{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:06:53Z","timestamp":1789506413973,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jcin.2025.11.015","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T19:30:31Z","timestamp":1770665431000},"page":"316-327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of Intravenous Antiplatelet Therapy in Acute Myocardial Infarction With Cardiogenic Shock"],"prefix":"10.1016","volume":"19","author":[{"given":"Anthony","family":"Elhadad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"El Zouhayri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Silvain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Kerneis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9400-1324","authenticated-orcid":false,"given":"David","family":"Sulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki","family":"Procopi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Devos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Beaupr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Charleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Giovachini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Ferrante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassim","family":"Braik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Guedeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Barth\u00e9l\u00e9my","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Combes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Chommeloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Rouanet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Zeitouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jcin.2025.11.015_bib1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000590","article-title":"Trends in incidence, management, and outcomes of cardiogenic shock complicating ST-elevation myocardial infarction in the United States","volume":"3","author":"Kolte","year":"2014","journal-title":"J Am Heart Assoc"},{"issue":"14","key":"10.1016\/j.jcin.2025.11.015_bib2","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJMoa2307227","article-title":"Extracorporeal life support in infarct-related cardiogenic shock","volume":"389","author":"Thiele","year":"2023","journal-title":"N Engl J Med"},{"issue":"25","key":"10.1016\/j.jcin.2025.11.015_bib3","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa1710261","article-title":"PCI strategies in patients with acute myocardial infarction and cardiogenic shock","volume":"377","author":"Thiele","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jcin.2025.11.015_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4244\/EIJV9I1A10","article-title":"Incidence and predictors of stent thrombosis: a single-centre study of 5,833 consecutive patients undergoing coronary artery stenting","volume":"9","author":"Iqbal","year":"2013","journal-title":"EuroIntervention"},{"issue":"10","key":"10.1016\/j.jcin.2025.11.015_bib5","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.jcin.2020.02.042","article-title":"Frequency and impact of bleeding on outcome in patients with cardiogenic shock","volume":"13","author":"Freund","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"issue":"6","key":"10.1016\/j.jcin.2025.11.015_bib6","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1002\/ehf2.13643","article-title":"Antithrombotic and anticoagulation therapies in cardiogenic shock: a critical review of the published literature","volume":"8","author":"Radu","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"8","key":"10.1016\/j.jcin.2025.11.015_bib7","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/ejhf.1922","article-title":"Epidemiology, pathophysiology and contemporary management of cardiogenic shock\u2014a position statement from the Heart Failure Association of the European Society of Cardiology","volume":"22","author":"Chioncel","year":"2020","journal-title":"Eur J Heart Fail"},{"issue":"4","key":"10.1016\/j.jcin.2025.11.015_bib8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1177\/1074248415571456","article-title":"Antiplatelet therapy considerations in ischemic cardiogenic shock: implications of metabolic bioactivation","volume":"20","author":"Weeks","year":"2015","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.jcin.2025.11.015_bib9","first-page":"517","article-title":"Antithrombotic therapy in patients with complex percutaneous coronary intervention and cardiogenic shock","volume":"13","author":"Larrubia Valle","year":"2024","journal-title":"Interv Cardiol Clin"},{"issue":"25","key":"10.1016\/j.jcin.2025.11.015_bib10","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1056\/NEJM200106213442503","article-title":"Platelet glycoprotein IIb\/IIIa inhibition with coronary stenting for acute myocardial infarction","volume":"344","author":"Montalescot","year":"2001","journal-title":"N Engl J Med"},{"issue":"9909","key":"10.1016\/j.jcin.2025.11.015_bib11","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/S0140-6736(13)61615-3","article-title":"Effect of cangrelor on periprocedural outcomes in percutaneous coronary interventions: a pooled analysis of patient-level data","volume":"382","author":"Steg","year":"2013","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.jcin.2025.11.015_bib12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.acvd.2024.07.059","article-title":"Ten-year trends in characteristics, management and outcomes of patients admitted with cardiogenic shock in the ACTION-SHOCK cohort","volume":"117","author":"Sulman","year":"2024","journal-title":"Arch Cardiovasc Dis"},{"issue":"6","key":"10.1016\/j.jcin.2025.11.015_bib13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/ehjcvp\/pvaf019","article-title":"Pre-treatment with P2Y12 inhibitors in acute myocardial infarction with cardiogenic shock","volume":"11","author":"Elhadad","year":"2025","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"9","key":"10.1016\/j.jcin.2025.11.015_bib14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jacc.2022.01.018","volume":"79","author":"Naidu","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jcin.2025.11.015_bib15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/CIRCULATIONAHA.119.040167","article-title":"Defining high bleeding risk in patients undergoing percutaneous coronary intervention","volume":"140","author":"Urban","year":"2019","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.jcin.2025.11.015_bib16","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1161\/CIRCULATIONAHA.117.029289","article-title":"Standardized end point definitions for coronary intervention trials: the Academic Research Consortium-2 consensus document","volume":"137","author":"Garcia-Garcia","year":"2018","journal-title":"Circulation"},{"issue":"20","key":"10.1016\/j.jcin.2025.11.015_bib17","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"issue":"23","key":"10.1016\/j.jcin.2025.11.015_bib18","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.jcin.2025.11.015_bib19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/01.CIR.93.5.879","article-title":"TIMI frame count: a quantitative method of assessing coronary artery flow","volume":"93","author":"Gibson","year":"1996","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.jcin.2025.11.015_bib20","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1161\/CIR.0000000000000525","article-title":"Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association","volume":"136","author":"van Diepen","year":"2017","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.jcin.2025.11.015_bib21","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.4244\/EIJ-D-16-00398","article-title":"The Effect of Ticagrelor Administered Through a Nasogastric Tube to Comatose Patients Undergoing Acute Percutaneous Coronary Intervention: the TICOMA study","volume":"12","author":"Ratcovich","year":"2017","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jcin.2025.11.015_bib22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.resuscitation.2019.02.008","article-title":"Cangrelor in cardiogenic shock and after cardiopulmonary resuscitation: a global, multicenter, matched pair analysis with oral P2Y12 inhibition from the IABP-SHOCK II trial","volume":"137","author":"Droppa","year":"2019","journal-title":"Resuscitation"},{"issue":"7","key":"10.1016\/j.jcin.2025.11.015_bib23","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jcin.2025.01.451","article-title":"Cangrelor during percutaneous coronary intervention in patients with cardiogenic shock or cardiac arrest","volume":"18","author":"Emilsson","year":"2025","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jcin.2025.11.015_bib24","series-title":"DAPT-SHOCK-AMI trial: cangrelor in cardiogenic shock","year":"2025"},{"issue":"1","key":"10.1016\/j.jcin.2025.11.015_bib25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s40560-020-00502-y","article-title":"Glycoprotein IIb\/IIIa inhibitors for cardiogenic shock complicating acute myocardial infarction: a systematic review, meta-analysis, and meta-regression","volume":"8","author":"Saleiro","year":"2020","journal-title":"J Intensive Care"},{"issue":"12","key":"10.1016\/j.jcin.2025.11.015_bib26","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.3390\/medicina60122092","article-title":"Anti-platelet therapy with cangrelor in cardiogenic shock patients: a systematic review and single-arm meta-analysis","volume":"60","author":"D\u2019Andria Ursoleo","year":"2024","journal-title":"Medicina (Kaunas)"},{"issue":"15","key":"10.1016\/j.jcin.2025.11.015_bib27","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJMoa2312572","article-title":"Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock","volume":"390","author":"M\u00f8ller","year":"2024","journal-title":"N Engl J Med"}],"container-title":["JACC: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879825029541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936879825029541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T19:30:38Z","timestamp":1770665438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936879825029541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1936879825029541"],"URL":"https:\/\/doi.org\/10.1016\/j.jcin.2025.11.015","relation":{},"ISSN":["1936-8798"],"issn-type":[{"value":"1936-8798","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and Safety of Intravenous Antiplatelet Therapy in Acute Myocardial Infarction With Cardiogenic Shock","name":"articletitle","label":"Article Title"},{"value":"JACC: Cardiovascular Interventions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcin.2025.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}