{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T22:42:41Z","timestamp":1764628961406,"version":"3.46.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011608","name":"Soci\u00e9t\u00e9 Canadienne de P\u00e9diatrie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["canadianjournalofophthalmology.ca","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jcjo.2025.05.005","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:02:20Z","timestamp":1749168140000},"page":"e851-e857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating drug-induced optic nerve hypoplasia and septo-optic dysplasia from the FDA adverse events database"],"prefix":"10.1016","volume":"60","author":[{"given":"Ayesh","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal O.","family":"Azhari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Gise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5609-7153","authenticated-orcid":false,"given":"Omar","family":"Solyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelrahman M.","family":"Elhusseiny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcjo.2025.05.005_bib0001","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.survophthal.2013.02.004","article-title":"Prenatal determinants of optic nerve hypoplasia: review of suggested correlates and future focus","volume":"58","author":"Garcia-Filion","year":"2013","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijscr.2023.108575","article-title":"The clinical aspects of septo-optic dysplasia: a narrative review with illustrative case report","volume":"109","author":"Al-Salihi","year":"2023","journal-title":"Int J Surg Case Rep"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0003","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/pch\/pxx118","article-title":"Increasing incidence of optic nerve hypoplasia\/septo-optic dysplasia spectrum: geographic clustering in Northern Canada","volume":"22","author":"Khaper","year":"2017","journal-title":"Paediatr Child Health"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0004","series-title":"Canadian Paediatric Surveillance Program 2022 Results","first-page":"30","article-title":"Optic nerve hypoplasia and septo-optic dysplasia","author":"Amed","year":"2023"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/bjo.62.1.3","article-title":"Maternal anticonvulsants and optic nerve hypoplasia","volume":"62","author":"Hoyt","year":"1978","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0006","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1034\/j.1600-0420.2002.800313.x","article-title":"Optic nerve hypoplasia: Risk factors and epidemiology","volume":"80","author":"Tornqvist","year":"2002","journal-title":"Acta Ophthalmol Scand"},{"year":"2002","author":"Lepakhin","series-title":"Safety of medicines: a guide to detecting and reporting adverse drug reactions","key":"10.1016\/j.jcjo.2025.05.005_bib0007"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0008","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7150\/ijms.7967","article-title":"Commonality of drug-associated adverse events detected by 4 commonly used data mining algorithms","volume":"11","author":"Sakaeda","year":"2014","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0009","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2165\/00002018-200225060-00001","article-title":"Use of screening algorithms and computer systems to efficiently signal higher-than-expected combinations of drugs and events in the US FDA\u2019s spontaneous reports database","volume":"25","author":"Szarfman","year":"2002","journal-title":"Drug Saf"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0010","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/pds.677","article-title":"Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports","volume":"10","author":"Evans","year":"2001","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0011","doi-asserted-by":"crossref","DOI":"10.1038\/s41433-025-03808-z","article-title":"Drug-induced tubulointerstitial nephritis and uveitis syndrome in a nationwide surveillance","author":"Ali","year":"2025","journal-title":"Eye (Lond)"},{"unstructured":"Ahmed I, Poncet A. PhViD: an R package for pharmacovigilance signal detection. 2016 [cited 2025 Apr 21]. Available fromhttps:\/\/www.researchgate.net\/publication\/303894843_PhViD_An_R_package_for_PharmacoVigilance_signal_Detection.","key":"10.1016\/j.jcjo.2025.05.005_bib0012"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0013","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ejhg.2009.125","article-title":"Septo-optic dysplasia","volume":"18","author":"Webb","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0014","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/dmcn.15678","article-title":"Risk factors in children with optic nerve hypoplasia and septo-optic dysplasia","volume":"66","author":"Salman","year":"2024","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0015","first-page":"29","article-title":"Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia","volume":"10","author":"Kahn","year":"2017","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104647","article-title":"Prenatal exposure to benzodiazepines and Z-drugs in humans and risk of adverse neurodevelopmental outcomes in offspring: a systematic review","volume":"137","author":"Wang","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0017","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41433-023-02644-3","article-title":"Impaired vision in children prenatally exposed to methadone: an observational cohort study","volume":"38","author":"Hamilton","year":"2024","journal-title":"Eye"},{"doi-asserted-by":"crossref","unstructured":"Benzodiazepines\/opioids. Reactions Weekly 2007;1159:8.","key":"10.1016\/j.jcjo.2025.05.005_bib0018","DOI":"10.2165\/00128415-200711590-00020"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0019","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jaapos.2017.05.025","article-title":"Sensorimotor outcomes in children with prenatal exposure to methadone","volume":"21","author":"Yoo","year":"2017","journal-title":"J AAPOS"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2023.1139378","article-title":"In utero methadone exposure permanently alters anatomical and functional connectivity: a preclinical evaluation","volume":"11","author":"Chin","year":"2023","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0021","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2025.0274","article-title":"Following the developing brain affected by opioid exposure","author":"Madurai","year":"2025","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jcjo.2025.05.005_bib0022","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12916-018-1193-5","article-title":"Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births","volume":"16","author":"Gao","year":"2018","journal-title":"BMC Med"}],"container-title":["Canadian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418225002431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008418225002431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T22:39:59Z","timestamp":1764628799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008418225002431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0008418225002431"],"URL":"https:\/\/doi.org\/10.1016\/j.jcjo.2025.05.005","relation":{},"ISSN":["0008-4182"],"issn-type":[{"type":"print","value":"0008-4182"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating drug-induced optic nerve hypoplasia and septo-optic dysplasia from the FDA adverse events database","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Ophthalmology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcjo.2025.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}