{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:43:27Z","timestamp":1792532607758,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["SKL202302002"],"award-info":[{"award-number":["SKL202302002"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171388"],"award-info":[{"award-number":["82171388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jcis.2025.02.125","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:08Z","timestamp":1739923208000},"page":"44-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Nanozyme as tumor energy homeostasis disruptor mediated ferroptosis for high-efficiency radiotherapy"],"prefix":"10.1016","volume":"688","author":[{"given":"Xingchen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Zvyagin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiejun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-4240","authenticated-orcid":false,"given":"Quan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcis.2025.02.125_b0005","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/cac2.12226","article-title":"Combined treatment of non\u2010small cell lung cancer using radiotherapy and immunotherapy: challenges and updates","volume":"41","author":"Shang","year":"2021","journal-title":"Cancer Commun."},{"key":"10.1016\/j.jcis.2025.02.125_b0010","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41419-024-06484-1","article-title":"Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1\/Rad51 axis","volume":"15","author":"Chen","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jcis.2025.02.125_b0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s40880-017-0261-0","article-title":"Survival and prognostic factors of non-small cell lung cancer patients with postoperative locoregional recurrence treated with radical radiotherapy","volume":"36","author":"Ma","year":"2017","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.jcis.2025.02.125_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122537","article-title":"\u201cOn\/off\u201d-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX","volume":"307","author":"Li","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2025.02.125_b0025","article-title":"Synergistic effect of ferroptosis\u2010inducing nanoparticles and X\u2010ray irradiation combination therapy","volume":"20","author":"Bae","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.jcis.2025.02.125_b0030","article-title":"High-Z elements dominated bismuth-based heterojunction nano-semiconductor for radiotherapy-enhanced sonodynamic breast cancer therapy","author":"Zhu","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2025.02.125_b0035","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1016\/j.cclet.2022.03.054","article-title":"Emerging nanozymes for potentiating radiotherapy and radiation protection","volume":"33","author":"Chong","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jcis.2025.02.125_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122746","article-title":"Local delivery of carboplatin-loaded hydrogel and calcium carbonate enables two-stage drug release for limited-dose radiation to eliminate mouse malignant glioma","volume":"312","author":"Hsu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2025.02.125_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.155437","article-title":"In situ enzymatic peptide-based nanomedicine with combined effects for enhanced tumor radio-immunotherapy","volume":"498","author":"Gao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jcis.2025.02.125_b0050","article-title":"Precise Design of TiO 2 @CoO x Heterostructure via Atomic Layer Deposition for Synergistic Sono\u2010Chemodynamic Oncotherapy","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jcis.2025.02.125_b0055","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1007\/s12274-021-3337-8","article-title":"X-ray sensitive high-Z metal nanocrystals for cancer imaging and therapy","volume":"14","author":"Zheng","year":"2021","journal-title":"Nano Res."},{"key":"10.1016\/j.jcis.2025.02.125_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121811","article-title":"Enhancing anti-tumor effect of ultrasensitive bimetallic RuCu nanoparticles as radiosensitizers with dual enzyme-like activities","volume":"290","author":"Hu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2025.02.125_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2024.02.160","article-title":"Tumor microenvironment sensitization via dual-catalysis of carbon-based nanoenzyme for enhanced photodynamic therapy","author":"Feng","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2025.02.125_b0070","doi-asserted-by":"crossref","first-page":"11345","DOI":"10.1021\/acsnano.3c00350","article-title":"Glutathione-exhausting nanoprobes for NIR-II fluorescence imaging-guided surgery and boosting radiation therapy efficacy via ferroptosis in breast cancer","volume":"17","author":"Wei","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcis.2025.02.125_b0075","article-title":"Gold mineralized \u201chybrid nanozyme bomb\u201d for NIR-II triggered tumor effective permeation and cocktail therapy","volume":"35","author":"Liu","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jcis.2025.02.125_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.149752","article-title":"Facile manganese ion-coordination assembly of nanogels for synergistic cancer chemo\u2013chemodynamic-immunotherapy","volume":"485","author":"Zhu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jcis.2025.02.125_b0085","doi-asserted-by":"crossref","first-page":"11492","DOI":"10.1021\/acsnano.3c01369","article-title":"Tumor-generated reactive oxygen species storm for high-performance ferroptosis therapy","volume":"17","author":"Huang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcis.2025.02.125_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122675","article-title":"In situ hydrogel based on Cu\u2013Fe3O4 nanoclusters exploits oxidative stress and the ferroptosis\/cuproptosis pathway for chemodynamic therapy","volume":"311","author":"Zhang","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2025.02.125_b0095","doi-asserted-by":"crossref","first-page":"9491","DOI":"10.1002\/anie.201916142","article-title":"Specific \u201cUnlocking\u201d of a nanozyme\u2010based butterfly effect to break the evolutionary fitness of chaotic tumors","volume":"59","author":"Zhen","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2025.02.125_b0100","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/s12951-023-02158-w","article-title":"Glucose oxidase and metal catalysts combined tumor synergistic therapy: mechanism, advance and nanodelivery system","volume":"21","author":"Fu","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jcis.2025.02.125_b0105","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201903895","article-title":"Recent advances in glucose\u2010oxidase\u2010based nanocomposites for tumor therapy","volume":"15","author":"Wang","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.jcis.2025.02.125_b0110","article-title":"Glucose-Responsive hydrogel optimizing Fenton reaction to eradicate multidrug-resistant bacteria for infected diabetic wound healing","volume":"487","author":"Li","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jcis.2025.02.125_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119848","article-title":"Iridium\/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer","volume":"238","author":"Wei","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2025.02.125_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2024.11.057","article-title":"pH-activated metal\u2013organic layer nanozyme for ferroptosis tumor therapy","author":"Gong","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2025.02.125_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135309","article-title":"Tumor microenvironments self-activated cascade catalytic nanoscale metal organic frameworks as ferroptosis inducer for radiosensitization","volume":"437","author":"Liang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jcis.2025.02.125_b0130","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/s12951-021-01209-4","article-title":"Preparation, toxicity reduction and radiation therapy application of gold nanorods","volume":"19","author":"Xie","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jcis.2025.02.125_b0135","article-title":"Oxygen vacancy\u2010rich manganese nanoflowers as ferroptosis inducers for tumor radiotherapy","author":"Liu","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.jcis.2025.02.125_b0140","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202212510","article-title":"A self\u2010enhancing nanoreactor reinforces radioimmunotherapy by reprogramming nutrients and redox metabolisms","volume":"33","author":"Hou","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jcis.2025.02.125_b0145","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202302493","article-title":"A novel photosynthetic biohybrid system for microenvironment regulation of diabetes retinopathy through continuous oxygen supply and nanozyme cascade reaction","volume":"33","author":"Zhou","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jcis.2025.02.125_b0150","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10555-019-09794-5","article-title":"The Warburg metabolism fuels tumor metastasis","volume":"38","author":"Lu","year":"2019","journal-title":"Cancer Metast. Rev."},{"key":"10.1016\/j.jcis.2025.02.125_b0155","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jcis.2023.07.139","article-title":"Biomimetic dual-nanozymes with catalytic cascade reactions against diabetic wound infection","volume":"651","author":"Li","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2025.02.125_b0160","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jcis.2023.10.037","article-title":"Ultrasmall Au\/Pt-loaded biocompatible albumin nanospheres to enhance photodynamic\/catalytic therapy via triple amplification of glucose-oxidase\/catalase\/peroxidase","volume":"654","author":"Hao","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2025.02.125_b0165","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202210037","article-title":"Boosting ferroptosis therapy with iridium single\u2010atom nanocatalyst in ultralow metal content","volume":"35","author":"Cheng","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jcis.2025.02.125_b0170","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202206286","article-title":"Bioactive iridium nanoclusters with glutathione depletion ability for enhanced sonodynamic\u2010triggered ferroptosis\u2010like cancer cell death","volume":"34","author":"Nie","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jcis.2025.02.125_b0175","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jcis.2025.02.125_b0180","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202302141","article-title":"Multifunctional Au@AgBiS2 nanoparticles as high\u2010efficiency radiosensitizers to induce pyroptosis for cancer radioimmunotherapy","volume":"10","author":"Xiao","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jcis.2025.02.125_b0185","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s13238-021-00841-y","article-title":"Ferroptosis, radiotherapy, and combination therapeutic strategies","volume":"12","author":"Lei","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.jcis.2025.02.125_b0190","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jcis.2025.02.125_b0195","doi-asserted-by":"crossref","first-page":"10309","DOI":"10.1002\/anie.201804466","article-title":"BSA\u2010IrO2: Catalase\u2010like nanoparticles with high photothermal conversion efficiency and a high X\u2010ray absorption coefficient for anti\u2010inflammation and antitumor theranostics","volume":"57","author":"Zhen","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2025.02.125_b0200","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jcis.2025.02.125_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jcis.2025.02.125_b0210","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jcis.2023.08.109","article-title":"Cancer cell membrane biomimetic nanosystem for homologous targeted dual-mode imaging and combined therapy","volume":"652","author":"Li","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2025.02.125_b0215","doi-asserted-by":"crossref","first-page":"9914","DOI":"10.1002\/anie.201908712","article-title":"Aggregation\u2010induced emission gold clustoluminogens for enhanced low\u2010dose X\u2010ray\u2010induced photodynamic therapy","volume":"59","author":"Sun","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2025.02.125_b0220","article-title":"Photoacoustic imaging\u2010guided synergistic photothermal\/radiotherapy using plasmonic Bi\/Bi2 O3\u2212x nanoparticles","volume":"32","author":"Huang","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jcis.2025.02.125_b0225","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202103765","article-title":"In situ nanozyme\u2010amplified NIR\u2010II phototheranostics for tumor\u2010specific imaging and therapy","volume":"31","author":"Ma","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jcis.2025.02.125_b0230","article-title":"Modulating the coordination environment of carbon\u2010dot\u2010supported Fe single\u2010atom nanozymes for enhanced tumor therapy","volume":"20","author":"Han","year":"2024","journal-title":"Small"}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979725004850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979725004850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T18:58:39Z","timestamp":1745348319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979725004850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":46,"alternative-id":["S0021979725004850"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2025.02.125","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanozyme as tumor energy homeostasis disruptor mediated ferroptosis for high-efficiency radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2025.02.125","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}