{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:41:41Z","timestamp":1768621301227,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Anesthesia"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jclinane.2016.04.048","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T22:05:47Z","timestamp":1464818747000},"page":"365-372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Effects of remifentanil, nitroglycerin, and sevoflurane on the corrected QT and Tp-e intervals during controlled hypotensive anesthesia"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-015X","authenticated-orcid":false,"given":"Nuran Kavun","family":"\u00c7imen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahad\u0131r","family":"K\u00f6sem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolga","family":"\u00c7imen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyfi","family":"Kartal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fcnyamin","family":"Muslu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safinaz","family":"Karabay\u0131rl\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet","family":"G\u00f6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"K\u0131l\u0131n\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jclinane.2016.04.048_bb0005","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1017\/S0265021502001370","article-title":"Long QT syndrome and anaesthesia","volume":"19","author":"Wisely","year":"2002","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0010","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1213\/00000539-198704000-00015","article-title":"Congenital long QT syndrome: changes in QT interval during anesthesia with thiopental, vecuronium, fentanyl, and isoflurane","volume":"66","author":"Wilton","year":"1987","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jelectrocard.2004.09.001","article-title":"Drug-induced QT dispersion: does it predict the risk of torsade de pointes?","volume":"38","author":"Shah","year":"2005","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0020","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.hrthm.2004.09.011","article-title":"Role of transmural dispersion of repolarization in the genesis of drug-induced torsades de pointes","volume":"2","author":"Antzelevitch","year":"2005","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0025","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0735-1097(03)00713-7","article-title":"Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance","volume":"42","author":"Yan","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0030","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1161\/01.CIR.98.18.1928","article-title":"Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome","volume":"98","author":"Yan","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0035","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/j.1540-8167.1999.tb00287.x","article-title":"The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart","volume":"10","author":"Antzelevitch","year":"1999","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0040","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10877-012-9420-7","article-title":"Differential effects of propofol and sevoflurane on QT interval during anesthetic induction","volume":"27","author":"Oji","year":"2013","journal-title":"J Clin Monit Comput"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0045","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00003643-200503000-00002","article-title":"The effect of inhalational anaesthetics on QTc interval","volume":"22","author":"Karagoz","year":"2005","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0050","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/00003643-200407000-00011","article-title":"The effects of sevoflurane, isoflurane and desflurane on QT interval of the ECG","volume":"21","author":"Yildirim","year":"2004","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0055","first-page":"701","article-title":"Intraoperative torsade de pointes ventricular tachycardia and ventricular fibrillation during sevoflurane anesthesia","volume":"86","author":"Abe","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0060","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3349\/ymj.2011.52.2.333","article-title":"The effects of a single bolus of remifentanil on corrected QT interval change during sevoflurane induction","volume":"52","author":"Kim","year":"2011","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0065","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/CIRCEP.110.960658","article-title":"Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death","volume":"4","author":"Panikkath","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0070","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/bja\/aet412","article-title":"Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity","volume":"112","author":"Staikou","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0075","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/ALN.0b013e3181f26d34","article-title":"Modeling the effect of sevoflurane on corrected QT prolongation: a pharmacodynamic analysis","volume":"113","author":"Han","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0080","first-page":"105","article-title":"Torsade de pointes during sevoflurane anesthesia and fluconazole infusion in a patient with long QT syndrome. A case report","volume":"62","author":"Tacken","year":"2011","journal-title":"Acta Anaesthesiol Belg"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0085","first-page":"1090","article-title":"Torsade de pointes (TdP) observed during general anesthesia for cerebral aneurysm clipping in a patient with QT prolongation","volume":"60","author":"Tajiri","year":"2011","journal-title":"Masui"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0090","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4097\/kjae.2014.66.1.80","article-title":"Torsade de pointes in liver transplantation recipient after induction of general anesthesia: a case report","volume":"66","author":"Chung","year":"2014","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0095","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1213\/01.ane.0000252417.23986.6e","article-title":"A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children","volume":"104","author":"Whyte","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1213\/01.ANE.0000140781.18391.41","article-title":"The effects of propofol and sevoflurane on the QT interval and transmural dispersion of repolarization in children","volume":"100","author":"Whyte","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0105","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1213\/ANE.0b013e3181cde713","article-title":"Sevoflurane causes greater QTc interval prolongation in elderly patients than in younger patients","volume":"110","author":"Nakao","year":"2010","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0110","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S1607-551X(10)70074-7","article-title":"Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals","volume":"26","author":"Hanci","year":"2010","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00000539-200001000-00006","article-title":"Sevoflurane, but not propofol, significantly prolongs the Q-T interval","volume":"90","author":"Kleinsasser","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0120","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2044.2007.05372.x","article-title":"The effect of bolus administration of remifentanil on QTc interval during induction of sevoflurane anaesthesia","volume":"63","author":"Kweon","year":"2008","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0125","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2143\/AC.60.5.2004964","article-title":"Comparison of the effects of desflurane and sevoflurane on the QTc interval and QT dispersion","volume":"60","author":"Silay","year":"2005","journal-title":"Acta Cardiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0971-9784.51361","article-title":"A comparison of the effects of desflurane, sevoflurane and propofol on QT, QTc, and P dispersion on ECG","volume":"12","author":"Kazanci","year":"2009","journal-title":"Ann Card Anaesth"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0135","series-title":"Investigative electrocardiography in epidemiological studies and clinical trials","first-page":"201","author":"Rautaharju","year":"2007"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0140","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jelectrocard.2008.07.016","article-title":"T(p-e)\/QT ratio as an index of arrhythmogenesis","volume":"41","author":"Gupta","year":"2008","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0145","first-page":"160","article-title":"QT interval and QT dispersion during the induction of anesthesia and tracheal intubation: a comparison of remifentanil and fentanyl","volume":"77","author":"Cafiero","year":"2011","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0150","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/bja\/80.6.800","article-title":"Synergistic antinociceptive interaction between sevoflurane and intrathecal fentanyl in dogs","volume":"80","author":"Ma","year":"1998","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0155","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0002-9149(74)90610-9","article-title":"Beneficial electrophysiologic effects of nitroglycerin during acute myocardial infarction","volume":"33","author":"Kent","year":"1974","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0160","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/01.CIR.52.6.1050","article-title":"Electrophysiologic effects of nitroglycerin during experimental coronary occlusion","volume":"52","author":"Levites","year":"1975","journal-title":"Circulation"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0165","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/00005344-198109000-00001","article-title":"Electrophysiologic and antiarrhythmic effects of nitroglycerin in man","volume":"3","author":"Hoelzer","year":"1981","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jclinane.2016.04.048_bb0170","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0002-9149(96)00468-7","article-title":"Evaluation of five QT correction formulas using a software-assisted method of continuous QT measurement from 24-hour Holter recordings","volume":"78","author":"Molnar","year":"1996","journal-title":"Am J Cardiol"}],"container-title":["Journal of Clinical Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095281801630160X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095281801630160X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:09:23Z","timestamp":1760605763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095281801630160X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":34,"alternative-id":["S095281801630160X"],"URL":"https:\/\/doi.org\/10.1016\/j.jclinane.2016.04.048","relation":{},"ISSN":["0952-8180"],"issn-type":[{"value":"0952-8180","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of remifentanil, nitroglycerin, and sevoflurane on the corrected QT and Tp-e intervals during controlled hypotensive anesthesia","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jclinane.2016.04.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}