{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:37:18Z","timestamp":1793173038687,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["canadianjournalofophthalmology.ca","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jcjo.2024.08.004","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T13:11:13Z","timestamp":1724332273000},"page":"e366-e374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A modified trabeculectomy technique with direct filtration into the Tenon's capsule"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-6176","authenticated-orcid":false,"given":"Kaku","family":"Itoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Suetake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misaki","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-7042","authenticated-orcid":false,"given":"Hiroyasu","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurie","family":"Omori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcjo.2024.08.004_bib0001","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0002-9394(68)91288-9","article-title":"Trabeculectomy. Preliminary report of a new method","volume":"66","author":"Cairns","year":"1968","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.survophthal.2011.07.005","article-title":"The changing conceptual basis of trabeculectomy: a review of past and current surgical techniques","volume":"57","author":"Razeghinejad","year":"2012","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0003","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1001\/archophthalmol.2010.348","article-title":"Trabeculectomy with mitomycin for open-angle glaucoma in phakic vs pseudophakic eyes after phacoemulsification","volume":"129","author":"Takihara","year":"2011","journal-title":"Arch Ophthalmol (Chicago, Ill: 1960)"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241569","article-title":"A Tenon's capsule\/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery","volume":"15","author":"Kozdon","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00660815","article-title":"[Demonstration of aqueous outflow patterns of normal and glaucomatous human eyes through the injection of fluorescein solution in the anterior chamber (author's transl)]","volume":"199","author":"Benedikt","year":"1976","journal-title":"Albrecht Von Graefes Arch Klin Exp Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0006","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0002-9394(01)01432-5","article-title":"Late-onset transconjunctival oozing and point leak of aqueous humor from filtering bleb after trabeculectomy","volume":"133","author":"Matsuo","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0007","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00417-014-2872-3","article-title":"Evaluation of filtering blebs exhibiting transconjunctival oozing using anterior segment optical coherence tomography","volume":"253","author":"Nakashima","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0008","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1007\/s00417-002-0567-7","article-title":"Ultrasound biomicroscopy images: long-term results after deep sclerectomy with collagen implant","volume":"240","author":"Kazakova","year":"2002","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0009","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1097\/IJG.0b013e31829ea2c8","article-title":"Visante anterior segment optical coherence tomography analysis of morphologic changes after deep sclerectomy with intraoperative mitomycin-C and no implant use","volume":"23","author":"P\u00e9rez-Rico","year":"2014","journal-title":"J Glaucoma"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0010","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/BF00190712","article-title":"Histopathology of episcleral fibrosis after trabeculectomy with and without mitomycin C","volume":"234","author":"Mietz","year":"1996","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0011","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00061198-200106000-00017","article-title":"Trabeculectomy, risk factors for failure and the preoperative state of the conjunctiva","volume":"10","author":"Broadway","year":"2001","journal-title":"J Glaucoma"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0012","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0002-9394(83)90026-0","article-title":"Suture lysis by laser and goniolens","volume":"95","author":"Lieberman","year":"1983","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0013","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/bjo.80.7.624","article-title":"Enhancement of post trabeculectomy bleb formation by laser suture lysis","volume":"80","author":"Singh","year":"1996","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0014","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/1120672120901699","article-title":"A standardized protocol of laser suture lysis in postoperative management in trabeculectomy with mitomycin C: One-year study","volume":"31","author":"Mano","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0015","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1034\/j.1600-0420.1999.770324.x","article-title":"A new device for ocular massage after trabeculectomy","volume":"77","author":"Quaranta","year":"1999","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0016","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3129\/i08-006","article-title":"Finger massage versus a novel massage device after trabeculectomy","volume":"43","author":"Gouws","year":"2008","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0017","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0039-6257(03)00038-9","article-title":"Antifibrotics and wound healing in glaucoma surgery","volume":"48","author":"Lama","year":"2003","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0018","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.ophtha.2006.01.062","article-title":"Trabeculectomy with mitomycin C: outcomes and risk factors for failure in phakic open-angle glaucoma","volume":"113","author":"Fontana","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0019","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/bjo.2005.077800","article-title":"Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks","volume":"90","author":"Anand","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0020","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1136\/bjo.2008.140939","article-title":"Nine-year follow-up of trabeculectomy with or without low-dosage mitomycin-c in primary open-angle glaucoma","volume":"92","author":"Reibaldi","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4310258","article-title":"Safety and efficacy of bleb needling with antimetabolite after trabeculectomy failure in glaucoma patients: a systemic review and meta-analysis","volume":"2020","author":"Chen","year":"2020","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0022","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0039-6257(87)90091-9","article-title":"Wound healing in glaucoma filtering surgery","volume":"32","author":"Skuta","year":"1987","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0023","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/IJG.0000000000001226","article-title":"Comparison of efficacy and safety of bleb needle revision with and without 5-fluorouracil for failing trabeculectomy bleb","volume":"28","author":"Kim","year":"2019","journal-title":"J Glaucoma"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0024","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/S0161-6420(96)30403-X","article-title":"Slit-lamp needle revision of failed filtering blebs using mitomycin C","volume":"103","author":"Mardelli","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0025","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1136\/bjo.87.11.1430","article-title":"Late bleb needling","volume":"87","author":"Ung","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0026","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/aos.14452","article-title":"Needling after trabeculectomy\u2014does augmentation by anti-metabolites provide better outcomes and is mitomycin C better than 5-fluoruracil? A systematic review with network meta-analyses","volume":"98","author":"Halili","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0027","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0002-9394(14)72010-0","article-title":"Needle elevation of the scleral flap for failing filtration blebs after trabeculectomy with mitomycin C","volume":"122","author":"Greenfield","year":"1996","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0028","first-page":"915","article-title":"Blunt needle revision with viscoelastic materials via the anterior chamber for early failed filtering blebs after trabeculectomy","volume":"6","author":"Kinoshita","year":"2012","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0029","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0002-9394(01)01232-6","article-title":"Risk factors for failure of 5-fluorouracil needling revision for failed conjunctival filtration blebs","volume":"132","author":"Shin","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0030","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.ophtha.2007.10.023","article-title":"Needling revision of trabeculectomies bleb morphology and long-term survival","volume":"115","author":"Rotchford","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0031","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s004170100275","article-title":"Accumulation of latent transforming growth factor-beta binding protein-1 and TGF beta 1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts","volume":"239","author":"Saika","year":"2001","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0032","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00061198-200204000-00008","article-title":"Effects of tranilast on filtering blebs: a pilot study","volume":"11","author":"Chihara","year":"2002","journal-title":"J Glaucoma"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0033","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1167\/iovs.07-0878","article-title":"Potential role of Rho-associated protein kinase inhibitor Y-27632 in glaucoma filtration surgery","volume":"48","author":"Honjo","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0034","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1034\/j.1600-0420.2003.00069.x","article-title":"Effects of thick Tenon's capsule on primary trabeculectomy with mitomycin-C","volume":"81","author":"Akarsu","year":"2003","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0035","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/j.ophtha.2015.07.028","article-title":"Long-term outcomes of trabeculectomy augmented with mitomycin C undertaken within the first 2 years of life","volume":"122","author":"Jayaram","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0036","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ogla.2018.06.003","article-title":"Treatment outcomes of mitomycin C-augmented trabeculectomy, sub-tenon injection versus soaked sponges, after 3 years of follow-up: a randomized clinical trial","volume":"1","author":"Esfandiari","year":"2018","journal-title":"Ophthalmol Glaucoma"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0037","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ajo.2020.03.002","article-title":"A comparison of trabeculectomy surgery outcomes with mitomycin-C applied by intra-tenon injection versus sponge","volume":"216","author":"Lim","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0038","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1111\/aos.14195","article-title":"Effectiveness of trabeculectomy with mitomycin C for glaucomatous eyes with low intraocular pressure on treatment eye drops","volume":"98","author":"Yuasa","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0039","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ophtha.2008.08.009","article-title":"Long-term outcomes of intraoperative 5-fluorouracil versus intraoperative mitomycin C in primary trabeculectomy surgery","volume":"116","author":"Palanca-Capistrano","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0040","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1016\/j.ophtha.2013.07.049","article-title":"Trabeculectomy in the 21st century: a multicenter analysis","volume":"120","author":"Kirwan","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0041","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/IJG.0b013e3181911271","article-title":"Long-term outcomes of needle revision of trabeculectomy blebs with mitomycin C and 5-fluorouracil: a comparative safety and efficacy report","volume":"18","author":"Anand","year":"2009","journal-title":"J Glaucoma"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0042","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4103\/2008-322X.194150","article-title":"Intraoperative optical coherence tomography guided bleb needling","volume":"11","author":"Dada","year":"2016","journal-title":"J Ophthalmic Vis Res"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0043","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/ceo.12897","article-title":"Classification of needling for trabeculectomy blebs","volume":"45","author":"King","year":"2017","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0044","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1177\/1120672120959548","article-title":"Needling revision with marking maneuver to locate the scleral flap","volume":"31","author":"Guti\u00e9rrez-Ortiz","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00061198-200502000-00009","article-title":"Needle revision of failed filtering blebs using 5-Fluorouracil and a combined ab-externo and ab-interno approach","volume":"14","author":"Pasternack","year":"2005","journal-title":"J Glaucoma"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0046","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0161-6420(01)01016-8","article-title":"Predictors for success of needle revision of failing filtration blebs","volume":"109","author":"Hawkins","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0047","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/1874364101610010068","article-title":"Current and future techniques in wound healing modulation after glaucoma filtering surgeries","volume":"10","author":"Masoumpour","year":"2016","journal-title":"Open Ophthalmol J"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0048","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1083\/jcb.122.1.103","article-title":"Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts","volume":"122","author":"Desmouli\u00e8re","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0049","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exer.2015.03.021","article-title":"Conjunctival fibrosis following filtering glaucoma surgery","volume":"142","author":"Schlunck","year":"2016","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jcjo.2024.08.004_bib0050","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0021-5198(19)32428-X","article-title":"Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages","volume":"60","author":"Suzawa","year":"1992","journal-title":"Jpn J Pharmacol"}],"container-title":["Canadian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418224002497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418224002497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T03:58:22Z","timestamp":1750132702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008418224002497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0008418224002497"],"URL":"https:\/\/doi.org\/10.1016\/j.jcjo.2024.08.004","relation":{},"ISSN":["0008-4182"],"issn-type":[{"value":"0008-4182","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A modified trabeculectomy technique with direct filtration into the Tenon's capsule","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcjo.2024.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of Canadian Ophthalmological Society.","name":"copyright","label":"Copyright"}]}}