{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:34:45Z","timestamp":1787236485715,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["23 2613 Fk"],"award-info":[{"award-number":["23 2613 Fk"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska Lakaresallskapet","doi-asserted-by":"publisher","award":["SLS-971390"],"award-info":[{"award-number":["SLS-971390"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Region Stockholm","doi-asserted-by":"publisher","award":["FoUI-981345"],"award-info":[{"award-number":["FoUI-981345"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","canadianjournalofophthalmology.ca","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jcjo.2024.07.014","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T13:46:13Z","timestamp":1723556773000},"page":"e240-e252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tailoring surveillance imaging in uveal melanoma based on individual metastatic risk"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-7031","authenticated-orcid":false,"given":"Anna","family":"Hagstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1563-1202","authenticated-orcid":false,"given":"Hans","family":"Witzenhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-8911","authenticated-orcid":false,"given":"Gustav","family":"St\u00e5lhammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcjo.2024.07.014_bib0001","doi-asserted-by":"crossref","first-page":"pkad097","DOI":"10.1093\/jncics\/pkad097","article-title":"Comprehensive causes of death in uveal melanoma: mortality in 1530 consecutively diagnosed patients followed until death","volume":"7","author":"Stalhammar","year":"2023","journal-title":"JNCI Cancer Spectr"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0002","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.ophtha.2016.01.023","article-title":"Uveal melanomas with SF3B1 mutations: A distinct subclass associated with late-onset metastases","volume":"123","author":"Yavuzyigitoglu","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0003","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajo.2011.03.004","article-title":"Surveillance testing for metastasis from primary uveal melanoma and effect on patient survival","volume":"152","author":"Augsburger","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0004","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/bjophthalmol-2012-302323","article-title":"MRI in the detection of hepatic metastases from high-risk uveal melanoma: a prospective study in 188 patients","volume":"97","author":"Marshall","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0005","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1056\/NEJMoa2103485","article-title":"Overall survival benefit with tebentafusp in metastatic uveal melanoma","volume":"385","author":"Nathan","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0006","first-page":"1868","article-title":"Risk-stratified systemic surveillance in uveal melanoma","volume":"103","author":"Davanzo","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0007","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0140-6736(96)90736-9","article-title":"Prognostic implications of monosomy 3 in uveal melanoma","volume":"347","author":"Prescher","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0008","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/PAT.0000000000000002","article-title":"BAP1 protein loss by immunohistochemistry: a potentially useful tool for prognostic prediction in patients with uveal melanoma","volume":"45","author":"Shah","year":"2013","journal-title":"Pathology"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0009","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.ophtha.2012.02.017","article-title":"Collaborative Ocular Oncology Group report number 1: Prospective validation of a multi-gene prognostic assay in uveal melanoma","volume":"119","author":"Onken","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0010","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1158\/1078-0432.CCR-15-2071","article-title":"PRAME as an independent biomarker for metastasis in uveal melanoma","volume":"22","author":"Field","year":"2016","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0011","series-title":"AJCC Cancer Staging Manual Ch. 67","first-page":"805","author":"Kivel\u00e4","year":"2017"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0012","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ophtha.2023.10.026","article-title":"Improved staging of ciliary body and choroidal melanomas based on estimation of tumor volume and competing risk analyses","volume":"131","author":"Stalhammar","year":"2023","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0013","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2020"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0014","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1001\/archopht.1992.01080140101036","article-title":"A review of mortality from choroidal melanoma. II. A meta-analysis of 5-year mortality rates following enucleation, 1966 through 1988","volume":"110","author":"Diener-West","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43856-022-00082-y","article-title":"Long-term relative survival in uveal melanoma: a systematic review and meta-analysis","volume":"2","author":"St\u00e5lhammar","year":"2022","journal-title":"Commun Med"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0016","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1136\/bjsports-2017-097500","article-title":"Is subsequent lower limb injury associated with previous injury? A systematic review and meta-analysis","volume":"51","author":"Toohey","year":"2017","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0017","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ajo.2018.07.045","article-title":"Gene expression profiling and PRAME status versus tumor-node-metastasis staging for prognostication in uveal melanoma","volume":"195","author":"Cai","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0018","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ng.2523","article-title":"Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma","volume":"45","author":"Harbour","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0019","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/02713683.2016.1245422","article-title":"Clinicopathological characteristics and prognosis for survival after enucleation of uveal melanoma in Chinese patients: Long-term follow-up","volume":"42","author":"Yue","year":"2017","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0020","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1136\/bjophthalmol-2020-317714","article-title":"Optimising prediction of early metastasis-free survival in uveal melanoma using a four-category model incorporating gene expression profile and tumour size","volume":"106","author":"Roelofs","year":"2022","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2019.151432","article-title":"Expression of BAP1 and ATM proteins: Association with AJCC tumor category in uveal melanoma","volume":"44","author":"Jha","year":"2020","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0022","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000508382","article-title":"Gene expression profiling in uveal melanoma: Five-year prospective outcomes and meta-analysis","volume":"6","author":"Aaberg","year":"2020","journal-title":"Ocul Oncol Pathol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0023","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/bjophthalmol-2020-316498","article-title":"Nuclear expression of BAP-1 in transvitreal incisional biopsies and subsequent enucleation of eyes with posterior choroidal melanoma","volume":"105","author":"Herrspiegel","year":"2021","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0024","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ophtha.2023.01.020","article-title":"Validation of the prognostic usefulness of the gene expression profiling test in patients with uveal melanoma","volume":"130","author":"Miguez","year":"2023","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0025","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.3747\/co.23.2859","article-title":"Management of uveal melanoma: a consensus-based provincial clinical practice guideline","volume":"23","author":"Weis","year":"2016","journal-title":"Curr Oncol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0026","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/j.ejca.2015.07.013","article-title":"Uveal Melanoma UK National Guidelines","volume":"51","author":"Nathan","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0027","doi-asserted-by":"crossref","first-page":"364","DOI":"10.6004\/jnccn.2021.0018","article-title":"NCCN GuidelinesR Insights: Melanoma: Cutaneous, Version 2.2021","volume":"19","author":"Swetter","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0028","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1136\/bjophthalmol-2020-317949","article-title":"Patients presenting with metastases: stage IV uveal melanoma, an international study","volume":"106","author":"Garg","year":"2022","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0029","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1167\/iovs.03-0538","article-title":"Very long-term prognosis of patients with malignant uveal melanoma","volume":"44","author":"Kujala","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0030","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12885-023-10757-x","article-title":"A serum protein signature at the time of uveal melanoma diagnosis predicts long-term patient survival","volume":"23","author":"Herrspiegel","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0031","unstructured":"Statistics Sweden. Population Statistics, Statistics Sweden, SCB tryck, Stockholm, Sweden, 2020."},{"key":"10.1016\/j.jcjo.2024.07.014_bib0032","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1001\/jamaophthalmol.2018.2466","article-title":"Survival rates in patients after treatment for metastasis from uveal melanoma","volume":"136","author":"Lane","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.annonc.2020.08.1266","article-title":"1143P Nivolumab and ipilimumab (N+I) is active in patients (pts) with metastatic uveal melanoma (mUM) with extra-hepatic only involvement: Pooled analysis from 2 phase II trials","volume":"31","author":"Rodriguez","year":"2020","journal-title":"Annals Oncol"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0034","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.ophtha.2018.03.011","article-title":"The Cancer Genome Atlas Project: an integrated molecular view of uveal melanoma","volume":"125","author":"Jager","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.compbiomed.2018.09.024","article-title":"Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model","volume":"102","author":"Eleuteri","year":"2018","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.jcjo.2024.07.014_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers15092610","article-title":"Sensitivity and specificity of different prognostic systems in guiding surveillance for metastases in uveal melanoma","volume":"15","author":"Robinson","year":"2023","journal-title":"Cancers (Basel)"}],"container-title":["Canadian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418224002400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418224002400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T17:26:08Z","timestamp":1742232368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008418224002400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0008418224002400"],"URL":"https:\/\/doi.org\/10.1016\/j.jcjo.2024.07.014","relation":{},"ISSN":["0008-4182"],"issn-type":[{"value":"0008-4182","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tailoring surveillance imaging in uveal melanoma based on individual metastatic risk","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcjo.2024.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of Canadian Ophthalmological Society.","name":"copyright","label":"Copyright"}]}}