{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:32:33Z","timestamp":1789623153198,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005242","name":"Universit\u00e9 de Montr\u00e9al","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["canadianjournalofophthalmology.ca","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jcjo.2019.05.009","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T17:08:16Z","timestamp":1565024896000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Ocular syphilis: case series (2000\u20132015) from 2 tertiary care centres in Montreal, Canada"],"prefix":"10.1016","volume":"55","author":[{"given":"Julie","family":"Vadboncoeur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie-Claude","family":"Labb\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Fortin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0735-0452","authenticated-orcid":false,"given":"Bouchra","family":"Serhir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Rabia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinda","family":"Najem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Jaworski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9e","family":"Aubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcjo.2019.05.009_bib0001","unstructured":"Institut National de Sant\u00e9 Publique (INSPQ). Portrait des infections transmissibles sexuellement et par le sang au Qu\u00e9bec: ann\u00e9e 2015 (et projections 2016). https:\/\/www.inspq.qc.ca\/sites\/default\/files\/publications\/2201_portrait_infections_transmissibles_sexuellement_sang_2015_0.pdf."},{"key":"10.1016\/j.jcjo.2019.05.009_bib0002","first-page":"5392","article-title":"British Ocular Syphilis Study (BOSS): 2-year national surveillance study of intraocular inflammation secondary to ocular syphilis","volume":"55","author":"Matthew","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0003","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","article-title":"Standardization of Uveitis Nomenclature (SUN) Working Group: standardization of uveitis nomenclature for reporting clinical data: results of the first international workshop","volume":"140","author":"Jabs","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0004","first-page":"229","article-title":"Central nervous system manifestations in human immunodeficiency virus infections without AIDS","volume":"5","author":"Collier","year":"1992","journal-title":"JAIDS"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0005","first-page":"777","article-title":"CSF changes in a longitudinal study of 124 neurologically normal HIV-1-infected U.S. Air Force personnel","volume":"4","author":"Marshall","year":"1991","journal-title":"JAIDS"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0006","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0161-6420(90)32419-3","article-title":"Ocular syphilis","volume":"97","author":"Tamesis","year":"1990","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0007","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0161-6420(97)30089-X","article-title":"Syphilis exposure in patients with uveitis","volume":"104","author":"Barile","year":"1997","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2014.10.030","article-title":"Clinical features and incidence rates of ocular complications in patients with ocular syphilis","volume":"159","author":"Moradi","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0009","series-title":"Clinical advisory: ocular syphilis in the United States 2015","year":"2016"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0039-6257(92)90138-J","article-title":"Ocular syphilis","volume":"37","author":"Margo","year":"1992","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0011","series-title":"Ocular Infection and Immunity","first-page":"1437","article-title":"Syphilis","author":"Wilhelmus","year":"1996"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0012","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1097\/00002030-200410210-00012","article-title":"Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections","volume":"18","author":"Buchacz","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0013","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/OLQ.0b013e3181b6f0cc","article-title":"Syphilis epidemiology and clinical outcomes in HIV-infected and HIV-uninfected patients in Kaiser Permanente Northern California","volume":"37","author":"Horberg","year":"2010","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0014","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/09273948.2013.829106","article-title":"Syphilitic uveitis in a Singaporean population","volume":"22","author":"Yap","year":"2014","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/09273940902741709","article-title":"Ocular syphilis\u2014back again: understanding recent increases in the incidence of ocular syphilitic disease","volume":"17","author":"Fonollosa","year":"2009","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0016","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1097\/IAE.0b013e3182509796","article-title":"Ocular manifestations of syphilitic uveitis in chinese patients","volume":"32","author":"Yang","year":"2012","journal-title":"Retina"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0017","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/bjo.2007.133843","article-title":"Syphilitic uveitis: an Asian perspective","volume":"92","author":"Anshu","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0018","first-page":"7770","article-title":"Ocular syphilis: an alarming infectious eye disease","volume":"8","author":"Shen","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0019","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1442-9071.2010.02383.x","article-title":"Syphilitic retinitis and uveitis in HIV-positive adults","volume":"38","author":"Hughes","year":"2010","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0020","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.revmed.2015.07.008","article-title":"Ocular syphilis: a retrospective study of 27 cases in Nantes University Hospital (France) from 2000 to 2013","volume":"36","author":"Carbonni\u00e8re","year":"2015","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0021","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1136\/bjophthalmol-2014-306168","article-title":"Syphilis uveitis and optic neuritis in Sydney, Australia","volume":"99","author":"Northey","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0022","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3341\/kjo.2016.30.5.360","article-title":"Non-human immunodeficiency virus-related ocular syphilis in a Korean population: clinical manifestations and treatment outcomes","volume":"30","author":"Kim","year":"2016","journal-title":"Korean J Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0023","first-page":"147","article-title":"Clinical manifestations and outcomes of syphilis-associated uveitis in Northern Spain","volume":"24","author":"Fonollosa","year":"2016","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0024","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/sti.2010.043042","article-title":"Ocular syphilis among HIV-infected patients: a systematic analysis of the literature","volume":"87","author":"Tucker","year":"2011","journal-title":"Sex Transm Infect"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12879-016-1586-z","article-title":"Clinical manifestations and cerebrospinal fluid status in ocular syphilis in HIV-negative patients","volume":"16","author":"Dai","year":"2016","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0026","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1001\/archopht.1997.01100150471003","article-title":"Syphilitic uveitis in human immunodeficiency virus infected patients","volume":"115","author":"Shalaby","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0027","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1097\/IAE.0b013e31825f3851","article-title":"International Syphilis Study Group. Acute syphilitic posterior placoid chorioretinitis: report of a case series and comprehensive review of the literature","volume":"32","author":"Eandi","year":"2012","journal-title":"Retina"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0028","article-title":"How to recognize ocular syphilis","author":"Wender","year":"2008","journal-title":"Rev Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0029","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1097\/QAD.0b013e32833bfe21","article-title":"Occurrence, risk factors, diagnosis and treatment of syphilis in the prospective observational Swiss HIV Cohort Study","volume":"24","author":"Thurnheer","year":"2010","journal-title":"AIDS"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0030","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1442-9071.2010.02203.x","article-title":"Syphilitic uveitis: a review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus-positive and negative patients","volume":"38","author":"Amaratunge","year":"2010","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0031","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"Workowski","year":"2015","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0032","unstructured":"Public Health Agency of Canada. Canadian Guidelines on Sexually Transmitted Infections. Last update 2016. http:\/\/www.phac-aspc.gc.ca\/std-mts\/sti-its\/cgsti-ldcits\/section-5\u201310-eng.php."},{"key":"10.1016\/j.jcjo.2019.05.009_bib0033","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/jdv.12734","article-title":"2014 European guideline on the management of syphilis","volume":"28","author":"Janier","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0034","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1056\/NEJM199204163261606","article-title":"Acquired syphilis in adults","volume":"326","author":"Hook","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0035","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/infdis\/158.1.193","article-title":"Cerebrospinal fluid abnormalities in patients without AIDS who are seropositive for the human immunodeficiency virus","volume":"158","author":"Appleman","year":"1988","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0036","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1097\/00002030-199908200-00008","article-title":"Cerebrospinal fluid HIV-1 RNA levels in asymptomatic patients with early stage chronic HIV-1 infection: support for the hypothesis of local virus replication","volume":"13","author":"Garc\u00eda","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0037","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1086\/381227","article-title":"Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features","volume":"189","author":"Marra","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcjo.2019.05.009_bib0038","unstructured":"Institut national de sant\u00e9 publique du Qu\u00e9bec. Report of the subcommittee \u00c9preuves de d\u00e9tection de la syphilis: highlights, 2011. https:\/\/www.inspq.qc.ca\/sites\/default\/files\/publications\/1232_reportsubcommitteesyphilishighlights.pdf."},{"key":"10.1016\/j.jcjo.2019.05.009_bib0039","unstructured":"Institut national de sant\u00e9 publique du Qu\u00e9bec. Mise \u00e0 jour des algorithmes de s\u00e9rodiagnostic de la syphilis, 2016. https:\/\/www.inspq.qc.ca\/sites\/default\/files\/publications\/2064_algorithmes_serodiagnostic_syphilis.pdf."}],"container-title":["Canadian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418218309578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418218309578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:23:52Z","timestamp":1762104232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008418218309578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0008418218309578"],"URL":"https:\/\/doi.org\/10.1016\/j.jcjo.2019.05.009","relation":{},"ISSN":["0008-4182"],"issn-type":[{"value":"0008-4182","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ocular syphilis: case series (2000\u20132015) from 2 tertiary care centres in Montreal, Canada","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcjo.2019.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}