{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:04:58Z","timestamp":1790827498164,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51803001"],"award-info":[{"award-number":["51803001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51603001"],"award-info":[{"award-number":["51603001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51503001"],"award-info":[{"award-number":["51503001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation of Education Department of Anhui Province of China","award":["KJ2018ZD003"],"award-info":[{"award-number":["KJ2018ZD003"]}]},{"name":"Research Foundation of Education Department of Anhui Province of China","award":["KJ2018A0006"],"award-info":[{"award-number":["KJ2018A0006"]}]},{"DOI":"10.13039\/501100002729","name":"Anhui University","doi-asserted-by":"publisher","award":["AU02303203"],"award-info":[{"award-number":["AU02303203"]}],"id":[{"id":"10.13039\/501100002729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jcis.2020.01.029","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T13:26:44Z","timestamp":1579008404000},"page":"254-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["pH-sensitive pluronic micelles combined with oxidative stress amplification for enhancing multidrug resistance breast cancer therapy"],"prefix":"10.1016","volume":"565","author":[{"given":"Xu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3521-4888","authenticated-orcid":false,"given":"Rupei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcis.2020.01.029_b0005","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.drudis.2018.05.037","article-title":"Supermolecular drug challenge to overcome drug resistance in cancer cells","volume":"23","author":"Yasuhiko","year":"2018","journal-title":"Drug Discov. Today."},{"key":"10.1016\/j.jcis.2020.01.029_b0010","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.7150\/thno.22679","article-title":"Stimuli-responsive nanomedicines for overcoming cancer multidrug resistance","volume":"8","author":"Zhou","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.jcis.2020.01.029_b0015","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7150\/thno.21674","article-title":"Current challenges of cancer anti-angiogenic therapy and the promise of nanotherapeutics","volume":"8","author":"Abdalla","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.jcis.2020.01.029_b0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijpharm.2015.04.048","article-title":"Pluronic-based functional polymeric mixed micelles for co-delivery of doxorubicin and paclitaxel to multidrug resistant tumor","volume":"488","author":"Chen","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jcis.2020.01.029_b0025","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.actbio.2017.05.012","article-title":"Chemosensitizing indomethacin-conjugated chitosan oligosaccharide nanoparticles for tumor-targeted drug delivery","volume":"57","author":"Lee","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jcis.2020.01.029_b0030","first-page":"1","article-title":"Small and innovative molecules as new strategy to revert MDR","volume":"4","author":"Laura","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jcis.2020.01.029_b0035","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1517\/13543784.2012.679339","article-title":"Investigational ABC transporter inhibitors","volume":"21","author":"Marco","year":"2012","journal-title":"Expert Opin. Inv. Drug."},{"key":"10.1016\/j.jcis.2020.01.029_b0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1517\/17425255.4.2.205","article-title":"Development of inhibitors of ATP-binding cassette drug transporters\u2013present status and challenges","volume":"4","author":"Shukla","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.jcis.2020.01.029_b0045","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1166\/jbn.2016.2231","article-title":"Amphiphilic copolymeric micelles for doxorubicin and curcumin co-delivery to reverse multidrug resistance in breast cancer","volume":"12","author":"Lv","year":"2016","journal-title":"J. Biomed. Nanotechn."},{"key":"10.1016\/j.jcis.2020.01.029_b0050","doi-asserted-by":"crossref","first-page":"425103","DOI":"10.1088\/0957-4484\/27\/42\/425103","article-title":"Disulfide-crosslinked nanomicelles confer cancer-specific drug delivery and improve efficacy of paclitaxel in bladder cancer","volume":"27","author":"Pan","year":"2016","journal-title":"Nanotechnology"},{"key":"10.1016\/j.jcis.2020.01.029_b0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12013-010-9125-9","article-title":"Clinical evaluation of targeted arterial infusion of verapamil in the interventional chemotherapy of primary hepatocellular carcinoma","volume":"59","author":"Huang","year":"2011","journal-title":"Cell Biochem. Bioph."},{"key":"10.1016\/j.jcis.2020.01.029_b0060","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1039\/c2cs15327k","article-title":"Design of polymeric nanoparticles for biomedical delivery applications","volume":"41","author":"Elsabahy","year":"2012","journal-title":"Che. Soc. Rev."},{"key":"10.1016\/j.jcis.2020.01.029_b0065","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1002\/anie.201603967","article-title":"Tunable-sized polymeric micelles and their assembly for the preparation of large mesoporous platinum nanoparticles","volume":"55","author":"Jiang","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2020.01.029_b0070","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/1061186X.2017.1289538","article-title":"Recent progress in drug delivery of pluronic P123: pharmaceutical perspectives","volume":"25","author":"Zhao","year":"2017","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jcis.2020.01.029_b0075","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijpharm.2018.11.064","article-title":"Pluronics: intelligent building units for targeted cancer therapy and molecular imaging","volume":"556","author":"Khaliq","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jcis.2020.01.029_b0080","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2019.05.026","article-title":"Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors","volume":"306","author":"Hu","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jcis.2020.01.029_b0085","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0169-409X(02)00047-9","article-title":"Pluronic\u00ae block copolymers for overcoming drug resistance in cancer","volume":"54","author":"Kabanov","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jcis.2020.01.029_b0090","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jconrel.2008.04.013","article-title":"Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers","volume":"130","author":"Elena","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jcis.2020.01.029_b0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.colsurfb.2016.02.033","article-title":"pH-responsive copolymers based on pluronic P123-poly(-amino ester): synthesis, characterization and application of copolymer micelles","volume":"142","author":"Cai","year":"2016","journal-title":"Colloids Surf. B. Biointerfaces"},{"key":"10.1016\/j.jcis.2020.01.029_b0100","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1002\/jps.10190","article-title":"Distribution, metabolism and excretion of a novel surface-avtive agent, purified poloxamer 188, in rats, dogs and humans","volume":"91","author":"Grindel","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jcis.2020.01.029_b0105","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1016\/j.biomaterials.2010.12.039","article-title":"Multifunctional pluronic P123\/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors","volume":"32","author":"Zhang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2020.01.029_b0110","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1016\/j.biomaterials.2012.03.013","article-title":"Poly(caprolactone)-modified pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors","volume":"33","author":"Wang","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2020.01.029_b0115","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3390\/ma8020379","article-title":"Preparation of pH sensitive pluronic-docetaxel conjugate micelles to balance the stability and controlled release issues","volume":"8","author":"Liang","year":"2015","journal-title":"Materials"},{"key":"10.1016\/j.jcis.2020.01.029_b0120","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.biomaterials.2006.09.035","article-title":"Shell-crosslinked pluronic L121 micelles as a drug delivery vehicle","volume":"28","author":"Yang","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2020.01.029_b0125","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.addr.2013.04.011","article-title":"Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor","volume":"65","author":"Yin","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jcis.2020.01.029_b0130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.actbio.2014.09.014","article-title":"PH-sensitive nanoparticles of poly(L-histidine)\u2013poly(lactide-co-glycolide)\u2013tocopheryl polyethylene glycol succinateorf anti-tumor drug delivery","volume":"11","author":"Li","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jcis.2020.01.029_b0135","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.carbpol.2016.11.049","article-title":"Atrial natriuretic peptide-conjugated chitosan-hydrazone-mPEG copolymer nanoparticles as pH-responsive carriers for intracellular delivery of prednisone","volume":"157","author":"Kumar","year":"2017","journal-title":"Carbohyd. Polym."},{"key":"10.1016\/j.jcis.2020.01.029_b0140","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/mabi.201400395","article-title":"Diblock copolymers of polyethylene glycol and a polymethacrylamide with side-chains containing twin ortho ester rings: synthesis, characterization, and evaluation as potential pH-responsive micelles","volume":"15","author":"Zhou","year":"2015","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jcis.2020.01.029_b0145","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/j.polymer.2014.04.036","article-title":"PEGylated block copolymers containing tertiary amine side-chains cleavable via acid-labile ortho ester linkages for pH-triggered release of DNA","volume":"55","author":"Lai","year":"2014","journal-title":"Polymer"},{"key":"10.1016\/j.jcis.2020.01.029_b0150","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s11426-018-9269-6","article-title":"Dual-stimuli-sensitive poly (ortho ester disulfide urethanes)-based nanospheres with rapid intracellular drug release for enhanced chemotherapy","volume":"61","author":"Huang","year":"2018","journal-title":"Sc. China Chem."},{"key":"10.1016\/j.jcis.2020.01.029_b0155","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.msec.2018.09.029","article-title":"PH-sensitive amphiphilic triblock copolymers containing ortho ester main-chains as efficient drug delivery platforms","volume":"94","author":"Wang","year":"2019","journal-title":"Mat. Sci. Eng. C. Mater."},{"key":"10.1016\/j.jcis.2020.01.029_b0160","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ejpb.2018.05.011","article-title":"Acid-degradable lactobionic acid-modified soy protein nanogels crosslinked by ortho ester linkage for efficient antitumor in vivo","volume":"128","author":"Cheng","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jcis.2020.01.029_b0165","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.colsurfb.2012.08.062","article-title":"Nano-formulation of paclitaxel by vitamin E succinate functionalized pluronic micelles for enhanced encapsulation, stability and cytotoxicity","volume":"102","author":"Tao","year":"2013","journal-title":"Colloids Surf. B. Biointerfaces"},{"key":"10.1016\/j.jcis.2020.01.029_b0170","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1039\/C5PY01811K","article-title":"\u03b1-TOS-based RAFT block copolymers and their NPs for the treatment of Cancer","volume":"7","author":"Palao-Suay","year":"2016","journal-title":"Polym. Chem."},{"key":"10.1016\/j.jcis.2020.01.029_b0175","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1054\/bjoc.2000.1559","article-title":"Selective cancer cell killing by \u03b1-tocopheryl succinate","volume":"84","author":"Neuzil","year":"2000","journal-title":"Brit. J. Cancer."},{"key":"10.1016\/j.jcis.2020.01.029_b0180","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.1039\/C7TB01031A","article-title":"A pH sensitive polymeric micelle for co-delivery of doxorubicin and \u03b1-tOS for colon cancer therapy","volume":"5","author":"Debele","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jcis.2020.01.029_b0185","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2147\/IJN.S127417","article-title":"Rational design of multifunctional micelles against doxorubicin-sensitive and doxorubicin-resistant MCF-7 human breast cancer cells","volume":"12","author":"Hong","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jcis.2020.01.029_b0190","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1039\/C8TB02742K","article-title":"Acid-breakable TPGS-functionalized and diallyl disulfide-crosslinked nanogels for enhanced inhibition of MCF-7\/ADR solid tumours","volume":"7","author":"Sun","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jcis.2020.01.029_b0195","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1021\/bm7008747","article-title":"An acid-labile block copolymer of PDMAEMA and PEG as potential carrier for intelligent gene delivery systems","volume":"9","author":"Lin","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jcis.2020.01.029_b0200","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1021\/la504378m","article-title":"Nile red dye in aqueous surfactant and micellar solution","volume":"31","author":"Kurniasih","year":"2015","journal-title":"Langmuir"},{"key":"10.1016\/j.jcis.2020.01.029_b0205","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jcis.2018.04.084","article-title":"Hybrid pH-sensitive nanogels surface-functionalized with collagenase for enhanced Tumor penetration","volume":"525","author":"Wang","year":"2018","journal-title":"J. Colloid Interf. Sci."},{"key":"10.1016\/j.jcis.2020.01.029_b0210","doi-asserted-by":"crossref","first-page":"9602","DOI":"10.1016\/j.biomaterials.2013.08.032","article-title":"Reversing multidrug resistance by intracellular delivery of pluronic P85 unimers","volume":"34","author":"Hong","year":"2013","journal-title":"Biomaterial"},{"key":"10.1016\/j.jcis.2020.01.029_b0215","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.7150\/thno.15156","article-title":"Phenylboronic acid-mediated tumor targeting of chitosan nanoparticles","volume":"9","author":"Wang","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.jcis.2020.01.029_b0220","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ijpharm.2015.10.009","article-title":"Co-delivery of docetaxel and chloroquine via PEO\u2013PPO\u2013PCL\/TPGS micelles for overcoming multidrug resistance","volume":"495","author":"Shi","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jcis.2020.01.029_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.msec.2017.08.026","article-title":"Folic acid grafted and tertiary amino based pH-responsive pentablock polymeric micelles for targeting anticancer drug delivery","volume":"82","author":"Chen","year":"2018","journal-title":"Mat. Sci. Eng. C. Mater."},{"key":"10.1016\/j.jcis.2020.01.029_b0230","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1039\/C4TB02016B","article-title":"Fine-tuning thermoresponsive functional poly (\u03b5-caprolactone)s to enhance micelle stability and drug loading","volume":"3","author":"Elizabeth","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jcis.2020.01.029_b0235","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1745-7254.2006.00340.x","article-title":"Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with pluronic P123","volume":"27","author":"Han","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jcis.2020.01.029_b0240","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1021\/acsnano.5b02017","article-title":"The role of micelle size in tumor accumulation, penetration, and treatment","volume":"9","author":"Wang","year":"2015","journal-title":"ACS Nano."},{"key":"10.1016\/j.jcis.2020.01.029_b0245","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.eurpolymj.2017.08.023","article-title":"PH-sensitive poly(ortho ester urethanes) copolymers with controlled degradation kinetic: synthesis, characterization, and in vitro evaluation as drug carriers","volume":"95","author":"Fu","year":"2017","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.jcis.2020.01.029_b0250","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1039\/c2cs15327k","article-title":"Design of polymeric nanoparticles for biomedical delivery applications","volume":"41","author":"Mahmoud","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jcis.2020.01.029_b0255","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.colsurfb.2019.05.042","article-title":"Co-delivery of DOX and PDTC by pH-sensitive nanoparticles to overcome multidrug resistance in breast cancer","volume":"181","author":"Cheng","year":"2019","journal-title":"Colloid. Surface. B"},{"issue":"32","key":"10.1016\/j.jcis.2020.01.029_b0260","doi-asserted-by":"crossref","first-page":"28597","DOI":"10.1021\/acsami.9b05855","article-title":"Self-assembled indomethacin dimer nanoparticles loaded with doxorubicin for combination therapy in resistant breast cancer","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl. Mater. Inter."},{"key":"10.1016\/j.jcis.2020.01.029_b0265","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.2147\/IJN.S153094","article-title":"Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers","volume":"13","author":"Arjun","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jcis.2020.01.029_b0270","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1016\/j.biomaterials.2012.06.048","article-title":"Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells","volume":"33","author":"Zhang","year":"2012","journal-title":"Biomaterial"},{"key":"10.1016\/j.jcis.2020.01.029_b0275","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ejpb.2010.04.017","article-title":"Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123\/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance","volume":"75","author":"Wei","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jcis.2020.01.029_b0280","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0168-3659(03)00218-9","article-title":"Drug delivery in polymeric micelles: from in vitro to in vivo","volume":"91","author":"Rapoport","year":"2003","journal-title":"J. Control. Release."},{"key":"10.1016\/j.jcis.2020.01.029_b0285","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1074\/jbc.M110.186643","article-title":"Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II","volume":"286","author":"Dong","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jcis.2020.01.029_b0290","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1712","article-title":"Targeting mitochondria metabolism for cancer therapy","volume":"11","author":"Weinberg","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jcis.2020.01.029_b0295","doi-asserted-by":"crossref","first-page":"42465","DOI":"10.1038\/srep42465","article-title":"pH-sensitive micelles for the intracellular co-delivery of curcumin and pluronic L61 unimers for synergistic reversal effect of multidrug resistance","volume":"7","author":"Hong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jcis.2020.01.029_b0300","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1023\/A:1016061006256","article-title":"Bcl-2 family of proteins: life-or-death switch in mitochondria","volume":"22","author":"Tsujimoto","year":"2002","journal-title":"Bioscience Rep."},{"key":"10.1016\/j.jcis.2020.01.029_b0305","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s10495-006-0525-7","article-title":"Role of the mitochondrial membrane permeability transition in cell death","volume":"12","author":"Tsujimoto","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.jcis.2020.01.029_b0310","doi-asserted-by":"crossref","first-page":"6337","DOI":"10.2147\/IJN.S119839","article-title":"Preparation and antitumor evaluation of selfassembling oleanolic acid-loaded pluronic P105\/d-\u03b1-tocopheryl polyethylene glycol succinate mixed micelles for non-small-cell lung cancer treatment","volume":"11","author":"Zhong","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jcis.2020.01.029_b0315","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10637-010-9399-1","article-title":"A phase 2 Study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction","volume":"29","author":"Valle","year":"2011","journal-title":"Invest. New Drug."},{"key":"10.1016\/j.jcis.2020.01.029_b0320","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1166\/nnl.2017.2589","article-title":"Recent progress of doxorubicin nanomedicine in hematologic malignancies","volume":"9","author":"Qu","year":"2017","journal-title":"Nanosci. Nanotech. Lett."}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979720300308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979720300308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:25:39Z","timestamp":1758266739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979720300308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":64,"alternative-id":["S0021979720300308"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2020.01.029","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"pH-sensitive pluronic micelles combined with oxidative stress amplification for enhancing multidrug resistance breast cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2020.01.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}