{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:14:12Z","timestamp":1783109652063,"version":"3.54.6"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jcis.2019.10.118","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T17:58:36Z","timestamp":1572631116000},"page":"690-700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Protective properties of mesocellular silica foams against aggregation and enzymatic hydrolysis of loaded proteins for oral protein delivery"],"prefix":"10.1016","volume":"560","author":[{"given":"Ye","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9788-9333","authenticated-orcid":false,"given":"Siling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcis.2019.10.118_b0005","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.biotechadv.2014.07.006","article-title":"A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules","volume":"32","author":"Choonara","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jcis.2019.10.118_b0010","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1016\/j.biomaterials.2013.07.021","article-title":"Combination Therapy via oral co-administration of insulin- and exendin-4-loaded nanoparticles to treat type 2 diabetic rats undergoing OGTT","volume":"34","author":"Chuang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2019.10.118_b0015","doi-asserted-by":"crossref","first-page":"9678","DOI":"10.1016\/j.biomaterials.2013.08.048","article-title":"Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2019.10.118_b0020","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.copbio.2014.08.001","article-title":"Protein aggregation and its impact on product quality","volume":"30","author":"Roberts","year":"2014","journal-title":"Curr. Opin. Biotech."},{"key":"10.1016\/j.jcis.2019.10.118_b0025","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1002\/anie.201300958","article-title":"Glucose- and pH-responsive controlled release of cargo from protein-gated carbohydrate-functionalized mesoporous silica nanocontainers","volume":"52","author":"Wu","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2019.10.118_b0030","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cis.2013.08.010","article-title":"Enzymes immobilized in mesoporous silica: a physical\u2013chemical perspective","volume":"205","author":"Carlsson","year":"2014","journal-title":"Adv. Colloid. Interfac."},{"key":"10.1016\/j.jcis.2019.10.118_b0035","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/adfm.200600578","article-title":"Colloidal suspensions of nanometer-sized mesoporous silica","volume":"17","author":"Moller","year":"2007","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jcis.2019.10.118_b0040","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/anie.200460892","article-title":"Generalized fluorocarbon-surfactantmediated synthesis of nanoparticles with various mesoporous structures","volume":"44","author":"Han","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2019.10.118_b0045","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1039\/c3cs35405a","article-title":"Synthesis of mesoporous silica nanoparticles","volume":"42","author":"Wu","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jcis.2019.10.118_b0050","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.micromeso.2008.12.019","article-title":"Synthesis of spherical mesoporous silica nanoparticles with nanometer-size controllable pores and outer diameters","volume":"120","author":"Nandiyanto","year":"2009","journal-title":"Micropor. Mesopor. Mat."},{"key":"10.1016\/j.jcis.2019.10.118_b0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejpb.2010.05.010","article-title":"Inclusion of telmisartan in mesocellular foam nanoparticles: drug loading and release property","volume":"76","author":"Zhang","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jcis.2019.10.118_b0060","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1016\/j.biomaterials.2014.04.104","article-title":"Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers","volume":"35","author":"Shrestha","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2019.10.118_b0065","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1021\/mp5003015","article-title":"Biocompatible and mucoadhesive bacterial cellulose-g-poly(acrylic acid) hydrogels for oral protein delivery","volume":"11","author":"Ahmad","year":"2014","journal-title":"Mol. Pharmaceut."},{"key":"10.1016\/j.jcis.2019.10.118_b0070","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/bm0607776","article-title":"Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery","volume":"8","author":"Lin","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jcis.2019.10.118_b0075","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1021\/mp500809f","article-title":"Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Pharmaceutics"},{"key":"10.1016\/j.jcis.2019.10.118_b0080","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bej.2012.02.002","article-title":"Effect of (\u2212)-epigallocatechin-3-gallate on human insulin fibrillation\/aggregation kinetics","volume":"63","author":"Wang","year":"2012","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.jcis.2019.10.118_b0085","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/abio.2000.4880","article-title":"Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set","volume":"287","author":"Narasimha","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jcis.2019.10.118_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jlumin.2014.10.025","article-title":"Spectroscopic study of the interaction of insulin and its aptamer-sensitive optical detection of insulin","volume":"159","author":"Verdian-Doghaei","year":"2015","journal-title":"J. Lumin."},{"key":"10.1016\/j.jcis.2019.10.118_b0095","doi-asserted-by":"crossref","first-page":"6866","DOI":"10.1021\/la800548p","article-title":"Characterization of globular protein solutions by dynamic light scattering, electrophoretic mobility, and viscosity measurements","volume":"24","author":"Barbara","year":"2008","journal-title":"Langmuir"},{"key":"10.1016\/j.jcis.2019.10.118_b0100","doi-asserted-by":"crossref","first-page":"47115","DOI":"10.1074\/jbc.M408179200","article-title":"Mechanisms of dense core vesicle recapture following \u201ckiss and run\u201d (\u201ccavicapture\u201d) exocytosis in insulin-secreting cells","volume":"279","author":"Tsuboi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jcis.2019.10.118_b0105","first-page":"2001","article-title":"Elucidating the mechanisms of protein antigen adsorption to the CAF\/NAF liposomal vaccine adjuvant systems: effect of charge, fluidity and antigen-to-lipid ratio","volume":"2014","author":"Hamborg","year":"1838","journal-title":"BBA-Biomembranes"},{"key":"10.1016\/j.jcis.2019.10.118_b0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2016.04.012","article-title":"Dual chitosan\/albumin-coated alginate\/dextran sulfate nanoparticles for enhanced oral delivery of insulin","volume":"232","author":"Lopes","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jcis.2019.10.118_b0115","doi-asserted-by":"crossref","first-page":"8582","DOI":"10.1002\/anie.200705238","article-title":"Proteins in Mesoporous Silicates","volume":"47","author":"Hudson","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2019.10.118_b0120","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1107\/S0907444913009050","article-title":"On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin","volume":"69","author":"Liebschner","year":"2013","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jcis.2019.10.118_b0125","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1021\/bm100814n","article-title":"Interactions between antimalarial indolone-N-oxide derivatives and human serum albumin","volume":"11","author":"Ibrahim","year":"2010","journal-title":"Biomacromolecules"}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979719313128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979719313128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:23:55Z","timestamp":1758266635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979719313128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":25,"alternative-id":["S0021979719313128"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2019.10.118","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective properties of mesocellular silica foams against aggregation and enzymatic hydrolysis of loaded proteins for oral protein delivery","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2019.10.118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}