{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:06:38Z","timestamp":1791072398911,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008985","name":"Diab\u00e8te Qu\u00e9bec","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008985","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["canadianjournalofdiabetes.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Diabetes"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.jcjd.2015.01.291","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T23:25:11Z","timestamp":1428621911000},"page":"373-382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["In\u00a0Vitro Evaluation of Hypoglycemic Agents to Target Human Islet Amyloid Polypeptide: A Key Protein Involved in Amyloid Deposition and Beta-Cell Loss"],"prefix":"10.1016","volume":"39","author":[{"given":"Jessica S.","family":"Fortin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Benoit-Biancamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcjd.2015.01.291_bib1","unstructured":"www.diabetes.org. Accessed September 20th, 2014."},{"key":"10.1016\/j.jcjd.2015.01.291_bib2","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.2337\/dc12-0413","article-title":"Management of hyperglycemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)","volume":"35","author":"Inzucchi","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2015.01.291_bib3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.biocel.2006.09.007","article-title":"Apoptosis in the pathophysiology of diabetes mellitus","volume":"39","author":"Lee","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jcjd.2015.01.291_bib4","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.febslet.2013.01.017","article-title":"Mechanisms of islet amyloidosis toxicity in type 2 diabetes","volume":"587","author":"Abedini","year":"2013","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jcjd.2015.01.291_bib5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1152\/physrev.00042.2009","article-title":"Islet amyloid polypeptide, islet amyloid, and diabetes mellitus","volume":"91","author":"Westermark","year":"2011","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcjd.2015.01.291_bib6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0925-4439(01)00078-3","article-title":"Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology","volume":"1537","author":"Jaikaran","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcjd.2015.01.291_bib7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0303-7207(02)00266-6","article-title":"Role of islet amyloid in type\u00a02 diabetes mellitus: Consequence or cause?","volume":"197","author":"Hoppener","year":"2002","journal-title":"Molec Cell Endocrinol"},{"key":"10.1016\/j.jcjd.2015.01.291_bib8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.transproceed.2012.05.079","article-title":"Rosiglitazone treatment does not decrease amyloid deposition in transplanted islets from transgenic mice expressing human islet amyloid polypeptide","volume":"45","author":"Udayasankar","year":"2013","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jcjd.2015.01.291_bib9","doi-asserted-by":"crossref","first-page":"E475","DOI":"10.1152\/ajpendo.00025.2013","article-title":"One year of sitagliptin treatment protects against islet amyloid-associated beta-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice","volume":"305","author":"Aston-Mourney","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jcjd.2015.01.291_bib10","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.2337\/diabetes.54.7.2235","article-title":"Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide","volume":"54","author":"Hull","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jcjd.2015.01.291_bib11","doi-asserted-by":"crossref","first-page":"19279","DOI":"10.1073\/pnas.1305517110","article-title":"Islet amyloid polypeptide toxicity and membrane interactions","volume":"110","author":"Cao","year":"2013","journal-title":"Proc Nat Acad Sci U S A"},{"key":"10.1016\/j.jcjd.2015.01.291_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.febslet.2010.11.050","article-title":"Porcine islet amyloid polypeptide fragments are refractory to amyloid formation","volume":"585","author":"Zhang","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jcjd.2015.01.291_bib13","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0076-6879(04)83013-1","article-title":"Computation and analysis of protein circular dichroism spectra","volume":"383","author":"Sreerama","year":"2004","journal-title":"Meth Enzymol"},{"key":"10.1016\/j.jcjd.2015.01.291_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/ar000214l","article-title":"Rapid photochemical cross-linking: A new tool for studies of metastable, amyloidogenic protein assemblies","volume":"37","author":"Bitan","year":"2004","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.jcjd.2015.01.291_bib15","first-page":"175","article-title":"ASK1-P38 pathway is important for anoikis induced by microtubule-targeting aryl chloroethylureas","volume":"13","author":"Fortin","year":"2010","journal-title":"J\u00a0Pharm Pharmaceut Sci"},{"key":"10.1016\/j.jcjd.2015.01.291_bib16","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1139\/Y10-084","article-title":"Chloroethyl urea derivatives block tumour growth and thioredoxin-1 nuclear translocation","volume":"88","author":"Patenaude","year":"2010","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jcjd.2015.01.291_bib17","doi-asserted-by":"crossref","first-page":"19285","DOI":"10.1073\/pnas.1314481110","article-title":"Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient beta-sheet","volume":"110","author":"Buchanan","year":"2013","journal-title":"Proc Nat Acad Sci U S A"},{"key":"10.1016\/j.jcjd.2015.01.291_bib18","doi-asserted-by":"crossref","first-page":"13992","DOI":"10.1073\/pnas.0906471106","article-title":"Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons","volume":"106","author":"Guardado-Mendoza","year":"2009","journal-title":"Proc Nat Acad Sci U S A"},{"key":"10.1016\/j.jcjd.2015.01.291_bib19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2353\/ajpath.2010.090532","article-title":"Evidence for proteotoxicity in beta cells in type 2 diabetes: Toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway","volume":"176","author":"Gurlo","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcjd.2015.01.291_bib20","doi-asserted-by":"crossref","first-page":"13147","DOI":"10.1021\/jf201702h","article-title":"Coffee components inhibit amyloid formation of human islet amyloid polypeptide in\u00a0vitro: Possible link between coffee consumption and diabetes mellitus","volume":"59","author":"Cheng","year":"2011","journal-title":"J\u00a0Agricul Food Chem"},{"key":"10.1016\/j.jcjd.2015.01.291_bib21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3109\/13506129.2011.627956","article-title":"Ferret islet amyloid polypeptide (IAPP): Characterization of in\u00a0vitro and in\u00a0vivo amyloidogenicity","volume":"18","author":"Paulsson","year":"2011","journal-title":"Amyloid"},{"key":"10.1016\/j.jcjd.2015.01.291_bib22","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbagen.2009.02.013","article-title":"Amyloid inhibitors enhance survival of cultured human islets","volume":"1790","author":"Potter","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcjd.2015.01.291_bib23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbrc.2012.02.042","article-title":"Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide","volume":"419","author":"Cheng","year":"2012","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/j.jcjd.2015.01.291_bib24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3109\/13506129.2010.530008","article-title":"The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity","volume":"17","author":"Daval","year":"2010","journal-title":"Amyloid"},{"key":"10.1016\/j.jcjd.2015.01.291_bib25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/pro.2023","article-title":"Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers","volume":"21","author":"Noor","year":"2012","journal-title":"Protein Sci"},{"key":"10.1016\/j.jcjd.2015.01.291_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3109\/13506129.2012.762761","article-title":"IAPP aggregation and cellular toxicity are inhibited by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose","volume":"20","author":"Bruno","year":"2013","journal-title":"Amyloid"},{"key":"10.1016\/j.jcjd.2015.01.291_bib27","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1021\/bi2015162","article-title":"Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols","volume":"51","author":"Cao","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.jcjd.2015.01.291_bib28","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.bpj.2011.02.010","article-title":"Resveratrol inhibits the formation of multiple-layered beta-sheet oligomers of the human islet amyloid polypeptide segment 22-27","volume":"100","author":"Jiang","year":"2011","journal-title":"Biophys J"},{"key":"10.1016\/j.jcjd.2015.01.291_bib29","doi-asserted-by":"crossref","first-page":"e34647","DOI":"10.1371\/journal.pone.0034647","article-title":"Salvianolic acid B prevents bone loss in prednisone-treated rats through stimulation of osteogenesis and bone marrow angiogenesis","volume":"7","author":"Cui","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jcjd.2015.01.291_bib30","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.chembiol.2009.08.013","article-title":"A\u00a0peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes","volume":"16","author":"Hebda","year":"2009","journal-title":"Chem Biol"},{"key":"10.1016\/j.jcjd.2015.01.291_bib31","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1016\/j.biomaterials.2014.06.056","article-title":"Inhibition of islet amyloid polypeptide fibril formation by selenium-containing phycocyanin and prevention of beta cell apoptosis","volume":"35","author":"Li","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcjd.2015.01.291_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.fob.2012.02.001","article-title":"Inhibitory effects of choline-O-sulfate on amyloid formation of human islet amyloid polypeptide","volume":"2","author":"Hagihara","year":"2012","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.jcjd.2015.01.291_bib33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejphar.2013.03.017","article-title":"Inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salen derivatives","volume":"707","author":"Bahramikia","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jcjd.2015.01.291_bib34","doi-asserted-by":"crossref","first-page":"e65579","DOI":"10.1371\/journal.pone.0065579","article-title":"Exploring the influence of carbon nanoparticles on the\u00a0formation of beta-sheet-rich oligomers of IAPP(2)(2)(-)(2)(8) peptide by molecular dynamics simulation","volume":"8","author":"Guo","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jcjd.2015.01.291_bib35","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0022-2836(02)00164-X","article-title":"Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis","volume":"318","author":"Scrocchi","year":"2002","journal-title":"J\u00a0Molec Biol"},{"key":"10.1016\/j.jcjd.2015.01.291_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.biophys.050708.133622","article-title":"The interplay of catalysis and toxicity by amyloid intermediates on lipid bilayers: Insights from type II diabetes","volume":"38","author":"Hebda","year":"2009","journal-title":"Ann Rev Biophys"},{"key":"10.1016\/j.jcjd.2015.01.291_bib37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0009-9236(03)00014-6","article-title":"A\u00a0study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus","volume":"73","author":"Watanabe","year":"2003","journal-title":"Clin Pharmacol Therapeut"}],"container-title":["Canadian Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499267115003251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499267115003251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:28:07Z","timestamp":1761492487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499267115003251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1499267115003251"],"URL":"https:\/\/doi.org\/10.1016\/j.jcjd.2015.01.291","relation":{},"ISSN":["1499-2671"],"issn-type":[{"value":"1499-2671","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0Vitro Evaluation of Hypoglycemic Agents to Target Human Islet Amyloid Polypeptide: A Key Protein Involved in Amyloid Deposition and Beta-Cell Loss","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Diabetes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcjd.2015.01.291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}