{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:49:01Z","timestamp":1793296141291,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016106","name":"Science and Technology Bureau of Zhenjiang","doi-asserted-by":"publisher","award":["JC2025039"],"award-info":[{"award-number":["JC2025039"]}],"id":[{"id":"10.13039\/501100016106","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013094","name":"Science and Technology Planning Social Development Project of Zhenjiang City","doi-asserted-by":"publisher","award":["SH2025034"],"award-info":[{"award-number":["SH2025034"]}],"id":[{"id":"10.13039\/501100013094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jcis.2026.141264","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:41:20Z","timestamp":1785825680000},"page":"141264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P3","title":["A brain-targeted biomimetic iron-porphyrin covalent organic framework nanoplatform for Alzheimer's disease: synergistic intervention via antioxidant, A\u03b2-regulating and immunomodulatory effects"],"prefix":"10.1016","volume":"724","author":[{"given":"Yujiao","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liran","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jcis.2026.141264_bb0005","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jalz.2015.02.003","article-title":"2015 Alzheimer\u2019s disease facts and figures","volume":"11","author":"Association A S","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jcis.2026.141264_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102309","article-title":"Mechanistic insights and emerging therapeutic stratagems for Alzheimer\u2019s disease","volume":"97","author":"Rajendran","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jcis.2026.141264_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2023.104324","article-title":"MoS2 quantum dots based on lipid drug delivery system for combined therapy against Alzheimer\u2019s disease","volume":"82","author":"Qi","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"2","key":"10.1016\/j.jcis.2026.141264_bb0020","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/procel\/pwae026","article-title":"Alzheimer\u2019s disease: insights into pathology, molecular mechanisms, and therapy","volume":"16","author":"Zheng","year":"2025","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.jcis.2026.141264_bb0025","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-025-00825-0","article-title":"Decoding microglial immunometabolism: a new frontier in Alzheimer\u2019s disease research","volume":"20","author":"Jung","year":"2025","journal-title":"Mol. Neurodegener."},{"issue":"7","key":"10.1016\/j.jcis.2026.141264_bb0030","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14856","article-title":"The neuroinflammatory role of microglia in Alzheimer\u2019s disease and their associated therapeutic targets","volume":"30","author":"Amelimojarad","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.jcis.2026.141264_bb0035","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3390\/ijms24010884","article-title":"Microglial activation and priming in Alzheimer\u2019s disease: state of the art and future perspectives","volume":"24","author":"Bivona","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jcis.2026.141264_bb0040","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12974-022-02613-9","article-title":"Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer\u2019s disease","volume":"19","author":"Li","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.jcis.2026.141264_bb0045","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S1474-4422(25)00024-9","article-title":"Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer\u2019s disease: an open-label extension of the phase 2\/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-Tu trial","volume":"24","author":"Bateman","year":"2025","journal-title":"Lancet Neurol."},{"issue":"10510","key":"10.1016\/j.jcis.2026.141264_bb0050","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/S0140-6736(25)01329-7","article-title":"Treatment for Alzheimer\u2019s disease","volume":"406","author":"Fox","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.jcis.2026.141264_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.125112","article-title":"Biofilm-modified Prussian blue improves memory function in late-stage Alzheimer\u2019s disease mice with triple therapy","volume":"670","author":"Li","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"19","key":"10.1016\/j.jcis.2026.141264_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202500498","article-title":"Biomaterials in Alzheimer\u2019s disease: an anti\u2010neuroinflammatory perspective","volume":"14","author":"Huang","year":"2025","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.jcis.2026.141264_bb0065","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1186\/s12951-025-03709-z","article-title":"Photothermal nano-agents: an innovative trident weapon for accurate and effective treatment of alzheimer\u2019s disease","volume":"23","author":"Chen","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jcis.2026.141264_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.138083","article-title":"Near-infrared light-triggered methylene blue\/berberine co-loaded polydopamine nanoparticles modified with sialic acid for Alzheimer\u2019s disease therapy","volume":"698","author":"Lv","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2026.141264_bb0075","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jconrel.2024.09.009","article-title":"Biofilm-camouflaged Prussian blue synergistic mitochondrial mass enhancement for Alzheimer\u2019s disease based on Cu2+ chelation and photothermal therapy","volume":"375","author":"Li","year":"2024","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.jcis.2026.141264_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202002090","article-title":"Covalent organic frameworks for biomedical applications","volume":"10","author":"Esrafili","year":"2021","journal-title":"Adv. Healthc. Mater."},{"issue":"5","key":"10.1016\/j.jcis.2026.141264_bb0085","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1021\/acs.accounts.4c00774","article-title":"Covalent metal\u2013organic frameworks: fusion of covalent organic frameworks and metal\u2013organic frameworks","volume":"58","author":"Wei","year":"2025","journal-title":"Acc. Chem. Res."},{"issue":"4","key":"10.1016\/j.jcis.2026.141264_bb0090","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1021\/acsami.2c19839","article-title":"Imine-linked covalent organic framework modulates oxidative stress in Alzheimer\u2019s disease","volume":"15","author":"Ren","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"12","key":"10.1016\/j.jcis.2026.141264_bb0095","doi-asserted-by":"crossref","first-page":"14583","DOI":"10.1021\/acsami.4c00122","article-title":"Fe-porphyrin cross-linked hydrogel for reactive oxygen species scavenging and oxygen generation in diabetic wounds","volume":"16","author":"Kim","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"20","key":"10.1016\/j.jcis.2026.141264_bb0100","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1039\/D2SC00253A","article-title":"Phosphorylation of covalent organic framework nanospheres for inhibition of amyloid-\u03b2 peptide fibrillation","volume":"13","author":"Yao","year":"2022","journal-title":"Chem. Sci."},{"issue":"30","key":"10.1016\/j.jcis.2026.141264_bb0105","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202502795","article-title":"Spatiotemporal targeted delivery of biomimetic bacterial outer membrane nanoparticles for enhanced spinal cord injury repair","volume":"37","author":"Li","year":"2025","journal-title":"Adv. Mater."},{"issue":"30","key":"10.1016\/j.jcis.2026.141264_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301592","article-title":"Neuroprotective effects of microglial membrane\u2010derived biomimetic particles for spinal cord injury","volume":"12","author":"Wang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jcis.2026.141264_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.161251","article-title":"Microglial membrane-coated nanoparticles for ACSL4-SIRNA delivery in Parkinson\u2019s disease","volume":"509","author":"Lu","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"38","key":"10.1016\/j.jcis.2026.141264_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202403473","article-title":"Nanomaterials that aid in the diagnosis and treatment of Alzheimer\u2019s disease, resolving blood\u2013brain barrier crossing ability","volume":"11","author":"Song","year":"2024","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.jcis.2026.141264_bb0125","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1021\/acsnano.4c14675","article-title":"Engineered extracellular vesicles modified by Angiopep-2 peptide promote targeted repair of spinal cord injury and brain inflammation","volume":"19","author":"Kong","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcis.2026.141264_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.163340","article-title":"TGN peptide and erythrocyte membrane dual-modified selenium-doped carbon quantum dots for multifaceted treatment of Alzheimer\u2019s disease","volume":"514","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"10","key":"10.1016\/j.jcis.2026.141264_bb0135","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/s41551-025-01392-x","article-title":"Multiplex imaging of amyloid-\u03b2 plaques dynamics in living brains with quinoline-malononitrile-based probes","volume":"9","author":"Dai","year":"2025","journal-title":"Nat. Biomed. Eng."},{"issue":"6","key":"10.1016\/j.jcis.2026.141264_bb0140","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1016\/j.apsb.2025.02.035","article-title":"Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged \u03b2-amyloid nanoscavenger for Alzheimer\u2019s disease therapy","volume":"15","author":"Xu","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.jcis.2026.141264_bb0145","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1038\/s41380-025-02901-9","article-title":"Synaptic vulnerability to amyloid-\u03b2 and tau pathologies differentially disrupts emotional and memory neural circuits","volume":"30","author":"Capilla-L\u00f3pez","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jcis.2026.141264_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121360","article-title":"Precise gene delivery systems with detachable albumin shell remodeling dysfunctional microglia by TREM2 for treatment of Alzheimer\u2019s disease","volume":"281","author":"Wang","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcis.2026.141264_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102838","article-title":"The evolution of Alzheimer\u2019s disease: From mitochondria to microglia","author":"Yang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jcis.2026.141264_bb0160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jmst.2025.04.081","article-title":"Multi-target nanocomposites for Alzheimer\u2019s treatment via microenvironment modulation and \u03b2-amyloid plaque clearance","volume":"248","author":"Hou","year":"2026","journal-title":"J. Mater. Sci. Technol."},{"issue":"2","key":"10.1016\/j.jcis.2026.141264_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202412184","article-title":"Microglial Lyzl4 facilitates \u03b2\u2010amyloid clearance in Alzheimer\u2019s disease","volume":"12","author":"Pan","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jcis.2026.141264_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.142955","article-title":"Engineered urinary-derived extracellular vesicles loaded nanoenzymes as Trojan horses to regulate the inflammatory microenvironment for treatment of Alzheimer\u2019s disease","volume":"465","author":"Bai","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jcis.2026.141264_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143882","article-title":"A novel AD theranostic platform with NIR-Li laser controlled drug release and real-time monitoring of therapeutic outcomes","volume":"469","author":"Qiu","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jcis.2026.141264_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2026.214728","article-title":"In-situ engineering of a covalent organic framework-based biomimetic nanoplatform for multi-target therapy of Alzheimer\u2019s disease","volume":"182","author":"Yan","year":"2026","journal-title":"Biomater. Adv."},{"issue":"5","key":"10.1016\/j.jcis.2026.141264_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70293","article-title":"Trailblazer-ALZ 4: a phase 3 trial comparing donanemab with aducanumab on amyloid plaque clearance in early, symptomatic Alzheimer\u2019s disease","volume":"21","author":"Salloway","year":"2025","journal-title":"Alzheimer\u2019s Dement."},{"issue":"5","key":"10.1016\/j.jcis.2026.141264_bb0190","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1002\/fsn3.4045","article-title":"A mixture of extracts from natural ingredients reduces the neurotoxic polarization of microglia via modulating NF\u2010\u03baB\/NF\u2010E2\u2010related factor 2 activation","volume":"12","author":"Gui","year":"2024","journal-title":"Food Sci. Nutr."}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979726014414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021979726014414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:03:24Z","timestamp":1787850204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021979726014414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":38,"alternative-id":["S0021979726014414"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2026.141264","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A brain-targeted biomimetic iron-porphyrin covalent organic framework nanoplatform for Alzheimer's disease: synergistic intervention via antioxidant, A\u03b2-regulating and immunomodulatory effects","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2026.141264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"141264"}}