{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:06:07Z","timestamp":1783688767857,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jcis.2020.05.088","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T11:19:44Z","timestamp":1590491984000},"page":"406-418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects"],"prefix":"10.1016","volume":"577","author":[{"given":"Seema","family":"Nandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sommerville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Nellenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Mihalko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Erb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald O.","family":"Freytes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureane","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dougald","family":"Monroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-1785","authenticated-orcid":false,"given":"Ashley C.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jcis.2020.05.088_b0005","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3324\/haematol.2009.006577","article-title":"The regulation of proplatelet production","volume":"94","author":"Geddis","year":"2009","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.jcis.2020.05.088_b0010","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.biomaterials.2012.09.074","article-title":"Approaches to synthetic platelet analogs","volume":"34","author":"Modery-Pawlowski","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2020.05.088_b0015","doi-asserted-by":"crossref","unstructured":"D.M. Monroe, M. Hoffman, What Does It Take to Make the Perfect Clot?, Arteriosclerosis, Thrombosis, and Vascular Biology 26(1) (2006) 41.","DOI":"10.1161\/01.ATV.0000193624.28251.83"},{"issue":"10","key":"10.1016\/j.jcis.2020.05.088_b0020","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1177\/1535370216647126","article-title":"Platelet-mimetic strategies for modulating the wound environment and inflammatory responses","volume":"241","author":"Nandi","year":"2016","journal-title":"Exp Biol Med (Maywood)"},{"issue":"10","key":"10.1016\/j.jcis.2020.05.088_b0025","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1182\/blood-2013-08-523860","article-title":"Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin","volume":"123","author":"Cines","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jcis.2020.05.088_b0030","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/s41467-017-00885-x","article-title":"Quantitative structural mechanobiology of platelet-driven blood clot contraction","volume":"8","author":"Kim","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jcis.2020.05.088_b0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1182\/blood-2015-05-647560","article-title":"Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood","volume":"127","author":"Tutwiler","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jcis.2020.05.088_b0040","series-title":"Fibrinogen and Fibrin, Advances in Protein","first-page":"247","author":"Weisel","year":"2005"},{"key":"10.1016\/j.jcis.2020.05.088_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2016.00341","article-title":"Engineered Biopolymeric Scaffolds for Chronic Wound Healing","volume":"7","author":"Dickinson","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jcis.2020.05.088_b0050","unstructured":"Injury Prevention & Control, 2017. https:\/\/www.cdc.gov\/injury\/wisqars\/LeadingCauses.html. (Accessed January 24 2020)."},{"key":"10.1016\/j.jcis.2020.05.088_b0055","unstructured":"Data & Statistics on Hemophilia, 2018. https:\/\/www.cdc.gov\/ncbddd\/hemophilia\/data.html. 2019)."},{"issue":"9","key":"10.1016\/j.jcis.2020.05.088_b0060","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1182\/blood-2006-05-020495","article-title":"Cutaneous wound healing is impaired in hemophilia B","volume":"108","author":"Hoffman","year":"2006","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jcis.2020.05.088_b0065","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2141.2005.05820.x","article-title":"High dose factor VIIa improves clot structure and stability in a model of haemophilia B","volume":"131","author":"Wolberg","year":"2005","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.jcis.2020.05.088_b0070","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1046\/j.1538-7836.2003.00242.x","article-title":"The role of recombinant factor VIIa (FVIIa) in fibrin structure in the absence of FVIII\/FIX","volume":"1","author":"He","year":"2003","journal-title":"J. Thromb. Haemost."},{"issue":"17","key":"10.1016\/j.jcis.2020.05.088_b0075","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.K.00521","article-title":"Wound Complications Following Rivaroxaban Administration: A Multicenter Comparison with Low-Molecular-Weight Heparins for Thromboprophylaxis in Lower Limb Arthroplasty","volume":"94","author":"Jameson","year":"2012","journal-title":"JBJS"},{"issue":"21","key":"10.1016\/j.jcis.2020.05.088_b0080","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1056\/NEJMc1111095","article-title":"Acutely Injured Patients on Dabigatran","volume":"365","author":"Cotton","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"10.1016\/j.jcis.2020.05.088_b0085","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMra1601561","article-title":"Von Willebrand\u2019s Disease","volume":"375","author":"Leebeek","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"51","key":"10.1016\/j.jcis.2020.05.088_b0090","doi-asserted-by":"crossref","first-page":"21495","DOI":"10.1073\/pnas.0907127106","article-title":"Red blood cell-mimicking synthetic biomaterial particles","volume":"106","author":"Doshi","year":"2009","journal-title":"PNAS"},{"key":"10.1016\/j.jcis.2020.05.088_b0095","doi-asserted-by":"crossref","unstructured":"D.A. Hickman, C.L. Pawlowski, A. Shevitz, N.F. Luc, A. Kim, A. Girish, J. Marks, S. Ganjoo, S. Huang, E. Niedoba, U.D.S. Sekhon, M. Sun, M. Dyer, M.D. Neal, V.S. Kashyap, A. Sen Gupta, Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve \u2018golden hour\u2019 survival in a porcine model of traumatic arterial hemorrhage, Sci Rep 8(1) (2018) 3118.","DOI":"10.1038\/s41598-018-21384-z"},{"issue":"12","key":"10.1016\/j.jcis.2020.05.088_b0100","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nmat4066","article-title":"Ultrasoft microgels displaying emergent platelet-like behaviours","volume":"13","author":"Brown","year":"2014","journal-title":"Nat. Mater."},{"issue":"47","key":"10.1016\/j.jcis.2020.05.088_b0105","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1002\/anie.200501321","article-title":"Soft Nanotechnology with Soft Nanoparticles","volume":"44","author":"Nayak","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"issue":"4","key":"10.1016\/j.jcis.2020.05.088_b0110","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1246\/bcsj.20180378","article-title":"Design of Temperature-Responsive Polymer-Grafted Surfaces for Cell Sheet Preparation and Manipulation","volume":"92","author":"Kobayashi","year":"2019","journal-title":"Bull. Chem. Soc. Jpn."},{"issue":"5","key":"10.1016\/j.jcis.2020.05.088_b0115","doi-asserted-by":"crossref","first-page":"849","DOI":"10.2217\/nnm.14.222","article-title":"Responsive cell\u2013material interfaces","volume":"10","author":"Dhowre","year":"2015","journal-title":"Nanomedicine"},{"issue":"6","key":"10.1016\/j.jcis.2020.05.088_b0120","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/cnma.201900207","article-title":"Materials Nanoarchitectonics as Cell Regulators","volume":"5","author":"Ariga","year":"2019","journal-title":"ChemNanoMat"},{"issue":"2","key":"10.1016\/j.jcis.2020.05.088_b0125","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1073\/pnas.1010013108","article-title":"Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles","volume":"108","author":"Merkel","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"28","key":"10.1016\/j.jcis.2020.05.088_b0130","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1002\/adma.201200607","article-title":"Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood","volume":"24","author":"Doshi","year":"2012","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jcis.2020.05.088_b0135","doi-asserted-by":"crossref","unstructured":"J.P. Bertram, C.A. Williams, R. Robinson, S.S. Segal, N.T. Flynn, E.B. Lavik, Synthetic Platelets: Nanotechnology to Halt Bleeding, Science translational medicine 1(11) (2009) 11ra22.","DOI":"10.1126\/scitranslmed.3000397"},{"issue":"10","key":"10.1016\/j.jcis.2020.05.088_b0140","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1039\/C5SM00047E","article-title":"Ultrasoft, highly deformable microgels","volume":"11","author":"Bachman","year":"2015","journal-title":"Soft Matter"},{"issue":"4","key":"10.1016\/j.jcis.2020.05.088_b0145","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1063\/1.479430","article-title":"Temperature sensitive microgel suspensions: Colloidal phase behavior and rheology of soft spheres","volume":"111","author":"Senff","year":"1999","journal-title":"J. Chem. Phys."},{"issue":"13","key":"10.1016\/j.jcis.2020.05.088_b0150","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1021\/la0269762","article-title":"Cross-Linker-Free N-Isopropylacrylamide Gel Nanospheres","volume":"19","author":"Gao","year":"2003","journal-title":"Langmuir"},{"issue":"2","key":"10.1016\/j.jcis.2020.05.088_b0155","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1021\/la0485982","article-title":"Influence of Secondary Components on the Synthesis of Self-Cross-Linked <i>N<\/i> -Isopropylacrylamide Microgels","volume":"21","author":"Gao","year":"2005","journal-title":"Langmuir"},{"key":"10.1016\/j.jcis.2020.05.088_b0160","doi-asserted-by":"crossref","unstructured":"D. Monroe, M. Hoffman, The clotting system - A major player in wound healing, Haemophilia 18 Suppl 5 (2012) 11-6.","DOI":"10.1111\/j.1365-2516.2012.02889.x"},{"issue":"2","key":"10.1016\/j.jcis.2020.05.088_b0165","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1039\/C8BM01201F","article-title":"Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes","volume":"7","author":"Nandi","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jcis.2020.05.088_b0170","first-page":"1457","article-title":"Study of poly (N-isopropylacrilamide-co-acrylic acid) (pNIPAM) microgel particle induced deformations of tissue mimicking phantom by ultrasound stimulation","author":"Joshi","year":"2017","journal-title":"Langmuir"},{"key":"10.1016\/j.jcis.2020.05.088_b0175","doi-asserted-by":"crossref","first-page":"1800042","DOI":"10.1002\/adbi.201800042","article-title":"Biomimetic Microgels with Controllable Deformability Improve Healing Outcomes","author":"Sproul","year":"2018","journal-title":"Adv. Biosyst."},{"key":"10.1016\/j.jcis.2020.05.088_b0180","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.biomaterials.2015.05.015","article-title":"DiameterJ: A validated open source nanofiber diameter measurement tool","volume":"61","author":"Hotaling","year":"2015","journal-title":"Biomaterials"},{"issue":"49","key":"10.1016\/j.jcis.2020.05.088_b0185","doi-asserted-by":"crossref","first-page":"E4698","DOI":"10.1073\/pnas.1311120110","article-title":"Design and formulation of functional pluripotent stem cell-derived cardiac microtissues","volume":"110","author":"Thavandiran","year":"2013","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.jcis.2020.05.088_b0190","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/CIRCRESAHA.109.211458","article-title":"Development of a drug screening platform based on engineered heart tissue","volume":"107","author":"Hansen","year":"2010","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.jcis.2020.05.088_b0195","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/ten.teb.2009.0445","article-title":"High-Content Drug Screening with Engineered Musculoskeletal Tissues","volume":"16","author":"Vandenburgh","year":"2010","journal-title":"Tissue Eng Part B Rev"},{"issue":"8","key":"10.1016\/j.jcis.2020.05.088_b0200","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.mee.2010.12.108","article-title":"Measurement of nonlinear mechanical properties of PDMS elastomer","volume":"88","author":"Kim","year":"2011","journal-title":"Microelectron. Eng."},{"issue":"4","key":"10.1016\/j.jcis.2020.05.088_b0205","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3390\/jdb2040198","article-title":"A Novel Three-Dimensional Wound Healing Model","volume":"2","author":"Chen","year":"2014","journal-title":"J. Dev. Biol."},{"issue":"3","key":"10.1016\/j.jcis.2020.05.088_b0210","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1160\/th15-06-0462","article-title":"Zinc promotes clot stability by accelerating clot formation and modifying fibrin structure","volume":"115","author":"Henderson","year":"2016","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.jcis.2020.05.088_b0215","unstructured":"Inhibitors and Hemophilia. https:\/\/www.cdc.gov\/ncbddd\/hemophilia\/inhibitors.html. 2019)."},{"issue":"5","key":"10.1016\/j.jcis.2020.05.088_b0220","doi-asserted-by":"crossref","DOI":"10.1097\/01.mbc.0000469521.23628.2d","article-title":"Platelet disorders: an overview","volume":"26","author":"Krishnegowda","year":"2015","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"1","key":"10.1016\/j.jcis.2020.05.088_b0225","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0006-3495(96)79602-9","article-title":"Measuring the viscoelastic properties of human platelets with the atomic force microscope","volume":"70","author":"Radmacher","year":"1996","journal-title":"Biophys. J ."},{"issue":"1","key":"10.1016\/j.jcis.2020.05.088_b0230","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nmat2903","article-title":"Mechanics and contraction dynamics of single platelets and implications for clot stiffening","volume":"10","author":"Lam","year":"2011","journal-title":"Nat. Mater."},{"issue":"7693","key":"10.1016\/j.jcis.2020.05.088_b0235","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature25742","article-title":"Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo","volume":"554","author":"Barriga","year":"2018","journal-title":"Nature"},{"issue":"5751","key":"10.1016\/j.jcis.2020.05.088_b0240","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue Cells Feel and Respond to the Stiffness of Their Substrate","volume":"310","author":"Discher","year":"2005","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.jcis.2020.05.088_b0245","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1529\/biophysj.106.101386","article-title":"Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates","volume":"93","author":"Solon","year":"2007","journal-title":"Biophys. J ."},{"key":"10.1016\/j.jcis.2020.05.088_b0250","doi-asserted-by":"crossref","unstructured":"E. Chee, S. Nandi, K. Nellenbach, E. Mihalko, D.B. Snider, L. Morrill, A. Bond, E. Sproul, J. Sollinger, G. Cruse, M. Hoffman, A.C. Brown, Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles, Journal of Biomedical Materials Research Part B: Applied Biomaterials n\/a(n\/a) (2020).","DOI":"10.1002\/jbm.b.34592"}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979720306986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979720306986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:36:13Z","timestamp":1758267373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979720306986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":50,"alternative-id":["S0021979720306986"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2020.05.088","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2020.05.088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}