial fibrillation: JACC review topic of the week","volume":"74","author":"Alkhouli","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib124","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/eurjpc\/zwab018","article-title":"Utility of the CHA2DS2-VASc score for predicting ischaemic stroke in patients with or without atrial fibrillation: a systematic review and meta-analysis","volume":"29","author":"Siddiqi","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib125","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.mayocp.2018.09.025","article-title":"Left atrial appendage occlusion for the unmet clinical needs of stroke prevention in nonvalvular atrial fibrillation","volume":"94","author":"Holmes","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jcin.2024.01.284_bib126","article-title":"Outcomes of elderly patients undergoing left atrial appendage closure","volume":"10","author":"Sanjoy","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2024.01.284_bib127","first-page":"669","article-title":"Left atrial appendage occlusion in the elderly: insights from PROTECT-AF, PREVAIL, and continuous access registries","volume":"9","author":"Sulaiman","year":"2023","journal-title":"J\u00a0Am Coll Cardiol EP"},{"key":"10.1016\/j.jcin.2024.01.284_bib128","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/europace\/euaa262","article-title":"Comparative data on left atrial appendage occlusion efficacy and clinical outcomes by age group in the Amplatzer Amulet Occluder Observational Study","volume":"23","author":"Freixa","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.jcin.2024.01.284_bib129","first-page":"1093","article-title":"Incidence and predictors of early death in patients undergoing percutaneous left atrial appendage closure","volume":"8","author":"Mesnier","year":"2022","journal-title":"J\u00a0Am Coll Cardiol EP"},{"key":"10.1016\/j.jcin.2024.01.284_bib130","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jcin.2022.02.009","article-title":"Clinical outcomes at 1 year following transcatheter left atrial appendage occlusion in the United States","volume":"15","author":"Price","year":"2022","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib131","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.jacc.2022.02.047","article-title":"Antithrombotic therapy after left atrial appendage occlusion in patients with atrial fibrillation","volume":"79","author":"Freeman","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib132","article-title":"The heart brain team and patient-centered management of ischemic stroke","volume":"1","author":"Alkhouli","year":"2022","journal-title":"J\u00a0Am Coll Cardiol Adv"},{"key":"10.1016\/j.jcin.2024.01.284_bib133","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.jacc.2017.07.724","article-title":"Cerebral amyloid angiopathy: diagnosis, clinical implications, and management strategies in atrial fibrillation","volume":"70","author":"DeSimone","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib134","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1016\/j.mayocp.2020.03.034","article-title":"Utility of HAS-BLED and CHA2DS2-VASc scores among patients with atrial fibrillation and imaging evidence of cerebral amyloid angiopathy","volume":"95","author":"Ward","year":"2020","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jcin.2024.01.284_bib135","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12975-020-00838-5","article-title":"Left atrial appendage closure for patients with cerebral amyloid angiopathy and atrial fibrillation: the LAA-CAA cohort","volume":"12","author":"Schrag","year":"2021","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.jcin.2024.01.284_bib136","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1093\/eurheartj\/ehz157","article-title":"Patent foramen ovale closure for secondary stroke prevention","volume":"40","author":"Alkhouli","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib137","article-title":"Effectiveness of transcatheter closure of patent foramen ovale in clinical practice","volume":"12","author":"Alkhouli","year":"2023","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2024.01.284_bib138","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.2169\/internalmedicine.54.3617","article-title":"Platypnea-orthodeoxia syndrome: an unusual complication of partial liver resection","volume":"54","author":"Alkhouli","year":"2015","journal-title":"Intern Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib139","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.121.011652","article-title":"Transcatheter closure of patent foramen ovale in older patients with cryptogenic thromboembolic events","volume":"15","author":"Alperi","year":"2022","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.01.284_bib140","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1212\/WNL.0000000000004199","article-title":"Age- and sex-specific analysis of patients with embolic stroke of undetermined source","volume":"89","author":"Ntaios","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.jcin.2024.01.284_bib141","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1001\/jamaneurol.2020.1948","article-title":"Prognosis of cryptogenic stroke with patent foramen ovale at older ages and implications for trials: a population-based study and systematic review","volume":"77","author":"Mazzucco","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jcin.2024.01.284_bib142","article-title":"SCAI guidelines for the management of patent foramen ovale","volume":"1","author":"Kavinsky","year":"2022","journal-title":"J\u00a0Soc Cardiovasc Angiogr Interv"},{"key":"10.1016\/j.jcin.2024.01.284_bib143","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib144","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijcard.2021.08.010","article-title":"Characteristics and outcomes of MitraClip in octogenarians: evidence from 1853 patients in the GIOTTO registry","volume":"342","author":"Giordano","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib145","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/joic.12455","article-title":"Percutaneous repair of severe mitral valve regurgitation secondary to chordae rupture in octogenarians using MitraClip","volume":"31","author":"Geis","year":"2018","journal-title":"J\u00a0Interv Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib146","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1001\/jama.2023.7089","article-title":"Transcatheter mitral valve repair for degenerative mitral regurgitation","volume":"329","author":"Makkar","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2024.01.284_bib147","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.jacc.2023.02.049","article-title":"1-Year outcomes of transcatheter tricuspid valve repair","volume":"81","author":"Kodali","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib148","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1056\/NEJMoa2300525","article-title":"Transcatheter repair for patients with tricuspid regurgitation","volume":"388","author":"Sorajja","year":"2023","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcin.2024.01.284_bib149","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/jama.279.5.371","article-title":"Health values of hospitalized patients 80 years or older","volume":"279","author":"Tsevat","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2024.01.284_bib150","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S1053-2498(01)00298-4","article-title":"Preferences for quality of life or survival expressed by patients with heart failure","volume":"20","author":"Lewis","year":"2001","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jcin.2024.01.284_bib151","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1161\/CIRCULATIONAHA.111.040022","article-title":"Health-related quality of life after transcatheter aortic valve replacement in inoperable patients with severe aortic stenosis","volume":"124","author":"Reynolds","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib152","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ahj.2022.10.080","article-title":"Days at home after transcatheter or surgical aortic valve replacement in high-risk patients","volume":"255","author":"Chung","year":"2023","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2024.01.284_bib153","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.jacc.2019.02.010","article-title":"Health Status after transcatheter mitral-valve repair in heart failure and secondary mitral regurgitation: COAPT trial","volume":"73","author":"Arnold","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib154","first-page":"70","article-title":"Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram","volume":"25","author":"Attia","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.01.284_bib155","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIR.0b013e31829e8807","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"128","author":"Yancy","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2024.01.284_bib156","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/ehjdh\/ztad015","article-title":"A\u00a0novel breakthrough in wrist-worn transdermal troponin-I-sensor assessment for acute myocardial infarction","volume":"4","author":"Sengupta","year":"2023","journal-title":"Eur Heart J Digit Health"},{"key":"10.1016\/j.jcin.2024.01.284_bib157","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jcin.2018.12.020","article-title":"The Vancouver 3M (Multidisciplinary, Multimodality, but Minimalist) clinical pathway facilitates safe next-day discharge home at low-, medium-, and high-volume transfemoral transcatheter aortic valve replacement centers: the 3M TAVR study","volume":"12","author":"Wood","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jcin.2024.01.284_bib158","first-page":"232","article-title":"Innovative clinical pathway shortened the length of hospital stay and prevented readmission in patients with acute decompensated heart failure","volume":"80","author":"Amioka","year":"2022","journal-title":"J\u00a0Cardiol"},{"issue":"3","key":"10.1016\/j.jcin.2024.01.284_bib159","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"for the Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879824003479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879824003479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:30:39Z","timestamp":1762597839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879824003479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":159,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1936879824003479"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2024.01.284","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronological vs Biological Age in Interventional Cardiology","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2024.01.284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}