{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T10:31:21Z","timestamp":1789295481921,"version":"build-2803163510"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022JJ30777"],"award-info":[{"award-number":["2022JJ30777"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012486","name":"Innovation-Driven Project of Central South University","doi-asserted-by":"publisher","award":["202045005"],"award-info":[{"award-number":["202045005"]}],"id":[{"id":"10.13039\/501100012486","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373871"],"award-info":[{"award-number":["82373871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2023BEG02038"],"award-info":[{"award-number":["2023BEG02038"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["1053320232473"],"award-info":[{"award-number":["1053320232473"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2023QYJC017"],"award-info":[{"award-number":["2023QYJC017"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jcis.2024.08.239","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T17:44:44Z","timestamp":1725212684000},"page":"174-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"PB","title":["Novel reduced heteropolyacid nanoparticles for effective treatment of drug-induced liver injury by manipulating reactive oxygen and nitrogen species and inflammatory signals"],"prefix":"10.1016","volume":"678","author":[{"given":"Yongqi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaohui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niansheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelong","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-5961","authenticated-orcid":false,"given":"Qiong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcis.2024.08.239_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2023.102955","article-title":"State-of-the-art advances in nanocomposite and bio-nanocomposite polymeric materials: A comprehensive review","volume":"318","author":"Anwer","year":"2023","journal-title":"Adv. Colloid Interface Sci."},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0010","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/d41573-024-00001-x","article-title":"2023 FDA approvals","volume":"23","author":"Mullard","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"issue":"17","key":"10.1016\/j.jcis.2024.08.239_b0015","doi-asserted-by":"crossref","first-page":"eadm9281","DOI":"10.1126\/sciadv.adm9281","article-title":"Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses","volume":"10","author":"March","year":"2024","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41572-019-0105-0","article-title":"Drug-induced liver injury","volume":"5","author":"Andrade","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"3","key":"10.1016\/j.jcis.2024.08.239_b0025","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1056\/NEJMra1816149","article-title":"Drug-Induced Liver Injury - Types and Phenotypes","volume":"381","author":"Hoofnagle","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jcis.2024.08.239_b0030","doi-asserted-by":"crossref","unstructured":"e.e.e. European Association for the Study of the Liver. Electronic address, C. Clinical Practice Guideline Panel, m. Panel, E.G.B. representative, EASL Clinical Practice Guidelines: Drug-induced liver injury, J Hepatol 70(6) (2019) 1222-1261.","DOI":"10.1016\/j.jhep.2019.02.014"},{"issue":"9","key":"10.1016\/j.jcis.2024.08.239_b0035","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1111\/liv.15262","article-title":"Incidence and risk factors of drug-induced liver injury","volume":"42","author":"Li","year":"2022","journal-title":"Liver Int."},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00228-004-0888-z","article-title":"Incidence of drug-induced liver injury in medical inpatients","volume":"61","author":"Meier","year":"2005","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"11","key":"10.1016\/j.jcis.2024.08.239_b0045","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1038\/ajg.2010.287","article-title":"Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality","volume":"105","author":"Devarbhavi","year":"2010","journal-title":"Am. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0050","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/liv.13535","article-title":"Acute liver failure induced by idiosyncratic reaction to drugs: Challenges in diagnosis and therapy","volume":"38","author":"Tujios","year":"2018","journal-title":"Liver Int."},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0055","first-page":"167","article-title":"Liver diseases in the Asia-Pacific region: a Lancet Gastroenterology & Hepatology Commission, Lancet","volume":"5","author":"Sarin","year":"2020","journal-title":"Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.jcis.2024.08.239_b0060","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1053\/j.gastro.2015.03.006","article-title":"United States Drug Induced Liver Injury, Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study","volume":"148","author":"Chalasani","year":"2015","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jcis.2024.08.239_b0065","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/gutjnl-2016-313369","article-title":"Drug-induced liver injury: recent advances in diagnosis and risk assessment","volume":"66","author":"Kullak-Ublick","year":"2017","journal-title":"Gut"},{"issue":"10201","key":"10.1016\/j.jcis.2024.08.239_b0070","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","article-title":"Acute liver failure","volume":"394","author":"Stravitz","year":"2019","journal-title":"Lancet"},{"issue":"10319","key":"10.1016\/j.jcis.2024.08.239_b0075","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(21)01701-3","article-title":"The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality","volume":"399","author":"Karlsen","year":"2022","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jcis.2024.08.239_b0080","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1053\/j.gastro.2019.02.002","article-title":"Incidence and Etiology of Drug-Induced Liver Injury in Mainland China","volume":"156","author":"Shen","year":"2019","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.jcis.2024.08.239_b0085","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.jhep.2021.06.021","article-title":"Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]","volume":"75","author":"Fernandez-Checa","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jcis.2024.08.239_b0090","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-pathmechdis-051122-094016","article-title":"Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury","volume":"19","author":"Jaeschke","year":"2024","journal-title":"Annu. Rev. Pathol."},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0095","first-page":"131","article-title":"Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update","volume":"4","author":"Yoon","year":"2016","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"4","key":"10.1016\/j.jcis.2024.08.239_b0100","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1172\/JCI59755","article-title":"The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation","volume":"122","author":"McGill","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jcis.2024.08.239_b0105","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.jcis.2024.08.239_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106361","article-title":"Progress in the treatment of drug-induced liver injury with natural products","volume":"183","author":"Sun","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.jcis.2024.08.239_b0115","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0016-5085(19)31662-2","article-title":"Drug Metabolism in Liver Disease: Identification of patients with impaired hepatic drug metabolism","volume":"75","author":"Farrell","year":"1978","journal-title":"Gastroenterology"},{"issue":"9554","key":"10.1016\/j.jcis.2024.08.239_b0120","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/S0140-6736(06)69874-7","article-title":"Paracetamol: are therapeutic doses entirely safe?","volume":"368","author":"Jalan","year":"2006","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.jcis.2024.08.239_b0125","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1016\/j.apsb.2021.09.023","article-title":"Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls","volume":"11","author":"Jaeschke","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0130","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3390\/livers3020014","article-title":"Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review","volume":"3","author":"Ramachandran","year":"2023","journal-title":"Livers"},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00018-023-05061-7","article-title":"Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction","volume":"81","author":"LeFort","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"issue":"10","key":"10.1016\/j.jcis.2024.08.239_b0140","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1073\/pnas.0510962103","article-title":"Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress","volume":"103","author":"Wang","year":"2006","journal-title":"PNAS"},{"key":"10.1016\/j.jcis.2024.08.239_b0145","article-title":"Harnessing reactive oxygen\/nitrogen species and inflammation: Nanodrugs for liver injury","volume":"13","author":"Liu","year":"2022","journal-title":"Mater Today Bio"},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0150","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/hep.27385","article-title":"Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury","volume":"61","author":"Lee","year":"2015","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0155","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1038\/s41467-024-50854-4","article-title":"Reprogramming the myocardial infarction microenvironment with melanin-based composite nanomedicines in mice","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.jcis.2024.08.239_b0160","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","article-title":"Reactive Oxygen Species in Metabolic and Inflammatory Signaling","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ. Res."},{"issue":"18","key":"10.1016\/j.jcis.2024.08.239_b0165","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.molcel.2021.08.018","article-title":"Redox metabolism: ROS as specific molecular regulators of cell signaling and function","volume":"81","author":"Lennicke","year":"2021","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.jcis.2024.08.239_b0170","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1053\/j.gastro.2008.07.006","article-title":"Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation","volume":"135","author":"Nakagawa","year":"2008","journal-title":"Gastroenterology"},{"issue":"20","key":"10.1016\/j.jcis.2024.08.239_b0175","doi-asserted-by":"crossref","first-page":"13565","DOI":"10.1074\/jbc.M708916200","article-title":"Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury","volume":"283","author":"Hanawa","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jcis.2024.08.239_b0180","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/hep.28486","article-title":"c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src","volume":"63","author":"Win","year":"2016","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jcis.2024.08.239_b0185","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/hep.31116","article-title":"c-Jun NH(2) -Terminal Protein Kinase Phosphorylates the Nrf2-ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen-Induced Liver Injury in Mice","volume":"71","author":"Chen","year":"2020","journal-title":"Hepatology"},{"issue":"18","key":"10.1016\/j.jcis.2024.08.239_b0190","doi-asserted-by":"crossref","first-page":"e2308239","DOI":"10.1002\/adma.202308239","article-title":"Revitalizing Ancient Mitochondria with Nano-Strategies: Mitochondria-Remedying Nanodrugs Concentrate on Disease Control","volume":"36","author":"Long","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jcis.2024.08.239_b0195","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0002-9343(70)80129-2","article-title":"The role of theliver in drug metabolism","volume":"49","author":"Remmer","year":"1970","journal-title":"Am. J. Med."},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/j.gastro.2006.03.045","article-title":"c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity","volume":"131","author":"Gunawan","year":"2006","journal-title":"Gastroenterology"},{"issue":"30","key":"10.1016\/j.jcis.2024.08.239_b0205","doi-asserted-by":"crossref","first-page":"21256","DOI":"10.1074\/jbc.M510644200","article-title":"JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells","volume":"281","author":"Kim","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0210","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1478-3231.2011.02501.x","article-title":"Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity","volume":"32","author":"Jaeschke","year":"2012","journal-title":"Liver Int."},{"issue":"49","key":"10.1016\/j.jcis.2024.08.239_b0215","doi-asserted-by":"crossref","first-page":"e2309370","DOI":"10.1002\/adma.202309370","article-title":"Precisely Inhibiting Excessive Intestinal Epithelial Cell Apoptosis to Efficiently Treat Inflammatory Bowel Disease with Oral Pifithrin-alpha Embedded Nanomedicine (OPEN)","volume":"35","author":"Wang","year":"2023","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.jcis.2024.08.239_b0220","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jhep.2016.11.017","article-title":"Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure","volume":"66","author":"Woolbright","year":"2017","journal-title":"J. Hepatol."},{"issue":"8035","key":"10.1016\/j.jcis.2024.08.239_b0225","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0140-6736(77)90612-2","article-title":"Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine","volume":"2","author":"Prescott","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.jcis.2024.08.239_b0230","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.redox.2016.10.001","article-title":"Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential","volume":"10","author":"Du","year":"2016","journal-title":"Redox Biol."},{"issue":"24","key":"10.1016\/j.jcis.2024.08.239_b0235","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJM198812153192401","article-title":"Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study","volume":"319","author":"Smilkstein","year":"1988","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.jcis.2024.08.239_b0240","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1056\/NEJMct0708278","article-title":"Acetylcysteine for acetaminophen poisoning","volume":"359","author":"Heard","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jcis.2024.08.239_b0245","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jconrel.2016.01.020","article-title":"Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination","volume":"240","author":"Zhang","year":"2016","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0250","doi-asserted-by":"crossref","first-page":"e2204397","DOI":"10.1002\/adma.202204397","article-title":"Tungsten-based Nanomaterials in the Biomedical Field: A Bibliometric Analysis of Research Progress and Prospects","volume":"35","author":"Gu","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jcis.2024.08.239_b0255","first-page":"381","article-title":"Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment","volume":"21","author":"Huang","year":"2023","journal-title":"Bioact. Mater."},{"issue":"23","key":"10.1016\/j.jcis.2024.08.239_b0260","doi-asserted-by":"crossref","first-page":"e2101331","DOI":"10.1002\/adhm.202101331","article-title":"Plasmonic Oxygen Defects in MO(3-)(x) (M = W or Mo) Nanomaterials: Synthesis, Modifications, and Biomedical Applications","volume":"10","author":"Zhou","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jcis.2024.08.239_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2024.114068","article-title":"Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions","volume":"180","author":"Xiang","year":"2024","journal-title":"Food Res. Int."},{"issue":"5","key":"10.1016\/j.jcis.2024.08.239_b0270","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1211\/jpp.62.05.0012","article-title":"Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice","volume":"62","author":"Rasool","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jcis.2024.08.239_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110985","article-title":"Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases","volume":"133","author":"Bai","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jcis.2024.08.239_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131350","article-title":"ToxDP2 Database: Toxicity prediction of dietary polyphenols","volume":"370","author":"Sinha","year":"2022","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.jcis.2024.08.239_b0285","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.catcom.2009.09.009","article-title":"Phosphotungstic acid salt of triphenyl(3-sulfopropyl)phosphonium: An efficient and reusable solid catalyst for esterification","volume":"11","author":"Zhang","year":"2009","journal-title":"Catal. Commun."},{"issue":"22","key":"10.1016\/j.jcis.2024.08.239_b0290","doi-asserted-by":"crossref","first-page":"e2300252","DOI":"10.1002\/adhm.202300252","article-title":"Natural Targeting Potent ROS-Eliminating Tungsten-Based Polyoxometalate Nanodots for Efficient Treatment of Pulmonary Hypertension","volume":"12","author":"Liu","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"3","key":"10.1016\/j.jcis.2024.08.239_b0295","first-page":"153","article-title":"Acetaminophen-induced Liver Injury: from Animal Models to Humans","volume":"2","author":"Jaeschke","year":"2014","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"4","key":"10.1016\/j.jcis.2024.08.239_b0300","doi-asserted-by":"crossref","first-page":"175","DOI":"10.5694\/mja2.50428","article-title":"Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand","volume":"212","author":"Chiew","year":"2020","journal-title":"Med. J. Aust."},{"issue":"11","key":"10.1016\/j.jcis.2024.08.239_b0305","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/nmat4718","article-title":"Mechanism of hard-nanomaterial clearance by the liver","volume":"15","author":"Tsoi","year":"2016","journal-title":"Nat. Mater."},{"issue":"4","key":"10.1016\/j.jcis.2024.08.239_b0310","first-page":"447","article-title":"N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H(2)S and Sulfane Sulfur Production, Cell","volume":"25","author":"Ezerina","year":"2018","journal-title":"Chem. Biol."},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0315","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2013.09.006","article-title":"Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits","volume":"141","author":"Rushworth","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"23","key":"10.1016\/j.jcis.2024.08.239_b0320","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.2174\/092986709788803097","article-title":"Current concepts of mechanisms in drug-induced hepatotoxicity","volume":"16","author":"Russmann","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jcis.2024.08.239_b0325","doi-asserted-by":"crossref","unstructured":"J.H. Vazquez, S. Kennon-McGill, S.D. Byrum, S.G. Mackintosh, H. Jaeschke, D.K. Williams, W.M. Lee, J.A. Dranoff, M.R. McGill, G. Acute Liver Failure Study, Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways, Toxicol Sci 187(1) (2022) 25-34.","DOI":"10.1093\/toxsci\/kfac015"},{"issue":"12","key":"10.1016\/j.jcis.2024.08.239_b0330","first-page":"4904","article-title":"Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents","volume":"24","author":"Nassini","year":"2010","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.jcis.2024.08.239_b0335","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/cpt.2888","article-title":"Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7)","volume":"113","author":"Chiew","year":"2023","journal-title":"Clin. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0340","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/0016-5085(95)90032-2","article-title":"Liver cell necrosis: cellular mechanisms and clinical implications","volume":"108","author":"Rosser","year":"1995","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0345","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/j.2040-4603.2013.tb00507.x","article-title":"Apoptosis and necrosis in the liver","volume":"3","author":"Guicciardi","year":"2013","journal-title":"Compr. Physiol."},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0350","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13578-022-00921-4","article-title":"The immunological mechanisms and therapeutic potential in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity","volume":"12","author":"Li","year":"2022","journal-title":"Cell Biosci."},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0355","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jcis.2024.08.239_b0360","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094557","article-title":"Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models","volume":"22","author":"Gerussi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.jcis.2024.08.239_b0365","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/hep.26196","article-title":"Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice","volume":"57","author":"Proctor","year":"2013","journal-title":"Hepatology"},{"issue":"36","key":"10.1016\/j.jcis.2024.08.239_b0370","doi-asserted-by":"crossref","first-page":"e2301585","DOI":"10.1002\/adma.202301585","article-title":"Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta(2) C Modified with Chondroitin Sulfate (TACS)","volume":"35","author":"Song","year":"2023","journal-title":"Adv. Mater."},{"issue":"6","key":"10.1016\/j.jcis.2024.08.239_b0375","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1053\/j.gastro.2008.03.002","article-title":"Cellular and molecular mechanisms of liver injury","volume":"134","author":"Malhi","year":"2008","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0380","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jhep.2021.10.011","article-title":"Long-term sequelae of drug-induced liver injury","volume":"76","author":"Bjornsson","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jcis.2024.08.239_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119544","article-title":"Drug-induced liver injury and prospect of cytokine based therapy; A focus on IL-2 based therapies","volume":"278","author":"Kumar","year":"2021","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.jcis.2024.08.239_b0390","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/glycob\/cwy113","article-title":"Absence of a human ortholog of rodent Kupffer cell galactose-binding receptor encoded by the CLEC4f gene","volume":"29","author":"Taylor","year":"2019","journal-title":"Glycobiology"},{"key":"10.1016\/j.jcis.2024.08.239_b0395","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2021.605392","article-title":"Recent Advances in Models of Immune-Mediated Drug-Induced Liver Injury","volume":"3","author":"Tasnim","year":"2021","journal-title":"Front Toxicol"},{"issue":"3","key":"10.1016\/j.jcis.2024.08.239_b0400","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jhep.2022.10.028","article-title":"Hepatocyte-specific Mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice","volume":"78","author":"Chen","year":"2023","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.jcis.2024.08.239_b0405","doi-asserted-by":"crossref","first-page":"e13040","DOI":"10.1111\/cpr.13040","article-title":"The complex roles of neutrophils in APAP-induced liver injury","volume":"54","author":"Guo","year":"2021","journal-title":"Cell Prolif."},{"issue":"7","key":"10.1016\/j.jcis.2024.08.239_b0410","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/bjp.2008.280","article-title":"Principles of safety pharmacology","volume":"154","author":"Pugsley","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0415","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: recent developments and future prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J Nanobiotechnology"},{"issue":"7257","key":"10.1016\/j.jcis.2024.08.239_b0420","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nature08302","article-title":"Molybdenum cofactors, enzymes and pathways","volume":"460","author":"Schwarz","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jcis.2024.08.239_b0425","doi-asserted-by":"crossref","unstructured":"M. Tenorio, N.G. Graciliano, F.A. Moura, A.C.M. Oliveira, M.O.F. Goulart, N-Acetylcysteine (NAC): Impacts on Human Health, Antioxidants (Basel) 10(6) (2021).","DOI":"10.3390\/antiox10060967"},{"issue":"7","key":"10.1016\/j.jcis.2024.08.239_b0430","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00011-011-0323-8","article-title":"Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages","volume":"60","author":"Palacio","year":"2011","journal-title":"Inflamm. Res."},{"issue":"2","key":"10.1016\/j.jcis.2024.08.239_b0435","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jhep.2015.04.016","article-title":"Drug-induced liver injury: Interactions between drug properties and host factors","volume":"63","author":"Chen","year":"2015","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.jcis.2024.08.239_b0440","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13020-021-00543-x","article-title":"Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs","volume":"16","author":"Zhou","year":"2021","journal-title":"Chin. Med."},{"issue":"7","key":"10.1016\/j.jcis.2024.08.239_b0445","article-title":"Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy","volume":"12","author":"Hammad","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"11","key":"10.1016\/j.jcis.2024.08.239_b0450","article-title":"NRF2 Activation and Downstream Effects: Focus on Parkinson's Disease and Brain Angiotensin","volume":"10","author":"Parga","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"7","key":"10.1016\/j.jcis.2024.08.239_b0455","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1016\/j.apsb.2022.02.025","article-title":"Current approaches of nanomedicines in the market and various stage of clinical translation","volume":"12","author":"Shan","year":"2022","journal-title":"Acta Pharm. Sin. B"}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979724020216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979724020216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:02:02Z","timestamp":1762196522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979724020216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":91,"alternative-id":["S0021979724020216"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2024.08.239","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel reduced heteropolyacid nanoparticles for effective treatment of drug-induced liver injury by manipulating reactive oxygen and nitrogen species and inflammatory signals","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2024.08.239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}