{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:30:07Z","timestamp":1792726207278,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003345","name":"CAMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jcin.2025.10.042","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T04:47:24Z","timestamp":1763614044000},"page":"422-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rationales Behind Physiology-Guided Revascularization"],"prefix":"10.1016","volume":"19","author":[{"given":"Rui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changdong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zening","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-6332","authenticated-orcid":false,"given":"Bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosheng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2019an","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianglong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinkai","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weida","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxian","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-6338","authenticated-orcid":false,"given":"Kefei","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2025.10.042_bib1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.jcin.2020.04.040","article-title":"The impact of coronary physiology on contemporary clinical decision making","volume":"13","author":"Kogame","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2025.10.042_bib2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/eurheartj\/ehy812","article-title":"Fractional flow reserve-guided percutaneous coronary intervention vs. medical therapy for patients with stable coronary lesions: meta-analysis of individual patient data","volume":"40","author":"Zimmermann","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2025.10.042_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJMoa0807611","article-title":"Fractional flow reserve versus angiography for guiding percutaneous coronary intervention","volume":"360","author":"Tonino","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcin.2025.10.042_bib4","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa1205361","article-title":"Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease","volume":"367","author":"De Bruyne","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcin.2025.10.042_bib5","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1056\/NEJMoa1700445","article-title":"Use of the instantaneous wave-free ratio or fractional flow reserve in PCI","volume":"376","author":"Davies","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcin.2025.10.042_bib6","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa1616540","article-title":"Instantaneous wave-free ratio versus fractional flow reserve to guide PCI","volume":"376","author":"G\u00f6tberg","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcin.2025.10.042_bib7","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/S0140-6736(21)02248-0","article-title":"Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial","volume":"398","author":"Xu","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jcin.2025.10.042_bib8","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/j.jacc.2022.09.007","article-title":"2-Year outcomes of angiographic quantitative flow ratio-guided coronary interventions","volume":"80","author":"Song","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2025.10.042_bib9","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jacc.2021.09.006","article-title":"2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Lawton","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2025.10.042_bib10","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2025.10.042_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4244\/EIJ-D-23-00194","article-title":"Applied coronary physiology for planning and guidance of percutaneous coronary interventions. A clinical consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the European Society of Cardiology","volume":"19","author":"Escaned","year":"2023","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2025.10.042_bib12","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.4244\/EIJ-D-21-00176","article-title":"Outcomes of quantitative flow ratio-based percutaneous coronary intervention in an all-comers study","volume":"17","author":"Zhang","year":"2022","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2025.10.042_bib13","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1016\/j.jacc.2017.10.035","article-title":"Diagnostic accuracy of angiography-based quantitative flow ratio measurements for online assessment of coronary stenosis","volume":"70","author":"Xu","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2025.10.042_bib14","first-page":"693","article-title":"Diagnostic performance of quantitative flow ratio in prospectively enrolled patients: an individual patient-data meta-analysis","volume":"94","author":"Westra","year":"2019","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2025.10.042_bib15","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1093\/eurheartj\/ehad318","article-title":"Left main bifurcation stenting: impact of residual ischaemia on cardiovascular mortality","volume":"44","author":"Wang","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2025.10.042_bib16","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1016\/j.jcin.2022.10.014","article-title":"Outcomes of functionally complete vs incomplete revascularization: insights from the FAVOR III China trial","volume":"15","author":"Zhang","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2025.10.042_bib17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/CIRCULATIONAHA.113.006646","article-title":"Outcome impact of coronary revascularization strategy reclassification with fractional flow reserve at time of diagnostic angiography: insights from a large French multicenter fractional flow reserve registry","volume":"129","author":"Van Belle","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2025.10.042_bib18","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1161\/CIRCULATIONAHA.117.028782","article-title":"Angiography versus hemodynamics to predict the natural history of coronary stenoses: Fractional Flow Reserve Versus Angiography in Multivessel Evaluation 2 substudy","volume":"137","author":"Ciccarelli","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2025.10.042_bib19","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jcin.2012.07.007","article-title":"Visual-functional mismatch between coronary angiography and fractional flow reserve","volume":"5","author":"Park","year":"2012","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2025.10.042_bib20","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1253\/circj.CJ-15-1402","article-title":"Impact of age on the functional significance of intermediate epicardial artery disease","volume":"80","author":"Jin","year":"2016","journal-title":"Circ J"},{"key":"10.1016\/j.jcin.2025.10.042_bib21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijcard.2014.09.010","article-title":"The impact of age on fractional flow reserve-guided percutaneous coronary intervention: a FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) trial substudy","volume":"177","author":"Lim","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2025.10.042_bib22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1056\/NEJMoa2300468","article-title":"Complete or culprit-only PCI in older patients with myocardial infarction","volume":"389","author":"Biscaglia","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcin.2025.10.042_bib23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.5603\/CJ.a2018.0105","article-title":"Reproducibility of quantitative flow ratio: an inter-core laboratory variability study","volume":"27","author":"Chang","year":"2020","journal-title":"Cardiol J"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879825027025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879825027025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T17:05:38Z","timestamp":1772298338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879825027025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1936879825027025"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2025.10.042","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationales Behind Physiology-Guided Revascularization","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2025.10.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}