{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:51:13Z","timestamp":1792799473343,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A2089"],"award-info":[{"award-number":["U23A2089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22403070"],"award-info":[{"award-number":["22403070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2025AFA009"],"award-info":[{"award-number":["2025AFA009"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015939","name":"Hubei Provincial Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["BCMM202402"],"award-info":[{"award-number":["BCMM202402"]}],"id":[{"id":"10.13039\/501100015939","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX20230268"],"award-info":[{"award-number":["BX20230268"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M742690"],"award-info":[{"award-number":["2023M742690"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jcis.2025.138044","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T02:34:21Z","timestamp":1748831661000},"page":"138044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Tumor microenvironment-responsive Cu\/CaO2 nanocomposites for amplified pyroptosis and cuproptosis"],"prefix":"10.1016","volume":"698","author":[{"given":"Haimei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-593X","authenticated-orcid":false,"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jcis.2025.138044_b0005","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrc3380","article-title":"Immunogenic cell death and damps in cancer therapy","volume":"12","author":"Krysko","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"12","key":"10.1016\/j.jcis.2025.138044_b0010","doi-asserted-by":"crossref","first-page":"11749","DOI":"10.1021\/acsnano.3c02592","article-title":"A near-infrared-II fluorescent nanocatalyst for enhanced CAR T cell therapy against solid tumor by immune reprogramming","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"issue":"7610","key":"10.1016\/j.jcis.2025.138044_b0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jcis.2025.138044_b0020","article-title":"Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy","volume":"7","author":"Gao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"30","key":"10.1016\/j.jcis.2025.138044_b0025","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202302141","article-title":"Multifunctional Au@AgBiS2 nanoparticles as high-efficiency radiosensitizers to induce pyroptosis for cancer radioimmunotherapy","volume":"10","author":"Xiao","year":"2023","journal-title":"Adv. Sci."},{"issue":"11","key":"10.1016\/j.jcis.2025.138044_b0030","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202209379","article-title":"A dual-responsive STAT3 inhibitor nanoprodrug combined with oncolytic virus elicits synergistic antitumor immune responses by igniting pyroptosis","volume":"35","author":"Su","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.jcis.2025.138044_b0035","first-page":"12","article-title":"The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis","volume":"14","author":"Han","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.jcis.2025.138044_b0040","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101971","article-title":"Nanocatalyst-mediated chemodynamic tumor therapy","volume":"11","author":"Zhang","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"6","key":"10.1016\/j.jcis.2025.138044_b0045","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1039\/D0CS00173B","article-title":"Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application","volume":"50","author":"Zhao","year":"2021","journal-title":"Chem. Soc. Rev."},{"issue":"8","key":"10.1016\/j.jcis.2025.138044_b0050","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/anie.201813702","article-title":"One-dimensional Fe2P acts as a Fenton agent in response to NIR II light and ultrasound for deep tumor synergetic theranostics","volume":"58","author":"Liu","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2025.138044_b0055","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jconrel.2020.01.008","article-title":"Ferroptosis-driven nanotherapeutics for cancer treatment","volume":"319","author":"Shan","year":"2020","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.jcis.2025.138044_b0060","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1021\/acs.nanolett.8b03178","article-title":"An adenosine triphosphate-responsive autocatalytic Fenton nanoparticle for tumor ablation with self-supplied H2O2 and acceleration of Fe(III)\/Fe(II) conversion","volume":"18","author":"Zhang","year":"2018","journal-title":"Nano Lett."},{"issue":"47","key":"10.1016\/j.jcis.2025.138044_b0065","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201701683","article-title":"Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy","volume":"29","author":"Tang","year":"2017","journal-title":"Adv. Mater."},{"issue":"12","key":"10.1016\/j.jcis.2025.138044_b0070","doi-asserted-by":"crossref","first-page":"11819","DOI":"10.1021\/acsnano.8b07635","article-title":"Cancer treatment through nanoparticle-facilitated Fenton reaction","volume":"12","author":"Ranji-Burachaloo","year":"2018","journal-title":"ACS Nano"},{"issue":"6586","key":"10.1016\/j.jcis.2025.138044_b0075","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jcis.2025.138044_b0080","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"11","key":"10.1016\/j.jcis.2025.138044_b0085","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.jcis.2025.138044_b0090","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41467-020-15591-4","article-title":"An open source and reduce expenditure ROS generation strategy for chemodynamic\/photodynamic synergistic therapy","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.jcis.2025.138044_b0095","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202002927","article-title":"Photodynamic-chemodynamic cascade reactions for efficient drug delivery and enhanced combination therapy","volume":"8","author":"Wang","year":"2021","journal-title":"Adv. Sci."},{"issue":"29","key":"10.1016\/j.jcis.2025.138044_b0100","doi-asserted-by":"crossref","first-page":"10470","DOI":"10.1021\/acs.analchem.2c01738","article-title":"Highly efficient GSH-responsive \u201coff-on\u201d NIR-II fluorescent Fenton nanocatalyst for multimodal imaging-guided photothermal\/chemodynamic synergistic cancer therapy","volume":"94","author":"Li","year":"2022","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.jcis.2025.138044_b0105","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41565-020-00843-7","article-title":"Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection","volume":"16","author":"Zhang","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.jcis.2025.138044_b0110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41427-021-00303-1","article-title":"Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment","volume":"13","author":"Shen","year":"2021","journal-title":"NPG Asia Mater."},{"issue":"9","key":"10.1016\/j.jcis.2025.138044_b0115","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1021\/acsnano.9b01740","article-title":"Magnetic reactive oxygen species nanoreactor for switchable magnetic resonance imaging guided cancer therapy based on pH-sensitive Fe5C2@Fe3O4 nanoparticles","volume":"13","author":"Yu","year":"2019","journal-title":"ACS Nano"},{"issue":"36","key":"10.1016\/j.jcis.2025.138044_b0120","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201902118","article-title":"Synthesis of CaO2 nanocrystals and their spherical aggregates with uniform sizes for use as a biodegradable bacteriostatic agent","volume":"15","author":"Shen","year":"2019","journal-title":"Small"},{"issue":"18","key":"10.1016\/j.jcis.2025.138044_b0125","doi-asserted-by":"crossref","first-page":"20682","DOI":"10.1021\/acsami.2c01782","article-title":"Open-source and reduced-expenditure nanosystem with ROS self-amplification and glutathione depletion for simultaneous augmented chemodynamic\/photodynamic therapy","volume":"14","author":"Chen","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jcis.2025.138044_b0130","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202307955","article-title":"[Ru(dpp)3]Cl2-embedded oxygen nano polymeric sensors: a promising tool for monitoring Intracellular and intratumoral oxygen gradients with high quantum yield and long lifetime","volume":"20","author":"Kumar","year":"2024","journal-title":"Small"},{"issue":"3","key":"10.1016\/j.jcis.2025.138044_b0135","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1007\/s12274-022-5226-1","article-title":"A bioactive nanocomposite sponge for simultaneous hemostasis and antimicrobial therapy","volume":"16","author":"Lei","year":"2023","journal-title":"Nano Res."},{"issue":"19","key":"10.1016\/j.jcis.2025.138044_b0140","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1039\/D2BM00845A","article-title":"Construction of a matchstick-shaped Au@ZnO@SiO2-ICG Janus nanomotor for light-triggered synergistic antibacterial therapy","volume":"10","author":"Liu","year":"2022","journal-title":"Biomater. Sci."},{"issue":"11","key":"10.1016\/j.jcis.2025.138044_b0145","doi-asserted-by":"crossref","first-page":"12541","DOI":"10.1021\/acsami.0c00112","article-title":"Gold-nanobipyramid-based nanotheranostics for dual-modality imaging-guided phototherapy","volume":"12","author":"Li","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"36","key":"10.1016\/j.jcis.2025.138044_b0150","doi-asserted-by":"crossref","first-page":"30306","DOI":"10.1021\/acsami.7b06446","article-title":"Janus silver\/silica nanoplatforms for light-activated liver cancer chemo\/photothermal therapy","volume":"9","author":"Wang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jcis.2025.138044_b0155","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jhazmat.2010.02.039","article-title":"Influence of experimental parameters on sonochemistry dosimetries: KI oxidation, Fricke reaction and H2O2 production","volume":"178","author":"Merouani","year":"2010","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jcis.2025.138044_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2023.108464","article-title":"The process of free radical generation in contact electrification at solid-liquid interface","volume":"112","author":"Zhao","year":"2023","journal-title":"Nano Energy"},{"issue":"17","key":"10.1016\/j.jcis.2025.138044_b0165","doi-asserted-by":"crossref","first-page":"12087","DOI":"10.1021\/jacs.4c02149","article-title":"Free radicals generated in perfluorocarbon\u2013water (liquid\u2013liquid) interfacial contact electrification and their application in cancer therapy","volume":"146","author":"Li","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jcis.2025.138044_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175491","article-title":"The protection impact of tectoridin on PCl2 cell preventing OGD\/R-caused damage through PI3K\/AKT signaling channel","volume":"941","author":"Chen","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.jcis.2025.138044_b0175","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41565-022-01125-0","article-title":"A pyroptosis nanotuner for cancer therapy","volume":"17","author":"Chen","year":"2022","journal-title":"Nat. Nanotechnol."},{"issue":"16","key":"10.1016\/j.jcis.2025.138044_b0180","doi-asserted-by":"crossref","first-page":"15449","DOI":"10.1021\/acsnano.3c01215","article-title":"Multifunctional calcium-manganese nanomodulator provides antitumor treatment and improved immunotherapy via reprogramming of the tumor microenvironment","volume":"17","author":"Luo","year":"2023","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.jcis.2025.138044_b0185","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1021\/acsnano.3c09499","article-title":"Advancing precision: a controllable self-synergistic nanoplatform initiating pyroptosis-based immunogenic cell death cascade for targeted tumor therapy","volume":"18","author":"Qin","year":"2024","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.jcis.2025.138044_b0190","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202300164","article-title":"High immunogenic cuproptosis evoked by in situ sulfidation-activated pyroptosis for tumor-Targeted immunotherapy of colorectal cancer","volume":"4","author":"Xiao","year":"2024","journal-title":"Small Sci."}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979725014353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979725014353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:12:48Z","timestamp":1752570768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979725014353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":38,"alternative-id":["S0021979725014353"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2025.138044","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor microenvironment-responsive Cu\/CaO2 nanocomposites for amplified pyroptosis and cuproptosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2025.138044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"138044"}}