{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:35:47Z","timestamp":1773131747581,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["canadianjournalofdiabetes.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Diabetes"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jcjd.2024.01.007","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T11:52:39Z","timestamp":1706529159000},"page":"233-243.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-7321","authenticated-orcid":false,"suffix":"Jr","given":"Mario B.","family":"Prado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Joy B.","family":"Adiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl","key":"10.1016\/j.jcjd.2024.01.007_bib1","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.2337\/dc23-S012","article-title":"Retinopathy, neuropathy, and foot care: Standards of care in diabetes---2023","volume":"46","author":"Elsayed","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2024.01.007_bib2","article-title":"Practical guidelines on the prevention and management of diabetes-related foot disease (IWGDF 2023 update)","author":"Schaper","year":"2023","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.jcjd.2024.01.007_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1900\/RDS.2009.6.230","article-title":"Alpha-lipoic acid and diabetic neuropathy","volume":"6","author":"Vallianou","year":"2009","journal-title":"Rev Diabet Studies"},{"key":"10.1016\/j.jcjd.2024.01.007_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1464-5491.2004.01109.x","article-title":"Treatment of symptomatic diabetic polyneuropathy with the antioxidant \u03b1-lipoic acid: A meta-analysis","volume":"21","author":"Ziegler","year":"2004","journal-title":"Diabet Med"},{"key":"10.1016\/j.jcjd.2024.01.007_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1212\/WNL.0000000000013038","article-title":"Oral and topical treatment of painful diabetic polyneuropathy: Practice guideline update summary: Report of the AAN Guideline Subcommittee","volume":"98","author":"Price","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.jcjd.2024.01.007_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/03007995.2018.1497958","article-title":"Non-pharmacologic treatments for symptoms of diabetic peripheral neuropathy: A systematic review","volume":"35","author":"Amato Nesbit","year":"2019","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jcjd.2024.01.007_bib7","series-title":"March Report 17-EHC005-EF","article-title":"Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy","author":"Dy","year":"2017"},{"key":"10.1016\/j.jcjd.2024.01.007_bib8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/BF00400603","article-title":"Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant-lipoic acid: A 3-week multicentre randomized controlled trial (ALADIN Study)","volume":"38","author":"Ziegler","year":"1995","journal-title":"Diabetologia"},{"key":"10.1016\/j.jcjd.2024.01.007_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/10715769900300721","article-title":"Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (c-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II)","volume":"31","author":"Reljanovic","year":"1999","journal-title":"Free Radic Res"},{"key":"10.1016\/j.jcjd.2024.01.007_bib10","article-title":"Effect of alpha-lipoic acid in the treatment of diabetic neuropathy: A systematic review","volume":"14","author":"Abubaker","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.jcjd.2024.01.007_bib11","author":"Ametov"},{"key":"10.1016\/j.jcjd.2024.01.007_bib12","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.2337\/dc06-1216","article-title":"Oral treatment with \u03b1-lipoic acid improves symptomatic diabetic polyneuropathy","volume":"29","author":"Ziegler","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2024.01.007_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1464-5491.1990.tb01397.x","article-title":"The effect of \u03b3-linolenic acid on human diabetic peripheral neuropathy: A double-blind placebo-controlled trial","volume":"7","author":"Jamal","year":"1990","journal-title":"Diabet Med"},{"key":"10.1016\/j.jcjd.2024.01.007_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2337\/diacare.16.1.8","article-title":"Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group","volume":"16","author":"Keen","year":"1993","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2024.01.007_bib15","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4093\/dmj.2019.0099","article-title":"\u03b3-Linolenic acid versus \u03b1-lipoic acid for treating painful diabetic neuropathy in adults: A 12-week, double-placebo, randomized, noninferiority trial","volume":"44","author":"Won","year":"2020","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.jcjd.2024.01.007_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/456279","article-title":"Alpha lipoic acid for symptomatic peripheral neuropathy in patients with diabetes: A meta-analysis of randomized controlled trials","volume":"2012","author":"Mijnhout","year":"2012","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.jcjd.2024.01.007_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1530\/EJE-12-0555","article-title":"A\u00a0systematic review and meta-analysis of \u03b1-lipoic acid in the treatment of diabetic peripheral neuropathy","volume":"167","author":"Han","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jcjd.2024.01.007_bib18","first-page":"377","article-title":"Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy","volume":"7","author":"McIlduff","year":"2011","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.jcjd.2024.01.007_bib19","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.2337\/dc11-0503","article-title":"Efficacy and safety of antioxidant treatment with \u03b1-lipoic acid over 4 years in diabetic polyneuropathy: The NATHAN 1 trial","volume":"34","author":"Ziegler","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2024.01.007_bib20","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.2337\/diacare.22.8.1296","article-title":"Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-lipoic acid in diabetic neuropathy","volume":"22","author":"Ziegler","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcjd.2024.01.007_bib21","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1046\/j.1464-5491.1999.00190.x","article-title":"Effects of 3-week oral treatment with the antioxidant thioctic acid (\u03b1-lipoic acid) in symptomatic diabetic polyneuropathy","volume":"16","author":"Ruhnau","year":"1999","journal-title":"Diabet Med"},{"key":"10.1016\/j.jcjd.2024.01.007_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1056-8727(03)00033-3","article-title":"Clinical experience with thioctacid (thioctic acid) in the treatment of distal symmetric polyneuropathy in Korean diabetic patients","volume":"18","author":"Hahm","year":"2004","journal-title":"J\u00a0Diabetes Complications"},{"key":"10.1016\/j.jcjd.2024.01.007_bib23","article-title":"Treatment with \u03b1-lipoic acid over 16 weeks in type 2 diabetic patients with symptomatic polyneuropathy who responded to initial 4-week high-dose loading","volume":"2015","author":"Garcia-Alcala","year":"2015","journal-title":"J\u00a0Diabetes Res"},{"key":"10.1016\/j.jcjd.2024.01.007_bib24","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000035368","article-title":"Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis","volume":"102","author":"Orellana-Donoso","year":"2023","journal-title":"Medicine"},{"key":"10.1016\/j.jcjd.2024.01.007_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11739-016-1583-7","article-title":"Network meta-analysis: An introduction for clinicians","volume":"12","author":"Rouse","year":"2017","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.jcjd.2024.01.007_bib26","doi-asserted-by":"crossref","DOI":"10.4178\/epih.e2017047","article-title":"Network meta-analysis: Application and practice using Stata","volume":"39","author":"Shim","year":"2017","journal-title":"Epidemiol Health"},{"key":"10.1016\/j.jcjd.2024.01.007_bib27","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1177\/1536867X1501500403","article-title":"Network meta-analysis","volume":"15","author":"White","year":"2015","journal-title":"Stata J"},{"key":"10.1016\/j.jcjd.2024.01.007_bib28","article-title":"The role of biofactors in diabetic microvascular complications","volume":"18","author":"Ziegler","year":"2021","journal-title":"Curr Diabetes Rev"},{"key":"10.1016\/j.jcjd.2024.01.007_bib29","first-page":"197","article-title":"The impact of alpha-lipoic acid on insulin resistance and inflammatory parameters in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy","volume":"8","author":"Serhiyenko","year":"2020","journal-title":"Am J Int Med"},{"key":"10.1016\/j.jcjd.2024.01.007_bib30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000358728","article-title":"Diabetic neuropathies: Diagnosis and management","volume":"98","author":"Deli","year":"2013","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jcjd.2024.01.007_bib31","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4239\/wjd.v6.i3.432","article-title":"Diabetic neuropathic pain: Physiopathology and treatment","volume":"6","author":"Schreiber","year":"2015","journal-title":"World J Diabetes"},{"key":"10.1016\/j.jcjd.2024.01.007_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu12113254","article-title":"Efficacy and safety of the combination of superoxide dismutase, alpha lipoic acid, vitamin B12, and carnitine for 12 months in patients with diabetic neuropathy","volume":"12","author":"Didangelos","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jcjd.2024.01.007_bib33","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/dc16-2042","article-title":"Diabetic neuropathy: A position statement by the American Diabetes Association","volume":"40","author":"Pop-Busui","year":"2017","journal-title":"Diabetes Care"}],"container-title":["Canadian Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499267124000236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1499267124000236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T21:57:21Z","timestamp":1767045441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1499267124000236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S1499267124000236"],"URL":"https:\/\/doi.org\/10.1016\/j.jcjd.2024.01.007","relation":{},"ISSN":["1499-2671"],"issn-type":[{"value":"1499-2671","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Diabetes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcjd.2024.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Canadian Diabetes Association.","name":"copyright","label":"Copyright"}]}}