{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:09:37Z","timestamp":1768079377644,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jcis.2025.138403","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:16:11Z","timestamp":1752570971000},"page":"138403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P1","title":["Lipid mesophases-nanoconfined water rules crystal symmetry during in-meso crystallization"],"prefix":"10.1016","volume":"700","author":[{"given":"Laura","family":"Baraldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Donat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Balestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Melegari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Zunzunegui Bru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph R.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Marchio'","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Mezzenga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jcis.2025.138403_bb0005","doi-asserted-by":"crossref","first-page":"18759","DOI":"10.3390\/molecules201018759","article-title":"Polymorph impact on the bioavailability and stability of poorly soluble drugs","volume":"20","author":"Censi","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jcis.2025.138403_bb0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-chembioeng-061010-114224","article-title":"Crystal polymorphism in chemical process development","volume":"2","author":"Lee","year":"2011","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"10.1016\/j.jcis.2025.138403_bb0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053230X14026843","article-title":"A comprehensive review of the lipid cubic phase or in Meso method for crystallizing membrane and soluble proteins and complexes","volume":"71","author":"Caffrey","year":"2015","journal-title":"Acta Crystallogr. Sect. F: Struct. Biol. Commun."},{"issue":"25","key":"10.1016\/j.jcis.2025.138403_bb0020","doi-asserted-by":"crossref","first-page":"14532","DOI":"10.1073\/pnas.93.25.14532","article-title":"Lipidic cubic phases: a novel concept for the crystallization of membrane proteins","volume":"93","author":"Landau","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.jcis.2025.138403_bb0025","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-02996-5","article-title":"Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains","volume":"9","author":"Zabara","year":"2018","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.jcis.2025.138403_bb0030","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1021\/jp963347q","article-title":"Crystallization of a polar protein and small molecules from the aqueous compartment of lipidic cubic phases","volume":"101","author":"Landau","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jcis.2025.138403_bb0035","first-page":"3","article-title":"Challenges and opportunities from water under soft Nanoconfinement. Frontiers","author":"Mezzenga","year":"2023","journal-title":"Soft Matter"},{"key":"10.1016\/j.jcis.2025.138403_bb0040","unstructured":"Vallooran, J. J.; Assenza, S.; Mezzenga, R. Spatiotemporal Control of Enzyme-Induced Crystallization Under Lyotropic Liquid Crystal Nanoconfinement. doi:https:\/\/doi.org\/10.3929\/ethz-b-000344953."},{"issue":"6","key":"10.1016\/j.jcis.2025.138403_bb0045","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1039\/D0NH00079E","article-title":"Lipid-based mesophases as matrices for nanoscale reactions","volume":"5","author":"Salvati Manni","year":"2020","journal-title":"Nanoscale Horiz."},{"issue":"47","key":"10.1016\/j.jcis.2025.138403_bb0050","doi-asserted-by":"crossref","first-page":"16455","DOI":"10.1021\/la303833s","article-title":"Diffusion, molecular separation, and drug delivery from lipid mesophases with tunable water channels","volume":"28","author":"Negrini","year":"2012","journal-title":"Langmuir"},{"issue":"7","key":"10.1016\/j.jcis.2025.138403_bb0055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1063\/PT.3.4522","article-title":"The physics of lipidic mesophase delivery systems","volume":"73","author":"Aleandri","year":"2020","journal-title":"Phys. Today"},{"issue":"1","key":"10.1016\/j.jcis.2025.138403_bb0060","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1021\/ja210006t","article-title":"Gel-induced selective crystallization of polymorphs","volume":"134","author":"Diao","year":"2012","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"10.1016\/j.jcis.2025.138403_bb0065","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1021\/cg9006185","article-title":"Phase behavior and polymorphism of organic crystals confined within nanoscale chambers","volume":"9","author":"Ha","year":"2009","journal-title":"Cryst. Growth Des."},{"issue":"7","key":"10.1016\/j.jcis.2025.138403_bb0070","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1039\/C3CS60234F","article-title":"Crystallization under nanoscale confinement","volume":"43","author":"Jiang","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jcis.2025.138403_bb0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/adma.202001068","article-title":"Crystallization in confinement","volume":"32","author":"Meldrum","year":"2020","journal-title":"Adv. Mater."},{"issue":"23","key":"10.1016\/j.jcis.2025.138403_bb0080","doi-asserted-by":"crossref","first-page":"21451","DOI":"10.1021\/acsanm.3c03934","article-title":"Review of crystallization in nanoconfinement created by emulsions and microemulsions for pharmaceutical applications","volume":"6","author":"Niyom","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"issue":"8","key":"10.1016\/j.jcis.2025.138403_bb0085","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1021\/acs.cgd.3c01082","article-title":"Crystallization and polymorphism under nanoconfinement","volume":"24","author":"Fellah","year":"2024","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jcis.2025.138403_bb0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jconrel.2014.05.052","article-title":"Controlling molecular transport and sustained drug release in lipid-based liquid crystalline mesophases","volume":"188","author":"Zabara","year":"2014","journal-title":"J. Control. Release"},{"issue":"9","key":"10.1016\/j.jcis.2025.138403_bb0095","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1021\/la200591u","article-title":"PH-responsive lyotropic liquid crystals for controlled drug delivery","volume":"27","author":"Negrini","year":"2011","journal-title":"Langmuir"},{"issue":"1","key":"10.1016\/j.jcis.2025.138403_bb0100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1039\/C6SC04126D","article-title":"Pharmaceutical polymorph control in a drug-mimetic supramolecular gel","volume":"8","author":"Foster","year":"2016","journal-title":"Chem. Sci."},{"issue":"1","key":"10.1016\/j.jcis.2025.138403_bb0105","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1021\/acs.cgd.1c00718","article-title":"Theophylline polymorph control by high-pressure pure CO2 via its monohydrate","volume":"22","author":"Hao","year":"2022","journal-title":"Cryst. Growth Des."},{"issue":"9","key":"10.1016\/j.jcis.2025.138403_bb0110","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1021\/acs.molpharmaceut.1c00476","article-title":"Understanding the metastability of theophylline FIII by means of low-frequency vibrational spectroscopy","volume":"18","author":"Paiva","year":"2021","journal-title":"Mol. Pharm."},{"issue":"11","key":"10.1016\/j.jcis.2025.138403_bb0115","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1021\/acs.molpharmaceut.5b00610","article-title":"Polymorphs of theophylline characterized by DNP enhanced solid-state NMR","volume":"12","author":"Pinon","year":"2015","journal-title":"Mol. Pharm."},{"issue":"12","key":"10.1016\/j.jcis.2025.138403_bb0120","doi-asserted-by":"crossref","DOI":"10.1107\/S010827011104786X","article-title":"Polymorphs of anhydrous theophylline: stable form IV consists of dimer pairs and metastable form i consists of hydrogen-bonded chains","volume":"67","author":"Khamar","year":"2011","journal-title":"Acta Crystallogr. C"},{"issue":"2","key":"10.1016\/j.jcis.2025.138403_bb0125","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1208\/s12249-011-9642-x","article-title":"Polymorph transformation in paracetamol monitored by in-line NIR spectroscopy during a cooling crystallization process","volume":"12","author":"Wang","year":"2011","journal-title":"AAPS PharmSciTech"},{"issue":"81","key":"10.1016\/j.jcis.2025.138403_bb0130","doi-asserted-by":"crossref","first-page":"12028","DOI":"10.1039\/C6CC05006A","article-title":"Stabilisation of metastable polymorphs: the case of paracetamol form III","volume":"52","author":"Telford","year":"2016","journal-title":"Chem. Commun."},{"issue":"4","key":"10.1016\/j.jcis.2025.138403_bb0135","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1021\/mp400768m","article-title":"Crystallization and phase changes in paracetamol from the amorphous solid to the liquid phase","volume":"11","author":"Sibik","year":"2014","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.jcis.2025.138403_bb0140","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/jps.10131","article-title":"Preparation and crystal structure of a trihydrate of paracetamol","volume":"91","author":"McGregor","year":"2002","journal-title":"J. Pharm. Sci."},{"issue":"82","key":"10.1016\/j.jcis.2025.138403_bb0145","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1039\/B406631F","article-title":"High-pressure recrystallisation - a route to new polymorphs and solvates","volume":"6","author":"Fabbiani","year":"2004","journal-title":"CrystEngComm"},{"issue":"46","key":"10.1016\/j.jcis.2025.138403_bb0150","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1039\/C6CC01032F","article-title":"Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment","volume":"52","author":"Agnew","year":"2016","journal-title":"Chem. Commun."},{"issue":"7","key":"10.1016\/j.jcis.2025.138403_bb0155","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1021\/acs.cgd.9b00473","article-title":"Melt crystallization for paracetamol polymorphism","volume":"19","author":"Shtukenberg","year":"2019","journal-title":"Cryst. Growth Des."},{"issue":"31","key":"10.1016\/j.jcis.2025.138403_bb0160","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1021\/jp411810y","article-title":"Polymorphism in paracetamol: evidence of additional forms IV and v at high pressure","volume":"118","author":"Smith","year":"2014","journal-title":"J. Phys. Chem. A"},{"issue":"3","key":"10.1016\/j.jcis.2025.138403_bb0165","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1107\/S010876810500546X","article-title":"Ab initio structure determination of the high-temperature phase of anhydrous caffeine by X-ray powder diffraction","volume":"61","author":"Derollez","year":"2005","journal-title":"Acta Crystallogr. B"},{"issue":"10","key":"10.1016\/j.jcis.2025.138403_bb0170","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1002\/chem.200600973","article-title":"The crystal structure of anhydrous \u03b2-caffeine as determined from X-ray powder-diffraction data","volume":"13","author":"Lehmann","year":"2007","journal-title":"Chem. A Eur. J."},{"issue":"6","key":"10.1016\/j.jcis.2025.138403_bb0175","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/1750-3841.15114","article-title":"Relative humidity\u2013temperature transition boundaries for anhydrous \u03b2-caffeine and caffeine hydrate crystalline forms","volume":"85","author":"Allan","year":"2020","journal-title":"J. Food Sci."},{"issue":"7","key":"10.1016\/j.jcis.2025.138403_bb0180","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3109\/03639045.2010.545416","article-title":"Polymorphic transformation of anhydrous caffeine under compression and grinding: a re-evaluation","volume":"37","author":"Mazel","year":"2011","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"15","key":"10.1016\/j.jcis.2025.138403_bb0185","doi-asserted-by":"crossref","first-page":"7970","DOI":"10.1021\/la800768v","article-title":"Tracing coffee tabletop traces","volume":"24","author":"Leiterer","year":"2008","journal-title":"Langmuir"},{"issue":"8","key":"10.1016\/j.jcis.2025.138403_bb0190","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1021\/cg070291o","article-title":"The structure of two anhydrous polymorphs of caffeine from single-crystal diffraction and ultrahigh-field solid-State13C NMR spectroscopy","volume":"7","author":"Enright","year":"2007","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jcis.2025.138403_bb0195","series-title":"SADABS-2008\/1 - Bruker AXS Area Detector Scaling and Absorption Correction Bruker AXS: Madison, Wisconsin, USA","article-title":"SADABS-2008\/1 - Bruker AXS Area Detector Scaling and Absorption Correction","author":"Sheldrick","year":"2008"},{"issue":"1","key":"10.1016\/j.jcis.2025.138403_bb0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053273314026370","article-title":"SHELXT - integrated space-group and crystal-structure determination","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/j.jcis.2025.138403_bb0205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr C Struct Chem"},{"issue":"2","key":"10.1016\/j.jcis.2025.138403_bb0210","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","article-title":"OLEX2: a complete structure solution, refinement and analysis program","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Cryst."},{"issue":"2","key":"10.1016\/j.jcis.2025.138403_bb0215","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1107\/S2052520616003954","article-title":"The Cambridge Structural Database","volume":"72","author":"Groom","year":"2016","journal-title":"Acta Crystallogr B Struct Sci Cryst Eng Mater"},{"issue":"3","key":"10.1016\/j.jcis.2025.138403_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/ph17030271","article-title":"Effect of hydration forms and polymer grades on theophylline controlled-release tablet: an assessment and evaluation","volume":"17","author":"Sakkal","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jcis.2025.138403_bb0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/adma.202001068","article-title":"Crystallization in confinement","volume":"32","author":"Meldrum","year":"2020","journal-title":"Adv. Mater."},{"issue":"5\u20136","key":"10.1016\/j.jcis.2025.138403_bb0230","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1365\/s10337-007-0510-5","article-title":"Simultaneous determination of paracetamol, caffeine, guaifenesin and preservatives in syrups by micellar LC","volume":"67","author":"Kulikov","year":"2008","journal-title":"Chromatographia"},{"issue":"1","key":"10.1016\/j.jcis.2025.138403_bb0235","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jps.24699","article-title":"Synergistic skin penetration enhancer and nanoemulsion formulations promote the human epidermal permeation of caffeine and naproxen","volume":"105","author":"Abd","year":"2016","journal-title":"J. Pharm. Sci."},{"issue":"36","key":"10.1016\/j.jcis.2025.138403_bb0240","doi-asserted-by":"crossref","first-page":"10174","DOI":"10.1021\/acs.jpcb.1c04360","article-title":"Interaction of caffeine with model lipid membranes","volume":"125","author":"Tavagnacco","year":"2021","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jcis.2025.138403_bb0245","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"Visual molecular dynamics","volume":"14","author":"William","year":"1996","journal-title":"J. Mol. Graph."}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979725017941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979725017941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T22:40:29Z","timestamp":1761777629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979725017941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":49,"alternative-id":["S0021979725017941"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2025.138403","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid mesophases-nanoconfined water rules crystal symmetry during in-meso crystallization","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2025.138403","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"138403"}}