{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:59:12Z","timestamp":1784084352724,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021-YGJC-16"],"award-info":[{"award-number":["2021-YGJC-16"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["N232410019"],"award-info":[{"award-number":["N232410019"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374016"],"award-info":[{"award-number":["22374016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jcis.2024.09.224","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T15:07:39Z","timestamp":1727536059000},"page":"335-348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"PA","title":["Engineering small extracellular vesicles with multivalent DNA probes for precise tumor targeting and enhanced synergistic therapy"],"prefix":"10.1016","volume":"679","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Fei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ju","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Yan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3834-1145","authenticated-orcid":false,"given":"Zhang-Run","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcis.2024.09.224_b0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2020.08.002","article-title":"An RNAi therapeutic, DFP-10825, for intraperitoneal and intrapleural malignant cancers","volume":"154\u2013155","author":"Ando","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.jcis.2024.09.224_b0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15104-3","article-title":"Cancer associated fibroblast FAK regulates malignant cell metabolism","volume":"11","author":"Demircioglu","year":"2020","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.jcis.2024.09.224_b0015","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.cell.2018.03.073","article-title":"Interfaces of malignant and immunologic clonal dynamics in ovarian cancer","volume":"173","author":"Zhang","year":"2018","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jcis.2024.09.224_b0020","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"10.1016\/j.jcis.2024.09.224_b0025","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1200\/JCO.22.02807","volume":"41","author":"Moy","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jcis.2024.09.224_b0030","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jconrel.2017.08.034","article-title":"Chemotherapy agent-unsaturated fatty acid prodrugs and prodrug-nanoplatforms for cancer chemotherapy","volume":"264","author":"Sun","year":"2017","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jcis.2024.09.224_b0035","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s40265-022-01828-7","article-title":"Intraperitoneal chemotherapy for unresectable peritoneal surface malignancies","volume":"83","author":"Guchelaar","year":"2023","journal-title":"Drugs"},{"issue":"23","key":"10.1016\/j.jcis.2024.09.224_b0040","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300490","article-title":"RuCu nanosheets with ultrahigh nanozyme activity for chemodynamic therapy","volume":"12","author":"Yang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"9","key":"10.1016\/j.jcis.2024.09.224_b0045","doi-asserted-by":"crossref","first-page":"11575","DOI":"10.1021\/acsami.2c22260","article-title":"NIR-II luminescent and multi-responsive rare earth nanocrystals for improved chemodynamic therapy","volume":"15","author":"Wei","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"15","key":"10.1016\/j.jcis.2024.09.224_b0050","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202300356","article-title":"Heterostructures with built-in electric fields for long-lasting chemodynamic therapy","volume":"62","author":"Zhang","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"issue":"17","key":"10.1016\/j.jcis.2024.09.224_b0055","doi-asserted-by":"crossref","first-page":"e202300162","DOI":"10.1002\/anie.202300162","article-title":"Type I photosensitizer targeting G-quadruplex RNA elicits augmented immunity for cancer ablation","volume":"62","author":"Chen","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"issue":"23","key":"10.1016\/j.jcis.2024.09.224_b0060","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202206091","article-title":"Anti-HER2 scFv-nCytc-modified lipid-encapsulated oxygen nanobubbles prepared with bulk nanobubble water for inducing apoptosis and improving photodynamic therapy","volume":"19","author":"Tian","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.jcis.2024.09.224_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101782","article-title":"Engineering layered double hydroxide-based sonocatalysts for enhanced sonodynamic-immunotherapy","volume":"49","author":"Wang","year":"2023","journal-title":"Nano Today"},{"issue":"10","key":"10.1016\/j.jcis.2024.09.224_b0070","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1021\/acs.analchem.2c05293","article-title":"Self-assembly-based nanoprobes for the simultaneous detection and downregulation of hsp90alpha mRNA to enhance photothermal therapy","volume":"95","author":"Guo","year":"2023","journal-title":"Anal. Chem."},{"issue":"10","key":"10.1016\/j.jcis.2024.09.224_b0075","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1021\/jacs.2c13701","article-title":"Homotypic membrane-enhanced blood-brain barrier crossing and glioblastoma targeting for precise surgical resection and photothermal therapy","volume":"145","author":"Zhang","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"10.1016\/j.jcis.2024.09.224_b0080","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1021\/acsnano.3c00032","article-title":"Integrating bacteria with a ternary combination of photosensitizers for monochromatic irradiation-mediated photoacoustic imaging-guided synergistic photothermal therapy","volume":"17","author":"Guo","year":"2023","journal-title":"ACS Nano"},{"issue":"19","key":"10.1016\/j.jcis.2024.09.224_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202211138","article-title":"Genetically programmable vesicles for enhancing CAR-T therapy against solid tumors","volume":"35","author":"Li","year":"2023","journal-title":"Adv. Mater."},{"issue":"9","key":"10.1016\/j.jcis.2024.09.224_b0090","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1021\/jacs.2c13010","article-title":"Bioorthogonal-activated in situ vaccine mediated by a COF-based catalytic platform for potent cancer immunotherapy","volume":"145","author":"Sun","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jcis.2024.09.224_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101702","article-title":"Tumor microenvironment-modulated multiple nanotherapeutic system for potent cancer immunotherapy and metastasis inhibition","volume":"48","author":"Li","year":"2023","journal-title":"Nano Today"},{"issue":"9","key":"10.1016\/j.jcis.2024.09.224_b0100","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202211402","article-title":"A near-infrared light-responsive ROS cascade nanoplatform for synergistic therapy potentiating antitumor immune responses","volume":"33","author":"Cen","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jcis.2024.09.224_b0105","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jconrel.2023.01.074","article-title":"Brain-neuron targeted nanoparticles for peptide synergy therapy at dual-target of Alzheimer's disease","volume":"355","author":"Guo","year":"2023","journal-title":"J. Control. Release"},{"issue":"22","key":"10.1016\/j.jcis.2024.09.224_b0110","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205511","article-title":"RhRu alloy-anchored mxene nanozyme for synergistic osteosarcoma therapy","volume":"19","author":"Liang","year":"2023","journal-title":"Small"},{"issue":"26","key":"10.1016\/j.jcis.2024.09.224_b0115","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202202966","article-title":"A dual-locked activatable phototheranostic probe for biomarker-regulated photodynamic and photothermal cancer therapy","volume":"61","author":"Wei","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"issue":"5","key":"10.1016\/j.jcis.2024.09.224_b0120","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1021\/jacs.1c13067","article-title":"In situ hypoxia-induced supramolecular perylene diimide radical anions in tumors for photothermal therapy with improved specificity","volume":"144","author":"Wang","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.jcis.2024.09.224_b0125","article-title":"Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jcis.2024.09.224_b0130","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.actbio.2023.01.010","article-title":"A copper-metal organic framework enhances the photothermal and chemodynamic properties of polydopamine for melanoma therapy","volume":"158","author":"Liu","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jcis.2024.09.224_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.142156","article-title":"Automatic-degradable Mo-doped W18O49 based nanotheranostics for CT\/FL imaging guided synergistic chemo\/photothermal\/chemodynamic therapy","volume":"462","author":"Tian","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"6478","key":"10.1016\/j.jcis.2024.09.224_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jcis.2024.09.224_b0145","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12254","article-title":"Release of VAMP5-positive extracellular vesicles by retinal Muller glia in vivo","volume":"11","author":"Demais","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jcis.2024.09.224_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101789","article-title":"Evaluating the defect targeting effects and osteogenesis promoting capacity of exosomes from 2D- and 3D-cultured human adipose-derived stem cells","volume":"49","author":"Chen","year":"2023","journal-title":"Nano Today"},{"issue":"18","key":"10.1016\/j.jcis.2024.09.224_b0155","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201707360","article-title":"Designer exosomes for active targeted chemo-photothermal synergistic tumor therapy","volume":"28","author":"Wang","year":"2018","journal-title":"Adv. Funct. Mater."},{"issue":"7","key":"10.1016\/j.jcis.2024.09.224_b0160","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1021\/acsami.2c18308","article-title":"Exosome-functionalized, drug-laden bone substitute along with an antioxidant herbal membrane for bone and periosteum regeneration in bone sarcoma","volume":"15","author":"Gupta","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jcis.2024.09.224_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.141730","article-title":"Multibiofunctional TFEB-engineered endothelial progenitor cell-derived extracellular vesicles\/hydrogel system for rescuing critical limb ischemia","volume":"460","author":"Zhao","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jcis.2024.09.224_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114751","article-title":"Hollow Prussian blue nanozyme-richened liposome for artificial neural network-assisted multimodal colorimetric-photothermal immunoassay on smartphone","volume":"218","author":"Yu","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jcis.2024.09.224_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121801","article-title":"Tumor oxygenation nanoliposome synergistic hypoxia-inducible-factor-1 inhibitor enhanced Iodine-125 seed brachytherapy for esophageal cancer","volume":"289","author":"Yao","year":"2022","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.jcis.2024.09.224_b0180","doi-asserted-by":"crossref","first-page":"17389","DOI":"10.1021\/acsnano.2c08446","article-title":"Polarization of tumor-associated macrophages promoted by vitamin C-loaded liposomes for cancer immunotherapy","volume":"16","author":"Ma","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcis.2024.09.224_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121723","article-title":"Inhibition of SerpinB9 to enhance granzyme B-based tumor therapy by using a modified biomimetic nanoplatform with a cascade strategy","volume":"288","author":"Han","year":"2022","journal-title":"Biomaterials"},{"issue":"35","key":"10.1016\/j.jcis.2024.09.224_b0190","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202303596","article-title":"Precise starving therapy via physiologically dependent photothermal conversion promoted mitochondrial calcification based on multi-functional gold nanoparticles for effective tumor treatment","volume":"33","author":"Chang","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jcis.2024.09.224_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122023","article-title":"Nanomedicines with high drug availability and drug sensitivity overcome hypoxia-associated drug resistance","volume":"294","author":"Liu","year":"2023","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.jcis.2024.09.224_b0200","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1021\/acsmaterialslett.2c01093","article-title":"Matrix metalloproteinase-2-induced morphologic transformation of self-assembled peptide nanocarriers inhibits tumor growth and metastasis","volume":"5","author":"Cao","year":"2023","journal-title":"ACS Mater. Lett."},{"issue":"9","key":"10.1016\/j.jcis.2024.09.224_b0205","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1021\/acs.analchem.1c04741","article-title":"Multivalent engineering of exosomes with activatable aptamer probes for specific regulation and monitoring of cell targeting","volume":"94","author":"Liu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jcis.2024.09.224_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.apcatb.2021.120317","article-title":"NIR enhanced peroxidase-like activity of Au@CeO2 hybrid nanozyme by plasmon-induced hot electrons and photothermal effect for bacteria killing","volume":"295","author":"Liu","year":"2021","journal-title":"Appl. Catal. B Environ."},{"issue":"3","key":"10.1016\/j.jcis.2024.09.224_b0215","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1021\/nn300315j","article-title":"Improved size-tunable synthesis of monodisperse gold nanorods through the use of aromatic additives","volume":"6","author":"Ye","year":"2012","journal-title":"ACS Nano"},{"issue":"13","key":"10.1016\/j.jcis.2024.09.224_b0220","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1021\/jacs.8b13062","article-title":"Site-selective growth of crystalline ceria with oxygen vacancies on gold nanocrystals for near-infrared nitrogen photofixation","volume":"141","author":"Jia","year":"2019","journal-title":"J. Am. Chem. Soc."},{"issue":"16","key":"10.1016\/j.jcis.2024.09.224_b0225","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1002\/anie.201411417","article-title":"A smart DNAzyme-MnO(2) nanosystem for efficient gene silencing","volume":"54","author":"Fan","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2024.09.224_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101599","article-title":"A general strategy for detection of tumor-derived extracellular vesicle microRNAs using aptamer-mediated vesicle fusion","volume":"46","author":"Cui","year":"2022","journal-title":"Nano Today"},{"issue":"9","key":"10.1016\/j.jcis.2024.09.224_b0235","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/adma.201204683","article-title":"Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy","volume":"25","author":"Liu","year":"2013","journal-title":"Adv. Mater."}],"updated-by":[{"DOI":"10.1016\/j.jcis.2025.137902","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000}}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979724022896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979724022896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:53:18Z","timestamp":1762195998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979724022896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":47,"alternative-id":["S0021979724022896"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2024.09.224","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering small extracellular vesicles with multivalent DNA probes for precise tumor targeting and enhanced synergistic therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2024.09.224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}