{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:34:29Z","timestamp":1793036069084,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jcin.2025.10.051","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T19:30:31Z","timestamp":1770665431000},"page":"302-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bleeding in Patients With Infarct-Related Cardiogenic Shock"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-6681","authenticated-orcid":false,"given":"Rikke","family":"S\u00f8rensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-5845","authenticated-orcid":false,"given":"Jacob Eifer","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5151-6400","authenticated-orcid":false,"given":"Christophe","family":"Vandenbriele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Eiskj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-7923","authenticated-orcid":false,"given":"Norman","family":"Mangner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Polzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Christian","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Skurk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-4068","authenticated-orcid":false,"given":"Peter","family":"Nordbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Clemmensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Panoulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Engstr\u00f8m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-3733","authenticated-orcid":false,"given":"Rasmus Paulin","family":"Beske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Frydland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-2429","authenticated-orcid":false,"given":"Lisette Okkels","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Junker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna Louise Junker","family":"Udesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Juhl","family":"Terkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Linke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Holmvang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcin.2025.10.051_bib1","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/j.jacc.2019.07.077","article-title":"Cardiogenic shock classification to predict mortality in the cardiac intensive care unit","volume":"74","author":"Jentzer","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2025.10.051_bib2","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/ejhf.1566","article-title":"Temporal trends in incidence and patient characteristics in cardiogenic shock following acute myocardial infarction from 2010 to 2017: a Danish cohort study","volume":"21","author":"Helgestad","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jcin.2025.10.051_bib3","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJMoa2307227","article-title":"Extracorporeal life support in infarct-related cardiogenic shock","volume":"389","author":"Thiele","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcin.2025.10.051_bib4","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1161\/CIRCULATIONAHA.120.048792","article-title":"Left ventricular unloading is associated with lower mortality in patients with cardiogenic shock treated with venoarterial extracorporeal membrane oxygenation: results from an international, multicenter cohort study","volume":"142","author":"Schrage","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2025.10.051_bib5","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.118.036614","article-title":"Impella support for acute myocardial infarction complicated by cardiogenic shock","volume":"139","author":"Schrage","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2025.10.051_bib6","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.jcin.2020.02.042","article-title":"Frequency and impact of bleeding on outcome in patients with cardiogenic shock","volume":"13","author":"Freund","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2025.10.051_bib7","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1001\/jamainternmed.2022.2735","article-title":"Clinical outcomes and cost associated with an intravascular microaxial left ventricular assist device vs intra-aortic balloon pump in patients presenting with acute myocardial infarction complicated by cardiogenic shock","volume":"182","author":"Miller","year":"2022","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jcin.2025.10.051_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/CIRCULATIONAHA.119.044007","article-title":"The evolving landscape of Impella use in the united states among patients undergoing percutaneous coronary intervention with mechanical circulatory support","volume":"141","author":"Amin","year":"2020","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.jcin.2025.10.051_bib9","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.3390\/jcm9061976","article-title":"Prognostic impact of active mechanical circulatory support in cardiogenic shock complicating acute myocardial infarction, results from the Culprit-Shock trial","volume":"9","author":"Feistritzer","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jcin.2025.10.051_bib10","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.jacc.2007.02.027","article-title":"Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY trial","volume":"49","author":"Manoukian","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2025.10.051_bib11","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.jcin.2012.05.010","article-title":"Association between periprocedural bleeding and long-term outcomes following percutaneous coronary intervention in older patients","volume":"5","author":"Rao","year":"2012","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2025.10.051_bib12","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/ejhf.3025","article-title":"Impella and venoarterial extracorporeal membrane oxygenation in cardiogenic shock complicating acute myocardial infarction","volume":"25","author":"Bogerd","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jcin.2025.10.051_bib13","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1056\/NEJMra1208626","article-title":"Bleeding and coagulopathies in critical care","volume":"370","author":"Hunt","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcin.2025.10.051_bib14","first-page":"399","article-title":"The evaluation and management of coagulopathies in the intensive therapy units","volume":"12","author":"Galli","year":"2023","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.jcin.2025.10.051_bib15","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJMoa2312572","article-title":"Microaxial flow pump or standard care in infarct-related cardiogenic shock","volume":"390","author":"Moller","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcin.2025.10.051_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ahj.2019.04.019","article-title":"Rationale and design of DanGer shock: Danish-German cardiogenic shock trial","volume":"214","author":"Udesen","year":"2019","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcin.2025.10.051_bib17","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2025.10.051_bib18","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.healun.2024.05.015","article-title":"Clinical outcomes among cardiogenic shock patients supported with high-capacity Impella axial flow pumps: a report from the Cardiogenic Shock Working Group","volume":"43","author":"Fried","year":"2024","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jcin.2025.10.051_bib19","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1001\/jama.2020.0254","article-title":"Association of use of an intravascular microaxial left ventricular assist device vs intra-aortic balloon pump with in-hospital mortality and major bleeding among patients with acute myocardial infarction complicated by cardiogenic shock","volume":"323","author":"Dhruva","year":"2020","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.jcin.2025.10.051_bib20","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.3390\/jcm9123803","article-title":"Long-term clinical outcome of cardiogenic shock patients undergoing Impella CP treatment vs. standard of care","volume":"9","author":"Scherer","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jcin.2025.10.051_bib21","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1093\/eurheartj\/ehz372","article-title":"Defining high bleeding risk in patients undergoing percutaneous coronary intervention: a consensus document from the Academic Research Consortium for High Bleeding Risk","volume":"40","author":"Urban","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcin.2025.10.051_bib22","doi-asserted-by":"crossref","first-page":"e1227","DOI":"10.4244\/EIJ-D-20-01076","article-title":"Veno-arterial extracorporeal membrane oxygenation (ECMO) in patients with cardiogenic shock: rationale and design of the randomised, multicentre, open-label EURO SHOCK trial","volume":"16","author":"Banning","year":"2021","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2025.10.051_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159973","article-title":"Dual antiplatelet therapy (DAPT) versus no antiplatelet therapy and incidence of major bleeding in patients on venoarterial extracorporeal membrane oxygenation","volume":"11","author":"Staudacher","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jcin.2025.10.051_bib24","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.jacc.2022.02.052","article-title":"Anticoagulation for percutaneous ventricular assist device-supported cardiogenic shock: JACC review topic of the week","volume":"79","author":"Vandenbriele","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcin.2025.10.051_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2023.131690","article-title":"Heparin dosing in patients with Impella-supported cardiogenic shock","volume":"399","author":"Vandenbriele","year":"2024","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcin.2025.10.051_bib26","first-page":"458","article-title":"European practices on antithrombotic management during percutaneous mechanical circulatory support in adults: a survey of the Association for Acute CardioVascular Care of the ESC and the European branch of the Extracorporeal Life Support Organization","volume":"13","author":"Van Edom","year":"2024","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.jcin.2025.10.051_bib27","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1161\/CIRCULATIONAHA.106.612812","article-title":"Adverse impact of bleeding on prognosis in patients with acute coronary syndromes","volume":"114","author":"Eikelboom","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jcin.2025.10.051_bib28","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00134-019-05897-3","article-title":"Why we need safer anticoagulant strategies for patients on short-term percutaneous mechanical circulatory support","volume":"46","author":"Vandenbriele","year":"2020","journal-title":"Intensive Care Med"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879825028250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879825028250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T19:30:35Z","timestamp":1770665435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879825028250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1936879825028250"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2025.10.051","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bleeding in Patients With Infarct-Related Cardiogenic Shock","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2025.10.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}