{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:40:52Z","timestamp":1761709252920,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["canadianjournalofdiabetes.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Diabetes"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jcjd.2016.06.002","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T22:15:35Z","timestamp":1470262535000},"page":"278-279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Excess Omega-6 Polyunsaturated Fatty Acid Intake Is Associated with Negative Cardiovascular, Intestinal and Metabolic Outcomes in Mice"],"prefix":"10.1016","volume":"40","author":[{"given":"Claire","family":"Sears","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjoy","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.jcjd.2016.06.002_bib0010","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.jcjd.2013.01.019","article-title":"Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada: Nutrition therapy","volume":"37","author":"Dworatzek","year":"2013","journal-title":"Can J Diabetes"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0015","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2337\/diacare.25.3.608","article-title":"The evidence for the effectiveness of medical nutrition therapy in diabetes management","volume":"25","author":"Pastors","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0020","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2337\/diacare.22.2.191","article-title":"Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes","volume":"22","author":"Pi-Sunyer","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0025","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0002-8223(95)00276-6","article-title":"Effectiveness of medical nutrition therapy provided by dietitians in the management of non-insulin-dependent diabetes mellitus: A randomized controlled clinical trial","volume":"95","author":"Franz","year":"1995","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0030","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0002-8223(98)00017-0","article-title":"The Diabetes Care and Education Dietetic Practice Group. Nutrition practice guidelines for type 1 diabetes mellitus positively affect dietitian practices and patient outcomes","volume":"98","author":"Kulkarni","year":"1998","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jada.2005.09.051","article-title":"A single nutrition counseling session with a registered dietitian improves short-term clinical outcomes for rural Kentucky patients with chronic diseases","volume":"106","author":"Gaetke","year":"2006","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3164\/jcbn.2008010","article-title":"Intervention with delivery of diabetic meals improves glycemic control in patients with type 2 diabetes mellitus","volume":"42","author":"Imai","year":"2008","journal-title":"J Clin Biochem Nutr"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2337\/dc09-1092","article-title":"Prospective randomized controlled trial to evaluate effectiveness of registered dietitian-led diabetes management on glycemic and diet control in a primary care setting in Taiwan","volume":"33","author":"Huang","year":"2010","journal-title":"Diabetes Care"},{"year":"2007","series-title":"Eating Well with Canada's Food Guide","author":"Health Canada","key":"10.1016\/j.jcjd.2016.06.002_bib0050"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0055","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11892-011-0178-y","article-title":"Fad diets in the treatment of diabetes","volume":"11","author":"Feinman","year":"2011","journal-title":"Curr Diab Rep"},{"year":"1989","series-title":"Diet and health: Implications for reducing chronic disease risk","author":"Council","key":"10.1016\/j.jcjd.2016.06.002_bib0060"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0065","doi-asserted-by":"crossref","unstructured":"Statistics Canada. Food statistics 2005. 2006. As cited in Ghosh S, Molcan E, DeCoffe D, et al. Diets rich in n-6 PUFA induce intestinal microbial dysbiosis in aged mice. Br J Nutr 2013;110:515\u201323.","DOI":"10.1017\/S0007114512005326"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0070","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the third report of the National Cholesterol Education Program (NCEP)","volume":"285","author":"Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0075","doi-asserted-by":"crossref","first-page":"23371","DOI":"10.1074\/jbc.M115.682195","article-title":"Excess linoleic acid increases collagen I\/III ratio and \u201cstiffens\u201d the heart muscle following high fat diets","volume":"290","author":"Beam","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0080","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/0735-1097(94)90612-2","article-title":"The neonatal heart has a relatively high content of total collagen and type I collagen, a condition that may explain the less compliant state","volume":"23","author":"Marijianowski","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0085","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nature07336","article-title":"Innate immunity and intestinal microbiota in the development of type 1 diabetes","volume":"455","author":"Wen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0090","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ijo.2012.33","article-title":"The type and quantity of dietary fat and carbohydrate alter faecal microbiome and short-chain fatty acid excretion in a metabolic syndrome \u201cat-risk\u201d population","volume":"37","author":"Fava","year":"2013","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0095","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: Human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0100","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1017\/S0007114512005326","article-title":"Diets rich in n-6 PUFA induce intestinal microbial dysbiosis in aged mice","volume":"110","author":"Ghosh","year":"2013","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1471-230X-9-61","article-title":"Small intestinal bacterial overgrowth mimicking acute flare as a pitfall in patients with Crohn's Disease","volume":"30","author":"Klaus","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0110","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/cdd.2013.138","article-title":"Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance","volume":"20","author":"Dalleau","year":"2013","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0115","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jnutbio.2014.11.004","article-title":"A high-fat diet rich in corn oil reduces spontaneous locomotor activity and induces insulin resistance in mice","volume":"26","author":"Wong","year":"2015","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jcjd.2016.06.002_bib0120","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000175332","article-title":"Plasma lipids in human linoleic acid deficiency","volume":"13","author":"Collins","year":"1971","journal-title":"Nutr Metab"}],"container-title":["Canadian Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499267116301927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499267116301927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:28:57Z","timestamp":1761492537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499267116301927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S1499267116301927"],"URL":"https:\/\/doi.org\/10.1016\/j.jcjd.2016.06.002","relation":{},"ISSN":["1499-2671"],"issn-type":[{"type":"print","value":"1499-2671"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excess Omega-6 Polyunsaturated Fatty Acid Intake Is Associated with Negative Cardiovascular, Intestinal and Metabolic Outcomes in Mice","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Diabetes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcjd.2016.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}]}}