{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:21:45Z","timestamp":1792185705369,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP133545"],"award-info":[{"award-number":["MOP133545"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PCL126613"],"award-info":[{"award-number":["PCL126613"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009227","name":"Department of Medicine, University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013528","name":"Diabetes Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013528","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["canadianjournalofdiabetes.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Diabetes"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jcjd.2022.07.004","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T18:28:04Z","timestamp":1659896884000},"page":"43-50.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations Among Biomarkers of Inflammation, Tubular Injury and Lipid Metabolism With Gestational Diabetes Mellitus Status, Microalbuminuria and Retinopathy in the Microalbuminuria and Retinopathy in Gestational Diabetes Study"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7947-1822","authenticated-orcid":false,"given":"Vikas S.","family":"Sridhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-8924","authenticated-orcid":false,"given":"Leif Erik","family":"Lovblom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-7584","authenticated-orcid":false,"given":"Denice S.","family":"Feig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Herer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Hladunewich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha P.","family":"Kohly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine L.","family":"Lipscombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7635-7407","authenticated-orcid":false,"given":"Paul M.","family":"Yip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Z.","family":"Cherney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-3628","authenticated-orcid":false,"given":"Baiju R.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcjd.2022.07.004_bib1","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3390\/ijms19113342","article-title":"The pathophysiology of gestational diabetes mellitus","volume":"19","author":"Plows","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcjd.2022.07.004_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11892-015-0699-x","article-title":"Prevalence of gestational diabetes and risk of progression to type 2 diabetes: A global perspective","volume":"16","author":"Zhu","year":"2016","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.jcjd.2022.07.004_bib3","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1007\/s001250050822","article-title":"NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X","volume":"40","author":"Pickup","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.jcjd.2022.07.004_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.15420\/ecr.2018.33.1","article-title":"The role of inflammation in diabetes: Current concepts and future perspectives","volume":"14","author":"Tsalamandris","year":"2019","journal-title":"Eur Cardiol"},{"key":"10.1016\/j.jcjd.2022.07.004_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2019-001061","article-title":"Association between pre-diabetes and microvascular and macrovascular disease in newly diagnosed type 2 diabetes","volume":"8","author":"Palladino","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10.1016\/j.jcjd.2022.07.004_bib6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.2337\/diacare.25.6.977","article-title":"longitudinal association of glycemia and microalbuminuria: The Framingham Offspring Study","volume":"25","author":"Meigs","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2022.07.004_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1464-5491.2007.02043.x","article-title":"The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program","volume":"24","year":"2007","journal-title":"Diabet Med"},{"key":"10.1016\/j.jcjd.2022.07.004_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109068","article-title":"Increased risk for microvascular complications among women with gestational diabetes in the third trimester of the Microalbuminuria and Retinopathy in Gestational Diabetes (MARIGOLD) Study","volume":"180","author":"Shah","year":"2021","journal-title":"Diabetes Res Clin Pract"},{"issue":"Suppl. 1","key":"10.1016\/j.jcjd.2022.07.004_bib9","first-page":"S1","article-title":"Diabetes Canada 2018 clinical practice guidelines","volume":"42","year":"2018","journal-title":"Can J Diabetes"},{"key":"10.1016\/j.jcjd.2022.07.004_bib10","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S2213-8587(13)70176-1","article-title":"Adipokines in gestational diabetes","volume":"2","author":"Fasshauer","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jcjd.2022.07.004_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0168-8227(01)00355-2","article-title":"Tumor necrosis factor system in insulin resistance in gestational diabetes","volume":"56","author":"Winkler","year":"2002","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jcjd.2022.07.004_bib12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/oby.2001.54","article-title":"Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion","volume":"9","author":"Vozarova","year":"2001","journal-title":"Obes Res"},{"key":"10.1016\/j.jcjd.2022.07.004_bib13","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1600-0412.2011.01094.x","article-title":"Circulating interleukin-6 concentrations during and after gestational diabetes mellitus","volume":"90","author":"Morisset","year":"2011","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.jcjd.2022.07.004_bib14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1055\/s-2008-1073166","article-title":"Circulating pro- and anti-inflammatory cytokines in Polish women with gestational diabetes","volume":"40","author":"Kuzmicki","year":"2008","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.jcjd.2022.07.004_bib15","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/MBC.0b013e3283540c2d","article-title":"Alterations of sympathetic nervous system, coagulation and platelet function in gestational diabetes","volume":"23","author":"Poyhonen-Alho","year":"2012","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.jcjd.2022.07.004_bib16","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1373\/clinchem.2011.169094","article-title":"The promise of angiogenic markers for the early diagnosis and prediction of preeclampsia","volume":"58","author":"Hagmann","year":"2012","journal-title":"Clin Chem"},{"key":"10.1016\/j.jcjd.2022.07.004_bib17","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/s41598-021-81785-5","article-title":"Placental and maternal sFlt1\/PlGF expression in gestational diabetes mellitus","volume":"11","author":"Nuzzo","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcjd.2022.07.004_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220650","article-title":"Changes in VEGF-related factors are associated with presence of inflammatory factors in carbohydrate metabolism disorders during pregnancy","volume":"14","author":"Sugimoto","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jcjd.2022.07.004_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182509","article-title":"Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1","volume":"12","author":"Troncoso","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jcjd.2022.07.004_bib20","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1161\/CIRCULATIONAHA.107.710830","article-title":"Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy","volume":"117","author":"Van Linthout","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jcjd.2022.07.004_bib21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2337\/dc16-1295","article-title":"Serum levels of apolipoproteins and incident type 2 diabetes: A prospective cohort study","volume":"40","author":"Brahimaj","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2022.07.004_bib22","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijcard.2008.12.066","article-title":"The paradox of high apolipoprotein A-I levels independently predicting incident type-2 diabetes among Turks","volume":"142","author":"Onat","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcjd.2022.07.004_bib23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2337\/dc10-0793","article-title":"Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids","volume":"34","author":"Sasongko","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2022.07.004_bib24","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/ATVBAHA.118.312282","article-title":"Apolipoprotein A-I protects against pregnancy-induced insulin resistance in rats","volume":"39","author":"Wu","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcjd.2022.07.004_bib25","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1161\/ATVBAHA.119.313195","article-title":"Serum apoA1 (apolipoprotein A-1), insulin resistance, and the risk of gestational diabetes mellitus in human pregnancy---brief report","volume":"39","author":"Retnakaran","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jcjd.2022.07.004_bib26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.117.311978","article-title":"Trials and tribulations of CETP inhibitors","volume":"122","author":"Tall","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jcjd.2022.07.004_bib27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0009-9120(98)00101-5","article-title":"Increased plasma apolipoprotein B-containing lipoproteins associated with increased urinary albumin within the microalbuminuria range in type 2 diabetes","volume":"32","author":"Hegele","year":"1999","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jcjd.2022.07.004_bib28","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/BF00274257","article-title":"Alterations in serum lipids and apolipoproteins in male type 1 (insulin-dependent) diabetic patients with microalbuminuria","volume":"32","author":"Dullaart","year":"1989","journal-title":"Diabetologia"},{"key":"10.1016\/j.jcjd.2022.07.004_bib29","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1681\/ASN.2013121256","article-title":"Apolipoprotein B attenuates albuminuria-associated cardiovascular disease in prevention of renal and vascular endstage disease (PREVEND) participants","volume":"25","author":"Corsetti","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jcjd.2022.07.004_bib30","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1210\/jc.2010-0361","article-title":"The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: Implications for future cardiovascular risk","volume":"95","author":"Retnakaran","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jcjd.2022.07.004_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2021.107880","article-title":"Relationships between inflammation, hemodynamic function and RAAS in longstanding type 1 diabetes and diabetic kidney disease","volume":"35","author":"Ambinathan","year":"2021","journal-title":"J\u00a0Diabetes Complications"},{"key":"10.1016\/j.jcjd.2022.07.004_bib32","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/j.1464-5491.2012.03651.x","article-title":"Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria","volume":"29","author":"Cherney","year":"2012","journal-title":"Diabet Med"},{"key":"10.1016\/j.jcjd.2022.07.004_bib33","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2008-2534","article-title":"Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications","volume":"94","author":"Goldberg","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jcjd.2022.07.004_bib34","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41591-019-0415-5","article-title":"A\u00a0signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes","volume":"25","author":"Niewczas","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jcjd.2022.07.004_bib35","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/CIRCULATIONAHA.108.777334","article-title":"Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events","volume":"118","author":"Mora","year":"2008","journal-title":"Circulation"}],"container-title":["Canadian Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499267122002131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499267122002131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:38:41Z","timestamp":1761493121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499267122002131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S1499267122002131"],"URL":"https:\/\/doi.org\/10.1016\/j.jcjd.2022.07.004","relation":{},"ISSN":["1499-2671"],"issn-type":[{"value":"1499-2671","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations Among Biomarkers of Inflammation, Tubular Injury and Lipid Metabolism With Gestational Diabetes Mellitus Status, Microalbuminuria and Retinopathy in the Microalbuminuria and Retinopathy in Gestational Diabetes Study","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Diabetes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcjd.2022.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Canadian Diabetes Association.","name":"copyright","label":"Copyright"}]}}