{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:28:53Z","timestamp":1793305733857,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009019","name":"Shenzhen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFE0202500"],"award-info":[{"award-number":["2022YFE0202500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jcis.2025.138790","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:37:36Z","timestamp":1755736656000},"page":"138790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"P1","title":["Engineering silica-stabilized Pickering emulsions as versatile protein carriers"],"prefix":"10.1016","volume":"702","author":[{"given":"Xin","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Chi","family":"Chio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Lung Steve","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"To","family":"Ngai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"34","key":"10.1016\/j.jcis.2025.138790_bb0005","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1002\/smll.201600877","article-title":"Recent studies of Pickering emulsions: particles make the difference","volume":"12","author":"Wu","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.jcis.2025.138790_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cocis.2020.04.010","article-title":"Pickering emulsions: versatility of colloidal particles and recent applications","volume":"49","author":"Jiang","year":"2020","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2025.138790_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cocis.2024.101827","article-title":"Pickering emulsions: microgels as alternative surfactants","volume":"73","author":"Guan","year":"2024","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2025.138790_bb0020","article-title":"Pickering emulsions for functional food systems","volume":"11","author":"Cheon","year":"2023","journal-title":"J. Agric. Food Res."},{"key":"10.1016\/j.jcis.2025.138790_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.138598","article-title":"Oleanolic acid nanoparticles-stabilized W\/O Pickering emulsions: fabrication, characterization, and delivery application","volume":"444","author":"Liu","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.jcis.2025.138790_bb0030","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.tifs.2020.04.020","article-title":"Food-grade Pickering emulsions for encapsulation and delivery of bioactives","volume":"100","author":"Mwangi","year":"2020","journal-title":"Trends Food Sci. Technol."},{"issue":"21","key":"10.1016\/j.jcis.2025.138790_bb0035","doi-asserted-by":"crossref","first-page":"6205","DOI":"10.1039\/D2SC01082H","article-title":"Non-covalent reconfigurable microgel colloidosomes with a well-defined bilayer shell","volume":"13","author":"Guan","year":"2022","journal-title":"Chem. Sci."},{"issue":"3","key":"10.1016\/j.jcis.2025.138790_bb0040","article-title":"Reaction-controlled microgel-lipase co-stabilized compartmentalized emulsion for recyclable biodiesel production","volume":"4","author":"Guan","year":"2023","journal-title":"Aggregate"},{"issue":"1","key":"10.1016\/j.jcis.2025.138790_bb0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1039\/D1SC05398A","article-title":"Engineering hybrid microgels as particulate emulsifiers for reversible Pickering emulsions","volume":"13","author":"Jiang","year":"2021","journal-title":"Chem. Sci."},{"issue":"2","key":"10.1016\/j.jcis.2025.138790_bb0050","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/vaccines3020320","article-title":"Vaccine adjuvants: from 1920 to 2015 and beyond","volume":"3","author":"Di Pasquale","year":"2015","journal-title":"Vaccines"},{"issue":"11","key":"10.1016\/j.jcis.2025.138790_bb0055","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/15058","article-title":"Advances in vaccine adjuvants","volume":"17","author":"Singh","year":"1999","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.jcis.2025.138790_bb0060","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41573-021-00163-y","article-title":"Emerging concepts in the science of vaccine adjuvants","volume":"20","author":"Pulendran","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7876","key":"10.1016\/j.jcis.2025.138790_bb0065","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/d41586-021-02483-w","article-title":"The tangled history of mRNA vaccines","volume":"597","author":"Dolgin","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jcis.2025.138790_bb0070","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41392-023-01425-4","article-title":"An RBD virus-like particle vaccine for SARS-CoV-2 induces cross-variant antibody responses in mice and macaques","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"32","key":"10.1016\/j.jcis.2025.138790_bb0075","doi-asserted-by":"crossref","first-page":"eadn7187","DOI":"10.1126\/sciadv.adn7187","article-title":"Saponin nanoparticle adjuvants incorporating toll-like receptor agonists drive distinct immune signatures and potent vaccine responses","volume":"10","author":"Ou","year":"2024","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.jcis.2025.138790_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/agt2.162","article-title":"Aggregating particles on the O\/W interface: tuning Pickering emulsion for the enhanced drug delivery systems","volume":"3","author":"Ming","year":"2022","journal-title":"Aggregate"},{"key":"10.1016\/j.jcis.2025.138790_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121313","article-title":"Engineering mannosylated Pickering emulsions for the targeted delivery of multicomponent vaccines","volume":"280","author":"Du","year":"2022","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.jcis.2025.138790_bb0090","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nmat5057","article-title":"Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination","volume":"17","author":"Xia","year":"2018","journal-title":"Nat. Mater."},{"issue":"40","key":"10.1016\/j.jcis.2025.138790_bb0095","article-title":"Particulate alum via Pickering emulsion for an enhanced COVID-19 vaccine adjuvant","volume":"32","author":"Peng","year":"2020","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.jcis.2025.138790_bb0100","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41392-023-01414-7","article-title":"Inside-out assembly of viral antigens for the enhanced vaccination","volume":"8","author":"Cao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.jcis.2025.138790_bb0105","doi-asserted-by":"crossref","first-page":"11403","DOI":"10.1021\/acsami.2c17505","article-title":"Acid-responsive immune-enhancing chitosan formulation capable of transforming from particle stabilization to polymer chain stabilization","volume":"15","author":"Zou","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jcis.2025.138790_bb0110","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jcis.2022.05.009","article-title":"Water-in-oil high internal phase Pickering emulsions formed by spontaneous interfacial hydrolysis of monomer oil","volume":"623","author":"Guan","year":"2022","journal-title":"J. Colloid Interface Sci."},{"issue":"8","key":"10.1016\/j.jcis.2025.138790_bb0115","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1021\/acs.langmuir.0c03658","article-title":"pH-sensitive W\/O Pickering high internal phase emulsions and W\/O\/W high internal water-phase double emulsions with tailored microstructures costabilized by lecithin and silica inorganic particles","volume":"37","author":"Guan","year":"2021","journal-title":"Langmuir"},{"issue":"1","key":"10.1016\/j.jcis.2025.138790_bb0120","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0021-9797(68)90272-5","article-title":"Controlled growth of monodisperse silica spheres in the micron size range","volume":"26","author":"St\u00f6ber","year":"1968","journal-title":"J. Colloid Interface Sci."},{"issue":"36","key":"10.1016\/j.jcis.2025.138790_bb0125","doi-asserted-by":"crossref","first-page":"11662","DOI":"10.1002\/anie.201805968","article-title":"All-silica submicrometer colloidosomes for cargo protection and tunable release","volume":"57","author":"Jiang","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jcis.2025.138790_bb0130","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jcis.2016.10.031","article-title":"Hydrophilic and hydrophobic modifications of colloidal silica particles for Pickering emulsions","volume":"487","author":"Bjorkegren","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2025.138790_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113053","article-title":"Silica nanoparticles: biomedical applications and toxicity","volume":"151","author":"Huang","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"31","key":"10.1016\/j.jcis.2025.138790_bb0140","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1039\/C4TB00510D","article-title":"Bioinspired silica as drug delivery systems and their biocompatibility","volume":"2","author":"Steven","year":"2014","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.jcis.2025.138790_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201902634","article-title":"Mesoporous silica nanoparticles for drug delivery","volume":"30","author":"Manzano","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jcis.2025.138790_bb0150","article-title":"Mesoporous silica nanoparticles: synthesis and multifaceted functionalization for controlled drug delivery","volume":"81","author":"Gupta","year":"2023","journal-title":"J. Drug Deliv. Sci. Techol."},{"issue":"13","key":"10.1016\/j.jcis.2025.138790_bb0155","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1039\/D1CS00659B","article-title":"Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?","volume":"51","author":"Vallet-Reg\u00ed","year":"2022","journal-title":"Chem. Soc. Rev."},{"issue":"6","key":"10.1016\/j.jcis.2025.138790_bb0160","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1021\/la991081j","article-title":"Catastrophic phase inversion of water-in-oil emulsions stabilized by hydrophobic silica","volume":"16","author":"Binks","year":"2000","journal-title":"Langmuir"},{"issue":"17","key":"10.1016\/j.jcis.2025.138790_bb0165","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1021\/la034264l","article-title":"Pickering emulsions: interfacial tension, colloidal layer morphology, and trapped-particle motion","volume":"19","author":"Vignati","year":"2003","journal-title":"Langmuir"},{"key":"10.1016\/j.jcis.2025.138790_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115906","article-title":"Investigating the effects of freezing temperature and oil content on the physiochemical characteristics and stability of oil-in-water emulsions under isochoric freezing conditions","volume":"204","author":"Atci","year":"2025","journal-title":"Food Res. Int."},{"issue":"1","key":"10.1016\/j.jcis.2025.138790_bb0175","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.foodhyd.2007.04.013","article-title":"Factors affecting the freeze\u2013thaw stability of emulsions","volume":"22","author":"Ghosh","year":"2008","journal-title":"Food Hydrocoll."},{"issue":"3","key":"10.1016\/j.jcis.2025.138790_bb0180","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41590-020-00850-9","article-title":"IL-2 regulates tumor-reactive CD8(+) T cell exhaustion by activating the aryl hydrocarbon receptor","volume":"22","author":"Liu","year":"2021","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.jcis.2025.138790_bb0185","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/sj.embor.7401099","article-title":"Interleukin 2: from immunostimulation to immunoregulation and back again","volume":"8","author":"Bachmann","year":"2007","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jcis.2025.138790_bb0190","doi-asserted-by":"crossref","first-page":"17007","DOI":"10.1038\/celldisc.2017.7","article-title":"Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine","volume":"3","author":"Liu","year":"2017","journal-title":"Cell Discov."},{"issue":"1","key":"10.1016\/j.jcis.2025.138790_bb0195","doi-asserted-by":"crossref","first-page":"13990","DOI":"10.1038\/s41598-018-32033-w","article-title":"Lipid-coated mesoporous silica nanoparticles for the delivery of the ML336 antiviral to inhibit encephalitic alphavirus infection","volume":"8","author":"LaBauve","year":"2018","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.jcis.2025.138790_bb0200","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1039\/c1cs15246g","article-title":"Mesoporous silica nanoparticles in biomedical applications","volume":"41","author":"Li","year":"2012","journal-title":"Chem. Soc. Rev."},{"issue":"9","key":"10.1016\/j.jcis.2025.138790_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/admi.201601103","article-title":"Effects of pore size and tethering on the diffusivity of lipids confined in mesoporous silica","volume":"4","author":"Schlipf","year":"2017","journal-title":"Adv. Mater. Interfaces"},{"issue":"31","key":"10.1016\/j.jcis.2025.138790_bb0210","doi-asserted-by":"crossref","first-page":"17450","DOI":"10.1021\/acsami.5b04992","article-title":"Ultradispersed palladium nanoparticles in three-dimensional dendritic mesoporous silica nanospheres: toward active and stable heterogeneous catalysts","volume":"7","author":"Shen","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979725021812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979725021812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:34:58Z","timestamp":1772814898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979725021812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":42,"alternative-id":["S0021979725021812"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2025.138790","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering silica-stabilized Pickering emulsions as versatile protein carriers","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2025.138790","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"138790"}}