{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:46:06Z","timestamp":1791945966910,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jcin.2024.08.042","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T14:10:58Z","timestamp":1732111858000},"page":"44-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Meta-Analysis of Dedicated vs Off-Label Transcatheter Devices for Native Aortic Regurgitation"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-3106","authenticated-orcid":false,"given":"Sahar","family":"Samimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha","family":"Hatab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Kharsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safi U.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rody G.","family":"Bou Chaaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-5706","authenticated-orcid":false,"given":"Fatima","family":"Qamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6339-1630","authenticated-orcid":false,"given":"Joe","family":"Aoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Zaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeen","family":"Faza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin D.","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Zoghbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Reardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-8133","authenticated-orcid":false,"given":"Neal S.","family":"Kleiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-3876","authenticated-orcid":false,"given":"Sachin S.","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jcin.2024.08.042_bib1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0002-9149(98)01064-9","article-title":"Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)","volume":"83","author":"Singh","year":"1999","journal-title":"Am J Cardiol"},{"issue":"9540","key":"10.1016\/j.jcin.2024.08.042_bib2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jcin.2024.08.042_bib3","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1080\/24748706.2021.1988779","article-title":"Treatment patterns, disparities, and management strategies impact clinical outcomes in patients with symptomatic severe aortic regurgitation","volume":"5","author":"Thourani","year":"2021","journal-title":"Struct Heart"},{"issue":"14","key":"10.1016\/j.jcin.2024.08.042_bib4","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/CIRCULATIONAHA.119.041080","article-title":"Contemporary presentation and management of valvular heart disease: the EURObservational Research Programme Valvular Heart Disease II Survey","volume":"140","author":"Iung","year":"2019","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.jcin.2024.08.042_bib5","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.jcin.2023.07.038","article-title":"Transcatheter aortic valve replacement for isolated aortic regurgitation using a new self-expanding TAVR system","volume":"16","author":"Adam","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"issue":"4","key":"10.1016\/j.jcin.2024.08.042_bib6","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jcin.2024.08.042_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1161\/CIRCULATIONAHA.104.488825","article-title":"Valvular heart disease: aortic regurgitation","volume":"112","author":"Bekeredjian","year":"2005","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.jcin.2024.08.042_bib8","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.amjcard.2018.05.044","article-title":"Usefulness of transcatheter aortic valve implantation for treatment of pure native aortic valve regurgitation","volume":"122","author":"De Backer","year":"2018","journal-title":"Am J Cardiol"},{"issue":"16","key":"10.1016\/j.jcin.2024.08.042_bib9","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.jcin.2023.07.026","article-title":"Transcatheter aortic valve replacement for pure native aortic valve regurgitation","volume":"16","author":"Poletti","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"issue":"16","key":"10.1016\/j.jcin.2024.08.042_bib10","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/j.jcin.2023.05.018","article-title":"Transcatheter treatment of native aortic valve regurgitation: the North American experience with a novel device","volume":"16","author":"Garcia","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"issue":"10435","key":"10.1016\/j.jcin.2024.08.042_bib11","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0140-6736(23)02806-4","article-title":"Transcatheter aortic valve implantation in patients with high-risk symptomatic native aortic regurgitation (ALIGN-AR): a prospective, multicentre, single-arm study","volume":"403","author":"Vahl","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2024.08.042_bib12","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jcin.2024.08.042_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.jcin.2024.08.042_bib14","unstructured":"Wells GA, Shea B, O\u2019Connell D, et al. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Ottawa Hospital Research Institute; 2014."},{"issue":"1","key":"10.1016\/j.jcin.2024.08.042_bib15","doi-asserted-by":"crossref","DOI":"10.1136\/bmjos-2020-100074","article-title":"Comparison of commonly used methods in random effects meta-analysis: application to preclinical data in drug discovery research","volume":"5","author":"Tanriver-Ayder","year":"2021","journal-title":"BMJ Open Sci"},{"issue":"14","key":"10.1016\/j.jcin.2024.08.042_bib16","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1161\/01.CIR.99.14.1851","article-title":"Mortality and morbidity of aortic regurgitation in clinical practice: a long-term follow-up study","volume":"99","author":"Dujardin","year":"1999","journal-title":"Circulation"},{"issue":"22","key":"10.1016\/j.jcin.2024.08.042_bib17","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.jcin.2016.08.049","article-title":"Transcatheter aortic valve replacement for the treatment of pure native aortic valve regurgitation: a systematic review","volume":"9","author":"Franzone","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"issue":"7","key":"10.1016\/j.jcin.2024.08.042_bib18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jacc.2016.05.065","article-title":"Predictors of early cerebrovascular events in patients with aortic stenosis undergoing transcatheter aortic valve replacement","volume":"68","author":"Auffret","year":"2016","journal-title":"Am J Cardiol"},{"issue":"13","key":"10.1016\/j.jcin.2024.08.042_bib19","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.jcin.2024.05.019","article-title":"Performance of purpose-built vs off-label transcatheter devices for aortic regurgitation: the PURPOSE study","volume":"17","author":"Poletti","year":"2024","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.08.042_bib20","series-title":"ALIGN-AR CAP: the Trilogy TAVR system and an update on the ALIGN AR study [conference presentation slides]","author":"Makkar","year":"2024"},{"issue":"17 suppl S","key":"10.1016\/j.jcin.2024.08.042_bib21","doi-asserted-by":"crossref","first-page":"B41","DOI":"10.1016\/j.jacc.2020.09.106","article-title":"TCT CONNECT-92 initial single-center experience with transfemoral transcatheter aortic valve replacement in patients with symptomatic severe aortic regurgitation","volume":"76","author":"Gogia","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jcin.2024.08.042_bib22","first-page":"1345","article-title":"The JUPITER registry: one-year outcomes of transapical aortic valve implantation using a second generation transcatheter heart valve for aortic regurgitation","volume":"91","author":"Silaschi","year":"2018","journal-title":"Catheter Cardiovasc Interv"},{"issue":"3","key":"10.1016\/j.jcin.2024.08.042_bib23","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/icvts\/ivu155","article-title":"Transcatheter aortic valve implantation of a second-generation valve for pure aortic regurgitation: procedural outcome, haemodynamic data and follow-up","volume":"19","author":"Schlingloff","year":"2014","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"10","key":"10.1016\/j.jcin.2024.08.042_bib24","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.jcin.2014.05.014","article-title":"Initial German experience with transapical implantation of a second-generation transcatheter heart valve for the treatment of aortic regurgitation","volume":"7","author":"Seiffert","year":"2014","journal-title":"JACC Cardiovasc Interv"},{"issue":"7","key":"10.1016\/j.jcin.2024.08.042_bib25","first-page":"224","article-title":"30-Day outcomes after surgical or transapical aortic valve replacement in symptomatic aortic regurgitation","volume":"9","author":"Kong","year":"2022","journal-title":"J\u00a0Cardiovasc Dev Dis"},{"issue":"4","key":"10.1016\/j.jcin.2024.08.042_bib26","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/jocs.16238","article-title":"One-year outcome after transcatheter aortic valve replacement for aortic regurgitation: a single-center study","volume":"37","author":"Liu","year":"2022","journal-title":"J\u00a0Card Surg"},{"issue":"5","key":"10.1016\/j.jcin.2024.08.042_bib27","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.athoracsur.2020.06.139","article-title":"Transcatheter aortic valve implantation with J-Valve: 2-year outcomes from a multicenter study","volume":"111","author":"Shi","year":"2021","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"10.1016\/j.jcin.2024.08.042_bib28","doi-asserted-by":"crossref","first-page":"538","DOI":"10.21037\/jtd.2020.01.04","article-title":"Transapical transcatheter aortic valve implantation for predominant aortic regurgitation with a self-expandable valve","volume":"12","author":"Liu","year":"2020","journal-title":"J\u00a0Thorac Dis"},{"key":"10.1016\/j.jcin.2024.08.042_bib29","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1016\/j.hlc.2019.02.076","article-title":"Treatment of pure aortic regurgitation using a novel second-generation transcatheter aortic valve implantation system real-world experience","volume":"28","author":"Liu","year":"2019","journal-title":"Heart Lung Circ"},{"issue":"suppl 1","key":"10.1016\/j.jcin.2024.08.042_bib30","first-page":"1146","article-title":"The clinical experience of J valve transapical transcatheter aortic valve replacement system in high-risk patients with severe pure aortic regurgitation","volume":"40","author":"Liu","year":"2019","journal-title":"Egypt Heart J"},{"issue":"5","key":"10.1016\/j.jcin.2024.08.042_bib31","first-page":"377","article-title":"A\u00a0versatile transapical device for aortic valvular disease: one-year outcomes of a multicenter study on the J-Valve system","volume":"72","author":"Tung","year":"2018","journal-title":"J\u00a0Cardiol"},{"issue":"2","key":"10.1016\/j.jcin.2024.08.042_bib32","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jtcvs.2017.09.015","article-title":"Transapical transcatheter aortic valve replacement with a novel transcatheter aortic valve replacement system in high-risk patients with severe aortic valve diseases","volume":"155","author":"Zhu","year":"2018","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"issue":"23","key":"10.1016\/j.jcin.2024.08.042_bib33","first-page":"2803","article-title":"Treatment of pure aortic regurgitation using a second-generation transcatheter aortic valve implantation system","volume":"67","author":"Zhu","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.08.042_bib34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijcard.2015.07.037","article-title":"Transapical transcatheter aortic valve implantation using a new second-generation TAVI system\u2014J-Valve\u2122 for high-risk patients with aortic valve diseases: initial results with 90-day follow-up","volume":"199","author":"Zhu","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2024.08.042_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.amjcard.2024.04.030","article-title":"Off-label use of balloon-expandable transcatheter valves to treat pure aortic regurgitation","volume":"222","author":"Orzalkiewicz","year":"2024","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.jcin.2024.08.042_bib36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.acvd.2022.12.003","article-title":"Transcatheter aortic valve implantation using the SAPIEN 3 valve to treat aortic regurgitation: the French multicentre S3AR study","volume":"116","author":"Delhomme","year":"2023","journal-title":"Arch Cardiovasc Dis"},{"issue":"12_suppl","key":"10.1016\/j.jcin.2024.08.042_bib37","doi-asserted-by":"crossref","first-page":"B173","DOI":"10.1016\/j.jacc.2022.08.504","article-title":"TCT-428 outcomes of patients undergoing TAVI for purely regurgitant native aortic valves with the current generation transcatheter aortic valve platforms","volume":"80","author":"Pracon","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jcin.2024.08.042_bib38","first-page":"1599","article-title":"Transcatheter aortic valve implantation in pure aortic regurgitation: hemodynamic and echocardiographic findings in bioprosthesis vs. native valve","volume":"99","author":"Paraggio","year":"2022","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2024.08.042_bib39","article-title":"Transcatheter treatment of native aortic valve regurgitation: results from an international registry using the transfemoral ACURATE neo valve","volume":"27","author":"Purita","year":"2020","journal-title":"Int J Cardiol Heart Vasc"},{"issue":"5","key":"10.1016\/j.jcin.2024.08.042_bib40","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.amjcard.2019.05.045","article-title":"Self-expanding valve system for treatment of native aortic regurgitation by transcatheter aortic valve implantation (from the STS\/ACC TVT Registry)","volume":"124","author":"Anwaruddin","year":"2019","journal-title":"Am J Cardiol"},{"issue":"9","key":"10.1016\/j.jcin.2024.08.042_bib41","first-page":"329","article-title":"Transfemoral implantation of the Acurate neo for the treatment of aortic regurgitation","volume":"30","author":"Toggweiler","year":"2018","journal-title":"J\u00a0Invasive Cardiol"},{"issue":"suppl 1","key":"10.1016\/j.jcin.2024.08.042_bib42","first-page":"ehx493","article-title":"P5433 comparison of the effectiveness of transcatheter aortic valve implantation in patients with pure native aortic valve regurgitation versus aortic stenosis","volume":"38","author":"Munoz Garcia","year":"2017","journal-title":"Egypt Heart J"},{"issue":"14","key":"10.1016\/j.jcin.2024.08.042_bib43","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/j.jcin.2015.08.022","article-title":"Transfemoral implantation of a fully repositionable and retrievable transcatheter valve for noncalcified pure aortic regurgitation","volume":"8","author":"Schofer","year":"2015","journal-title":"JACC Cardiovasc Interv"},{"issue":"11S","key":"10.1016\/j.jcin.2024.08.042_bib44","doi-asserted-by":"crossref","first-page":"B220","DOI":"10.1016\/j.jacc.2014.07.827","article-title":"TCT-755 transcatheter aortic valve implantation in patients with pure severe native aortic regurgitation: results after 3 year of follow-up","volume":"64","author":"Rossi","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jcin.2024.08.042_bib45","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4244\/EIJV10I6A127","article-title":"CoreValve implantation for severe aortic regurgitation: a multicentre registry","volume":"10","author":"Testa","year":"2014","journal-title":"EuroIntervention"},{"issue":"15","key":"10.1016\/j.jcin.2024.08.042_bib46","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.jacc.2013.01.018","article-title":"Transcatheter aortic valve implantation for pure severe native aortic valve regurgitation","volume":"61","author":"Roy","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.08.042_bib47","doi-asserted-by":"crossref","first-page":"B48","DOI":"10.1016\/j.jacc.2015.08.151","article-title":"TCT-105 transcatheter aortic valve implantation using a new second-generation TAVI system: J-ValveTM for high-risk patients with pure aortic regurgitation","volume":"66","author":"Guo","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2024.08.042_bib48","series-title":"Transcatheter aortic valve implantation for pure aortic valve regurgitation? Insights from the French-TAVI Nationwide French Registry: the PAVR study [conference presentation slides]","author":"Le Ruz","year":"2024"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879824011622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879824011622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:14:55Z","timestamp":1768270495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879824011622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1936879824011622"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2024.08.042","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meta-Analysis of Dedicated vs Off-Label Transcatheter Devices for Native Aortic Regurgitation","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2024.08.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier on behalf of the American College of Cardiology Foundation","name":"copyright","label":"Copyright"}]}}