{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:15:43Z","timestamp":1788498943182,"version":"build-2803163510"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JCIS Open"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jciso.2026.100201","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:48:10Z","timestamp":1787701690000},"page":"100201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cetuximab-loaded self-assembled polymeric nanoparticles for the integrin-targeted therapy of glioblastoma"],"prefix":"10.1016","volume":"23","author":[{"given":"Dhiraj","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Beloqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Sosnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jciso.2026.100201_bib1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jciso.2026.100201_bib2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.jciso.2026.100201_bib3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/jpm11040258","article-title":"Diagnosis and management of glioblastoma: a comprehensive perspective","volume":"11","author":"Gilard","year":"2021","journal-title":"J. Personalized Med."},{"key":"10.1016\/j.jciso.2026.100201_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijrobp.2011.06.1992","article-title":"Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma","volume":"83","author":"Minniti","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.jciso.2026.100201_bib5","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S1470-2045(12)70265-6","article-title":"Nordic clinical brain tumour study group (NCBTSG), temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the nordic randomised, phase 3 trial","volume":"13","author":"Malmstr\u00f6m","year":"2012","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jciso.2026.100201_bib6","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12885-019-5413-y","article-title":"Phase I\/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable or partially resectable glioblastoma: OLA-TMZ-RTE-01 trial protocol","volume":"19","author":"Lesueur","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jciso.2026.100201_bib7","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa043331","article-title":"MGMT gene silencing and benefit from temozolomide in glioblastoma","volume":"352","author":"Hegi","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jciso.2026.100201_bib8","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.15252\/emmm.201302627","article-title":"Emerging treatment strategies for glioblastoma multiforme","volume":"6","author":"Carlsson","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jciso.2026.100201_bib9","first-page":"299","article-title":"Management of glioblastoma: state of the art and future directions","volume":"70","author":"Tan","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jciso.2026.100201_bib10","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.1038\/s41467-023-41694-9","article-title":"Breaking barriers for glioblastoma with a path to enhanced drug delivery","volume":"14","author":"Noorani","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jciso.2026.100201_bib11","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.3390\/brainsci13111536","article-title":"Advances in glioblastoma therapy: an update on current approaches","volume":"13","author":"Angom","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.jciso.2026.100201_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41571-020-00447-z","article-title":"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","volume":"18","author":"Weller","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jciso.2026.100201_bib13","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/s41388-017-0045-7","article-title":"Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies","volume":"37","author":"An","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.jciso.2026.100201_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2022.105192","article-title":"Targeting angiogenesis in gliomas: potential role of phytochemicals","volume":"96","author":"Sanati","year":"2022","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.jciso.2026.100201_bib15","article-title":"The promise of DNA damage response inhibitors for the treatment of glioblastoma, neuro-oncol","volume":"3","author":"Majd","year":"2021","journal-title":"Adv"},{"key":"10.1016\/j.jciso.2026.100201_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s43440-021-00349-6","article-title":"How do phosphodiesterase-5 inhibitors affect cancer? A focus on glioblastoma multiforme","volume":"74","author":"Sanati","year":"2022","journal-title":"Pharmacol. Rep. PR"},{"key":"10.1016\/j.jciso.2026.100201_bib17","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s10787-025-01666-5","article-title":"A novel approach to glioblastoma multiforme treatment using modulation of key pathways by naturally occurring small molecules","volume":"33","author":"Afshari","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jciso.2026.100201_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","article-title":"Defining the role of mTOR in cancer","volume":"12","author":"Guertin","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jciso.2026.100201_bib19","first-page":"279","article-title":"Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance","volume":"347","author":"Fan","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jciso.2026.100201_bib20","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1073\/pnas.83.11.3825","article-title":"Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation","volume":"83","author":"Sunada","year":"1986","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jciso.2026.100201_bib21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4161\/cbt.24342","article-title":"Targeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab","volume":"14","author":"Iida","year":"2013","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.jciso.2026.100201_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/ma16165526","article-title":"Cetuximab-conjugated magnetic poly(Lactic-co-glycolic acid) nanoparticles for dual-targeted delivery of Irinotecan in glioma treatment","volume":"16","author":"Dash","year":"2023","journal-title":"Materials"},{"key":"10.1016\/j.jciso.2026.100201_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood-brain barrier: structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jciso.2026.100201_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119732","article-title":"Microphysiological systems for recapitulating physiology and function of blood-brain barrier","volume":"232","author":"Seo","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jciso.2026.100201_bib24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2174\/2405461504666190510121911","article-title":"Lipid based nanoparticles: current strategies for brain tumor targeting","volume":"4","author":"Mohanta","year":"2019","journal-title":"Curr. Nanomater."},{"key":"10.1016\/j.jciso.2026.100201_bib25","article-title":"Strategies facilitating the permeation of nanoparticles through blood-brain barrier: an insight towards the development of brain-targeted drug delivery system","volume":"86","author":"Mishra","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jciso.2026.100201_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.actbio.2025.02.065","article-title":"Polymer-based nanocarriers to transport therapeutic biomacromolecules across the blood-brain barrier","volume":"196","author":"Romero-Ben","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jciso.2026.100201_bib27","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41573-021-00139-y","article-title":"Strategies for delivering therapeutics across the blood-brain barrier","volume":"20","author":"Terstappen","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jciso.2026.100201_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.addr.2019.11.009","article-title":"The blood-brain barrier: physiology and strategies for drug delivery","volume":"165\u2013166","author":"Pandit","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jciso.2026.100201_bib29","article-title":"Nanoparticles mediated the diagnosis and therapy of glioblastoma: bypass or cross the blood-brain barrier","volume":"19","author":"Song","year":"2023","journal-title":"Small Weinh. Bergstr. Ger."},{"key":"10.1016\/j.jciso.2026.100201_bib30","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15571","article-title":"Functionalized nanoparticles crossing the brain\u2013blood barrier to target glioma cells","volume":"11","author":"Wu","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.jciso.2026.100201_bib31","article-title":"RGD-based self-assembling nanodrugs for improved tumor therapy","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jciso.2026.100201_bib32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12943-023-01865-0","article-title":"Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation","volume":"22","author":"Chehelgerdi","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jciso.2026.100201_bib33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jciso.2026.100201_bib34","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1021\/acsnano.3c10674","article-title":"Functionalized nanomaterials capable of crossing the blood\u2013brain barrier","volume":"18","author":"Zha","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jciso.2026.100201_bib35","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1039\/C8CS00805A","article-title":"Emerging blood\u2013brain- barrier-crossing nanotechnology for brain cancer theranostics","volume":"48","author":"Tang","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jciso.2026.100201_bib36","first-page":"1802","article-title":"Nanoparticle diagnostics and theranostics in the clinic","volume":"63","author":"Pallares","year":"2022","journal-title":"J. Nucl. Med. Off. Publ. Soc. Nucl. Med."},{"key":"10.1016\/j.jciso.2026.100201_bib37","doi-asserted-by":"crossref","first-page":"13925","DOI":"10.1021\/acsami.5b02708","article-title":"All-aqueous electrosprayed emulsion for templated fabrication of cytocompatible microcapsules","volume":"7","author":"Song","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jciso.2026.100201_bib38","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1039\/C7LC00696A","article-title":"Microfluidic generation of aqueous two-phase-system (ATPS) droplets by oil-droplet choppers","volume":"17","author":"Zhou","year":"2017","journal-title":"Lab Chip"},{"key":"10.1016\/j.jciso.2026.100201_bib39","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1039\/D5LC00194C","article-title":"Advances in nanoparticle synthesis assisted by microfluidics","volume":"25","author":"Mubashar Saeed","year":"2025","journal-title":"Lab Chip"},{"key":"10.1016\/j.jciso.2026.100201_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116126","article-title":"Chitosan-based colloidal polyelectrolyte complexes for drug delivery: a review","volume":"238","author":"Wu","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jciso.2026.100201_bib41","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.carbpol.2017.05.051","article-title":"Ternary polysaccharide complexes: colloidal drug delivery systems stabilized in physiological media","volume":"172","author":"Wu","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jciso.2026.100201_bib42","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4103\/0250-474X.58165","article-title":"Polyelectrolyte complexes: a review of their applicability in drug delivery technology","volume":"71","author":"Lankalapalli","year":"2009","journal-title":"Indian J. Pharmaceut. Sci."},{"key":"10.1016\/j.jciso.2026.100201_bib43","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1007\/s12221-025-00975-4","article-title":"Polyelectrolyte complex coacervates: structural insights, rheological perspectives, and industrial applications","volume":"26","author":"Jo","year":"2025","journal-title":"Fibers Polym."},{"key":"10.1016\/j.jciso.2026.100201_bib44","doi-asserted-by":"crossref","first-page":"7679","DOI":"10.1021\/acs.chemmater.0c01696","article-title":"Amphiphilic polymeric nanoparticles modified with a retro-enantio peptide shuttle target the brain of mice","volume":"32","author":"Bukchin","year":"2020","journal-title":"Chem. Mater."},{"key":"10.1016\/j.jciso.2026.100201_bib45","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1021\/acsanm.0c02888","article-title":"Amphiphilic polymeric nanoparticles modified with a protease-resistant peptide shuttle for the delivery of SN-38 in diffuse intrinsic pontine glioma","volume":"4","author":"Bukchin","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.jciso.2026.100201_bib46","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jcis.2024.11.132","article-title":"Doubly self-assembled dermatan sulfate\/chitosan nanoparticles for targeted siRNA delivery in cancer therapy","volume":"680","author":"Sader","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jciso.2026.100201_bib47","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1021\/la103800h","article-title":"Effect of poly(ethylene glycol) (PEG) spacers on the conformational properties of small peptides: a molecular dynamics study","volume":"27","author":"Xue","year":"2011","journal-title":"Langmuir"},{"key":"10.1016\/j.jciso.2026.100201_bib48","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/pharmaceutics13040529","article-title":"Excipient-free pure drug nanoparticles fabricated by microfluidic hydrodynamic focusing","volume":"13","author":"Sverdlov Arzi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jciso.2026.100201_bib49","article-title":"How to determine entrapment efficiency in lipid and polymeric nanoparticles: a methodological guide","volume":"29","author":"Baltz","year":"2026","journal-title":"Open"},{"key":"10.1016\/j.jciso.2026.100201_bib50","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1208\/s12248-010-9185-1","article-title":"DDSolver: an Add-In program for modeling and comparison of drug dissolution profiles","volume":"12","author":"Zhang","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.jciso.2026.100201_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/nano12020186","article-title":"Applications of chitosan-alginate-based nanoparticles\u2014an up-to-date review","volume":"12","author":"Niculescu","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jciso.2026.100201_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202201853","article-title":"Antibiotic-loaded amphiphilic chitosan nanoparticles target macrophages and kill an intracellular pathogen","volume":"18","author":"Trousil","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.jciso.2026.100201_bib53","series-title":"Encycl. Anal. Chem.","first-page":"1","article-title":"Interpretation of infrared spectra: a practical and systematic approach","author":"Miller","year":"2025"},{"key":"10.1016\/j.jciso.2026.100201_bib54","author":"Mourdikoudis"},{"key":"10.1016\/j.jciso.2026.100201_bib55","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1039\/D3MH00717K","article-title":"Dynamic light scattering and transmission electron microscopy in drug delivery: a roadmap for correct characterization of nanoparticles and interpretation of results","volume":"10","author":"Filippov","year":"2023","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.jciso.2026.100201_bib56","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0928-0987(01)00095-1","article-title":"Modeling and comparison of dissolution profiles","volume":"13","author":"Costa","year":"2001","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.jciso.2026.100201_bib62","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jneumeth.2012.10.001","article-title":"Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier","volume":"212","author":"Daniels","year":"2013","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jciso.2026.100201_bib57","unstructured":"ISO 10993-5:2009, ISO (n.d.). https:\/\/www.iso.org\/standard\/36406.html (accessed April 16, 2026)."},{"key":"10.1016\/j.jciso.2026.100201_bib58","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jbm.820250209","article-title":"Human endothelial cell interactions with surface-coupled adhesion peptides on a nonadhesive glass substrate and two polymeric biomaterials","volume":"25","author":"Massia","year":"1991","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jciso.2026.100201_bib59","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1016\/S0142-9612(03)00343-0","article-title":"RGD modified polymers: biomaterials for stimulated cell adhesion and beyond","volume":"24","author":"Hersel","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jciso.2026.100201_bib60","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/309030a0","article-title":"Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule","volume":"309","author":"Pierschbacher","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.jciso.2026.100201_bib61","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/2045-8118-10-16","article-title":"The hCMEC\/D3 cell line as a model of the human blood brain barrier","volume":"10","author":"Weksler","year":"2013","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.jciso.2026.100201_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0289970","article-title":"Application of in vitro transcytosis models to brain targeted biologics","volume":"18","author":"Deng","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jciso.2026.100201_bib64","doi-asserted-by":"crossref","first-page":"17745","DOI":"10.1021\/acsami.7b03682","article-title":"Stapled RGD peptide enables glioma-targeted drug delivery by overcoming multiple barriers","volume":"9","author":"Ruan","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jciso.2026.100201_bib65","series-title":"Methods Enzymol.","first-page":"157","article-title":"Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles","year":"2012"},{"key":"10.1016\/j.jciso.2026.100201_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082777","article-title":"Cellular density effect on RGD ligand internalization in glioblastoma for MRI application","volume":"8","author":"Moncelet","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jciso.2026.100201_bib67","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3390\/vaccines10040499","article-title":"EGFR-based targeted therapy for colorectal cancer\u2014promises and challenges","volume":"10","author":"Janani","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.jciso.2026.100201_bib73","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3390\/pharmaceutics14051053","article-title":"Integrin-\u03b1v\u03b23 as a therapeutic target in glioblastoma: back to the future?","volume":"14","author":"Echavidre","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jciso.2026.100201_bib68","first-page":"1895","article-title":"EGF receptor-targeted nanocarriers for enhanced cancer treatment","volume":"7","author":"Master","year":"2012","journal-title":"Nanomedicine (N. Y., NY, U. S.)"},{"key":"10.1016\/j.jciso.2026.100201_bib69","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ijrobp.2007.03.002","article-title":"In vitro responsiveness of glioma cell lines to multimodality treatment with radiotherapy, temozolomide, and epidermal growth factor receptor inhibition with cetuximab","volume":"68","author":"Combs","year":"2007","journal-title":"Int. J. Radiat. Oncol."},{"key":"10.1016\/j.jciso.2026.100201_bib70","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ccr.2005.03.003","article-title":"Structural basis for inhibition of the epidermal growth factor receptor by cetuximab","volume":"7","author":"Li","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jciso.2026.100201_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71396-x","article-title":"Microfluidic-assisted preparation of RGD-decorated nanoparticles: exploring integrin-facilitated uptake in cancer cell lines","volume":"10","author":"Rios De La Rosa","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jciso.2026.100201_bib74","doi-asserted-by":"crossref","first-page":"14541","DOI":"10.1073\/pnas.1006507107","article-title":"Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis","volume":"107","author":"Bhattacharyya","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jciso.2026.100201_bib75","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.1038\/srep07490","article-title":"Enhanced cytotoxic activity of cetuximab in EGFR-positive lung cancer by conjugating with gold nanoparticles","volume":"4","author":"Qian","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jciso.2026.100201_bib76","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.3390\/pharmaceutics15051431","article-title":"Establishment and validation of a new Co-Culture for the evaluation of the permeability through the blood\u2013brain barrier in patients with glioblastoma","volume":"15","author":"S\u00e1nchez-Dengra","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jciso.2026.100201_bib77","article-title":"Quantitative analysis of nanoparticle transport through in vitro blood-brain barrier models","volume":"4","author":"Berg","year":"2016","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.jciso.2026.100201_bib78","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ijpharm.2015.05.027","article-title":"Influence of glioma cells on a new co-culture in vitro blood\u2013brain barrier model for characterization and validation of permeability","volume":"490","author":"Mendes","year":"2015","journal-title":"Int. J. Pharm."}],"container-title":["JCIS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666934X26000322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666934X26000322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:25:38Z","timestamp":1788495938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666934X26000322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":78,"alternative-id":["S2666934X26000322"],"URL":"https:\/\/doi.org\/10.1016\/j.jciso.2026.100201","relation":{},"ISSN":["2666-934X"],"issn-type":[{"value":"2666-934X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cetuximab-loaded self-assembled polymeric nanoparticles for the integrin-targeted therapy of glioblastoma","name":"articletitle","label":"Article Title"},{"value":"JCIS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jciso.2026.100201","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100201"}}