{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:45:44Z","timestamp":1793090744337,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jcin.2024.05.018","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T14:52:02Z","timestamp":1720450322000},"page":"1559-1573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Impact of Intraprocedural Mitral Regurgitation and Gradient Following Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-4951","authenticated-orcid":false,"given":"Sebastian","family":"Ludwig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3607-2977","authenticated-orcid":false,"given":"Benedikt","family":"Koell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Weimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhairya","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-1493","authenticated-orcid":false,"given":"Lukas","family":"Stolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0780-8689","authenticated-orcid":false,"given":"Tetsu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-4384","authenticated-orcid":false,"given":"Andrea","family":"Scotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9077-1447","authenticated-orcid":false,"given":"Teresa","family":"Trenkwalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-6438","authenticated-orcid":false,"given":"Felix","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0698-4456","authenticated-orcid":false,"given":"Daryoush","family":"Samim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-3897","authenticated-orcid":false,"given":"Philipp","family":"von Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-3007","authenticated-orcid":false,"given":"Julien","family":"Dreyfus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Paradis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Karam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Bohbot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Melica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-3452","authenticated-orcid":false,"given":"Angelo","family":"Quagliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoan","family":"Lavie Badie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-3060","authenticated-orcid":false,"given":"Omar","family":"Chehab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1937-063X","authenticated-orcid":false,"given":"Simon","family":"Redwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lubos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6691-8568","authenticated-orcid":false,"given":"Marco","family":"Metra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Primerano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-8500","authenticated-orcid":false,"given":"Christos","family":"Iliadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Praz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Ger\u00e7ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-2819","authenticated-orcid":false,"given":"Erion","family":"Xhepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-343X","authenticated-orcid":false,"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Schofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Makkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Granada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4169-3766","authenticated-orcid":false,"given":"Thomas","family":"Modine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Hausleiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-2461","authenticated-orcid":false,"given":"Daniel","family":"Kalbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-7874","authenticated-orcid":false,"given":"Augustin","family":"Coisne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9540","key":"10.1016\/j.jcin.2024.05.018_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2024.05.018_bib2","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(09)60692-9","article-title":"Mitral regurgitation","volume":"373","author":"Enriquez-Sarano","year":"2009","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jcin.2024.05.018_bib3","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jcin.2024.05.018_bib4","first-page":"524","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease: developed by the Task Force for the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"75","author":"Vahanian","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"1","key":"10.1016\/j.jcin.2024.05.018_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.athoracsur.2021.07.030","article-title":"Transcatheter mitral valve therapy in the United States: a report from the STS-ACC TVT registry","volume":"113","author":"Mack","year":"2022","journal-title":"Ann Thorac Surg"},{"issue":"9","key":"10.1016\/j.jcin.2024.05.018_bib6","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jcin.2016.12.280","article-title":"Elevated mitral valve pressure gradient after MitraClip implantation deteriorates long-term outcome in patients with severe mitral regurgitation and severe heart failure","volume":"10","author":"Neuss","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"issue":"9","key":"10.1016\/j.jcin.2024.05.018_bib7","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jcin.2021.12.007","article-title":"Long-term outcomes of patients with elevated mitral valve pressure gradient after mitral valve edge-to-edge repair","volume":"15","author":"Koell","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.05.018_bib8","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.jcin.2022.01.281","article-title":"Prognostic value of increased mitral valve gradient after transcatheter edge-to-edge repair for primary mitral regurgitation","volume":"15","author":"Yoon","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.05.018_bib9","article-title":"Elevated mitral valve pressure gradient is predictive of long-term outcome after percutaneous edge-to-edge mitral valve repair in patients with degenerative mitral regurgitation (MR), but not in functional MR","volume":"8","author":"Patzelt","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jcin.2024.05.018_bib10","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1001\/jama.2023.7089","article-title":"Transcatheter mitral valve repair for degenerative mitral regurgitation","volume":"329","author":"Makkar","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jcin.2024.05.018_bib11","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1093\/ehjci\/jeab253","article-title":"Multi-modality imaging assessment of native valvular regurgitation: an EACVI and ESC council of valvular heart disease position paper","volume":"23","author":"Lancellotti","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jcin.2024.05.018_bib12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jacc.2015.05.049","article-title":"Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the Mitral Valve Academic Research Consortium","volume":"66","author":"Stone","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.05.018_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehab910","article-title":"Association of transcatheter edge-to-edge repair with improved survival in older patients with severe, symptomatic degenerative mitral regurgitation","author":"Benfari","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2024.05.018_bib14","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jcin.2022.12.015","article-title":"Intraprocedural residual mitral regurgitation and survival after transcatheter edge-to-edge repair","volume":"16","author":"Boekstegers","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.05.018_bib15","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/ejhf.2770","article-title":"Transcatheter edge-to-edge repair for secondary mitral regurgitation with third-generation devices in heart failure patients - results from the Global EXPAND Post-Market study","volume":"25","author":"Orban","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jcin.2024.05.018_bib16","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1016\/j.jcin.2023.09.029","article-title":"1-year outcomes with fourth-generation mitral valve transcatheter edge-to-edge repair from the EXPAND G4 Study","volume":"16","author":"von Bardeleben","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.05.018_bib17","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.jcin.2019.03.023","article-title":"Edge-to-edge mitral valve repair with extended clip arms: early experience from a multicenter observational study","volume":"12","author":"Praz","year":"2019","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.05.018_bib18","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jcin.2022.02.018","article-title":"Transmitral gradients following transcatheter edge-to-edge repair","volume":"15","author":"Hahn","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.05.018_bib19","first-page":"310","article-title":"Postprocedural trans-mitral gradient in patients with degenerative mitral regurgitation undergoing mitral valve transcatheter edge-to-edge repair","volume":"102","author":"De Felice","year":"2023","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.05.018_bib20","first-page":"637","article-title":"Mitral valve reserve in double-orifice technique: an exercise echocardiographic study","volume":"11","author":"Agricola","year":"2002","journal-title":"J\u00a0Heart Valve Dis"},{"key":"10.1016\/j.jcin.2024.05.018_bib21","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1016\/j.jcin.2023.10.006","article-title":"Estimating mitral valve area post\u2013transcatheter edge-to-edge repair","volume":"16","author":"Alexandrino","year":"2023","journal-title":"JACC Cardiovasc Interv"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879824008008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879824008008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:03:01Z","timestamp":1783368181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879824008008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":21,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S1936879824008008"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2024.05.018","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Intraprocedural Mitral Regurgitation and Gradient Following Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2024.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}