{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:32:53Z","timestamp":1793338373343,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22307012"],"award-info":[{"award-number":["22307012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["KJZD-K202501108"],"award-info":[{"award-number":["KJZD-K202501108"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["KJQN202501138"],"award-info":[{"award-number":["KJQN202501138"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012458","name":"Chongqing Basic Science and Advanced Technology Research Program","doi-asserted-by":"publisher","award":["2024CCZ096"],"award-info":[{"award-number":["2024CCZ096"]}],"id":[{"id":"10.13039\/501100012458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Colloid and Interface Science"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jcis.2026.141315","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T05:54:19Z","timestamp":1785995659000},"page":"141315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cascade-responsive biomimetic nanoparticles remodel tumor metabolism and potentiate ferroptosis for synergistic therapy of aggressive breast cancer"],"prefix":"10.1016","volume":"725","author":[{"given":"Nianting","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyuan","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcis.2026.141315_bb0005","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jcis.2026.141315_bb0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","article-title":"Current and future burden of breast cancer: global statistics for 2020 and 2040","volume":"66","author":"Arnold","year":"2022","journal-title":"Breast"},{"key":"10.1016\/j.jcis.2026.141315_bb0015","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jama.2018.19323","article-title":"Breast cancer treatment: a review","volume":"321","author":"Waks","year":"2019","journal-title":"Jama"},{"key":"10.1016\/j.jcis.2026.141315_bb0020","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.annonc.2021.09.019","article-title":"ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer","volume":"32","author":"Gennari","year":"2021","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.jcis.2026.141315_bb0025","first-page":"477","article-title":"Breast cancer statistics 2024","volume":"74","author":"Giaquinto","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jcis.2026.141315_bb0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jcis.2026.141315_bb0035","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1002\/med.21971","article-title":"(Nano)platforms in breast cancer therapy: drug\/gene delivery, advanced nanocarriers and immunotherapy","volume":"43","author":"Ashrafizadeh","year":"2023","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jcis.2026.141315_bb0040","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic reprogramming and cancer progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jcis.2026.141315_bb0045","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.jcis.2026.141315_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2022.102640","article-title":"Nanoparticles: from synthesis to applications and beyond","volume":"303","author":"Selmani","year":"2022","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.jcis.2026.141315_bb0055","doi-asserted-by":"crossref","DOI":"10.1126\/science.1230444","article-title":"The chemistry and applications of metal-organic frameworks","volume":"341","author":"Furukawa","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jcis.2026.141315_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202500724","article-title":"Self-disassembling macroporous metal-organic framework-based micromotors with magnetically controlled motion for sequential drug release","volume":"9","author":"Bujalance Fern\u00e1ndez","year":"2025","journal-title":"Small Methods"},{"key":"10.1016\/j.jcis.2026.141315_bb0065","doi-asserted-by":"crossref","first-page":"21939","DOI":"10.1038\/s41598-025-07752-6","article-title":"Antibacterial, self-healing, and pH-responsive PVA\/ZIF-8@tannic acid nanocomposite hydrogel for sustained delivery of garlic extract","volume":"15","author":"Behjat","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jcis.2026.141315_bb0070","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41568-025-00847-2","article-title":"Advancing engineering design strategies for targeted cancer nanomedicine","volume":"25","author":"Gomerdinger","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jcis.2026.141315_bb0075","doi-asserted-by":"crossref","first-page":"12620","DOI":"10.1039\/D5NR00794A","article-title":"Metal-organic frameworks: a biomimetic odyssey in cancer theranostics","volume":"17","author":"Soman","year":"2025","journal-title":"Nanoscale"},{"key":"10.1016\/j.jcis.2026.141315_bb0080","doi-asserted-by":"crossref","first-page":"8058","DOI":"10.1039\/D5NA00677E","article-title":"Hemoglobin-loaded ZIF-8 nanoparticles functionalized with human serum albumin as stealth, stable, and biocompatible oxygen carriers","volume":"7","author":"Douka","year":"2025","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.jcis.2026.141315_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179292","article-title":"ZIF-8 as a pH-responsive nanoplatform for 5-fluorouracil delivery in the chemotherapy of oral squamous cell carcinoma","volume":"25","author":"Hao","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jcis.2026.141315_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41568-025-00879-8","article-title":"Exploiting metabolic cell death for cancer therapy","volume":"26","author":"Mao","year":"2026","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jcis.2026.141315_bb0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jcis.2026.141315_bb0100","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.1021\/acsnano.2c05532","article-title":"Growth of ZIF-8 nanoparticles in situ on graphene oxide nanosheets: a multifunctional nanoplatform for combined ion-interference and photothermal therapy","volume":"16","author":"Lv","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcis.2026.141315_bb0105","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jcis.2026.141315_bb0110","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jcis.2026.141315_bb0115","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1158\/0008-5472.CAN-20-3477","article-title":"Ferroptosis inducers are a novel therapeutic approach for advanced pro state cancer","volume":"81","author":"Ghoochani","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.jcis.2026.141315_bb0120","doi-asserted-by":"crossref","first-page":"11492","DOI":"10.1021\/acsnano.3c01369","article-title":"Tumor-generated reactive oxygen species storm for high-performance Fer roptosis therapy","volume":"17","author":"Huang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcis.2026.141315_bb0125","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41418-019-0352-3","article-title":"Artemisinin compounds sensitize cancer cells to ferroptosis by regulat ing iron homeostasis","volume":"27","author":"Chen","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jcis.2026.141315_bb0130","article-title":"Chain architecture-engineered artesunate nanoassemblies target LONP1 t o induce oxidative damage for enhanced anti-tumor therapy","volume":"37","author":"Wang","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jcis.2026.141315_bb0135","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1186\/s12951-025-03569-7","article-title":"A GSH-consuming polymeric nanoparticles drives ferroptosis amplification and combines chemotherapy to amplify breast cancer treatment","volume":"23","author":"Pei","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jcis.2026.141315_bb0140","article-title":"A tandem-unlocked cascade nanoreactor for high-contrast magnetic resonance imaging-guided enhanced ferroptosis-chemo synergistic therapy","volume":"32","author":"Liu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.jcis.2026.141315_bb0145","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41568-024-00714-6","article-title":"Towards targeting the breast cancer immune microenvironment","volume":"24","author":"Harris","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jcis.2026.141315_bb0150","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1186\/s12951-025-03726-y","article-title":"Fe-doped phase-transition nanodroplets for synergistic photothermal and starvation-enhanced ferroptosis in cancer therapy","volume":"23","author":"Tian","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jcis.2026.141315_bb0155","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1039\/D4BM01095G","article-title":"Enhanced Fe(II)-artemisinin-mediated chemodynamic therapy with efficient Fe(III)\/Fe(II) conversion circulation for cancer treatment","volume":"12","author":"Xu","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jcis.2026.141315_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.137479","article-title":"FeS embedded bioreactor collaborate with artesunate for cascade-catalytic tumor ferroptosis","volume":"692","author":"Wang","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jcis.2026.141315_bb0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","article-title":"Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles","volume":"307","author":"Owens","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jcis.2026.141315_bb0170","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.coi.2015.06.013","article-title":"Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific \u2018Marker of Self\u2019 CD47, and target physical properties","volume":"35","author":"Sosale","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jcis.2026.141315_bb0175","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1039\/D4NH00457D","article-title":"On the design of cell membrane-coated nanoparticles to treat inflammatory conditions","volume":"10","author":"Marinho","year":"2024","journal-title":"Nanoscale Horiz."},{"key":"10.1016\/j.jcis.2026.141315_bb0180","doi-asserted-by":"crossref","first-page":"22298","DOI":"10.1021\/acsnano.4c06471","article-title":"Dual-action protein-siRNA conjugates for targeted disruption of CD47-signal regulatory protein \u03b1 axis in cancer therapy","volume":"18","author":"Lee","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcis.2026.141315_bb0185","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1021\/acsnano.2c08240","article-title":"Nanoparticle-mediated CD47-SIRP\u03b1 blockade and calreticulin exposure for improved Cancer chemo-immunotherapy","volume":"17","author":"Luo","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcis.2026.141315_bb0190","doi-asserted-by":"crossref","first-page":"10542","DOI":"10.1021\/acsnano.3c12615","article-title":"Zinc-Iron bimetallic peroxides modulate the tumor stromal microenvironment and enhance cell immunogenicity for enhanced breast Cancer immunotherapy therapy","volume":"18","author":"Lu","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcis.2026.141315_bb0195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41419-020-2384-5","article-title":"\"Iron free\" zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jcis.2026.141315_bb0200","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1021\/acsabm.2c00262","article-title":"Glucose-responsive ZIF-8 nanocomposites for targeted cancer therapy through combining starvation with stimulus-responsive nitric oxide synergistic treatment","volume":"5","author":"Liu","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.jcis.2026.141315_bb0205","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.apsb.2019.01.011","article-title":"Red blood cell membrane-camouflaged nanoparticles: a novel drug delive ry system for antitumor application","volume":"9","author":"Xia","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jcis.2026.141315_bb0210","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s11051-012-0920-7","article-title":"Colloidal stability of polymeric nanoparticles in biological fluids","volume":"14","author":"Lazzari","year":"2012","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.jcis.2026.141315_bb0215","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41586-021-03442-1","article-title":"Cell-programmed nutrient partitioning in the tumour microenvironment","volume":"593","author":"Reinfeld","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jcis.2026.141315_bb0220","doi-asserted-by":"crossref","first-page":"18932","DOI":"10.1021\/acsanm.4c02730","article-title":"Glucose oxidase-based pH\/ROS dual-sensitive nanoparticles for tumor starvation and oxidative therapy","volume":"7","author":"Chen","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.jcis.2026.141315_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2020.124990","article-title":"Construction and characterization of magnetic cascade metal-organic fr amework\/enzyme hybrid nanoreactors with enhanced effect on killing can cer cells","volume":"601","author":"Li","year":"2020","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."}],"container-title":["Journal of Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002197972601492X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002197972601492X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:15:05Z","timestamp":1793337305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002197972601492X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":45,"alternative-id":["S002197972601492X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcis.2026.141315","relation":{},"ISSN":["0021-9797"],"issn-type":[{"value":"0021-9797","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cascade-responsive biomimetic nanoparticles remodel tumor metabolism and potentiate ferroptosis for synergistic therapy of aggressive breast cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcis.2026.141315","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"141315"}}