{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:26:27Z","timestamp":1762104387871,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["canadianjournalofophthalmology.ca","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jcjo.2019.01.004","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T02:03:28Z","timestamp":1554257008000},"page":"626-634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prospective evaluation of aflibercept in pigment epithelial detachments secondary to neovascular age related macular degeneration"],"prefix":"10.1016","volume":"54","author":[{"given":"Vlad","family":"Diaconita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-6475","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faten","family":"Bahnacy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Gonder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcjo.2019.01.004_bib0001","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ajo.2007.06.014","article-title":"Optical coherence tomography identification of occult choroidal neovascularization in age-related macular degeneration","volume":"144","author":"Coscas","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0002","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00006982-199414020-00003","article-title":"Analysis of vascularized pigment epithelial detachments using indocyanine green videoangiography","volume":"14","author":"Yannuzzi","year":"1994","journal-title":"Retina"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0003","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3928\/23258160-20130313-12","article-title":"Increasing Volume of a Retinal Pigmented Epithelial Detachment as a Predictor of Submacular Hemorrhage During Anti-VEGF Therapy","volume":"44","author":"Alexandre","year":"2013","journal-title":"Ophthalmic Surg Lasers Imaging Retin"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0004","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/08820538.2011.570850","article-title":"Retinal pigment epithelial detachments in age-related macular degeneration\u202f: classification and therapeutic options","volume":"26","author":"Pepple","year":"2011","journal-title":"Semin Ophthalmol"},{"issue":"137","key":"10.1016\/j.jcjo.2019.01.004_bib0005","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ajo.2003.11.026","article-title":"Pathogenesis of lesions in late age-related macular disease","volume":"137","author":"Holz","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0006","first-page":"533","article-title":"Pigment epithelial detachment in the elderly","author":"Pauleikhoff","year":"2002","journal-title":"Vascular"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0007","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00166756","article-title":"Graefe's Archive Ophthalmology associated with drusen","author":"Hartnett","year":"1992","journal-title":"Am Graefe's Arch Clin Exp Ophthalmol"},{"issue":"6","key":"10.1016\/j.jcjo.2019.01.004_bib0008","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.ophtha.2013.12.029","article-title":"Morphologic parameters relevant for visual outcome during anti-angiogenic therapy of neovascular age-related macular degeneration","volume":"121","author":"Simader","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0009","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ophtha.2009.12.002","article-title":"Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: AREDS Report Number 28","volume":"117","author":"Cukras","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0010","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa054481","article-title":"Ranibizumab for neovascular age-related macular degeneration","volume":"355","author":"Rosenfeld","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0011","first-page":"1","article-title":"Ranibizumab and bevacizumab for neovascular age-related macular degeneration","volume":"364","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0012","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1167\/iovs.11-8130","article-title":"Assessment of differential pharmacodynamic effects using optical coherence tomography in neovascular age-related macular degeneration","volume":"53","author":"Keane","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0013","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/IAE.0000000000000056","article-title":"Pigment epithelial tears associated with anti-VEGF therapy: incidence, long-term visual outcome, and relationship with pigment epithelial detachment in age-related macular degeneration","volume":"34","author":"Doguizi","year":"2014","journal-title":"Retina"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0014","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1158\/1078-0432.CCR-12-2911","article-title":"Aflibercept","volume":"19","author":"Ciombor","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10456-011-9249-6","article-title":"Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab","volume":"15","author":"Papadopoulos","year":"2012","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0016","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/bjo.2007.134874","article-title":"Predicted biological activity of intravitreal VEGF Trap","volume":"92","author":"Stewart","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0017","doi-asserted-by":"crossref","first-page":"11393","DOI":"10.1073\/pnas.172398299","article-title":"VEGF-Trap: a VEGF blocker with potent antitumor effects","volume":"99","author":"Holash","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0018","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.ophtha.2012.09.006","article-title":"Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration","volume":"119","author":"Heier","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0019","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/bjophthalmol-2013-304474","article-title":"Early initial clinical experience with intravitreal aflibercept for wet age-related macular degeneration","volume":"98","author":"Ferrone","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0020","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/IAE.0000000000001318","article-title":"Intravitreal aflibercept in neovascular age-related macular degeneration with limited response to ranibizumab: a treat-and-extend trial","volume":"37","author":"Hatz","year":"2017","journal-title":"Retina"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0021","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1097\/IAE.0000000000000409","article-title":"Response of pigment epithelial detachments to intravitreal aflibercept among patients with treatment-resistant neovascular age-related macular degeneration","volume":"35","author":"Broadhead","year":"2015","journal-title":"Retina"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0022","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/bjophthalmol-2013-303155","article-title":"Imaging characteristics of neovascular pigment epithelial detachments and their response to anti-vascular endothelial growth factor therapy","volume":"97","author":"Punjabi","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0023","doi-asserted-by":"crossref","unstructured":"Pauleikhoff D, Spital G, Radermacher M, Dohrmann J, Lommatzsch A, Bird AC. Pigment epithelial detachment in the elderly. Vascular. 2002:533-538. doi:10.1007\/s00417-002-0505-8.","DOI":"10.1007\/s00417-002-0505-8"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0024","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/IAE.0000000000000749","article-title":"Aflibercept for the treatment of retinal pigment epithelial detachments","volume":"36","author":"He","year":"2016","journal-title":"Retina"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0025","doi-asserted-by":"crossref","first-page":"7874","DOI":"10.1167\/iovs.14-14610","article-title":"Efficacy of intravitreal injection of aflibercept in neovascular age-related macular degeneration with or without choroidal vascular hyperpermeability","volume":"55","author":"Hata","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0026","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10792-016-0294-4","article-title":"Intravitreal aflibercept in treatment-resistant pigment epithelial detachment","volume":"37","author":"Kocak","year":"2017","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0027","first-page":"29619","article-title":"Non-responsiveness to intravitreal aflibercept treatment in neovascular age-related macular degeneration: implications of serous pigment epithelial detachment","volume":"6","author":"Nagai","year":"2016","journal-title":"Nat Sci Rep"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0028","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.ophtha.2013.12.029","article-title":"Morphologic parameters relevant for visual outcome during anti-angiogenic therapy of neovascular age-related macular degeneration","volume":"121","author":"Simader","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0029","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1097\/IAE.0b013e3181d87e97","article-title":"Intravitreal bevacizumab in vascular pigment epithelium detachment as a result of subfoveal occult choroidal neovascularization in age-related macular degeneration","volume":"30","author":"Ach","year":"2010","journal-title":"Retina"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00166756","article-title":"Graefe's archive ophthalmology associated with drusen","volume":"230","author":"Hartnett","year":"1992","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0031","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/IAE.0b013e3181babda5","article-title":"Optical coherence tomography\u2013measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears associated with intravitreal bevacizumab injections","volume":"30","author":"Chan","year":"2010","journal-title":"Retina"},{"key":"10.1016\/j.jcjo.2019.01.004_bib0032","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00417-002-0505-8","article-title":"Pigment epithelial detachment in the elderly","volume":"240","author":"Pauleikhoff","year":"2002","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Canadian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418218307993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418218307993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:23:46Z","timestamp":1762104226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008418218307993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0008418218307993"],"URL":"https:\/\/doi.org\/10.1016\/j.jcjo.2019.01.004","relation":{},"ISSN":["0008-4182"],"issn-type":[{"type":"print","value":"0008-4182"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospective evaluation of aflibercept in pigment epithelial detachments secondary to neovascular age related macular degeneration","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcjo.2019.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}